Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cdc2-related kinase 12

Species:

Leishmania major

UniProt:

Q4QHZ5_LEIMA

TriTrypDb:

LmjF.09.0310 , LMJLV39_090008500 , LMJSD75_090008200

Length:

887

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0016592	mediator complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4QHZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHZ5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016192	vesicle-mediated transport	4	2
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	2
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	2
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0097472	cyclin-dependent protein kinase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	309	311	PF00675	0.704
CLV_NRD_NRD_1	359	361	PF00675	0.571
CLV_NRD_NRD_1	433	435	PF00675	0.636
CLV_NRD_NRD_1	579	581	PF00675	0.380
CLV_NRD_NRD_1	600	602	PF00675	0.380
CLV_NRD_NRD_1	806	808	PF00675	0.505
CLV_NRD_NRD_1	866	868	PF00675	0.462
CLV_NRD_NRD_1	883	885	PF00675	0.697
CLV_NRD_NRD_1	9	11	PF00675	0.719
CLV_PCSK_KEX2_1	207	209	PF00082	0.720
CLV_PCSK_KEX2_1	359	361	PF00082	0.571
CLV_PCSK_KEX2_1	433	435	PF00082	0.636
CLV_PCSK_KEX2_1	483	485	PF00082	0.415
CLV_PCSK_KEX2_1	492	494	PF00082	0.417
CLV_PCSK_KEX2_1	579	581	PF00082	0.380
CLV_PCSK_KEX2_1	806	808	PF00082	0.378
CLV_PCSK_KEX2_1	866	868	PF00082	0.462
CLV_PCSK_KEX2_1	883	885	PF00082	0.697
CLV_PCSK_KEX2_1	9	11	PF00082	0.719
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.720
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.380
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.380
CLV_PCSK_SKI1_1	417	421	PF00082	0.644
CLV_PCSK_SKI1_1	457	461	PF00082	0.442
CLV_PCSK_SKI1_1	492	496	PF00082	0.380
CLV_PCSK_SKI1_1	594	598	PF00082	0.380
CLV_PCSK_SKI1_1	611	615	PF00082	0.226
CLV_Separin_Metazoa	832	836	PF03568	0.380
DEG_Nend_UBRbox_3	1	3	PF02207	0.684
DEG_SCF_FBW7_1	361	366	PF00400	0.617
DEG_SCF_FBW7_2	855	862	PF00400	0.535
DEG_SPOP_SBC_1	248	252	PF00917	0.600
DEG_SPOP_SBC_1	67	71	PF00917	0.684
DOC_CKS1_1	122	127	PF01111	0.685
DOC_CKS1_1	188	193	PF01111	0.612
DOC_CKS1_1	649	654	PF01111	0.380
DOC_CKS1_1	856	861	PF01111	0.488
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.578
DOC_MAPK_gen_1	433	442	PF00069	0.646
DOC_MAPK_gen_1	483	491	PF00069	0.431
DOC_MAPK_gen_1	558	567	PF00069	0.380
DOC_MAPK_gen_1	594	600	PF00069	0.380
DOC_MAPK_gen_1	601	608	PF00069	0.317
DOC_MAPK_gen_1	611	620	PF00069	0.226
DOC_MAPK_gen_1	866	873	PF00069	0.367
DOC_MAPK_HePTP_8	555	567	PF00069	0.380
DOC_MAPK_MEF2A_6	433	442	PF00069	0.677
DOC_MAPK_MEF2A_6	558	567	PF00069	0.380
DOC_MAPK_RevD_3	589	602	PF00069	0.335
DOC_PP2B_LxvP_1	184	187	PF13499	0.627
DOC_PP2B_LxvP_1	245	248	PF13499	0.668
DOC_PP2B_LxvP_1	690	693	PF13499	0.380
DOC_PP2B_LxvP_1	834	837	PF13499	0.380
