LeishMANIAdb
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Putative drug resistence protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative drug resistence protein
Gene product:
integral membrane transport protein, putative
Species:
Leishmania major
UniProt:
Q4QHZ9_LEIMA
TriTrypDb:
LmjF.09.0270 , LMJLV39_090008100 * , LMJSD75_090007800 *
Length:
621

Annotations

LeishMANIAdb annotations

Related to yeast azole resistance protein AZR1 and aspergullus citrate exporter CEX1.. Expanded on multiple lineages

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 2
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4QHZ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHZ9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 10
GO:0022857 transmembrane transporter activity 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 285 289 PF00656 0.679
CLV_NRD_NRD_1 382 384 PF00675 0.449
CLV_NRD_NRD_1 607 609 PF00675 0.770
CLV_NRD_NRD_1 64 66 PF00675 0.262
CLV_PCSK_KEX2_1 607 609 PF00082 0.770
CLV_PCSK_KEX2_1 64 66 PF00082 0.324
CLV_PCSK_SKI1_1 145 149 PF00082 0.324
CLV_PCSK_SKI1_1 158 162 PF00082 0.324
CLV_PCSK_SKI1_1 383 387 PF00082 0.450
CLV_PCSK_SKI1_1 84 88 PF00082 0.314
DEG_APCC_DBOX_1 157 165 PF00400 0.524
DEG_APCC_DBOX_1 367 375 PF00400 0.397
DEG_MDM2_SWIB_1 352 360 PF02201 0.596
DEG_SCF_FBW7_1 233 240 PF00400 0.713
DOC_CDC14_PxL_1 546 554 PF14671 0.418
DOC_CYCLIN_RxL_1 380 388 PF00134 0.251
DOC_CYCLIN_RxL_1 81 88 PF00134 0.474
DOC_CYCLIN_yCln2_LP_2 268 271 PF00134 0.655
DOC_CYCLIN_yCln2_LP_2 87 93 PF00134 0.474
DOC_MAPK_gen_1 155 164 PF00069 0.465
DOC_MAPK_gen_1 380 389 PF00069 0.246
DOC_MAPK_HePTP_8 98 110 PF00069 0.474
DOC_MAPK_MEF2A_6 101 110 PF00069 0.524
DOC_MAPK_MEF2A_6 35 43 PF00069 0.537
DOC_MAPK_MEF2A_6 368 375 PF00069 0.264
DOC_MAPK_MEF2A_6 380 389 PF00069 0.246
DOC_MAPK_MEF2A_6 84 91 PF00069 0.524
DOC_MAPK_NFAT4_5 101 109 PF00069 0.474
DOC_MAPK_RevD_3 52 65 PF00069 0.524
DOC_PP1_RVXF_1 99 106 PF00149 0.524
DOC_PP2B_LxvP_1 13 16 PF13499 0.636
DOC_PP2B_LxvP_1 268 271 PF13499 0.756
DOC_PP2B_LxvP_1 547 550 PF13499 0.321
DOC_PP2B_LxvP_1 87 90 PF13499 0.474
DOC_PP2B_PxIxI_1 43 49 PF00149 0.492
DOC_USP7_MATH_1 177 181 PF00917 0.353
DOC_USP7_MATH_1 198 202 PF00917 0.355
DOC_USP7_MATH_1 211 215 PF00917 0.582
DOC_USP7_MATH_1 237 241 PF00917 0.726
DOC_USP7_MATH_1 272 276 PF00917 0.651
DOC_USP7_MATH_1 277 281 PF00917 0.645
DOC_USP7_MATH_1 298 302 PF00917 0.688
DOC_USP7_MATH_1 334 338 PF00917 0.688
DOC_USP7_MATH_1 399 403 PF00917 0.348
DOC_WW_Pin1_4 233 238 PF00397 0.706
DOC_WW_Pin1_4 302 307 PF00397 0.767
DOC_WW_Pin1_4 585 590 PF00397 0.578
LIG_14-3-3_CanoR_1 191 195 PF00244 0.324
LIG_14-3-3_CanoR_1 226 230 PF00244 0.627
LIG_14-3-3_CanoR_1 324 333 PF00244 0.712
LIG_14-3-3_CanoR_1 393 403 PF00244 0.324
LIG_14-3-3_CanoR_1 506 512 PF00244 0.507
LIG_14-3-3_CanoR_1 65 71 PF00244 0.490
LIG_Actin_WH2_2 157 172 PF00022 0.524
LIG_APCC_ABBAyCdc20_2 235 241 PF00400 0.671
LIG_BIR_III_4 466 470 PF00653 0.264
LIG_BRCT_BRCA1_1 179 183 PF00533 0.397
LIG_BRCT_BRCA1_1 201 205 PF00533 0.384
LIG_BRCT_BRCA1_1 407 411 PF00533 0.291
LIG_deltaCOP1_diTrp_1 361 367 PF00928 0.430
LIG_eIF4E_1 263 269 PF01652 0.672
LIG_FHA_1 205 211 PF00498 0.356
LIG_FHA_1 264 270 PF00498 0.718
LIG_FHA_1 281 287 PF00498 0.664
LIG_FHA_1 448 454 PF00498 0.403
LIG_FHA_1 541 547 PF00498 0.401
LIG_FHA_1 575 581 PF00498 0.471
LIG_FHA_2 255 261 PF00498 0.766
LIG_FHA_2 27 33 PF00498 0.603
LIG_FHA_2 356 362 PF00498 0.562
LIG_FHA_2 493 499 PF00498 0.465
LIG_FHA_2 543 549 PF00498 0.341
LIG_FHA_2 83 89 PF00498 0.524
LIG_HCF-1_HBM_1 5 8 PF13415 0.648
LIG_LIR_Apic_2 248 254 PF02991 0.696
LIG_LIR_Gen_1 189 200 PF02991 0.345
LIG_LIR_Gen_1 27 38 PF02991 0.573
LIG_LIR_Gen_1 354 365 PF02991 0.500
LIG_LIR_Gen_1 408 418 PF02991 0.306
LIG_LIR_Gen_1 69 77 PF02991 0.516
LIG_LIR_Nem_3 154 160 PF02991 0.502
LIG_LIR_Nem_3 180 186 PF02991 0.352
LIG_LIR_Nem_3 189 195 PF02991 0.243
LIG_LIR_Nem_3 202 208 PF02991 0.280
LIG_LIR_Nem_3 27 33 PF02991 0.547
LIG_LIR_Nem_3 289 295 PF02991 0.724
LIG_LIR_Nem_3 353 359 PF02991 0.502
LIG_LIR_Nem_3 361 366 PF02991 0.425
LIG_LIR_Nem_3 408 414 PF02991 0.306
LIG_LIR_Nem_3 444 448 PF02991 0.234
LIG_LIR_Nem_3 460 465 PF02991 0.324
LIG_LIR_Nem_3 531 537 PF02991 0.386
LIG_LIR_Nem_3 613 618 PF02991 0.485
LIG_LIR_Nem_3 69 73 PF02991 0.508
LIG_LIR_Nem_3 75 79 PF02991 0.520
LIG_LIR_Nem_3 96 100 PF02991 0.522
LIG_NRBOX 164 170 PF00104 0.342
LIG_PCNA_PIPBox_1 523 532 PF02747 0.326
LIG_Pex14_2 105 109 PF04695 0.326
LIG_Pex14_2 352 356 PF04695 0.603
LIG_Pex14_2 359 363 PF04695 0.574
LIG_Pex14_2 407 411 PF04695 0.326
LIG_Pex14_2 530 534 PF04695 0.397
LIG_PTB_Apo_2 99 106 PF02174 0.524
LIG_REV1ctd_RIR_1 139 149 PF16727 0.281
