Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHZ6_LEIMA

TriTrypDb:

LmjF.09.0300 , LMJLV39_090008400 , LMJSD75_090008100

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.772
CLV_C14_Caspase3-7	77	81	PF00656	0.638
CLV_NRD_NRD_1	162	164	PF00675	0.773
CLV_NRD_NRD_1	8	10	PF00675	0.575
CLV_PCSK_KEX2_1	162	164	PF00082	0.773
CLV_PCSK_KEX2_1	8	10	PF00082	0.575
CLV_PCSK_SKI1_1	162	166	PF00082	0.767
CLV_PCSK_SKI1_1	40	44	PF00082	0.554
DEG_APCC_DBOX_1	39	47	PF00400	0.598
DOC_CDC14_PxL_1	106	114	PF14671	0.693
DOC_PP4_FxxP_1	165	168	PF00568	0.749
DOC_USP7_MATH_1	11	15	PF00917	0.685
DOC_USP7_MATH_1	153	157	PF00917	0.757
DOC_USP7_MATH_1	82	86	PF00917	0.659
DOC_USP7_UBL2_3	166	170	PF12436	0.652
DOC_WW_Pin1_4	100	105	PF00397	0.720
LIG_14-3-3_CanoR_1	184	192	PF00244	0.678
LIG_14-3-3_CanoR_1	53	63	PF00244	0.726
LIG_FHA_2	136	142	PF00498	0.734
LIG_FHA_2	169	175	PF00498	0.546
LIG_FHA_2	70	76	PF00498	0.531
LIG_GBD_Chelix_1	117	125	PF00786	0.509
LIG_HP1_1	25	29	PF01393	0.645
LIG_SH2_STAP1	132	136	PF00017	0.582
LIG_SH2_STAP1	19	23	PF00017	0.564
LIG_SH2_STAT5	191	194	PF00017	0.701
LIG_SH3_3	147	153	PF00018	0.548
LIG_SH3_3	63	69	PF00018	0.764
LIG_SUMO_SIM_anti_2	126	135	PF11976	0.629
LIG_TRAF2_1	171	174	PF00917	0.533
MOD_CK1_1	134	140	PF00069	0.667
MOD_CK1_1	85	91	PF00069	0.746
MOD_CK2_1	11	17	PF00069	0.677
MOD_CK2_1	135	141	PF00069	0.729
MOD_CK2_1	153	159	PF00069	0.727
MOD_CK2_1	168	174	PF00069	0.483
MOD_CK2_1	192	198	PF00069	0.646
MOD_GlcNHglycan	201	205	PF01048	0.606
MOD_GlcNHglycan	224	227	PF01048	0.499
MOD_GlcNHglycan	54	57	PF01048	0.625
MOD_GlcNHglycan	87	90	PF01048	0.606
MOD_GSK3_1	131	138	PF00069	0.581
MOD_GSK3_1	69	76	PF00069	0.652
MOD_N-GLC_1	100	105	PF02516	0.687
MOD_N-GLC_1	73	78	PF02516	0.528
MOD_NEK2_1	117	122	PF00069	0.590
MOD_NEK2_1	185	190	PF00069	0.634
MOD_NEK2_1	212	217	PF00069	0.567
MOD_NEK2_2	224	229	PF00069	0.483
MOD_PKA_1	169	175	PF00069	0.643
MOD_PKA_2	183	189	PF00069	0.572
MOD_PKA_2	52	58	PF00069	0.596
MOD_PKA_2	67	73	PF00069	0.498
MOD_Plk_1	132	138	PF00069	0.495
MOD_Plk_4	117	123	PF00069	0.532
MOD_Plk_4	224	230	PF00069	0.614
MOD_Plk_4	62	68	PF00069	0.644
MOD_ProDKin_1	100	106	PF00069	0.716
MOD_SUMO_for_1	216	219	PF00179	0.667
TRG_ER_diArg_1	161	163	PF00400	0.772
TRG_ER_diArg_1	8	10	PF00400	0.575
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R6	Leptomonas seymouri	45%	94%
A0A3S7WQM1	Leishmania donovani	89%	100%
A4H5K4	Leishmania braziliensis	72%	99%
A4HTU2	Leishmania infantum	89%	100%
D0A9A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AMM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
V5B2V2	Trypanosoma cruzi	32%	100%