DOC_USP7_MATH_1	162	166	PF00917	0.639
DOC_USP7_MATH_1	217	221	PF00917	0.642
DOC_USP7_MATH_1	248	252	PF00917	0.663
DOC_USP7_MATH_1	260	264	PF00917	0.594
DOC_USP7_MATH_1	332	336	PF00917	0.572
DOC_USP7_MATH_1	504	508	PF00917	0.380
DOC_USP7_MATH_1	545	549	PF00917	0.380
DOC_USP7_MATH_1	570	574	PF00917	0.380
DOC_USP7_MATH_1	638	642	PF00917	0.370
DOC_USP7_MATH_1	67	71	PF00917	0.684
DOC_USP7_MATH_1	711	715	PF00917	0.483
DOC_USP7_UBL2_3	479	483	PF12436	0.380
DOC_WW_Pin1_4	121	126	PF00397	0.692
DOC_WW_Pin1_4	14	19	PF00397	0.660
DOC_WW_Pin1_4	187	192	PF00397	0.640
DOC_WW_Pin1_4	219	224	PF00397	0.723
DOC_WW_Pin1_4	263	268	PF00397	0.682
DOC_WW_Pin1_4	319	324	PF00397	0.792
DOC_WW_Pin1_4	328	333	PF00397	0.726
DOC_WW_Pin1_4	359	364	PF00397	0.643
DOC_WW_Pin1_4	365	370	PF00397	0.629
DOC_WW_Pin1_4	417	422	PF00397	0.634
DOC_WW_Pin1_4	427	432	PF00397	0.619
DOC_WW_Pin1_4	582	587	PF00397	0.380
DOC_WW_Pin1_4	63	68	PF00397	0.688
DOC_WW_Pin1_4	648	653	PF00397	0.380
DOC_WW_Pin1_4	842	847	PF00397	0.430
DOC_WW_Pin1_4	855	860	PF00397	0.549
LIG_14-3-3_CanoR_1	117	125	PF00244	0.664
LIG_14-3-3_CanoR_1	231	237	PF00244	0.593
LIG_14-3-3_CanoR_1	246	256	PF00244	0.600
LIG_14-3-3_CanoR_1	371	376	PF00244	0.768
LIG_14-3-3_CanoR_1	415	420	PF00244	0.616
LIG_14-3-3_CanoR_1	579	585	PF00244	0.281
LIG_14-3-3_CanoR_1	713	722	PF00244	0.382
LIG_14-3-3_CanoR_1	724	732	PF00244	0.380
LIG_14-3-3_CanoR_1	83	89	PF00244	0.642
LIG_BRCT_BRCA1_1	448	452	PF00533	0.611
LIG_FHA_1	135	141	PF00498	0.704
LIG_FHA_1	146	152	PF00498	0.600
LIG_FHA_1	172	178	PF00498	0.693
LIG_FHA_1	188	194	PF00498	0.539
LIG_FHA_1	232	238	PF00498	0.697
LIG_FHA_1	283	289	PF00498	0.627
LIG_FHA_1	307	313	PF00498	0.639
LIG_FHA_1	360	366	PF00498	0.678
LIG_FHA_1	383	389	PF00498	0.728
LIG_FHA_1	539	545	PF00498	0.402
LIG_FHA_1	569	575	PF00498	0.380
LIG_FHA_1	58	64	PF00498	0.656
LIG_FHA_1	649	655	PF00498	0.426
LIG_FHA_1	724	730	PF00498	0.380
LIG_FHA_1	843	849	PF00498	0.464
LIG_FHA_2	225	231	PF00498	0.668
LIG_FHA_2	456	462	PF00498	0.498
LIG_FHA_2	471	477	PF00498	0.245
LIG_FHA_2	583	589	PF00498	0.380
LIG_FHA_2	667	673	PF00498	0.395
LIG_FHA_2	715	721	PF00498	0.380
LIG_FHA_2	773	779	PF00498	0.380
LIG_FHA_2	827	833	PF00498	0.355
LIG_FHA_2	838	844	PF00498	0.418
LIG_LIR_Apic_2	199	205	PF02991	0.663
LIG_LIR_Apic_2	656	662	PF02991	0.341
LIG_LIR_Gen_1	410	421	PF02991	0.606
LIG_LIR_Gen_1	449	459	PF02991	0.491
LIG_LIR_Gen_1	780	789	PF02991	0.468
LIG_LIR_Nem_3	410	416	PF02991	0.671
LIG_LIR_Nem_3	449	455	PF02991	0.686
LIG_LIR_Nem_3	471	477	PF02991	0.417
LIG_LIR_Nem_3	780	786	PF02991	0.387
LIG_NRBOX	679	685	PF00104	0.380
LIG_PCNA_yPIPBox_3	456	468	PF02747	0.493
LIG_PCNA_yPIPBox_3	505	515	PF02747	0.335
LIG_Pex14_2	777	781	PF04695	0.380
LIG_Pex14_2	789	793	PF04695	0.272
LIG_SH2_CRK	851	855	PF00017	0.622
LIG_SH2_NCK_1	569	573	PF00017	0.380
LIG_SH2_STAP1	671	675	PF00017	0.380
LIG_SH2_STAT3	556	559	PF00017	0.380
LIG_SH2_STAT5	25	28	PF00017	0.618
LIG_SH2_STAT5	688	691	PF00017	0.323
LIG_SH2_STAT5	838	841	PF00017	0.476
LIG_SH3_1	153	159	PF00018	0.688
LIG_SH3_1	853	859	PF00018	0.526
LIG_SH3_2	856	861	PF14604	0.488
LIG_SH3_3	119	125	PF00018	0.707
LIG_SH3_3	153	159	PF00018	0.733
LIG_SH3_3	185	191	PF00018	0.638
LIG_SH3_3	213	219	PF00018	0.661
LIG_SH3_3	372	378	PF00018	0.675
LIG_SH3_3	437	443	PF00018	0.644
LIG_SH3_3	728	734	PF00018	0.369
LIG_SH3_3	853	859	PF00018	0.526
LIG_SUMO_SIM_anti_2	562	567	PF11976	0.380
LIG_SUMO_SIM_par_1	382	387	PF11976	0.552
LIG_TRAF2_1	302	305	PF00917	0.750
LIG_TRFH_1	688	692	PF08558	0.380
LIG_WW_1	692	695	PF00397	0.380
LIG_WW_3	80	84	PF00397	0.632
MOD_CDC14_SPxK_1	430	433	PF00782	0.664
MOD_CDK_SPxK_1	365	371	PF00069	0.636
MOD_CDK_SPxK_1	427	433	PF00069	0.682
MOD_CDK_SPxK_1	855	861	PF00069	0.542
MOD_CDK_SPxxK_3	427	434	PF00069	0.680
MOD_CK1_1	116	122	PF00069	0.699
MOD_CK1_1	12	18	PF00069	0.668
MOD_CK1_1	160	166	PF00069	0.686
MOD_CK1_1	263	269	PF00069	0.619
MOD_CK1_1	331	337	PF00069	0.648
MOD_CK1_1	367	373	PF00069	0.728
MOD_CK1_1	390	396	PF00069	0.647
MOD_CK1_1	411	417	PF00069	0.676
MOD_CK1_1	470	476	PF00069	0.380
MOD_CK1_1	61	67	PF00069	0.731
MOD_CK1_1	639	645	PF00069	0.358
MOD_CK1_1	653	659	PF00069	0.275
MOD_CK1_1	714	720	PF00069	0.380
MOD_CK1_1	72	78	PF00069	0.621
MOD_CK1_1	723	729	PF00069	0.380
MOD_CK2_1	224	230	PF00069	0.594
MOD_CK2_1	455	461	PF00069	0.472
MOD_CK2_1	470	476	PF00069	0.278
MOD_CK2_1	504	510	PF00069	0.402
MOD_CK2_1	582	588	PF00069	0.380
MOD_CK2_1	619	625	PF00069	0.335
MOD_CK2_1	714	720	PF00069	0.335
MOD_CK2_1	72	78	PF00069	0.730
MOD_CK2_1	772	778	PF00069	0.380
MOD_CK2_1	826	832	PF00069	0.380
MOD_DYRK1A_RPxSP_1	417	421	PF00069	0.622
MOD_GlcNHglycan	164	167	PF01048	0.648
MOD_GlcNHglycan	219	222	PF01048	0.728
MOD_GlcNHglycan	224	227	PF01048	0.709
MOD_GlcNHglycan	239	242	PF01048	0.572
MOD_GlcNHglycan	262	265	PF01048	0.659
MOD_GlcNHglycan	276	279	PF01048	0.736
MOD_GlcNHglycan	280	283	PF01048	0.718
MOD_GlcNHglycan	288	291	PF01048	0.661
MOD_GlcNHglycan	334	337	PF01048	0.613
MOD_GlcNHglycan	353	356	PF01048	0.784
MOD_GlcNHglycan	389	392	PF01048	0.689
MOD_GlcNHglycan	401	404	PF01048	0.584
MOD_GlcNHglycan	410	413	PF01048	0.621
MOD_GlcNHglycan	497	500	PF01048	0.256
MOD_GlcNHglycan	638	641	PF01048	0.348
MOD_GlcNHglycan	643	646	PF01048	0.348
MOD_GlcNHglycan	71	74	PF01048	0.718
MOD_GlcNHglycan	712	716	PF01048	0.380
MOD_GlcNHglycan	97	100	PF01048	0.667
MOD_GSK3_1	12	19	PF00069	0.685
MOD_GSK3_1	157	164	PF00069	0.641
MOD_GSK3_1	256	263	PF00069	0.629
MOD_GSK3_1	274	281	PF00069	0.654
MOD_GSK3_1	282	289	PF00069	0.659
MOD_GSK3_1	328	335	PF00069	0.584
MOD_GSK3_1	359	366	PF00069	0.707
MOD_GSK3_1	367	374	PF00069	0.660
MOD_GSK3_1	407	414	PF00069	0.656
MOD_GSK3_1	415	422	PF00069	0.538
MOD_GSK3_1	446	453	PF00069	0.608
MOD_GSK3_1	57	64	PF00069	0.733
MOD_GSK3_1	580	587	PF00069	0.329
MOD_GSK3_1	632	639	PF00069	0.352
MOD_GSK3_1	68	75	PF00069	0.634
MOD_GSK3_1	838	845	PF00069	0.377
MOD_N-GLC_1	143	148	PF02516	0.579
MOD_N-GLC_1	286	291	PF02516	0.709
MOD_NEK2_1	128	133	PF00069	0.582
MOD_NEK2_1	249	254	PF00069	0.670
MOD_NEK2_1	408	413	PF00069	0.638
MOD_NEK2_1	665	670	PF00069	0.380
MOD_NEK2_1	68	73	PF00069	0.693
MOD_NEK2_1	797	802	PF00069	0.417
MOD_NEK2_1	95	100	PF00069	0.664
MOD_NEK2_2	171	176	PF00069	0.633
MOD_NEK2_2	504	509	PF00069	0.380
MOD_PIKK_1	390	396	PF00454	0.652
MOD_PIKK_1	424	430	PF00454	0.734
MOD_PIKK_1	545	551	PF00454	0.380
MOD_PIKK_1	806	812	PF00454	0.380
MOD_PIKK_1	878	884	PF00454	0.658
MOD_PK_1	371	377	PF00069	0.652
MOD_PK_1	49	55	PF00069	0.708
MOD_PK_1	650	656	PF00069	0.380
MOD_PKA_1	806	812	PF00069	0.380
MOD_PKA_1	9	15	PF00069	0.711
MOD_PKA_2	116	122	PF00069	0.716
MOD_PKA_2	230	236	PF00069	0.578
MOD_PKA_2	317	323	PF00069	0.644
MOD_PKA_2	723	729	PF00069	0.431
MOD_PKA_2	806	812	PF00069	0.380
MOD_PKA_2	826	832	PF00069	0.199
MOD_PKA_2	9	15	PF00069	0.713
MOD_Plk_1	450	456	PF00069	0.516
MOD_Plk_1	545	551	PF00069	0.382
MOD_Plk_4	128	134	PF00069	0.626
MOD_Plk_4	21	27	PF00069	0.615
MOD_Plk_4	650	656	PF00069	0.376
MOD_Plk_4	733	739	PF00069	0.335
MOD_Plk_4	772	778	PF00069	0.380
MOD_ProDKin_1	121	127	PF00069	0.688
MOD_ProDKin_1	14	20	PF00069	0.658
MOD_ProDKin_1	187	193	PF00069	0.644
MOD_ProDKin_1	219	225	PF00069	0.727
MOD_ProDKin_1	263	269	PF00069	0.682
MOD_ProDKin_1	319	325	PF00069	0.794
MOD_ProDKin_1	328	334	PF00069	0.726
MOD_ProDKin_1	359	365	PF00069	0.646
MOD_ProDKin_1	417	423	PF00069	0.644
MOD_ProDKin_1	427	433	PF00069	0.614
MOD_ProDKin_1	582	588	PF00069	0.380
MOD_ProDKin_1	63	69	PF00069	0.688
MOD_ProDKin_1	648	654	PF00069	0.380
MOD_ProDKin_1	842	848	PF00069	0.442
MOD_ProDKin_1	855	861	PF00069	0.542
MOD_SUMO_rev_2	668	675	PF00179	0.380
TRG_DiLeu_BaEn_1	588	593	PF01217	0.380
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.643
TRG_DiLeu_BaLyEn_6	843	848	PF01217	0.581
TRG_ENDOCYTIC_2	474	477	PF00928	0.402
TRG_ENDOCYTIC_2	783	786	PF00928	0.380
TRG_ENDOCYTIC_2	851	854	PF00928	0.710
TRG_ER_diArg_1	175	178	PF00400	0.652
TRG_ER_diArg_1	208	211	PF00400	0.682
TRG_ER_diArg_1	359	361	PF00400	0.571
TRG_ER_diArg_1	433	436	PF00400	0.599
TRG_ER_diArg_1	695	698	PF00400	0.380
TRG_ER_diArg_1	8	10	PF00400	0.706
TRG_ER_diArg_1	806	808	PF00400	0.376
TRG_ER_diArg_1	865	867	PF00400	0.448
TRG_ER_diArg_1	883	885	PF00400	0.697
TRG_NLS_MonoExtC_3	206	211	PF00514	0.706
TRG_NLS_MonoExtN_4	204	211	PF00514	0.695
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	747	751	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQK2	Leishmania donovani	92%	100%
A4H5K5	Leishmania braziliensis	78%	100%
E9AMN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%