G10 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

G10 protein

Gene product:

G10 protein, putative

Species:

Leishmania major

UniProt:

Q4QI00_LEIMA

TriTrypDb:

LmjF.09.0260 , LMJLV39_090008000 , LMJSD75_090007700

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	2
GO:0005634	nucleus	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QI00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI00

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.313
CLV_NRD_NRD_1	192	194	PF00675	0.329
CLV_NRD_NRD_1	218	220	PF00675	0.348
CLV_NRD_NRD_1	55	57	PF00675	0.443
CLV_PCSK_KEX2_1	153	155	PF00082	0.313
CLV_PCSK_KEX2_1	192	194	PF00082	0.329
CLV_PCSK_KEX2_1	218	220	PF00082	0.328
CLV_PCSK_KEX2_1	57	59	PF00082	0.410
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.397
CLV_PCSK_SKI1_1	121	125	PF00082	0.343
CLV_PCSK_SKI1_1	183	187	PF00082	0.441
CLV_PCSK_SKI1_1	192	196	PF00082	0.400
CLV_PCSK_SKI1_1	30	34	PF00082	0.340
DEG_SPOP_SBC_1	88	92	PF00917	0.400
DOC_MAPK_gen_1	117	125	PF00069	0.455
DOC_USP7_MATH_1	47	51	PF00917	0.300
DOC_USP7_MATH_1	75	79	PF00917	0.452
DOC_USP7_MATH_1	83	87	PF00917	0.416
DOC_USP7_MATH_1	88	92	PF00917	0.352
DOC_USP7_MATH_2	74	80	PF00917	0.424
LIG_14-3-3_CanoR_1	162	171	PF00244	0.346
LIG_14-3-3_CanoR_1	193	203	PF00244	0.443
LIG_BRCT_BRCA1_1	219	223	PF00533	0.447
LIG_BRCT_BRCA1_1	49	53	PF00533	0.260
LIG_EVH1_2	11	15	PF00568	0.329
LIG_FHA_1	118	124	PF00498	0.329
LIG_FHA_1	142	148	PF00498	0.472
LIG_FHA_2	253	259	PF00498	0.677
LIG_FHA_2	31	37	PF00498	0.441
LIG_FHA_2	90	96	PF00498	0.447
LIG_LIR_Gen_1	120	128	PF02991	0.412
LIG_LIR_Nem_3	120	125	PF02991	0.441
LIG_SH2_PTP2	122	125	PF00017	0.424
LIG_SH2_STAP1	138	142	PF00017	0.441
LIG_SH2_STAP1	25	29	PF00017	0.348
LIG_SH2_STAT3	127	130	PF00017	0.441
LIG_SH2_STAT3	25	28	PF00017	0.470
LIG_SH2_STAT5	122	125	PF00017	0.322
LIG_SH2_STAT5	140	143	PF00017	0.368
LIG_SH3_1	101	107	PF00018	0.381
LIG_SH3_3	101	107	PF00018	0.330
LIG_SH3_3	258	264	PF00018	0.753
LIG_SH3_3	3	9	PF00018	0.457
LIG_SH3_3	68	74	PF00018	0.440
LIG_TRAF2_1	100	103	PF00917	0.447
LIG_TRAF2_1	255	258	PF00917	0.791
LIG_TRAF2_1	32	35	PF00917	0.441
LIG_TRAF2_2	11	16	PF00917	0.400
MOD_CK1_1	179	185	PF00069	0.396
MOD_CK2_1	252	258	PF00069	0.792
MOD_CK2_1	30	36	PF00069	0.410
MOD_GlcNHglycan	196	199	PF01048	0.405
MOD_GlcNHglycan	235	238	PF01048	0.399
MOD_GlcNHglycan	49	52	PF01048	0.405
MOD_GSK3_1	172	179	PF00069	0.354
MOD_GSK3_1	192	199	PF00069	0.470
MOD_GSK3_1	30	37	PF00069	0.373
MOD_GSK3_1	83	90	PF00069	0.409
MOD_NEK2_1	163	168	PF00069	0.346
MOD_NEK2_1	176	181	PF00069	0.325
MOD_NEK2_1	194	199	PF00069	0.473
MOD_PIKK_1	196	202	PF00454	0.470
MOD_PIKK_1	30	36	PF00454	0.389
MOD_PKA_1	192	198	PF00069	0.441
MOD_PKA_2	192	198	PF00069	0.402
MOD_PKA_2	217	223	PF00069	0.447
MOD_PKA_2	47	53	PF00069	0.478
MOD_SUMO_for_1	100	103	PF00179	0.424
MOD_SUMO_for_1	20	23	PF00179	0.441
MOD_SUMO_rev_2	35	40	PF00179	0.441
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.470
TRG_ENDOCYTIC_2	122	125	PF00928	0.424
TRG_ENDOCYTIC_2	160	163	PF00928	0.329
TRG_ER_diArg_1	119	122	PF00400	0.329
TRG_ER_diArg_1	153	155	PF00400	0.316
TRG_ER_diArg_1	192	194	PF00400	0.402
TRG_ER_diArg_1	56	59	PF00400	0.457
TRG_NLS_MonoExtC_3	55	60	PF00514	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF7	Leptomonas seymouri	62%	100%
A0A1X0P8N9	Trypanosomatidae	44%	100%
A0A3S5H6C0	Leishmania donovani	94%	99%
A0A422NIY1	Trypanosoma rangeli	41%	100%
A4HTX3	Leishmania infantum	94%	99%
D0A382	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
V5AWF3	Trypanosoma cruzi	41%	83%