Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHZ8_LEIMA

TriTrypDb:

LmjF.09.0280 , LMJLV39_090008200 , LMJSD75_090007900

Length:

779

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHZ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	40	44	PF00656	0.714
CLV_C14_Caspase3-7	60	64	PF00656	0.570
CLV_C14_Caspase3-7	603	607	PF00656	0.642
CLV_NRD_NRD_1	122	124	PF00675	0.430
CLV_NRD_NRD_1	186	188	PF00675	0.453
CLV_NRD_NRD_1	189	191	PF00675	0.461
CLV_NRD_NRD_1	204	206	PF00675	0.434
CLV_NRD_NRD_1	295	297	PF00675	0.516
CLV_NRD_NRD_1	348	350	PF00675	0.580
CLV_NRD_NRD_1	728	730	PF00675	0.455
CLV_NRD_NRD_1	747	749	PF00675	0.349
CLV_PCSK_FUR_1	187	191	PF00082	0.468
CLV_PCSK_KEX2_1	122	124	PF00082	0.429
CLV_PCSK_KEX2_1	185	187	PF00082	0.455
CLV_PCSK_KEX2_1	189	191	PF00082	0.461
CLV_PCSK_KEX2_1	204	206	PF00082	0.434
CLV_PCSK_KEX2_1	348	350	PF00082	0.580
CLV_PCSK_KEX2_1	728	730	PF00082	0.455
CLV_PCSK_KEX2_1	747	749	PF00082	0.349
CLV_PCSK_PC7_1	182	188	PF00082	0.467
CLV_PCSK_SKI1_1	104	108	PF00082	0.378
CLV_PCSK_SKI1_1	297	301	PF00082	0.563
CLV_PCSK_SKI1_1	349	353	PF00082	0.489
DEG_APCC_DBOX_1	295	303	PF00400	0.697
DEG_Nend_Nbox_1	1	3	PF02207	0.275
DEG_SCF_FBW7_1	487	493	PF00400	0.693
DOC_CKS1_1	199	204	PF01111	0.645
DOC_CKS1_1	487	492	PF01111	0.692
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.583
DOC_MAPK_gen_1	296	304	PF00069	0.715
DOC_MAPK_gen_1	767	777	PF00069	0.651
DOC_MAPK_MEF2A_6	296	304	PF00069	0.664
DOC_MAPK_MEF2A_6	317	326	PF00069	0.738
DOC_MAPK_MEF2A_6	718	727	PF00069	0.591
DOC_MAPK_MEF2A_6	770	779	PF00069	0.607
DOC_PP1_RVXF_1	566	572	PF00149	0.526
DOC_PP2B_LxvP_1	24	27	PF13499	0.578
DOC_PP2B_LxvP_1	393	396	PF13499	0.670
DOC_PP2B_LxvP_1	551	554	PF13499	0.603
DOC_PP2B_LxvP_1	75	78	PF13499	0.696
DOC_PP4_FxxP_1	522	525	PF00568	0.500
DOC_PP4_MxPP_1	485	488	PF00568	0.714
DOC_SPAK_OSR1_1	532	536	PF12202	0.636
DOC_USP7_MATH_1	162	166	PF00917	0.635
DOC_USP7_MATH_1	273	277	PF00917	0.641
DOC_USP7_MATH_1	333	337	PF00917	0.737
DOC_USP7_MATH_1	338	342	PF00917	0.732
DOC_USP7_MATH_1	37	41	PF00917	0.703
DOC_USP7_MATH_1	414	418	PF00917	0.692
DOC_USP7_MATH_1	490	494	PF00917	0.715
DOC_USP7_MATH_1	51	55	PF00917	0.612
DOC_USP7_MATH_1	511	515	PF00917	0.608
DOC_USP7_MATH_1	602	606	PF00917	0.634
DOC_USP7_MATH_1	615	619	PF00917	0.615
DOC_USP7_MATH_1	628	632	PF00917	0.581
DOC_USP7_MATH_1	705	709	PF00917	0.725
DOC_WW_Pin1_4	111	116	PF00397	0.630
DOC_WW_Pin1_4	198	203	PF00397	0.649
DOC_WW_Pin1_4	274	279	PF00397	0.686
DOC_WW_Pin1_4	32	37	PF00397	0.604
