Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QI23_LEIMA

TriTrypDb:

LmjF.09.0110 , LMJLV39_090006400 , LMJSD75_090006400

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QI23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.491
CLV_NRD_NRD_1	119	121	PF00675	0.520
CLV_NRD_NRD_1	136	138	PF00675	0.521
CLV_NRD_NRD_1	189	191	PF00675	0.448
CLV_NRD_NRD_1	192	194	PF00675	0.430
CLV_NRD_NRD_1	215	217	PF00675	0.490
CLV_NRD_NRD_1	25	27	PF00675	0.364
CLV_NRD_NRD_1	278	280	PF00675	0.397
CLV_NRD_NRD_1	305	307	PF00675	0.467
CLV_NRD_NRD_1	325	327	PF00675	0.401
CLV_NRD_NRD_1	332	334	PF00675	0.382
CLV_NRD_NRD_1	422	424	PF00675	0.368
CLV_NRD_NRD_1	427	429	PF00675	0.362
CLV_NRD_NRD_1	441	443	PF00675	0.357
CLV_NRD_NRD_1	533	535	PF00675	0.370
CLV_NRD_NRD_1	582	584	PF00675	0.796
CLV_NRD_NRD_1	657	659	PF00675	0.610
CLV_NRD_NRD_1	689	691	PF00675	0.527
CLV_NRD_NRD_1	96	98	PF00675	0.426
CLV_PCSK_FUR_1	190	194	PF00082	0.508
CLV_PCSK_KEX2_1	119	121	PF00082	0.541
CLV_PCSK_KEX2_1	136	138	PF00082	0.491
CLV_PCSK_KEX2_1	189	191	PF00082	0.409
CLV_PCSK_KEX2_1	192	194	PF00082	0.399
CLV_PCSK_KEX2_1	215	217	PF00082	0.490
CLV_PCSK_KEX2_1	25	27	PF00082	0.364
CLV_PCSK_KEX2_1	278	280	PF00082	0.599
CLV_PCSK_KEX2_1	325	327	PF00082	0.397
CLV_PCSK_KEX2_1	331	333	PF00082	0.374
CLV_PCSK_KEX2_1	427	429	PF00082	0.374
CLV_PCSK_KEX2_1	440	442	PF00082	0.368
CLV_PCSK_KEX2_1	533	535	PF00082	0.371
CLV_PCSK_KEX2_1	582	584	PF00082	0.796
CLV_PCSK_KEX2_1	657	659	PF00082	0.610
CLV_PCSK_KEX2_1	95	97	PF00082	0.400
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.386
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.413
CLV_PCSK_PC7_1	423	429	PF00082	0.468
CLV_PCSK_SKI1_1	366	370	PF00082	0.568
CLV_PCSK_SKI1_1	418	422	PF00082	0.327
CLV_PCSK_SKI1_1	424	428	PF00082	0.328
CLV_PCSK_SKI1_1	472	476	PF00082	0.335
CLV_PCSK_SKI1_1	82	86	PF00082	0.476
CLV_Separin_Metazoa	32	36	PF03568	0.344
DEG_APCC_DBOX_1	148	156	PF00400	0.431
DEG_APCC_DBOX_1	487	495	PF00400	0.565
DEG_COP1_1	623	633	PF00400	0.613
DEG_SPOP_SBC_1	203	207	PF00917	0.478
DEG_SPOP_SBC_1	585	589	PF00917	0.509
DEG_SPOP_SBC_1	612	616	PF00917	0.596
DOC_CKS1_1	381	386	PF01111	0.457
DOC_CYCLIN_RxL_1	330	338	PF00134	0.507
DOC_CYCLIN_RxL_1	76	89	PF00134	0.470
DOC_MAPK_gen_1	170	180	PF00069	0.522
DOC_MAPK_gen_1	25	33	PF00069	0.396
DOC_MAPK_gen_1	304	313	PF00069	0.531
DOC_MAPK_gen_1	331	337	PF00069	0.507
DOC_MAPK_gen_1	427	436	PF00069	0.345
DOC_MAPK_JIP1_4	307	313	PF00069	0.458
DOC_MAPK_MEF2A_6	173	182	PF00069	0.391
DOC_PP1_RVXF_1	225	231	PF00149	0.396
DOC_PP1_RVXF_1	416	423	PF00149	0.324
DOC_PP4_FxxP_1	509	512	PF00568	0.459
DOC_USP7_MATH_1	171	175	PF00917	0.354
DOC_USP7_MATH_1	202	206	PF00917	0.508
DOC_USP7_MATH_1	223	227	PF00917	0.524
DOC_USP7_MATH_1	458	462	PF00917	0.619
DOC_USP7_MATH_1	50	54	PF00917	0.546
DOC_USP7_MATH_1	553	557	PF00917	0.496
DOC_USP7_MATH_1	578	582	PF00917	0.792
DOC_USP7_MATH_1	585	589	PF00917	0.789
DOC_USP7_MATH_1	65	69	PF00917	0.455
DOC_USP7_MATH_1	669	673	PF00917	0.738
DOC_USP7_MATH_1	683	687	PF00917	0.491
DOC_USP7_MATH_1	702	706	PF00917	0.541
DOC_USP7_UBL2_3	366	370	PF12436	0.575
DOC_WW_Pin1_4	105	110	PF00397	0.614
DOC_WW_Pin1_4	215	220	PF00397	0.571
DOC_WW_Pin1_4	344	349	PF00397	0.454
DOC_WW_Pin1_4	380	385	PF00397	0.550
DOC_WW_Pin1_4	560	565	PF00397	0.583
DOC_WW_Pin1_4	633	638	PF00397	0.553
LIG_14-3-3_CanoR_1	173	179	PF00244	0.624
LIG_14-3-3_CanoR_1	297	305	PF00244	0.520
LIG_14-3-3_CanoR_1	5	13	PF00244	0.592
LIG_14-3-3_CanoR_1	567	572	PF00244	0.538
LIG_14-3-3_CanoR_1	624	631	PF00244	0.496
LIG_14-3-3_CanoR_1	66	75	PF00244	0.638
LIG_14-3-3_CanoR_1	682	688	PF00244	0.569
LIG_14-3-3_CterR_2	708	712	PF00244	0.458
LIG_APCC_ABBA_1	501	506	PF00400	0.529
LIG_APCC_ABBA_1	52	57	PF00400	0.373
LIG_APCC_ABBAyCdc20_2	251	257	PF00400	0.418
LIG_APCC_Cbox_2	481	487	PF00515	0.327
LIG_BIR_II_1	1	5	PF00653	0.497
LIG_BIR_III_2	515	519	PF00653	0.415
LIG_FHA_1	341	347	PF00498	0.422
LIG_FHA_1	385	391	PF00498	0.636
LIG_FHA_1	553	559	PF00498	0.540
LIG_FHA_1	650	656	PF00498	0.616
LIG_FHA_2	119	125	PF00498	0.519
LIG_FHA_2	146	152	PF00498	0.426
LIG_FHA_2	493	499	PF00498	0.452
LIG_FHA_2	587	593	PF00498	0.643
LIG_LIR_Apic_2	302	308	PF02991	0.546
LIG_LIR_Apic_2	506	512	PF02991	0.441
LIG_LIR_Apic_2	540	545	PF02991	0.411
LIG_LIR_Apic_2	559	564	PF02991	0.457
LIG_LIR_Apic_2	605	611	PF02991	0.621
LIG_LIR_Apic_2	686	692	PF02991	0.462
LIG_LIR_Gen_1	18	27	PF02991	0.439
LIG_LIR_Gen_1	461	471	PF02991	0.479
LIG_LIR_Gen_1	620	630	PF02991	0.496
LIG_LIR_Nem_3	18	22	PF02991	0.444
LIG_LIR_Nem_3	620	625	PF02991	0.496
LIG_Pex14_1	543	547	PF04695	0.552
LIG_Pex14_2	604	608	PF04695	0.618
LIG_RPA_C_Fungi	115	127	PF08784	0.393
LIG_SH2_CRK	305	309	PF00017	0.657
LIG_SH2_CRK	695	699	PF00017	0.473
LIG_SH2_NCK_1	547	551	PF00017	0.447
LIG_SH2_STAP1	224	228	PF00017	0.391
LIG_SH2_STAP1	255	259	PF00017	0.448
LIG_SH2_STAP1	55	59	PF00017	0.404
LIG_SH2_STAP1	651	655	PF00017	0.477
LIG_SH2_STAT3	239	242	PF00017	0.482
LIG_SH2_STAT3	639	642	PF00017	0.468
LIG_SH2_STAT5	19	22	PF00017	0.442
LIG_SH2_STAT5	262	265	PF00017	0.654
LIG_SH2_STAT5	464	467	PF00017	0.489
LIG_SH2_STAT5	639	642	PF00017	0.563
LIG_SH2_STAT5	651	654	PF00017	0.477
LIG_SH3_3	103	109	PF00018	0.534
LIG_SH3_3	44	50	PF00018	0.403
LIG_SH3_3	462	468	PF00018	0.609
LIG_SH3_3	504	510	PF00018	0.476
LIG_SH3_3	659	665	PF00018	0.499
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.398
LIG_SUMO_SIM_par_1	651	656	PF11976	0.475
LIG_TRAF2_1	495	498	PF00917	0.390
LIG_TRAF2_1	626	629	PF00917	0.487
LIG_TYR_ITIM	17	22	PF00017	0.444
LIG_TYR_ITIM	693	698	PF00017	0.472
LIG_WRC_WIRS_1	262	267	PF05994	0.399
MOD_CDK_SPxxK_3	344	351	PF00069	0.445
MOD_CDK_SPxxK_3	560	567	PF00069	0.736
MOD_CK1_1	118	124	PF00069	0.486
MOD_CK1_1	153	159	PF00069	0.491
MOD_CK1_1	174	180	PF00069	0.356
MOD_CK1_1	206	212	PF00069	0.466
MOD_CK1_1	270	276	PF00069	0.405
MOD_CK1_1	312	318	PF00069	0.515
MOD_CK1_1	321	327	PF00069	0.367
MOD_CK1_1	347	353	PF00069	0.503
MOD_CK1_1	492	498	PF00069	0.361
MOD_CK1_1	556	562	PF00069	0.494
MOD_CK1_1	563	569	PF00069	0.534
MOD_CK1_1	570	576	PF00069	0.617
MOD_CK1_1	588	594	PF00069	0.489
MOD_CK1_1	620	626	PF00069	0.528
MOD_CK1_1	632	638	PF00069	0.503
MOD_CK1_1	681	687	PF00069	0.574
MOD_CK2_1	145	151	PF00069	0.507
MOD_CK2_1	223	229	PF00069	0.395
MOD_CK2_1	492	498	PF00069	0.378
MOD_CK2_1	586	592	PF00069	0.671
MOD_CK2_1	623	629	PF00069	0.593
MOD_Cter_Amidation	23	26	PF01082	0.418
MOD_GlcNHglycan	155	158	PF01048	0.586
MOD_GlcNHglycan	172	176	PF01048	0.489
MOD_GlcNHglycan	208	211	PF01048	0.570
MOD_GlcNHglycan	212	215	PF01048	0.641
MOD_GlcNHglycan	221	224	PF01048	0.530
MOD_GlcNHglycan	269	272	PF01048	0.369
MOD_GlcNHglycan	373	376	PF01048	0.617
MOD_GlcNHglycan	402	405	PF01048	0.515
MOD_GlcNHglycan	407	410	PF01048	0.604
MOD_GlcNHglycan	461	464	PF01048	0.552
MOD_GlcNHglycan	578	581	PF01048	0.717
MOD_GlcNHglycan	631	634	PF01048	0.555
MOD_GlcNHglycan	683	686	PF01048	0.569
MOD_GlcNHglycan	698	701	PF01048	0.549
MOD_GlcNHglycan	709	712	PF01048	0.553
MOD_GSK3_1	105	112	PF00069	0.691
MOD_GSK3_1	174	181	PF00069	0.377
MOD_GSK3_1	202	209	PF00069	0.446
MOD_GSK3_1	215	222	PF00069	0.568
MOD_GSK3_1	270	277	PF00069	0.379
MOD_GSK3_1	296	303	PF00069	0.563
MOD_GSK3_1	340	347	PF00069	0.647
MOD_GSK3_1	371	378	PF00069	0.699
MOD_GSK3_1	380	387	PF00069	0.553
MOD_GSK3_1	552	559	PF00069	0.598
MOD_GSK3_1	563	570	PF00069	0.508
MOD_GSK3_1	574	581	PF00069	0.532
MOD_GSK3_1	584	591	PF00069	0.788
MOD_GSK3_1	611	618	PF00069	0.526
MOD_GSK3_1	629	636	PF00069	0.453
MOD_GSK3_1	649	656	PF00069	0.511
MOD_GSK3_1	664	671	PF00069	0.511
MOD_GSK3_1	681	688	PF00069	0.502
MOD_GSK3_1	696	703	PF00069	0.481
MOD_GSK3_1	7	14	PF00069	0.484
MOD_NEK2_1	261	266	PF00069	0.486
MOD_NEK2_1	296	301	PF00069	0.488
MOD_NEK2_1	405	410	PF00069	0.451
MOD_NEK2_1	617	622	PF00069	0.560
MOD_NEK2_2	309	314	PF00069	0.449
MOD_NEK2_2	446	451	PF00069	0.484
MOD_NEK2_2	50	55	PF00069	0.393
MOD_PIKK_1	377	383	PF00454	0.520
MOD_PIKK_1	571	577	PF00454	0.732
MOD_PIKK_1	623	629	PF00454	0.542
MOD_PKA_2	118	124	PF00069	0.591
MOD_PKA_2	159	165	PF00069	0.442
MOD_PKA_2	296	302	PF00069	0.536
MOD_PKA_2	375	381	PF00069	0.534
MOD_PKA_2	400	406	PF00069	0.404
MOD_PKA_2	459	465	PF00069	0.535
MOD_PKA_2	556	562	PF00069	0.496
MOD_PKA_2	623	629	PF00069	0.616
MOD_PKA_2	65	71	PF00069	0.440
MOD_PKA_2	663	669	PF00069	0.693
MOD_PKA_2	681	687	PF00069	0.570
MOD_PKB_1	560	568	PF00069	0.470
MOD_PKB_1	694	702	PF00069	0.464
MOD_Plk_1	178	184	PF00069	0.610
MOD_Plk_1	446	452	PF00069	0.450
MOD_Plk_1	492	498	PF00069	0.371
MOD_Plk_1	50	56	PF00069	0.382
MOD_Plk_4	309	315	PF00069	0.584
MOD_Plk_4	50	56	PF00069	0.389
MOD_Plk_4	635	641	PF00069	0.525
MOD_Plk_4	644	650	PF00069	0.535
MOD_ProDKin_1	105	111	PF00069	0.613
MOD_ProDKin_1	215	221	PF00069	0.568
MOD_ProDKin_1	344	350	PF00069	0.451
MOD_ProDKin_1	380	386	PF00069	0.552
MOD_ProDKin_1	560	566	PF00069	0.584
MOD_ProDKin_1	633	639	PF00069	0.554
MOD_SUMO_for_1	48	51	PF00179	0.376
TRG_DiLeu_BaEn_1	29	34	PF01217	0.337
TRG_DiLeu_BaEn_1	416	421	PF01217	0.372
TRG_DiLeu_BaEn_4	431	437	PF01217	0.357
TRG_ENDOCYTIC_2	19	22	PF00928	0.473
TRG_ENDOCYTIC_2	262	265	PF00928	0.580
TRG_ENDOCYTIC_2	464	467	PF00928	0.489
TRG_ENDOCYTIC_2	695	698	PF00928	0.473
TRG_ER_diArg_1	136	139	PF00400	0.391
TRG_ER_diArg_1	189	192	PF00400	0.441
TRG_ER_diArg_1	215	217	PF00400	0.502
TRG_ER_diArg_1	25	27	PF00400	0.359
TRG_ER_diArg_1	278	280	PF00400	0.591
TRG_ER_diArg_1	325	327	PF00400	0.507
TRG_ER_diArg_1	331	333	PF00400	0.509
TRG_ER_diArg_1	398	401	PF00400	0.419
TRG_ER_diArg_1	440	442	PF00400	0.437
TRG_ER_diArg_1	533	536	PF00400	0.388
TRG_NLS_Bipartite_1	81	99	PF00514	0.364
TRG_NLS_MonoExtN_4	366	373	PF00514	0.467
TRG_NLS_MonoExtN_4	93	99	PF00514	0.339
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	333	338	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHI3	Leptomonas seymouri	54%	97%
A0A0S4JTQ5	Bodo saltans	29%	94%
A0A1X0NN57	Trypanosomatidae	35%	100%
A0A3R7NK16	Trypanosoma rangeli	37%	100%
A0A3S5H6B0	Leishmania donovani	93%	100%
A4H5I9	Leishmania braziliensis	74%	100%
A4HTT0	Leishmania infantum	93%	100%
D0A991	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ALI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AML3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BSF1	Trypanosoma cruzi	37%	100%