Sperm-tail PG-rich repeat-containing protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4586), putative

Species:

Leishmania major

UniProt:

Q4QI05_LEIMA

TriTrypDb:

LmjF.09.0210 , LMJLV39_090007500 , LMJSD75_090007200

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	20
GO:0005815	microtubule organizing center	2	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

Q4QI05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.296
CLV_NRD_NRD_1	178	180	PF00675	0.304
CLV_NRD_NRD_1	236	238	PF00675	0.304
CLV_PCSK_KEX2_1	16	18	PF00082	0.234
CLV_PCSK_KEX2_1	173	175	PF00082	0.296
CLV_PCSK_KEX2_1	185	187	PF00082	0.274
CLV_PCSK_KEX2_1	221	223	PF00082	0.280
CLV_PCSK_KEX2_1	34	36	PF00082	0.219
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.234
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.226
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.280
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.219
CLV_PCSK_SKI1_1	174	178	PF00082	0.261
DEG_Nend_Nbox_1	1	3	PF02207	0.409
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.476
DOC_PP4_FxxP_1	2	5	PF00568	0.433
DOC_PP4_FxxP_1	61	64	PF00568	0.473
DOC_USP7_MATH_1	190	194	PF00917	0.453
DOC_USP7_MATH_1	229	233	PF00917	0.527
DOC_USP7_MATH_1	46	50	PF00917	0.476
DOC_USP7_MATH_1	55	59	PF00917	0.473
DOC_USP7_MATH_1	67	71	PF00917	0.419
DOC_USP7_UBL2_3	95	99	PF12436	0.500
DOC_WW_Pin1_4	186	191	PF00397	0.470
DOC_WW_Pin1_4	220	225	PF00397	0.380
LIG_14-3-3_CanoR_1	222	230	PF00244	0.470
LIG_AP2alpha_2	45	47	PF02296	0.410
LIG_BRCT_BRCA1_1	57	61	PF00533	0.513
LIG_CSL_BTD_1	239	242	PF09270	0.513
LIG_CSL_BTD_1	280	283	PF09270	0.433
LIG_FHA_1	182	188	PF00498	0.530
LIG_FHA_1	213	219	PF00498	0.461
LIG_FHA_1	292	298	PF00498	0.493
LIG_FHA_2	103	109	PF00498	0.409
LIG_FHA_2	121	127	PF00498	0.482
LIG_LIR_Apic_2	58	64	PF02991	0.414
LIG_LIR_Gen_1	45	55	PF02991	0.443
LIG_LIR_Nem_3	101	106	PF02991	0.436
LIG_LIR_Nem_3	115	121	PF02991	0.427
LIG_LIR_Nem_3	147	153	PF02991	0.423
LIG_LIR_Nem_3	287	292	PF02991	0.475
LIG_LIR_Nem_3	41	47	PF02991	0.450
LIG_LIR_Nem_3	54	59	PF02991	0.346
LIG_Pex14_2	61	65	PF04695	0.476
LIG_SH2_CRK	150	154	PF00017	0.451
LIG_SH2_CRK	289	293	PF00017	0.512
LIG_SH2_CRK	299	303	PF00017	0.436
LIG_SH2_CRK	56	60	PF00017	0.513
LIG_SH2_NCK_1	299	303	PF00017	0.469
LIG_SH2_NCK_1	56	60	PF00017	0.390
LIG_SH2_SRC	299	302	PF00017	0.538
LIG_SH2_STAT5	150	153	PF00017	0.464
LIG_SH2_STAT5	163	166	PF00017	0.429
LIG_SH2_STAT5	291	294	PF00017	0.524
LIG_SH2_STAT5	56	59	PF00017	0.390
LIG_SH2_STAT5	7	10	PF00017	0.436
LIG_SH3_2	217	222	PF14604	0.408
LIG_SH3_3	137	143	PF00018	0.467
LIG_SH3_3	161	167	PF00018	0.455
LIG_SH3_3	214	220	PF00018	0.405
LIG_SH3_3	236	242	PF00018	0.457
LIG_SH3_3	277	283	PF00018	0.434
LIG_SH3_3	83	89	PF00018	0.415
LIG_WRC_WIRS_1	103	108	PF05994	0.409
LIG_WRPW_2	278	281	PF00400	0.433
LIG_WW_1	4	7	PF00397	0.500
MOD_CDC14_SPxK_1	189	192	PF00782	0.410
MOD_CDK_SPxK_1	186	192	PF00069	0.410
MOD_CK1_1	223	229	PF00069	0.491
MOD_CK1_1	93	99	PF00069	0.463
MOD_CK2_1	102	108	PF00069	0.409
MOD_Cter_Amidation	235	238	PF01082	0.252
MOD_GlcNHglycan	192	195	PF01048	0.269
MOD_GlcNHglycan	196	199	PF01048	0.237
MOD_GlcNHglycan	231	234	PF01048	0.342
MOD_GlcNHglycan	31	34	PF01048	0.296
MOD_GlcNHglycan	69	72	PF01048	0.239
MOD_GlcNHglycan	79	82	PF01048	0.333
MOD_GlcNHglycan	96	99	PF01048	0.140
MOD_GSK3_1	144	151	PF00069	0.456
MOD_GSK3_1	186	193	PF00069	0.505
MOD_GSK3_1	72	79	PF00069	0.535
MOD_GSK3_1	90	97	PF00069	0.405
MOD_N-GLC_1	67	72	PF02516	0.320
MOD_NEK2_1	201	206	PF00069	0.462
MOD_NEK2_1	29	34	PF00069	0.511
MOD_PIKK_1	223	229	PF00454	0.485
MOD_PKA_1	144	150	PF00069	0.421
MOD_PKA_1	94	100	PF00069	0.506
MOD_Plk_1	274	280	PF00069	0.440
MOD_Plk_1	40	46	PF00069	0.513
MOD_ProDKin_1	186	192	PF00069	0.470
MOD_ProDKin_1	220	226	PF00069	0.380
MOD_SUMO_rev_2	259	268	PF00179	0.485
TRG_ENDOCYTIC_2	103	106	PF00928	0.452
TRG_ENDOCYTIC_2	150	153	PF00928	0.449
TRG_ENDOCYTIC_2	289	292	PF00928	0.484
TRG_ENDOCYTIC_2	56	59	PF00928	0.433
TRG_ENDOCYTIC_2	7	10	PF00928	0.441
TRG_ER_diArg_1	172	174	PF00400	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4L7	Leptomonas seymouri	76%	100%
A0A0N1I8Z0	Leptomonas seymouri	31%	100%
A0A0S4IYY4	Bodo saltans	40%	100%
A0A0S4KM52	Bodo saltans	29%	100%
A0A1X0NMW4	Trypanosomatidae	50%	100%
A0A1X0NRI3	Trypanosomatidae	30%	100%
A0A3Q8IGT8	Leishmania donovani	31%	100%
A0A3S5H6B7	Leishmania donovani	98%	100%
A0A422NDP9	Trypanosoma rangeli	49%	100%
A0A422NZ19	Trypanosoma rangeli	27%	100%
A4H5J6	Leishmania braziliensis	88%	100%
A4HGN9	Leishmania braziliensis	31%	100%
A4HTT9	Leishmania infantum	98%	100%
A4I3R2	Leishmania infantum	31%	100%
D0A896	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A995	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AMM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B005	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q0P4C5	Danio rerio	27%	98%
Q3U1D9	Mus musculus	28%	97%
Q4Q880	Leishmania major	31%	100%
V5BSF6	Trypanosoma cruzi	46%	100%