LeishMANIAdb
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CHASE domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CHASE domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QHZ4_LEIMA
TriTrypDb:
LmjF.09.0320 , LMJLV39_090008600 * , LMJLV39_090008800 , LMJSD75_090008300 *
Length:
918

Annotations

LeishMANIAdb annotations

Appears to be an enzyme-linked receptor, putatively a receptor nucleotide cyclase (cAMP synthase).. Expanded on the Leishmaniid lineage. The first helical segment is very similar to a signal peptide.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4QHZ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHZ4

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 6
GO:0006163 purine nucleotide metabolic process 5 6
GO:0006164 purine nucleotide biosynthetic process 6 6
GO:0006171 cAMP biosynthetic process 8 6
GO:0006725 cellular aromatic compound metabolic process 3 6
GO:0006753 nucleoside phosphate metabolic process 4 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009058 biosynthetic process 2 6
GO:0009117 nucleotide metabolic process 5 6
GO:0009150 purine ribonucleotide metabolic process 6 6
GO:0009152 purine ribonucleotide biosynthetic process 7 6
GO:0009165 nucleotide biosynthetic process 6 6
GO:0009187 cyclic nucleotide metabolic process 6 6
GO:0009190 cyclic nucleotide biosynthetic process 7 6
GO:0009259 ribonucleotide metabolic process 5 6
GO:0009260 ribonucleotide biosynthetic process 6 6
GO:0009987 cellular process 1 6
GO:0018130 heterocycle biosynthetic process 4 6
GO:0019438 aromatic compound biosynthetic process 4 6
GO:0019637 organophosphate metabolic process 3 6
GO:0019693 ribose phosphate metabolic process 4 6
GO:0034641 cellular nitrogen compound metabolic process 3 6
GO:0034654 nucleobase-containing compound biosynthetic process 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0044249 cellular biosynthetic process 3 6
GO:0044271 cellular nitrogen compound biosynthetic process 4 6
GO:0044281 small molecule metabolic process 2 6
GO:0046058 cAMP metabolic process 7 6
GO:0046390 ribose phosphate biosynthetic process 5 6
GO:0046483 heterocycle metabolic process 3 6
GO:0052652 cyclic purine nucleotide metabolic process 6 6
GO:0055086 nucleobase-containing small molecule metabolic process 3 6
GO:0071704 organic substance metabolic process 2 6
GO:0072521 purine-containing compound metabolic process 4 6
GO:0072522 purine-containing compound biosynthetic process 5 6
GO:0090407 organophosphate biosynthetic process 4 6
GO:1901135 carbohydrate derivative metabolic process 3 6
GO:1901137 carbohydrate derivative biosynthetic process 4 6
GO:1901293 nucleoside phosphate biosynthetic process 5 6
GO:1901360 organic cyclic compound metabolic process 3 6
