VTC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

catalytic subunit of the vacuolar transporter chaperone 4, putative

Species:

Leishmania major

UniProt:

Q4QI04_LEIMA

TriTrypDb:

LmjF.09.0220 , LMJLV39_090007600 , LMJSD75_090007300

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0020022	acidocalcisome	5	2
GO:0032991	protein-containing complex	1	2
GO:0033254	vacuolar transporter chaperone complex	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0101031	protein folding chaperone complex	3	2
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	2

Expansion

Sequence features

Q4QI04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI04

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006797	polyphosphate metabolic process	4	2
GO:0006799	polyphosphate biosynthetic process	4	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	427	431	PF00656	0.490
CLV_C14_Caspase3-7	808	812	PF00656	0.413
CLV_NRD_NRD_1	212	214	PF00675	0.249
CLV_NRD_NRD_1	275	277	PF00675	0.249
CLV_NRD_NRD_1	327	329	PF00675	0.249
CLV_NRD_NRD_1	355	357	PF00675	0.336
CLV_NRD_NRD_1	629	631	PF00675	0.367
CLV_NRD_NRD_1	63	65	PF00675	0.378
CLV_NRD_NRD_1	764	766	PF00675	0.332
CLV_NRD_NRD_1	769	771	PF00675	0.387
CLV_NRD_NRD_1	801	803	PF00675	0.634
CLV_PCSK_FUR_1	762	766	PF00082	0.327
CLV_PCSK_KEX2_1	105	107	PF00082	0.468
CLV_PCSK_KEX2_1	212	214	PF00082	0.249
CLV_PCSK_KEX2_1	275	277	PF00082	0.249
CLV_PCSK_KEX2_1	326	328	PF00082	0.249
CLV_PCSK_KEX2_1	354	356	PF00082	0.335
CLV_PCSK_KEX2_1	605	607	PF00082	0.514
CLV_PCSK_KEX2_1	629	631	PF00082	0.356
CLV_PCSK_KEX2_1	675	677	PF00082	0.435
CLV_PCSK_KEX2_1	764	766	PF00082	0.332
CLV_PCSK_KEX2_1	769	771	PF00082	0.387
CLV_PCSK_KEX2_1	801	803	PF00082	0.634
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.475
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.249
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.335
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.514
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.435
CLV_PCSK_PC7_1	323	329	PF00082	0.249
CLV_PCSK_PC7_1	765	771	PF00082	0.402
CLV_PCSK_SKI1_1	105	109	PF00082	0.370
CLV_PCSK_SKI1_1	213	217	PF00082	0.249
CLV_PCSK_SKI1_1	269	273	PF00082	0.274
CLV_PCSK_SKI1_1	28	32	PF00082	0.331
CLV_PCSK_SKI1_1	383	387	PF00082	0.259
CLV_PCSK_SKI1_1	392	396	PF00082	0.234
CLV_PCSK_SKI1_1	531	535	PF00082	0.427
CLV_PCSK_SKI1_1	675	679	PF00082	0.468
CLV_PCSK_SKI1_1	686	690	PF00082	0.306
CLV_PCSK_SKI1_1	717	721	PF00082	0.648
CLV_PCSK_SKI1_1	81	85	PF00082	0.428
CLV_PCSK_SKI1_1	92	96	PF00082	0.456
CLV_Separin_Metazoa	122	126	PF03568	0.475
DEG_APCC_KENBOX_2	34	38	PF00400	0.646
DOC_CKS1_1	41	46	PF01111	0.534
DOC_CYCLIN_RxL_1	101	111	PF00134	0.678
DOC_CYCLIN_RxL_1	714	724	PF00134	0.441
DOC_MAPK_gen_1	212	221	PF00069	0.490
DOC_MAPK_gen_1	245	254	PF00069	0.458
DOC_MAPK_gen_1	64	72	PF00069	0.527
DOC_MAPK_HePTP_8	501	513	PF00069	0.664
DOC_MAPK_MEF2A_6	230	237	PF00069	0.474
DOC_MAPK_MEF2A_6	504	513	PF00069	0.675
DOC_MAPK_MEF2A_6	65	74	PF00069	0.533
DOC_PP1_RVXF_1	248	255	PF00149	0.483
DOC_PP1_RVXF_1	529	535	PF00149	0.630
DOC_PP2B_LxvP_1	198	201	PF13499	0.735
DOC_PP2B_LxvP_1	719	722	PF13499	0.439
DOC_SPAK_OSR1_1	328	332	PF12202	0.510
DOC_USP7_MATH_1	204	208	PF00917	0.706
DOC_USP7_MATH_1	259	263	PF00917	0.460
DOC_USP7_MATH_1	365	369	PF00917	0.499
DOC_USP7_MATH_1	39	43	PF00917	0.600
DOC_USP7_MATH_1	576	580	PF00917	0.706
DOC_USP7_MATH_1	6	10	PF00917	0.540
DOC_USP7_MATH_1	654	658	PF00917	0.645
DOC_USP7_UBL2_3	101	105	PF12436	0.725
DOC_USP7_UBL2_3	241	245	PF12436	0.458
DOC_USP7_UBL2_3	678	682	PF12436	0.640
DOC_WW_Pin1_4	255	260	PF00397	0.460
DOC_WW_Pin1_4	40	45	PF00397	0.537
DOC_WW_Pin1_4	428	433	PF00397	0.490
DOC_WW_Pin1_4	726	731	PF00397	0.424
LIG_14-3-3_CanoR_1	130	140	PF00244	0.535
LIG_14-3-3_CanoR_1	184	192	PF00244	0.560
LIG_14-3-3_CanoR_1	212	216	PF00244	0.460
LIG_14-3-3_CanoR_1	412	420	PF00244	0.465
LIG_14-3-3_CanoR_1	504	511	PF00244	0.620
LIG_14-3-3_CanoR_1	563	569	PF00244	0.576
LIG_14-3-3_CanoR_1	92	97	PF00244	0.630
LIG_Actin_WH2_2	112	127	PF00022	0.492
LIG_Actin_WH2_2	370	385	PF00022	0.460
LIG_APCC_ABBA_1	312	317	PF00400	0.449
LIG_APCC_ABBA_1	639	644	PF00400	0.614
LIG_APCC_ABBAyCdc20_2	8	14	PF00400	0.521
LIG_BRCT_BRCA1_1	206	210	PF00533	0.620
LIG_BRCT_BRCA1_1	711	715	PF00533	0.518
LIG_BRCT_BRCA1_1	809	813	PF00533	0.425
LIG_BRCT_BRCA1_2	711	717	PF00533	0.524
LIG_EH1_1	225	233	PF00400	0.449
LIG_eIF4E_1	683	689	PF01652	0.556
LIG_FHA_1	132	138	PF00498	0.539
LIG_FHA_1	25	31	PF00498	0.537
LIG_FHA_1	369	375	PF00498	0.423
LIG_FHA_1	484	490	PF00498	0.512
LIG_FHA_1	515	521	PF00498	0.583
LIG_FHA_1	539	545	PF00498	0.671
LIG_FHA_1	634	640	PF00498	0.645
LIG_FHA_1	645	651	PF00498	0.726
LIG_FHA_1	69	75	PF00498	0.569
LIG_FHA_1	738	744	PF00498	0.372
LIG_FHA_1	782	788	PF00498	0.331
LIG_FHA_2	200	206	PF00498	0.734
LIG_FHA_2	237	243	PF00498	0.449
LIG_FHA_2	292	298	PF00498	0.535
LIG_FHA_2	41	47	PF00498	0.528
LIG_FHA_2	425	431	PF00498	0.528
LIG_FHA_2	505	511	PF00498	0.575
LIG_FHA_2	591	597	PF00498	0.727
LIG_FHA_2	806	812	PF00498	0.362
LIG_FHA_2	82	88	PF00498	0.582
LIG_GBD_Chelix_1	115	123	PF00786	0.287
LIG_LIR_Gen_1	163	174	PF02991	0.513
LIG_LIR_Gen_1	179	189	PF02991	0.503
LIG_LIR_Gen_1	297	306	PF02991	0.451
LIG_LIR_Gen_1	45	56	PF02991	0.506
LIG_LIR_Gen_1	486	496	PF02991	0.505
LIG_LIR_Gen_1	555	565	PF02991	0.534
LIG_LIR_Gen_1	734	744	PF02991	0.290
LIG_LIR_Gen_1	751	761	PF02991	0.189
LIG_LIR_Gen_1	781	789	PF02991	0.323
LIG_LIR_Gen_1	790	799	PF02991	0.297
LIG_LIR_Nem_3	155	160	PF02991	0.523
LIG_LIR_Nem_3	163	169	PF02991	0.489
LIG_LIR_Nem_3	172	178	PF02991	0.463
LIG_LIR_Nem_3	179	185	PF02991	0.476
LIG_LIR_Nem_3	253	257	PF02991	0.505
LIG_LIR_Nem_3	297	302	PF02991	0.451
LIG_LIR_Nem_3	306	312	PF02991	0.453
LIG_LIR_Nem_3	364	369	PF02991	0.461
LIG_LIR_Nem_3	45	51	PF02991	0.514
LIG_LIR_Nem_3	555	560	PF02991	0.538
LIG_LIR_Nem_3	618	623	PF02991	0.566
LIG_LIR_Nem_3	635	640	PF02991	0.584
LIG_LIR_Nem_3	703	708	PF02991	0.422
LIG_LIR_Nem_3	734	739	PF02991	0.364
LIG_LIR_Nem_3	751	757	PF02991	0.207
LIG_LIR_Nem_3	781	785	PF02991	0.323
LIG_LIR_Nem_3	790	794	PF02991	0.308
LIG_LIR_Nem_3	9	15	PF02991	0.521
LIG_LYPXL_S_1	11	15	PF13949	0.314
LIG_LYPXL_SIV_4	437	445	PF13949	0.449
LIG_MYND_1	617	621	PF01753	0.687
LIG_PCNA_yPIPBox_3	168	180	PF02747	0.585
LIG_PDZ_Class_3	808	813	PF00595	0.352
LIG_Pex14_1	157	161	PF04695	0.605
LIG_Pex14_1	732	736	PF04695	0.353
LIG_Pex14_1	782	786	PF04695	0.406
LIG_PTB_Apo_2	264	271	PF02174	0.490
LIG_Rb_LxCxE_1	442	459	PF01857	0.449
LIG_RPA_C_Fungi	760	772	PF08784	0.468
LIG_SH2_CRK	147	151	PF00017	0.431
LIG_SH2_CRK	166	170	PF00017	0.376
LIG_SH2_CRK	182	186	PF00017	0.403
LIG_SH2_CRK	48	52	PF00017	0.378
LIG_SH2_CRK	557	561	PF00017	0.403
LIG_SH2_CRK	666	670	PF00017	0.619
LIG_SH2_CRK	754	758	PF00017	0.317
LIG_SH2_GRB2like	265	268	PF00017	0.387
LIG_SH2_NCK_1	166	170	PF00017	0.497
LIG_SH2_NCK_1	438	442	PF00017	0.302
LIG_SH2_NCK_1	557	561	PF00017	0.441
LIG_SH2_SRC	475	478	PF00017	0.317
LIG_SH2_SRC	754	757	PF00017	0.336
LIG_SH2_SRC	774	777	PF00017	0.245
LIG_SH2_STAP1	291	295	PF00017	0.387
LIG_SH2_STAP1	3	7	PF00017	0.528
LIG_SH2_STAP1	48	52	PF00017	0.499
LIG_SH2_STAP1	557	561	PF00017	0.418
LIG_SH2_STAP1	774	778	PF00017	0.496
LIG_SH2_STAT5	161	164	PF00017	0.507
LIG_SH2_STAT5	21	24	PF00017	0.371
LIG_SH2_STAT5	426	429	PF00017	0.372
LIG_SH2_STAT5	634	637	PF00017	0.473
LIG_SH2_STAT5	756	759	PF00017	0.402
LIG_SH2_STAT5	82	85	PF00017	0.441
LIG_SH3_1	230	236	PF00018	0.317
LIG_SH3_3	146	152	PF00018	0.445
LIG_SH3_3	230	236	PF00018	0.317
LIG_SH3_3	38	44	PF00018	0.438
LIG_SH3_3	774	780	PF00018	0.503
LIG_SH3_5	553	557	PF00018	0.487
LIG_SUMO_SIM_anti_2	746	751	PF11976	0.307
LIG_SUMO_SIM_par_1	68	73	PF11976	0.381
LIG_SUMO_SIM_par_1	740	746	PF11976	0.309
LIG_TRAF2_1	170	173	PF00917	0.471
LIG_TRAF2_1	301	304	PF00917	0.449
LIG_TRAF2_1	361	364	PF00917	0.386
LIG_TRAF2_1	84	87	PF00917	0.511
LIG_TRFH_1	380	384	PF08558	0.317
LIG_TRFH_1	637	641	PF08558	0.526
LIG_TYR_ITIM	664	669	PF00017	0.621
LIG_TYR_ITIM	752	757	PF00017	0.314
LIG_TYR_ITIM	772	777	PF00017	0.339
LIG_TYR_ITSM	553	560	PF00017	0.475
LIG_UBA3_1	30	35	PF00899	0.426
LIG_WRC_WIRS_1	237	242	PF05994	0.336
LIG_WRC_WIRS_1	634	639	PF05994	0.545
LIG_WRC_WIRS_1	788	793	PF05994	0.381
MOD_CK1_1	199	205	PF00069	0.706
MOD_CK1_1	258	264	PF00069	0.327
MOD_CK1_1	368	374	PF00069	0.328
MOD_CK1_1	406	412	PF00069	0.299
MOD_CK1_1	431	437	PF00069	0.348
MOD_CK2_1	167	173	PF00069	0.367
MOD_CK2_1	199	205	PF00069	0.703
MOD_CK2_1	240	246	PF00069	0.395
MOD_CK2_1	291	297	PF00069	0.422
MOD_CK2_1	356	362	PF00069	0.359
MOD_CK2_1	40	46	PF00069	0.424
MOD_CK2_1	445	451	PF00069	0.403
MOD_CK2_1	47	53	PF00069	0.374
MOD_CK2_1	504	510	PF00069	0.459
MOD_CK2_1	81	87	PF00069	0.476
MOD_Cter_Amidation	673	676	PF01082	0.554
MOD_GlcNHglycan	101	104	PF01048	0.598
MOD_GlcNHglycan	192	195	PF01048	0.526
MOD_GlcNHglycan	319	322	PF01048	0.317
MOD_GlcNHglycan	413	416	PF01048	0.353
MOD_GlcNHglycan	577	581	PF01048	0.614
MOD_GlcNHglycan	8	11	PF01048	0.431
MOD_GSK3_1	236	243	PF00069	0.317
MOD_GSK3_1	255	262	PF00069	0.118
MOD_GSK3_1	317	324	PF00069	0.304
MOD_GSK3_1	368	375	PF00069	0.280
MOD_GSK3_1	424	431	PF00069	0.387
MOD_GSK3_1	540	547	PF00069	0.577
MOD_GSK3_1	576	583	PF00069	0.587
MOD_GSK3_1	584	591	PF00069	0.575
MOD_GSK3_1	640	647	PF00069	0.663
MOD_GSK3_1	684	691	PF00069	0.419
MOD_GSK3_1	77	84	PF00069	0.407
MOD_GSK3_1	805	812	PF00069	0.532
MOD_GSK3_1	90	97	PF00069	0.478
MOD_N-GLC_1	356	361	PF02516	0.359
MOD_N-GLC_1	90	95	PF02516	0.529
MOD_NEK2_1	240	245	PF00069	0.317
MOD_NEK2_1	47	52	PF00069	0.379
MOD_NEK2_1	632	637	PF00069	0.615
MOD_NEK2_1	70	75	PF00069	0.461
MOD_NEK2_1	701	706	PF00069	0.410
MOD_NEK2_1	708	713	PF00069	0.346
MOD_NEK2_2	236	241	PF00069	0.316
MOD_NEK2_2	259	264	PF00069	0.306
MOD_NEK2_2	478	483	PF00069	0.317
MOD_NEK2_2	633	638	PF00069	0.553
MOD_NEK2_2	709	714	PF00069	0.410
MOD_PIKK_1	204	210	PF00454	0.538
MOD_PIKK_1	385	391	PF00454	0.302
MOD_PIKK_1	538	544	PF00454	0.573
MOD_PIKK_1	95	101	PF00454	0.647
MOD_PKA_2	190	196	PF00069	0.536
MOD_PKA_2	211	217	PF00069	0.302
MOD_PKA_2	403	409	PF00069	0.302
MOD_PKA_2	411	417	PF00069	0.302
MOD_PKA_2	424	430	PF00069	0.334
MOD_PKA_2	503	509	PF00069	0.448
MOD_PKB_1	287	295	PF00069	0.359
MOD_Plk_1	90	96	PF00069	0.501
MOD_Plk_2-3	167	173	PF00069	0.472
MOD_Plk_4	259	265	PF00069	0.302
MOD_Plk_4	281	287	PF00069	0.302
MOD_Plk_4	342	348	PF00069	0.378
MOD_Plk_4	47	53	PF00069	0.396
MOD_Plk_4	478	484	PF00069	0.306
MOD_Plk_4	615	621	PF00069	0.525
MOD_Plk_4	684	690	PF00069	0.432
MOD_Plk_4	778	784	PF00069	0.308
MOD_Plk_4	787	793	PF00069	0.290
MOD_ProDKin_1	255	261	PF00069	0.317
MOD_ProDKin_1	40	46	PF00069	0.424
MOD_ProDKin_1	428	434	PF00069	0.359
MOD_ProDKin_1	726	732	PF00069	0.545
MOD_SUMO_rev_2	17	27	PF00179	0.489
MOD_SUMO_rev_2	305	314	PF00179	0.309
MOD_SUMO_rev_2	375	385	PF00179	0.339
MOD_SUMO_rev_2	50	56	PF00179	0.433
MOD_SUMO_rev_2	596	603	PF00179	0.718
MOD_SUMO_rev_2	60	67	PF00179	0.179
MOD_SUMO_rev_2	648	657	PF00179	0.672
TRG_DiLeu_BaEn_1	281	286	PF01217	0.317
TRG_DiLeu_BaEn_2	121	127	PF01217	0.344
TRG_DiLeu_BaEn_2	334	340	PF01217	0.422
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.594
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.440
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.614
TRG_ENDOCYTIC_2	12	15	PF00928	0.376
TRG_ENDOCYTIC_2	147	150	PF00928	0.432
TRG_ENDOCYTIC_2	166	169	PF00928	0.269
TRG_ENDOCYTIC_2	182	185	PF00928	0.361
TRG_ENDOCYTIC_2	438	441	PF00928	0.335
TRG_ENDOCYTIC_2	48	51	PF00928	0.380
TRG_ENDOCYTIC_2	557	560	PF00928	0.409
TRG_ENDOCYTIC_2	561	564	PF00928	0.365
TRG_ENDOCYTIC_2	634	637	PF00928	0.462
TRG_ENDOCYTIC_2	666	669	PF00928	0.622
TRG_ENDOCYTIC_2	754	757	PF00928	0.293
TRG_ENDOCYTIC_2	774	777	PF00928	0.245
TRG_ENDOCYTIC_2	803	806	PF00928	0.398
TRG_ER_diArg_1	275	277	PF00400	0.302
TRG_ER_diArg_1	286	289	PF00400	0.302
TRG_ER_diArg_1	327	329	PF00400	0.302
TRG_ER_diArg_1	402	405	PF00400	0.332
TRG_ER_diArg_1	762	765	PF00400	0.411
TRG_ER_diArg_1	801	803	PF00400	0.561
TRG_NLS_MonoExtC_3	769	775	PF00514	0.479
TRG_NLS_MonoExtN_4	323	330	PF00514	0.302
TRG_NLS_MonoExtN_4	352	358	PF00514	0.422
TRG_NLS_MonoExtN_4	769	774	PF00514	0.483
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.250
TRG_Pf-PMV_PEXEL_1	566	571	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C3	Leptomonas seymouri	81%	99%
A0A0S4J2S6	Bodo saltans	57%	100%
A0A0S4JCW1	Bodo saltans	25%	83%
A0A1X0NMU3	Trypanosomatidae	69%	100%
A0A3S7WQI7	Leishmania donovani	97%	100%
A0A422NDG2	Trypanosoma rangeli	68%	100%
A4H5J7	Leishmania braziliensis	88%	99%
A4HTX5	Leishmania infantum	97%	100%
D0A996	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AMM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P78810	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
V5BIC5	Trypanosoma cruzi	67%	100%