DOC_WW_Pin1_4	336	341	PF00397	0.777
DOC_WW_Pin1_4	355	360	PF00397	0.785
DOC_WW_Pin1_4	486	491	PF00397	0.741
DOC_WW_Pin1_4	493	498	PF00397	0.657
DOC_WW_Pin1_4	505	510	PF00397	0.599
LIG_14-3-3_CanoR_1	158	167	PF00244	0.684
LIG_14-3-3_CanoR_1	282	291	PF00244	0.736
LIG_14-3-3_CanoR_1	321	327	PF00244	0.685
LIG_14-3-3_CanoR_1	384	393	PF00244	0.686
LIG_14-3-3_CanoR_1	568	572	PF00244	0.540
LIG_14-3-3_CanoR_1	770	776	PF00244	0.621
LIG_14-3-3_CanoR_1	89	94	PF00244	0.667
LIG_Actin_WH2_2	304	319	PF00022	0.683
LIG_BIR_III_4	332	336	PF00653	0.752
LIG_BRCT_BRCA1_1	513	517	PF00533	0.621
LIG_DCNL_PONY_1	1	4	PF03556	0.275
LIG_EH1_1	208	216	PF00400	0.634
LIG_eIF4E_1	71	77	PF01652	0.650
LIG_FHA_1	232	238	PF00498	0.583
LIG_FHA_1	350	356	PF00498	0.661
LIG_FHA_1	410	416	PF00498	0.673
LIG_FHA_1	588	594	PF00498	0.507
LIG_FHA_1	770	776	PF00498	0.595
LIG_FHA_1	86	92	PF00498	0.652
LIG_FHA_1	96	102	PF00498	0.580
LIG_FHA_2	58	64	PF00498	0.681
LIG_LIR_Gen_1	207	218	PF02991	0.580
LIG_LIR_Gen_1	88	94	PF02991	0.584
LIG_LIR_Nem_3	126	130	PF02991	0.597
LIG_LIR_Nem_3	207	213	PF02991	0.586
LIG_LIR_Nem_3	66	70	PF02991	0.604
LIG_LIR_Nem_3	733	739	PF02991	0.604
LIG_LIR_Nem_3	88	93	PF02991	0.588
LIG_LYPXL_yS_3	736	739	PF13949	0.609
LIG_MYND_1	674	678	PF01753	0.660
LIG_NRBOX	1	7	PF00104	0.275
LIG_PCNA_yPIPBox_3	716	729	PF02747	0.598
LIG_Pex14_1	127	131	PF04695	0.667
LIG_PTAP_UEV_1	588	593	PF05743	0.589
LIG_SH2_CRK	71	75	PF00017	0.712
LIG_SH2_CRK	84	88	PF00017	0.551
LIG_SH2_GRB2like	252	255	PF00017	0.628
LIG_SH2_NCK_1	84	88	PF00017	0.665
LIG_SH2_PTP2	90	93	PF00017	0.585
LIG_SH2_STAP1	131	135	PF00017	0.710
LIG_SH2_STAP1	252	256	PF00017	0.630
LIG_SH2_STAT3	383	386	PF00017	0.633
LIG_SH2_STAT3	528	531	PF00017	0.528
LIG_SH2_STAT5	20	23	PF00017	0.388
LIG_SH2_STAT5	648	651	PF00017	0.666
LIG_SH2_STAT5	84	87	PF00017	0.602
LIG_SH2_STAT5	90	93	PF00017	0.600
LIG_SH3_2	674	679	PF14604	0.680
LIG_SH3_3	30	36	PF00018	0.598
LIG_SH3_3	316	322	PF00018	0.709
LIG_SH3_3	460	466	PF00018	0.637
LIG_SH3_3	484	490	PF00018	0.722
LIG_SH3_3	586	592	PF00018	0.528
LIG_SH3_3	67	73	PF00018	0.630
LIG_SH3_3	671	677	PF00018	0.692
LIG_SH3_5	436	440	PF00018	0.669
LIG_Sin3_3	594	601	PF02671	0.532
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.648
LIG_SUMO_SIM_anti_2	721	726	PF11976	0.595
LIG_SUMO_SIM_par_1	303	309	PF11976	0.710
LIG_SUMO_SIM_par_1	471	476	PF11976	0.598
LIG_TYR_ITIM	101	106	PF00017	0.580
LIG_TYR_ITIM	734	739	PF00017	0.602
LIG_UBA3_1	730	738	PF00899	0.619
LIG_WW_2	674	677	PF00397	0.651
LIG_WW_3	676	680	PF00397	0.683
MOD_CDK_SPK_2	111	116	PF00069	0.630