GO:1901362 organic cyclic compound biosynthetic process 4 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1901566 organonitrogen compound biosynthetic process 4 6
GO:1901576 organic substance biosynthetic process 3 6
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 607 611 PF00656 0.478
CLV_C14_Caspase3-7 693 697 PF00656 0.508
CLV_C14_Caspase3-7 747 751 PF00656 0.434
CLV_NRD_NRD_1 205 207 PF00675 0.383
CLV_NRD_NRD_1 265 267 PF00675 0.431
CLV_NRD_NRD_1 730 732 PF00675 0.675
CLV_NRD_NRD_1 849 851 PF00675 0.604
CLV_NRD_NRD_1 878 880 PF00675 0.604
CLV_PCSK_KEX2_1 194 196 PF00082 0.373
CLV_PCSK_KEX2_1 265 267 PF00082 0.431
CLV_PCSK_KEX2_1 730 732 PF00082 0.681
CLV_PCSK_KEX2_1 849 851 PF00082 0.604
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.327
CLV_PCSK_SKI1_1 499 503 PF00082 0.651
CLV_PCSK_SKI1_1 518 522 PF00082 0.577
CLV_PCSK_SKI1_1 526 530 PF00082 0.563
CLV_PCSK_SKI1_1 723 727 PF00082 0.637
CLV_PCSK_SKI1_1 788 792 PF00082 0.671
CLV_PCSK_SKI1_1 804 808 PF00082 0.567
CLV_PCSK_SKI1_1 833 837 PF00082 0.580
CLV_PCSK_SKI1_1 850 854 PF00082 0.631
CLV_PCSK_SKI1_1 879 883 PF00082 0.529
DEG_APCC_DBOX_1 787 795 PF00400 0.396
DEG_SPOP_SBC_1 484 488 PF00917 0.367
DOC_CKS1_1 174 179 PF01111 0.606
DOC_CYCLIN_yClb5_NLxxxL_5 325 331 PF00134 0.508
DOC_CYCLIN_yCln2_LP_2 790 796 PF00134 0.387
DOC_CYCLIN_yCln2_LP_2 835 841 PF00134 0.397
DOC_MAPK_gen_1 206 212 PF00069 0.533
DOC_MAPK_gen_1 381 389 PF00069 0.585
DOC_MAPK_MEF2A_6 797 805 PF00069 0.438
DOC_PP1_RVXF_1 802 808 PF00149 0.422
DOC_PP1_RVXF_1 831 837 PF00149 0.374
DOC_PP2B_LxvP_1 72 75 PF13499 0.421
DOC_PP2B_LxvP_1 839 842 PF13499 0.407
DOC_PP4_FxxP_1 566 569 PF00568 0.377
DOC_PP4_FxxP_1 855 858 PF00568 0.384
DOC_USP7_MATH_1 14 18 PF00917 0.507
DOC_USP7_MATH_1 144 148 PF00917 0.526
DOC_USP7_MATH_1 180 184 PF00917 0.617
DOC_USP7_MATH_1 372 376 PF00917 0.579
DOC_USP7_MATH_1 379 383 PF00917 0.505
DOC_USP7_MATH_1 567 571 PF00917 0.371
DOC_USP7_MATH_1 668 672 PF00917 0.583
DOC_USP7_MATH_1 676 680 PF00917 0.567
DOC_USP7_MATH_1 689 693 PF00917 0.465
DOC_USP7_MATH_1 725 729 PF00917 0.510
DOC_USP7_MATH_1 906 910 PF00917 0.454
DOC_USP7_MATH_2 60 66 PF00917 0.460
DOC_WW_Pin1_4 173 178 PF00397 0.578
DOC_WW_Pin1_4 235 240 PF00397 0.635
DOC_WW_Pin1_4 387 392 PF00397 0.678
DOC_WW_Pin1_4 47 52 PF00397 0.490
DOC_WW_Pin1_4 5 10 PF00397 0.456
DOC_WW_Pin1_4 618 623 PF00397 0.441
DOC_WW_Pin1_4 679 684 PF00397 0.469
DOC_WW_Pin1_4 698 703 PF00397 0.574
DOC_WW_Pin1_4 769 774 PF00397 0.490
DOC_WW_Pin1_4 77 82 PF00397 0.469
DOC_WW_Pin1_4 900 905 PF00397 0.493
LIG_14-3-3_CanoR_1 15 19 PF00244 0.505
LIG_14-3-3_CanoR_1 198 203 PF00244 0.613
LIG_14-3-3_CanoR_1 265 272 PF00244 0.663
LIG_14-3-3_CanoR_1 286 294 PF00244 0.586
LIG_14-3-3_CanoR_1 526 532 PF00244 0.326
