DNA replication licensing factor MCM4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM4, putative

Species:

Leishmania major

UniProt:

Q4QI01_LEIMA

TriTrypDb:

LmjF.09.0250 , LMJLV39_090007900 , LMJSD75_090007600

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0032991	protein-containing complex	1	12
GO:0042555	MCM complex	2	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QI01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI01

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0000727	double-strand break repair via break-induced replication	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006268	DNA unwinding involved in DNA replication	9	2
GO:0006270	DNA replication initiation	5	12
GO:0006271	DNA strand elongation involved in DNA replication	6	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0022616	DNA strand elongation	5	2
GO:0032392	DNA geometric change	7	2
GO:0032508	DNA duplex unwinding	8	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	2
GO:0051276	chromosome organization	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0071103	DNA conformation change	6	2
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1902292	cell cycle DNA replication initiation	3	2
GO:1902315	nuclear cell cycle DNA replication initiation	4	2
GO:1902975	mitotic DNA replication initiation	4	2
GO:1903047	mitotic cell cycle process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003697	single-stranded DNA binding	5	2
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.430
CLV_C14_Caspase3-7	305	309	PF00656	0.293
CLV_C14_Caspase3-7	671	675	PF00656	0.594
CLV_NRD_NRD_1	26	28	PF00675	0.313
CLV_NRD_NRD_1	43	45	PF00675	0.313
CLV_NRD_NRD_1	595	597	PF00675	0.221
CLV_NRD_NRD_1	627	629	PF00675	0.631
CLV_NRD_NRD_1	821	823	PF00675	0.459
CLV_NRD_NRD_1	829	831	PF00675	0.385
CLV_PCSK_KEX2_1	26	28	PF00082	0.313
CLV_PCSK_KEX2_1	399	401	PF00082	0.229
CLV_PCSK_KEX2_1	43	45	PF00082	0.313
CLV_PCSK_KEX2_1	595	597	PF00082	0.221
CLV_PCSK_KEX2_1	627	629	PF00082	0.650
CLV_PCSK_KEX2_1	782	784	PF00082	0.278
CLV_PCSK_KEX2_1	821	823	PF00082	0.459
CLV_PCSK_KEX2_1	828	830	PF00082	0.413
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.229
CLV_PCSK_PC1ET2_1	782	784	PF00082	0.278
CLV_PCSK_PC1ET2_1	828	830	PF00082	0.477
CLV_PCSK_PC7_1	22	28	PF00082	0.320
CLV_PCSK_SKI1_1	131	135	PF00082	0.254
CLV_PCSK_SKI1_1	297	301	PF00082	0.378
CLV_PCSK_SKI1_1	400	404	PF00082	0.211
CLV_PCSK_SKI1_1	519	523	PF00082	0.211
CLV_PCSK_SKI1_1	791	795	PF00082	0.522
CLV_PCSK_SKI1_1	80	84	PF00082	0.250
CLV_PCSK_SKI1_1	845	849	PF00082	0.371
CLV_Separin_Metazoa	313	317	PF03568	0.523
CLV_Separin_Metazoa	81	85	PF03568	0.412
DEG_APCC_DBOX_1	399	407	PF00400	0.411
DEG_APCC_DBOX_1	435	443	PF00400	0.513
DEG_APCC_DBOX_1	518	526	PF00400	0.411
DEG_APCC_DBOX_1	577	585	PF00400	0.411
DEG_Kelch_Keap1_1	485	490	PF01344	0.411
DEG_Kelch_Keap1_1	637	642	PF01344	0.512
DEG_Nend_UBRbox_3	1	3	PF02207	0.488
DEG_SPOP_SBC_1	425	429	PF00917	0.542
DOC_CKS1_1	342	347	PF01111	0.637
DOC_MAPK_DCC_7	181	191	PF00069	0.411
DOC_MAPK_gen_1	181	191	PF00069	0.411
DOC_MAPK_gen_1	766	775	PF00069	0.411
DOC_MAPK_MEF2A_6	102	109	PF00069	0.463
DOC_MAPK_MEF2A_6	184	191	PF00069	0.411
DOC_MAPK_MEF2A_6	436	443	PF00069	0.411
DOC_MAPK_MEF2A_6	578	586	PF00069	0.411
DOC_MAPK_MEF2A_6	90	97	PF00069	0.423
DOC_MAPK_RevD_3	582	596	PF00069	0.478
DOC_PP2B_PxIxI_1	186	192	PF00149	0.421
DOC_USP7_MATH_1	426	430	PF00917	0.513
DOC_USP7_MATH_1	517	521	PF00917	0.421
DOC_USP7_MATH_1	544	548	PF00917	0.411
DOC_USP7_MATH_1	55	59	PF00917	0.517
DOC_USP7_MATH_1	554	558	PF00917	0.411
DOC_USP7_MATH_1	617	621	PF00917	0.625
DOC_USP7_MATH_1	740	744	PF00917	0.443
DOC_USP7_UBL2_3	240	244	PF12436	0.513
DOC_USP7_UBL2_3	76	80	PF12436	0.513
DOC_WW_Pin1_4	162	167	PF00397	0.503
DOC_WW_Pin1_4	245	250	PF00397	0.439
DOC_WW_Pin1_4	254	259	PF00397	0.383
DOC_WW_Pin1_4	285	290	PF00397	0.513
DOC_WW_Pin1_4	341	346	PF00397	0.658
DOC_WW_Pin1_4	611	616	PF00397	0.692
LIG_14-3-3_CanoR_1	43	47	PF00244	0.370
LIG_14-3-3_CanoR_1	57	61	PF00244	0.378
LIG_14-3-3_CanoR_1	650	658	PF00244	0.725
LIG_14-3-3_CanoR_1	759	767	PF00244	0.482
LIG_14-3-3_CanoR_1	836	842	PF00244	0.416
LIG_14-3-3_CanoR_1	90	94	PF00244	0.479
LIG_Actin_WH2_2	122	139	PF00022	0.463
LIG_AP2alpha_1	21	25	PF02296	0.391
LIG_APCC_ABBA_1	18	23	PF00400	0.440
LIG_APCC_ABBA_1	234	239	PF00400	0.411
LIG_APCC_ABBA_1	602	607	PF00400	0.411
LIG_APCC_ABBA_1	685	690	PF00400	0.465
LIG_APCC_ABBAyCdc20_2	412	418	PF00400	0.513
LIG_BIR_III_4	664	668	PF00653	0.782
LIG_BRCT_BRCA1_1	431	435	PF00533	0.513
LIG_CaM_IQ_9	196	212	PF13499	0.435
LIG_Clathr_ClatBox_1	800	804	PF01394	0.491
LIG_eIF4E_1	130	136	PF01652	0.463
LIG_eIF4E_1	237	243	PF01652	0.513
LIG_eIF4E_1	77	83	PF01652	0.470
LIG_FHA_1	114	120	PF00498	0.516
LIG_FHA_1	29	35	PF00498	0.453
LIG_FHA_1	294	300	PF00498	0.368
LIG_FHA_1	342	348	PF00498	0.657
LIG_FHA_1	363	369	PF00498	0.541
LIG_FHA_1	477	483	PF00498	0.411
LIG_FHA_1	486	492	PF00498	0.411
LIG_FHA_1	516	522	PF00498	0.411
LIG_FHA_1	528	534	PF00498	0.411
LIG_FHA_1	544	550	PF00498	0.411
LIG_FHA_1	795	801	PF00498	0.457
LIG_FHA_1	836	842	PF00498	0.449
LIG_FHA_1	882	888	PF00498	0.475
LIG_FHA_1	90	96	PF00498	0.521
LIG_FHA_2	303	309	PF00498	0.304
LIG_FHA_2	669	675	PF00498	0.651
LIG_LIR_Gen_1	369	378	PF02991	0.466
LIG_LIR_Gen_1	379	389	PF02991	0.416
LIG_LIR_Gen_1	5	16	PF02991	0.503
LIG_LIR_Gen_1	509	517	PF02991	0.411
LIG_LIR_Gen_1	577	586	PF02991	0.411
LIG_LIR_Gen_1	708	718	PF02991	0.411
LIG_LIR_Gen_1	866	871	PF02991	0.424
LIG_LIR_Gen_1	94	105	PF02991	0.541
LIG_LIR_Nem_3	127	133	PF02991	0.478
LIG_LIR_Nem_3	23	28	PF02991	0.339
LIG_LIR_Nem_3	369	374	PF02991	0.438
LIG_LIR_Nem_3	379	384	PF02991	0.443
LIG_LIR_Nem_3	5	11	PF02991	0.518
LIG_LIR_Nem_3	577	582	PF02991	0.411
LIG_LIR_Nem_3	708	713	PF02991	0.413
LIG_LIR_Nem_3	716	722	PF02991	0.414
LIG_LIR_Nem_3	866	870	PF02991	0.428
LIG_LIR_Nem_3	94	100	PF02991	0.463
LIG_NRBOX	438	444	PF00104	0.513
LIG_NRBOX	580	586	PF00104	0.411
LIG_NRBOX	78	84	PF00104	0.412
LIG_NRBOX	822	828	PF00104	0.441
LIG_Pex14_1	197	201	PF04695	0.513
LIG_Pex14_2	21	25	PF04695	0.247
LIG_Pex14_2	579	583	PF04695	0.411
LIG_SH2_CRK	381	385	PF00017	0.409
LIG_SH2_PTP2	710	713	PF00017	0.435
LIG_SH2_PTP2	734	737	PF00017	0.478
LIG_SH2_STAP1	226	230	PF00017	0.411
LIG_SH2_STAP1	381	385	PF00017	0.435
LIG_SH2_STAP1	8	12	PF00017	0.510
LIG_SH2_STAT3	71	74	PF00017	0.467
LIG_SH2_STAT3	831	834	PF00017	0.435
LIG_SH2_STAT5	10	13	PF00017	0.372
LIG_SH2_STAT5	108	111	PF00017	0.532
LIG_SH2_STAT5	28	31	PF00017	0.411
LIG_SH2_STAT5	467	470	PF00017	0.411
LIG_SH2_STAT5	710	713	PF00017	0.423
LIG_SH2_STAT5	734	737	PF00017	0.411
LIG_SH2_STAT5	78	81	PF00017	0.464
LIG_SH2_STAT5	831	834	PF00017	0.446
LIG_SH3_3	109	115	PF00018	0.480
LIG_SH3_3	339	345	PF00018	0.706
LIG_SH3_3	35	41	PF00018	0.541
LIG_SH3_3	489	495	PF00018	0.411
LIG_SH3_3	694	700	PF00018	0.416
LIG_SH3_3	855	861	PF00018	0.556
LIG_SUMO_SIM_anti_2	132	137	PF11976	0.547
LIG_SUMO_SIM_anti_2	866	872	PF11976	0.355
LIG_SUMO_SIM_par_1	837	843	PF11976	0.488
LIG_SUMO_SIM_par_1	91	96	PF11976	0.437
LIG_TRAF2_1	640	643	PF00917	0.606
LIG_TRAF2_1	72	75	PF00917	0.495
LIG_UBA3_1	172	176	PF00899	0.513
LIG_WRC_WIRS_1	29	34	PF05994	0.468
LIG_WRC_WIRS_1	385	390	PF05994	0.411
LIG_WRC_WIRS_1	877	882	PF05994	0.379
MOD_CDK_SPK_2	611	616	PF00069	0.489
MOD_CDK_SPxK_1	285	291	PF00069	0.513
MOD_CK1_1	157	163	PF00069	0.422
MOD_CK1_1	343	349	PF00069	0.713
MOD_CK1_1	42	48	PF00069	0.463
MOD_CK1_1	429	435	PF00069	0.489
MOD_CK1_1	58	64	PF00069	0.499
MOD_CK1_1	611	617	PF00069	0.610
MOD_CK1_1	705	711	PF00069	0.207
MOD_CK1_1	743	749	PF00069	0.463
MOD_CK1_1	771	777	PF00069	0.513
MOD_CK2_1	232	238	PF00069	0.434
MOD_CK2_1	637	643	PF00069	0.711
MOD_CK2_1	837	843	PF00069	0.353
MOD_CK2_1	88	94	PF00069	0.435
MOD_Cter_Amidation	625	628	PF01082	0.731
MOD_GlcNHglycan	122	125	PF01048	0.318
MOD_GlcNHglycan	206	209	PF01048	0.324
MOD_GlcNHglycan	358	361	PF01048	0.505
MOD_GlcNHglycan	421	424	PF01048	0.262
MOD_GlcNHglycan	431	434	PF01048	0.314
MOD_GlcNHglycan	468	471	PF01048	0.230
MOD_GlcNHglycan	48	51	PF01048	0.240
MOD_GlcNHglycan	610	613	PF01048	0.601
MOD_GlcNHglycan	619	622	PF01048	0.705
MOD_GlcNHglycan	637	642	PF01048	0.700
MOD_GlcNHglycan	747	750	PF01048	0.246
MOD_GlcNHglycan	785	788	PF01048	0.218
MOD_GlcNHglycan	852	855	PF01048	0.598
MOD_GlcNHglycan	871	874	PF01048	0.299
MOD_GSK3_1	2	9	PF00069	0.583
MOD_GSK3_1	298	305	PF00069	0.353
MOD_GSK3_1	384	391	PF00069	0.411
MOD_GSK3_1	410	417	PF00069	0.513
MOD_GSK3_1	42	49	PF00069	0.440
MOD_GSK3_1	425	432	PF00069	0.513
MOD_GSK3_1	449	456	PF00069	0.411
MOD_GSK3_1	466	473	PF00069	0.411
MOD_GSK3_1	56	63	PF00069	0.519
MOD_GSK3_1	633	640	PF00069	0.737
MOD_GSK3_1	644	651	PF00069	0.736
MOD_GSK3_1	663	670	PF00069	0.692
MOD_GSK3_1	741	748	PF00069	0.437
MOD_GSK3_1	791	798	PF00069	0.427
MOD_GSK3_1	876	883	PF00069	0.376
MOD_N-GLC_1	232	237	PF02516	0.227
MOD_N-GLC_1	333	338	PF02516	0.725
MOD_NEK2_1	340	345	PF00069	0.679
MOD_NEK2_1	362	367	PF00069	0.546
MOD_NEK2_1	370	375	PF00069	0.450
MOD_NEK2_1	384	389	PF00069	0.357
MOD_NEK2_1	407	412	PF00069	0.411
MOD_NEK2_1	606	611	PF00069	0.584
MOD_NEK2_1	880	885	PF00069	0.410
MOD_NEK2_2	108	113	PF00069	0.513
MOD_NEK2_2	714	719	PF00069	0.421
MOD_PIKK_1	449	455	PF00454	0.411
MOD_PIKK_1	554	560	PF00454	0.432
MOD_PIKK_1	644	650	PF00454	0.649
MOD_PKA_2	180	186	PF00069	0.411
MOD_PKA_2	315	321	PF00069	0.536
MOD_PKA_2	42	48	PF00069	0.425
MOD_PKA_2	544	550	PF00069	0.440
MOD_PKA_2	56	62	PF00069	0.516
MOD_PKA_2	649	655	PF00069	0.719
MOD_PKA_2	714	720	PF00069	0.425
MOD_PKA_2	740	746	PF00069	0.435
MOD_PKA_2	758	764	PF00069	0.435
MOD_PKA_2	835	841	PF00069	0.406
MOD_PKA_2	89	95	PF00069	0.455
MOD_Plk_1	202	208	PF00069	0.489
MOD_Plk_1	232	238	PF00069	0.427
MOD_Plk_1	6	12	PF00069	0.401
MOD_Plk_1	644	650	PF00069	0.649
MOD_Plk_1	771	777	PF00069	0.453
MOD_Plk_1	95	101	PF00069	0.469
MOD_Plk_4	154	160	PF00069	0.529
MOD_Plk_4	232	238	PF00069	0.421
MOD_Plk_4	265	271	PF00069	0.490
MOD_Plk_4	298	304	PF00069	0.510
MOD_Plk_4	410	416	PF00069	0.513
MOD_Plk_4	544	550	PF00069	0.425
MOD_Plk_4	571	577	PF00069	0.414
MOD_Plk_4	6	12	PF00069	0.401
MOD_Plk_4	600	606	PF00069	0.411
MOD_Plk_4	702	708	PF00069	0.528
MOD_Plk_4	714	720	PF00069	0.494
MOD_Plk_4	753	759	PF00069	0.411
MOD_ProDKin_1	162	168	PF00069	0.503
MOD_ProDKin_1	245	251	PF00069	0.439
MOD_ProDKin_1	254	260	PF00069	0.383
MOD_ProDKin_1	285	291	PF00069	0.513
MOD_ProDKin_1	341	347	PF00069	0.659
MOD_ProDKin_1	611	617	PF00069	0.696
MOD_SUMO_rev_2	235	242	PF00179	0.421
MOD_SUMO_rev_2	774	784	PF00179	0.418
TRG_DiLeu_BaEn_1	238	243	PF01217	0.435
TRG_DiLeu_BaEn_1	438	443	PF01217	0.478
TRG_DiLeu_BaEn_1	494	499	PF01217	0.427
TRG_DiLeu_BaEn_1	866	871	PF01217	0.350
TRG_ENDOCYTIC_2	130	133	PF00928	0.505
TRG_ENDOCYTIC_2	266	269	PF00928	0.453
TRG_ENDOCYTIC_2	381	384	PF00928	0.421
TRG_ENDOCYTIC_2	710	713	PF00928	0.411
TRG_ENDOCYTIC_2	734	737	PF00928	0.411
TRG_ENDOCYTIC_2	8	11	PF00928	0.500
TRG_ER_diArg_1	25	27	PF00400	0.513
TRG_ER_diArg_1	595	597	PF00400	0.421
TRG_ER_diArg_1	627	629	PF00400	0.683
TRG_ER_diArg_1	820	822	PF00400	0.483
TRG_ER_diArg_1	829	831	PF00400	0.379
TRG_NES_CRM1_1	562	572	PF08389	0.513
TRG_Pf-PMV_PEXEL_1	821	825	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	830	834	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P860	Leptomonas seymouri	31%	90%
A0A0N1I383	Leptomonas seymouri	77%	88%
A0A0S4IW18	Bodo saltans	56%	100%
A0A1X0NNF6	Trypanosomatidae	58%	98%
A0A1X0NZT6	Trypanosomatidae	30%	95%
A0A3R7K9K0	Trypanosoma rangeli	30%	100%
A0A3R7NBN0	Trypanosoma rangeli	30%	94%
A0A3S7WQI8	Leishmania donovani	97%	100%
A0A3S7WY81	Leishmania donovani	30%	100%
A0A422NDD9	Trypanosoma rangeli	59%	100%
A4FUD9	Bos taurus	33%	100%
A4H5K0	Leishmania braziliensis	87%	97%
A4HDE7	Leishmania braziliensis	29%	100%
A4HGC9	Leishmania braziliensis	30%	92%
A4HTX2	Leishmania infantum	97%	100%
A4I0T0	Leishmania infantum	30%	100%
B8AZ14	Oryza sativa subsp. indica	31%	100%
B8AZ99	Oryza sativa subsp. indica	30%	100%
B8BKI8	Oryza sativa subsp. indica	29%	93%
B9FKM7	Oryza sativa subsp. japonica	31%	100%
D0A7X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	94%
D0A999	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
D3ZVK1	Rattus norvegicus	30%	100%
E1BPX4	Bos taurus	30%	100%
E9AMM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AWT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AZQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B059	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
I0IUP3	Gallus gallus	30%	100%
P24279	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	92%
P25205	Homo sapiens	33%	100%
P25206	Mus musculus	32%	100%
P29458	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	96%
P29469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P30664	Xenopus laevis	43%	100%
P30665	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	96%
P30666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P33991	Homo sapiens	43%	100%
P49717	Mus musculus	43%	100%
P49739	Xenopus laevis	32%	100%
Q0DHC4	Oryza sativa subsp. japonica	30%	100%
Q0V9Q6	Xenopus tropicalis	30%	100%
Q21902	Caenorhabditis elegans	28%	100%
Q26454	Drosophila melanogaster	41%	100%
Q28BS0	Xenopus tropicalis	31%	100%
Q29JI9	Drosophila pseudoobscura pseudoobscura	32%	100%
Q2R482	Oryza sativa subsp. japonica	29%	93%
Q43704	Zea mays	30%	100%
Q498J7	Xenopus laevis	31%	100%
Q4Q826	Leishmania major	30%	100%
Q4Q8I2	Leishmania major	31%	92%
Q4QAP2	Leishmania major	30%	100%
Q5F310	Xenopus laevis	29%	100%
Q5JKB0	Oryza sativa subsp. japonica	42%	100%
Q5R8G6	Pongo abelii	33%	100%
Q5XK83	Xenopus laevis	43%	100%
Q5ZMN2	Gallus gallus	32%	100%
Q6GL41	Xenopus tropicalis	43%	100%
Q7Q0Q1	Anopheles gambiae	32%	100%
Q7ZXZ0	Xenopus laevis	31%	100%
Q86B14	Dictyostelium discoideum	27%	100%
Q95XQ8	Caenorhabditis elegans	41%	100%
Q9CWV1	Mus musculus	31%	100%
Q9FL33	Arabidopsis thaliana	30%	100%
Q9LPD9	Arabidopsis thaliana	28%	96%
Q9SF37	Arabidopsis thaliana	29%	100%
Q9SX03	Zea mays	30%	100%
Q9SX04	Zea mays	30%	100%
Q9UJA3	Homo sapiens	29%	100%
Q9V461	Drosophila melanogaster	33%	100%
Q9VF30	Drosophila melanogaster	25%	100%
Q9XYU1	Drosophila melanogaster	31%	100%
V5BAH7	Trypanosoma cruzi	30%	100%
V5BQA9	Trypanosoma cruzi	30%	100%
V5BSG2	Trypanosoma cruzi	58%	100%