MOD_CDK_SPxK_1	198	204	PF00069	0.648
MOD_CDK_SPxK_1	336	342	PF00069	0.700
MOD_CDK_SPxK_1	493	499	PF00069	0.689
MOD_CDK_SPxxK_3	198	205	PF00069	0.701
MOD_CK1_1	156	162	PF00069	0.655
MOD_CK1_1	165	171	PF00069	0.657
MOD_CK1_1	177	183	PF00069	0.712
MOD_CK1_1	284	290	PF00069	0.687
MOD_CK1_1	334	340	PF00069	0.818
MOD_CK1_1	364	370	PF00069	0.714
MOD_CK1_1	375	381	PF00069	0.719
MOD_CK1_1	416	422	PF00069	0.657
MOD_CK1_1	445	451	PF00069	0.600
MOD_CK1_1	493	499	PF00069	0.685
MOD_CK1_1	587	593	PF00069	0.586
MOD_CK1_1	605	611	PF00069	0.577
MOD_CK1_1	684	690	PF00069	0.743
MOD_CK1_1	697	703	PF00069	0.633
MOD_CK2_1	111	117	PF00069	0.633
MOD_CK2_1	89	95	PF00069	0.597
MOD_DYRK1A_RPxSP_1	486	490	PF00069	0.691
MOD_GlcNHglycan	138	141	PF01048	0.581
MOD_GlcNHglycan	148	151	PF01048	0.449
MOD_GlcNHglycan	160	163	PF01048	0.558
MOD_GlcNHglycan	168	171	PF01048	0.449
MOD_GlcNHglycan	206	209	PF01048	0.502
MOD_GlcNHglycan	239	242	PF01048	0.377
MOD_GlcNHglycan	271	274	PF01048	0.441
MOD_GlcNHglycan	286	289	PF01048	0.539
MOD_GlcNHglycan	308	311	PF01048	0.570
MOD_GlcNHglycan	313	316	PF01048	0.525
MOD_GlcNHglycan	332	336	PF01048	0.518
MOD_GlcNHglycan	363	366	PF01048	0.477
MOD_GlcNHglycan	39	42	PF01048	0.516
MOD_GlcNHglycan	424	427	PF01048	0.582
MOD_GlcNHglycan	45	48	PF01048	0.468
MOD_GlcNHglycan	455	458	PF01048	0.466
MOD_GlcNHglycan	501	504	PF01048	0.475
MOD_GlcNHglycan	505	508	PF01048	0.430
MOD_GlcNHglycan	513	516	PF01048	0.382
MOD_GlcNHglycan	53	56	PF01048	0.419
MOD_GlcNHglycan	608	611	PF01048	0.466
MOD_GlcNHglycan	630	633	PF01048	0.497
MOD_GlcNHglycan	634	637	PF01048	0.566
MOD_GlcNHglycan	679	682	PF01048	0.524
MOD_GlcNHglycan	696	699	PF01048	0.433
MOD_GlcNHglycan	707	710	PF01048	0.446
MOD_GlcNHglycan	749	752	PF01048	0.500
MOD_GSK3_1	131	138	PF00069	0.757
MOD_GSK3_1	153	160	PF00069	0.757
MOD_GSK3_1	162	169	PF00069	0.647
MOD_GSK3_1	170	177	PF00069	0.638
MOD_GSK3_1	269	276	PF00069	0.579
MOD_GSK3_1	334	341	PF00069	0.700
MOD_GSK3_1	374	381	PF00069	0.791
MOD_GSK3_1	394	401	PF00069	0.688
MOD_GSK3_1	405	412	PF00069	0.668
MOD_GSK3_1	413	420	PF00069	0.679
MOD_GSK3_1	422	429	PF00069	0.708
MOD_GSK3_1	486	493	PF00069	0.666
MOD_GSK3_1	499	506	PF00069	0.611
MOD_GSK3_1	601	608	PF00069	0.712
MOD_GSK3_1	624	631	PF00069	0.660
MOD_GSK3_1	642	649	PF00069	0.652
MOD_GSK3_1	677	684	PF00069	0.685
MOD_GSK3_1	703	710	PF00069	0.672
MOD_GSK3_1	85	92	PF00069	0.599
MOD_N-GLC_1	375	380	PF02516	0.489
MOD_N-GLC_1	493	498	PF02516	0.470
MOD_N-GLC_1	687	692	PF02516	0.506
MOD_NEK2_1	178	183	PF00069	0.679
MOD_NEK2_1	292	297	PF00069	0.636
MOD_NEK2_1	311	316	PF00069	0.653
MOD_NEK2_1	398	403	PF00069	0.676
MOD_NEK2_1	644	649	PF00069	0.629
MOD_NEK2_1	682	687	PF00069	0.744
MOD_NEK2_1	730	735	PF00069	0.588
MOD_NEK2_1	766	771	PF00069	0.657
MOD_NEK2_1	8	13	PF00069	0.312
MOD_NEK2_1	83	88	PF00069	0.622
MOD_NEK2_2	224	229	PF00069	0.591
MOD_NEK2_2	442	447	PF00069	0.624
MOD_PIKK_1	282	288	PF00454	0.721
MOD_PIKK_1	646	652	PF00454	0.662
MOD_PKA_1	204	210	PF00069	0.667
MOD_PKA_1	747	753	PF00069	0.697
MOD_PKA_2	153	159	PF00069	0.682
MOD_PKA_2	181	187	PF00069	0.667
MOD_PKA_2	204	210	PF00069	0.693
MOD_PKA_2	281	287	PF00069	0.738
MOD_PKA_2	567	573	PF00069	0.540
MOD_PKA_2	664	670	PF00069	0.742
MOD_PKA_2	747	753	PF00069	0.726
MOD_PKA_2	766	772	PF00069	0.520
MOD_Plk_1	375	381	PF00069	0.760
MOD_Plk_1	584	590	PF00069	0.525
MOD_Plk_1	652	658	PF00069	0.734
MOD_Plk_1	687	693	PF00069	0.706
MOD_Plk_1	94	100	PF00069	0.635
MOD_Plk_2-3	471	477	PF00069	0.603
MOD_Plk_4	394	400	PF00069	0.677
MOD_Plk_4	442	448	PF00069	0.623
MOD_ProDKin_1	111	117	PF00069	0.633
MOD_ProDKin_1	198	204	PF00069	0.648
MOD_ProDKin_1	274	280	PF00069	0.690
MOD_ProDKin_1	32	38	PF00069	0.606
MOD_ProDKin_1	336	342	PF00069	0.778
MOD_ProDKin_1	355	361	PF00069	0.784
MOD_ProDKin_1	486	492	PF00069	0.742
MOD_ProDKin_1	493	499	PF00069	0.659
MOD_ProDKin_1	505	511	PF00069	0.598
MOD_SUMO_for_1	228	231	PF00179	0.578
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.717
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.671
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.513
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.703
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.588
TRG_ENDOCYTIC_2	103	106	PF00928	0.581
TRG_ENDOCYTIC_2	20	23	PF00928	0.388
TRG_ENDOCYTIC_2	576	579	PF00928	0.522
TRG_ENDOCYTIC_2	67	70	PF00928	0.751
TRG_ENDOCYTIC_2	71	74	PF00928	0.710
TRG_ENDOCYTIC_2	736	739	PF00928	0.609
TRG_ENDOCYTIC_2	84	87	PF00928	0.546
TRG_ENDOCYTIC_2	90	93	PF00928	0.518
TRG_ER_diArg_1	122	125	PF00400	0.626
TRG_ER_diArg_1	185	187	PF00400	0.665
TRG_ER_diArg_1	188	190	PF00400	0.667
TRG_ER_diArg_1	203	205	PF00400	0.619
TRG_ER_diArg_1	256	259	PF00400	0.571
TRG_ER_diArg_1	727	729	PF00400	0.653
TRG_ER_diArg_1	747	749	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	728	732	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK26	Leptomonas seymouri	42%	93%
A0A3S5H6C2	Leishmania donovani	91%	100%
A4H5K2	Leishmania braziliensis	69%	100%
A4HTU0	Leishmania infantum	91%	99%
E9AMM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%