LIG_14-3-3_CanoR_1 593 599 PF00244 0.495
LIG_14-3-3_CanoR_1 617 622 PF00244 0.573
LIG_14-3-3_CanoR_1 738 746 PF00244 0.486
LIG_14-3-3_CanoR_1 849 858 PF00244 0.395
LIG_Actin_RPEL_3 376 395 PF02755 0.539
LIG_Clathr_ClatBox_1 778 782 PF01394 0.458
LIG_deltaCOP1_diTrp_1 297 302 PF00928 0.515
LIG_FHA_1 100 106 PF00498 0.389
LIG_FHA_1 109 115 PF00498 0.274
LIG_FHA_1 188 194 PF00498 0.591
LIG_FHA_1 308 314 PF00498 0.533
LIG_FHA_1 339 345 PF00498 0.647
LIG_FHA_1 365 371 PF00498 0.567
LIG_FHA_1 390 396 PF00498 0.539
LIG_FHA_1 458 464 PF00498 0.375
LIG_FHA_1 485 491 PF00498 0.347
LIG_FHA_1 595 601 PF00498 0.463
LIG_FHA_1 628 634 PF00498 0.443
LIG_FHA_1 785 791 PF00498 0.393
LIG_FHA_1 81 87 PF00498 0.411
LIG_FHA_1 811 817 PF00498 0.388
LIG_FHA_1 880 886 PF00498 0.331
LIG_FHA_2 363 369 PF00498 0.552
LIG_FHA_2 502 508 PF00498 0.423
LIG_FHA_2 571 577 PF00498 0.367
LIG_FHA_2 8 14 PF00498 0.510
LIG_Integrin_RGD_1 748 750 PF01839 0.664
LIG_LIR_Apic_2 549 555 PF02991 0.381
LIG_LIR_Apic_2 671 676 PF02991 0.422
LIG_LIR_Apic_2 853 858 PF02991 0.395
LIG_LIR_Gen_1 143 153 PF02991 0.531
LIG_LIR_Gen_1 256 264 PF02991 0.676
LIG_LIR_Gen_1 356 362 PF02991 0.654
LIG_LIR_Gen_1 384 394 PF02991 0.577
LIG_LIR_Gen_1 592 601 PF02991 0.457
LIG_LIR_Gen_1 630 640 PF02991 0.445
LIG_LIR_Gen_1 808 816 PF02991 0.393
LIG_LIR_Nem_3 111 116 PF02991 0.396
LIG_LIR_Nem_3 143 148 PF02991 0.576
LIG_LIR_Nem_3 169 174 PF02991 0.550
LIG_LIR_Nem_3 256 262 PF02991 0.681
LIG_LIR_Nem_3 297 303 PF02991 0.540
LIG_LIR_Nem_3 328 332 PF02991 0.530
LIG_LIR_Nem_3 356 360 PF02991 0.679
LIG_LIR_Nem_3 384 389 PF02991 0.575
LIG_LIR_Nem_3 401 406 PF02991 0.234
LIG_LIR_Nem_3 592 598 PF02991 0.438
LIG_LIR_Nem_3 630 635 PF02991 0.424
LIG_LIR_Nem_3 808 812 PF02991 0.384
LIG_LIR_Nem_3 830 835 PF02991 0.396
LIG_LIR_Nem_3 97 101 PF02991 0.290
LIG_NRBOX 630 636 PF00104 0.379
LIG_PCNA_PIPBox_1 859 868 PF02747 0.368
LIG_PDZ_Class_2 913 918 PF00595 0.452
LIG_SH2_CRK 259 263 PF00017 0.573
LIG_SH2_CRK 673 677 PF00017 0.483
LIG_SH2_CRK 76 80 PF00017 0.462
LIG_SH2_CRK 809 813 PF00017 0.395
LIG_SH2_CRK 832 836 PF00017 0.431
LIG_SH2_NCK_1 259 263 PF00017 0.573
LIG_SH2_SRC 259 262 PF00017 0.545
LIG_SH2_SRC 818 821 PF00017 0.460
LIG_SH2_STAP1 357 361 PF00017 0.569
LIG_SH2_STAP1 531 535 PF00017 0.334
LIG_SH2_STAT3 477 480 PF00017 0.373
LIG_SH2_STAT5 192 195 PF00017 0.575
LIG_SH2_STAT5 329 332 PF00017 0.580
LIG_SH2_STAT5 489 492 PF00017 0.348
LIG_SH2_STAT5 632 635 PF00017 0.458
LIG_SH2_STAT5 673 676 PF00017 0.480
LIG_SH2_STAT5 827 830 PF00017 0.353
LIG_SH2_STAT5 99 102 PF00017 0.352
LIG_SH3_3 223 229 PF00018 0.566
LIG_SH3_3 236 242 PF00018 0.556
LIG_SH3_3 366 372 PF00018 0.632
LIG_SH3_3 45 51 PF00018 0.557
LIG_SH3_3 790 796 PF00018 0.462
LIG_SUMO_SIM_anti_2 392 398 PF11976 0.533
LIG_SUMO_SIM_anti_2 405 410 PF11976 0.260