LIG_SH2_CRK 157 161 PF00017 0.524
LIG_SH2_CRK 192 196 PF00017 0.324
LIG_SH2_CRK 292 296 PF00017 0.701
LIG_SH2_CRK 537 541 PF00017 0.339
LIG_SH2_CRK 615 619 PF00017 0.484
LIG_SH2_CRK 70 74 PF00017 0.509
LIG_SH2_NCK_1 70 74 PF00017 0.549
LIG_SH2_PTP2 372 375 PF00017 0.281
LIG_SH2_PTP2 76 79 PF00017 0.464
LIG_SH2_PTP2 97 100 PF00017 0.474
LIG_SH2_STAP1 192 196 PF00017 0.324
LIG_SH2_STAP1 30 34 PF00017 0.544
LIG_SH2_STAP1 70 74 PF00017 0.488
LIG_SH2_STAT5 25 28 PF00017 0.567
LIG_SH2_STAT5 263 266 PF00017 0.676
LIG_SH2_STAT5 357 360 PF00017 0.489
LIG_SH2_STAT5 372 375 PF00017 0.273
LIG_SH2_STAT5 403 406 PF00017 0.397
LIG_SH2_STAT5 456 459 PF00017 0.292
LIG_SH2_STAT5 76 79 PF00017 0.455
LIG_SH2_STAT5 97 100 PF00017 0.474
LIG_SH3_3 171 177 PF00018 0.312
LIG_SH3_3 38 44 PF00018 0.563
LIG_Sin3_3 265 272 PF02671 0.642
LIG_SUMO_SIM_anti_2 75 81 PF11976 0.529
LIG_SUMO_SIM_par_1 206 212 PF11976 0.384
LIG_TRAF2_1 16 19 PF00917 0.648
LIG_TRAF2_1 240 243 PF00917 0.695
LIG_TRAF2_1 344 347 PF00917 0.646
LIG_TRAF2_1 573 576 PF00917 0.444
LIG_TYR_ITIM 190 195 PF00017 0.324
LIG_TYR_ITIM 28 33 PF00017 0.548
LIG_TYR_ITIM 355 360 PF00017 0.578
LIG_TYR_ITIM 95 100 PF00017 0.564
LIG_WRC_WIRS_1 386 391 PF05994 0.242
LIG_WRC_WIRS_1 442 447 PF05994 0.200
LIG_WW_3 481 485 PF00397 0.535
MOD_CK1_1 134 140 PF00069 0.379
MOD_CK1_1 228 234 PF00069 0.670
MOD_CK1_1 275 281 PF00069 0.732
MOD_CK1_1 301 307 PF00069 0.697
MOD_CK1_1 329 335 PF00069 0.694
MOD_CK1_1 568 574 PF00069 0.488
MOD_CK1_1 69 75 PF00069 0.442
MOD_CK2_1 237 243 PF00069 0.672
MOD_CK2_1 26 32 PF00069 0.571
MOD_CK2_1 538 544 PF00069 0.353
MOD_CK2_1 570 576 PF00069 0.437
MOD_Cter_Amidation 62 65 PF01082 0.260
MOD_GlcNHglycan 133 136 PF01048 0.327
MOD_GlcNHglycan 165 168 PF01048 0.313
MOD_GlcNHglycan 179 182 PF01048 0.398
MOD_GlcNHglycan 186 189 PF01048 0.554
MOD_GlcNHglycan 196 199 PF01048 0.452
MOD_GlcNHglycan 279 282 PF01048 0.491
MOD_GlcNHglycan 288 291 PF01048 0.566
MOD_GlcNHglycan 328 331 PF01048 0.544
MOD_GlcNHglycan 334 337 PF01048 0.549
MOD_GlcNHglycan 459 462 PF01048 0.366
MOD_GlcNHglycan 50 53 PF01048 0.277
MOD_GSK3_1 119 126 PF00069 0.395
MOD_GSK3_1 190 197 PF00069 0.316
MOD_GSK3_1 221 228 PF00069 0.602
MOD_GSK3_1 229 236 PF00069 0.586
MOD_GSK3_1 277 284 PF00069 0.741
MOD_GSK3_1 298 305 PF00069 0.660
MOD_GSK3_1 320 327 PF00069 0.701
MOD_GSK3_1 351 358 PF00069 0.514
MOD_GSK3_1 538 545 PF00069 0.333
MOD_GSK3_1 566 573 PF00069 0.473
MOD_GSK3_1 574 581 PF00069 0.562
MOD_GSK3_1 614 621 PF00069 0.486
MOD_N-GLC_1 119 124 PF02516 0.411
MOD_NEK2_1 194 199 PF00069 0.327
MOD_NEK2_1 229 234 PF00069 0.646
MOD_NEK2_1 26 31 PF00069 0.607
MOD_NEK2_1 286 291 PF00069 0.696
MOD_NEK2_1 350 355 PF00069 0.573
MOD_NEK2_1 385 390 PF00069 0.298
MOD_NEK2_1 405 410 PF00069 0.447
MOD_NEK2_1 82 87 PF00069 0.536
MOD_NEK2_2 221 226 PF00069 0.569
MOD_NEK2_2 334 339 PF00069 0.678
MOD_PIKK_1 209 215 PF00454 0.407
MOD_PIKK_1 568 574 PF00454 0.463
MOD_PKA_2 190 196 PF00069 0.341
MOD_PKA_2 225 231 PF00069 0.578
MOD_PKA_2 286 292 PF00069 0.600
MOD_PKB_1 324 332 PF00069 0.685
MOD_Plk_1 123 129 PF00069 0.272
MOD_Plk_2-3 542 548 PF00069 0.330
MOD_Plk_4 112 118 PF00069 0.366
MOD_Plk_4 123 129 PF00069 0.288
MOD_Plk_4 190 196 PF00069 0.278
MOD_Plk_4 351 357 PF00069 0.524
MOD_Plk_4 374 380 PF00069 0.457
MOD_Plk_4 399 405 PF00069 0.286
MOD_Plk_4 507 513 PF00069 0.481
MOD_Plk_4 542 548 PF00069 0.367
MOD_Plk_4 57 63 PF00069 0.485
MOD_Plk_4 578 584 PF00069 0.410
MOD_ProDKin_1 233 239 PF00069 0.710
MOD_ProDKin_1 302 308 PF00069 0.769
MOD_ProDKin_1 585 591 PF00069 0.580
TRG_DiLeu_BaEn_4 575 581 PF01217 0.522
TRG_DiLeu_BaLyEn_6 559 564 PF01217 0.310
TRG_ENDOCYTIC_2 157 160 PF00928 0.524
TRG_ENDOCYTIC_2 192 195 PF00928 0.230
TRG_ENDOCYTIC_2 25 28 PF00928 0.611
TRG_ENDOCYTIC_2 292 295 PF00928 0.700
TRG_ENDOCYTIC_2 30 33 PF00928 0.573
TRG_ENDOCYTIC_2 357 360 PF00928 0.521
TRG_ENDOCYTIC_2 362 365 PF00928 0.293
TRG_ENDOCYTIC_2 372 375 PF00928 0.243
TRG_ENDOCYTIC_2 514 517 PF00928 0.520
TRG_ENDOCYTIC_2 615 618 PF00928 0.487
TRG_ENDOCYTIC_2 70 73 PF00928 0.457
TRG_ENDOCYTIC_2 76 79 PF00928 0.416
TRG_ENDOCYTIC_2 97 100 PF00928 0.564
TRG_ER_diArg_1 606 608 PF00400 0.581
TRG_ER_diArg_1 64 66 PF00400 0.524
TRG_NES_CRM1_1 412 424 PF08389 0.342
TRG_Pf-PMV_PEXEL_1 84 88 PF00026 0.242

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWA0 Leptomonas seymouri 62% 100%
A0A1X0NN50 Trypanosomatidae 37% 100%
A0A3S5H6C1 Leishmania donovani 94% 100%
A0A422NDI8 Trypanosoma rangeli 35% 100%
A4HTX4 Leishmania infantum 94% 100%
D0A9A1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AMM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5B2U4 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS