Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NRDE protein, putative

Species:

Leishmania major

UniProt:

Q4QI06_LEIMA

TriTrypDb:

LmjF.09.0200 , LMJLV39_090007400 , LMJSD75_090007100

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QI06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.442
CLV_NRD_NRD_1	233	235	PF00675	0.569
CLV_NRD_NRD_1	47	49	PF00675	0.424
CLV_NRD_NRD_1	70	72	PF00675	0.394
CLV_PCSK_KEX2_1	233	235	PF00082	0.569
CLV_PCSK_KEX2_1	47	49	PF00082	0.453
CLV_PCSK_KEX2_1	70	72	PF00082	0.394
CLV_PCSK_SKI1_1	172	176	PF00082	0.456
CLV_PCSK_SKI1_1	208	212	PF00082	0.517
CLV_PCSK_SKI1_1	356	360	PF00082	0.567
DEG_APCC_DBOX_1	207	215	PF00400	0.516
DEG_Nend_UBRbox_4	1	3	PF02207	0.337
DEG_SPOP_SBC_1	319	323	PF00917	0.692
DEG_SPOP_SBC_1	455	459	PF00917	0.445
DOC_PP2B_LxvP_1	215	218	PF13499	0.578
DOC_PP2B_PxIxI_1	14	20	PF00149	0.437
DOC_PP4_FxxP_1	349	352	PF00568	0.559
DOC_PP4_FxxP_1	421	424	PF00568	0.530
DOC_SPAK_OSR1_1	62	66	PF12202	0.337
DOC_USP7_MATH_1	148	152	PF00917	0.757
DOC_USP7_MATH_1	239	243	PF00917	0.716
DOC_USP7_MATH_1	443	447	PF00917	0.650
DOC_USP7_MATH_1	49	53	PF00917	0.343
DOC_USP7_MATH_1	501	505	PF00917	0.736
DOC_WW_Pin1_4	184	189	PF00397	0.671
DOC_WW_Pin1_4	324	329	PF00397	0.572
DOC_WW_Pin1_4	372	377	PF00397	0.414
DOC_WW_Pin1_4	497	502	PF00397	0.702
DOC_WW_Pin1_4	69	74	PF00397	0.394
LIG_14-3-3_CanoR_1	100	110	PF00244	0.608
LIG_14-3-3_CanoR_1	431	436	PF00244	0.336
LIG_Actin_WH2_2	480	497	PF00022	0.501
LIG_BRCT_BRCA1_1	400	404	PF00533	0.670
LIG_BRCT_BRCA1_1	417	421	PF00533	0.516
LIG_BRCT_BRCA1_1	59	63	PF00533	0.394
LIG_eIF4E_1	221	227	PF01652	0.533
LIG_FHA_1	121	127	PF00498	0.645
LIG_FHA_1	154	160	PF00498	0.715
LIG_FHA_1	175	181	PF00498	0.591
LIG_FHA_1	28	34	PF00498	0.337
LIG_FHA_1	294	300	PF00498	0.515
LIG_FHA_1	302	308	PF00498	0.496
LIG_FHA_1	321	327	PF00498	0.426
LIG_FHA_1	37	43	PF00498	0.328
LIG_FHA_1	455	461	PF00498	0.563
LIG_FHA_1	472	478	PF00498	0.576
LIG_FHA_2	138	144	PF00498	0.749
LIG_FHA_2	190	196	PF00498	0.773
LIG_FHA_2	379	385	PF00498	0.641
LIG_FHA_2	80	86	PF00498	0.557
LIG_LIR_Apic_2	158	164	PF02991	0.704
LIG_LIR_Apic_2	418	424	PF02991	0.525
LIG_LIR_Nem_3	12	17	PF02991	0.321
LIG_LIR_Nem_3	52	56	PF02991	0.318
LIG_LIR_Nem_3	60	66	PF02991	0.318
LIG_PAM2_1	101	113	PF00658	0.591
LIG_Pex14_2	421	425	PF04695	0.535
LIG_SH2_CRK	161	165	PF00017	0.722
LIG_SH2_CRK	485	489	PF00017	0.514
LIG_SH2_NCK_1	161	165	PF00017	0.685
LIG_SH2_SRC	161	164	PF00017	0.685
LIG_SH2_STAT5	261	264	PF00017	0.497
LIG_SH2_STAT5	286	289	PF00017	0.507
LIG_SH2_STAT5	388	391	PF00017	0.670
LIG_SH2_STAT5	415	418	PF00017	0.459
LIG_SH3_1	70	76	PF00018	0.437
LIG_SH3_3	129	135	PF00018	0.546
LIG_SH3_3	270	276	PF00018	0.576
LIG_SH3_3	307	313	PF00018	0.523
LIG_SH3_3	475	481	PF00018	0.473
LIG_SH3_3	70	76	PF00018	0.358
LIG_SUMO_SIM_par_1	434	439	PF11976	0.398
LIG_TYR_ITIM	483	488	PF00017	0.464
LIG_WW_1	218	221	PF00397	0.609
MOD_CK1_1	204	210	PF00069	0.699
MOD_CK1_1	249	255	PF00069	0.752
MOD_CK1_1	321	327	PF00069	0.625
MOD_CK1_1	454	460	PF00069	0.537
MOD_CK1_1	497	503	PF00069	0.530
MOD_CK2_1	137	143	PF00069	0.743
MOD_CK2_1	189	195	PF00069	0.697
MOD_CK2_1	357	363	PF00069	0.575
MOD_CK2_1	378	384	PF00069	0.612
MOD_GlcNHglycan	202	206	PF01048	0.726
MOD_GlcNHglycan	248	251	PF01048	0.759
MOD_GlcNHglycan	252	255	PF01048	0.685
MOD_GlcNHglycan	323	326	PF01048	0.650
MOD_GlcNHglycan	359	362	PF01048	0.556
MOD_GlcNHglycan	391	394	PF01048	0.662
MOD_GlcNHglycan	453	456	PF01048	0.673
MOD_GlcNHglycan	496	499	PF01048	0.656
MOD_GlcNHglycan	59	62	PF01048	0.394
MOD_GlcNHglycan	79	82	PF01048	0.422
MOD_GSK3_1	246	253	PF00069	0.771
MOD_GSK3_1	27	34	PF00069	0.424
MOD_GSK3_1	320	327	PF00069	0.597
MOD_GSK3_1	329	336	PF00069	0.471
MOD_GSK3_1	427	434	PF00069	0.393
MOD_GSK3_1	451	458	PF00069	0.662
MOD_GSK3_1	497	504	PF00069	0.707
MOD_GSK3_1	75	82	PF00069	0.559
MOD_GSK3_1	98	105	PF00069	0.723
MOD_LATS_1	244	250	PF00433	0.775
MOD_N-GLC_1	250	255	PF02516	0.699
MOD_N-GLC_2	145	147	PF02516	0.572
MOD_NEK2_1	174	179	PF00069	0.574
MOD_NEK2_1	201	206	PF00069	0.744
MOD_NEK2_1	260	265	PF00069	0.473
MOD_NEK2_1	282	287	PF00069	0.434
MOD_NEK2_1	35	40	PF00069	0.474
MOD_NEK2_1	354	359	PF00069	0.592
MOD_NEK2_1	389	394	PF00069	0.654
MOD_NEK2_1	416	421	PF00069	0.459
MOD_NEK2_1	453	458	PF00069	0.442
MOD_NEK2_1	77	82	PF00069	0.709
MOD_PIKK_1	471	477	PF00454	0.585
MOD_PK_1	466	472	PF00069	0.354
MOD_PKA_2	27	33	PF00069	0.361
MOD_PKA_2	494	500	PF00069	0.656
MOD_Plk_1	354	360	PF00069	0.575
MOD_Plk_1	398	404	PF00069	0.680
MOD_Plk_1	466	472	PF00069	0.448
MOD_Plk_4	121	127	PF00069	0.664
MOD_Plk_4	282	288	PF00069	0.447
MOD_Plk_4	416	422	PF00069	0.439
MOD_Plk_4	431	437	PF00069	0.284
MOD_Plk_4	456	462	PF00069	0.433
MOD_Plk_4	49	55	PF00069	0.318
MOD_ProDKin_1	184	190	PF00069	0.674
MOD_ProDKin_1	324	330	PF00069	0.568
MOD_ProDKin_1	372	378	PF00069	0.418
MOD_ProDKin_1	497	503	PF00069	0.705
MOD_ProDKin_1	69	75	PF00069	0.394
MOD_SUMO_for_1	352	355	PF00179	0.575
TRG_DiLeu_BaEn_2	11	17	PF01217	0.437
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.586
TRG_ENDOCYTIC_2	221	224	PF00928	0.457
TRG_ENDOCYTIC_2	485	488	PF00928	0.491
TRG_ER_diArg_1	232	234	PF00400	0.552
TRG_NES_CRM1_1	24	36	PF08389	0.431
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R3	Leptomonas seymouri	45%	100%
A0A1X0NNG0	Trypanosomatidae	33%	100%
A0A3R7K8K9	Trypanosoma rangeli	33%	100%
A0A3S5H6B6	Leishmania donovani	92%	100%
A4HTT8	Leishmania infantum	92%	100%
E9AML9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BMV9	Trypanosoma cruzi	33%	100%