LIG_SUMO_SIM_anti_2 597 604 PF11976 0.458
LIG_SUMO_SIM_anti_2 777 782 PF11976 0.403
LIG_SUMO_SIM_par_1 453 461 PF11976 0.313
LIG_SUMO_SIM_par_1 777 782 PF11976 0.460
LIG_TRAF2_1 10 13 PF00917 0.513
LIG_TRAF2_1 42 45 PF00917 0.505
LIG_TRAF2_1 504 507 PF00917 0.479
LIG_WRC_WIRS_1 296 301 PF05994 0.539
MOD_CK1_1 167 173 PF00069 0.598
MOD_CK1_1 17 23 PF00069 0.492
MOD_CK1_1 183 189 PF00069 0.549
MOD_CK1_1 240 246 PF00069 0.626
MOD_CK1_1 295 301 PF00069 0.592
MOD_CK1_1 347 353 PF00069 0.541
MOD_CK1_1 364 370 PF00069 0.503
MOD_CK1_1 382 388 PF00069 0.549
MOD_CK1_1 488 494 PF00069 0.347
MOD_CK1_1 50 56 PF00069 0.485
MOD_CK1_1 570 576 PF00069 0.361
MOD_CK1_1 679 685 PF00069 0.578
MOD_CK1_1 698 704 PF00069 0.539
MOD_CK1_1 706 712 PF00069 0.511
MOD_CK1_1 713 719 PF00069 0.515
MOD_CK1_1 80 86 PF00069 0.454
MOD_CK1_1 894 900 PF00069 0.492
MOD_CK2_1 246 252 PF00069 0.612
MOD_CK2_1 39 45 PF00069 0.495
MOD_CK2_1 500 506 PF00069 0.472
MOD_CK2_1 570 576 PF00069 0.369
MOD_CK2_1 7 13 PF00069 0.511
MOD_CK2_1 748 754 PF00069 0.431
MOD_CK2_1 768 774 PF00069 0.585
MOD_CK2_1 892 898 PF00069 0.529
MOD_GlcNHglycan 125 128 PF01048 0.371
MOD_GlcNHglycan 130 133 PF01048 0.360
MOD_GlcNHglycan 142 145 PF01048 0.249
MOD_GlcNHglycan 217 220 PF01048 0.294
MOD_GlcNHglycan 22 25 PF01048 0.652
MOD_GlcNHglycan 255 258 PF01048 0.476
MOD_GlcNHglycan 32 35 PF01048 0.675
MOD_GlcNHglycan 349 352 PF01048 0.378
MOD_GlcNHglycan 41 44 PF01048 0.659
MOD_GlcNHglycan 587 590 PF01048 0.646
MOD_GlcNHglycan 627 630 PF01048 0.652
MOD_GlcNHglycan 678 681 PF01048 0.689
MOD_GlcNHglycan 696 700 PF01048 0.798
MOD_GlcNHglycan 705 709 PF01048 0.677
MOD_GlcNHglycan 737 741 PF01048 0.758
MOD_GSK3_1 1 8 PF00069 0.460
MOD_GSK3_1 140 147 PF00069 0.521
MOD_GSK3_1 183 190 PF00069 0.620
MOD_GSK3_1 198 205 PF00069 0.500
MOD_GSK3_1 246 253 PF00069 0.613
MOD_GSK3_1 264 271 PF00069 0.580
MOD_GSK3_1 332 339 PF00069 0.687
MOD_GSK3_1 343 350 PF00069 0.592
MOD_GSK3_1 385 392 PF00069 0.608
MOD_GSK3_1 398 405 PF00069 0.348
MOD_GSK3_1 484 491 PF00069 0.354
MOD_GSK3_1 542 549 PF00069 0.543
MOD_GSK3_1 585 592 PF00069 0.425
MOD_GSK3_1 600 607 PF00069 0.565
MOD_GSK3_1 703 710 PF00069 0.528
MOD_GSK3_1 715 722 PF00069 0.481
MOD_GSK3_1 744 751 PF00069 0.531
MOD_GSK3_1 80 87 PF00069 0.433
MOD_GSK3_1 887 894 PF00069 0.449
MOD_GSK3_1 896 903 PF00069 0.474
MOD_N-GLC_1 178 183 PF02516 0.571
MOD_N-GLC_1 286 291 PF02516 0.427
MOD_N-GLC_1 307 312 PF02516 0.337
MOD_N-GLC_1 617 622 PF02516 0.633
MOD_NEK2_1 1 6 PF00069 0.504
MOD_NEK2_1 202 207 PF00069 0.568
MOD_NEK2_1 402 407 PF00069 0.481
MOD_NEK2_1 417 422 PF00069 0.522
MOD_NEK2_1 485 490 PF00069 0.349
MOD_NEK2_1 500 505 PF00069 0.353
MOD_NEK2_1 527 532 PF00069 0.319
MOD_NEK2_1 546 551 PF00069 0.517
MOD_NEK2_1 585 590 PF00069 0.443
MOD_NEK2_1 601 606 PF00069 0.434
MOD_NEK2_1 828 833 PF00069 0.361
MOD_NEK2_1 86 91 PF00069 0.597
MOD_NEK2_1 891 896 PF00069 0.523
MOD_NEK2_2 108 113 PF00069 0.300
MOD_NEK2_2 372 377 PF00069 0.574
MOD_NEK2_2 627 632 PF00069 0.413
MOD_PIKK_1 50 56 PF00454 0.502
MOD_PIKK_1 7 13 PF00454 0.511
MOD_PIKK_1 725 731 PF00454 0.480
MOD_PIKK_1 80 86 PF00454 0.469
MOD_PIKK_1 873 879 PF00454 0.383
MOD_PIKK_1 892 898 PF00454 0.388
MOD_PKA_1 265 271 PF00069 0.546
MOD_PKA_1 879 885 PF00069 0.325
MOD_PKA_2 123 129 PF00069 0.572
MOD_PKA_2 14 20 PF00069 0.501
MOD_PKA_2 264 270 PF00069 0.630
MOD_PKA_2 285 291 PF00069 0.580
MOD_PKA_2 382 388 PF00069 0.574
MOD_PKA_2 601 607 PF00069 0.618
MOD_Plk_1 362 368 PF00069 0.564
MOD_Plk_1 897 903 PF00069 0.524
MOD_Plk_4 108 114 PF00069 0.294
MOD_Plk_4 14 20 PF00069 0.501
MOD_Plk_4 144 150 PF00069 0.539
MOD_Plk_4 198 204 PF00069 0.626
MOD_Plk_4 295 301 PF00069 0.540
MOD_Plk_4 382 388 PF00069 0.696
MOD_Plk_4 402 408 PF00069 0.401
MOD_Plk_4 485 491 PF00069 0.347
MOD_Plk_4 567 573 PF00069 0.364
MOD_Plk_4 627 633 PF00069 0.454
MOD_Plk_4 668 674 PF00069 0.478
MOD_Plk_4 68 74 PF00069 0.463
MOD_Plk_4 774 780 PF00069 0.416
MOD_Plk_4 94 100 PF00069 0.354
MOD_ProDKin_1 173 179 PF00069 0.586
MOD_ProDKin_1 235 241 PF00069 0.631
MOD_ProDKin_1 387 393 PF00069 0.676
MOD_ProDKin_1 47 53 PF00069 0.488
MOD_ProDKin_1 5 11 PF00069 0.456
MOD_ProDKin_1 618 624 PF00069 0.438
MOD_ProDKin_1 679 685 PF00069 0.471
MOD_ProDKin_1 698 704 PF00069 0.573
MOD_ProDKin_1 769 775 PF00069 0.491
MOD_ProDKin_1 77 83 PF00069 0.467
MOD_ProDKin_1 900 906 PF00069 0.488
TRG_DiLeu_BaEn_1 524 529 PF01217 0.498
TRG_DiLeu_BaEn_1 754 759 PF01217 0.484
TRG_DiLeu_BaEn_1 774 779 PF01217 0.389
TRG_DiLeu_BaEn_1 820 825 PF01217 0.449
TRG_DiLeu_BaEn_4 446 452 PF01217 0.389
TRG_DiLeu_BaLyEn_6 523 528 PF01217 0.397
TRG_DiLeu_BaLyEn_6 790 795 PF01217 0.464
TRG_ENDOCYTIC_2 259 262 PF00928 0.579
TRG_ENDOCYTIC_2 357 360 PF00928 0.573
TRG_ENDOCYTIC_2 595 598 PF00928 0.470
TRG_ENDOCYTIC_2 632 635 PF00928 0.415
TRG_ENDOCYTIC_2 809 812 PF00928 0.385
TRG_ENDOCYTIC_2 832 835 PF00928 0.397
TRG_ER_diArg_1 264 266 PF00400 0.632
TRG_ER_diArg_1 380 383 PF00400 0.657
TRG_ER_diArg_1 848 850 PF00400 0.398
TRG_Pf-PMV_PEXEL_1 788 792 PF00026 0.741

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C6 Leptomonas seymouri 41% 100%
A0A3S5H6C4 Leishmania donovani 48% 100%
A0A3S7WQJ6 Leishmania donovani 89% 100%
A4H5K6 Leishmania braziliensis 66% 100%
A4H5K7 Leishmania braziliensis 45% 100%
A4HTU4 Leishmania infantum 90% 100%
A4HTU5 Leishmania infantum 48% 100%
E9AMN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9AMN2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
Q4QHZ3 Leishmania major 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS