LeishMANIAdb
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CHASE domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CHASE domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QHZ3_LEIMA
TriTrypDb:
LmjF.09.0330 , LMJLV39_090008800 * , LMJSD75_090008400 *
Length:
846

Annotations

LeishMANIAdb annotations

Appears to be an enzyme-linked receptor, putatively a receptor nucleotide cyclase (cAMP synthase).. Expanded on the Leishmaniid lineage. The first helical segment is very similar to a signal peptide.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4QHZ3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHZ3

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 6
GO:0006163 purine nucleotide metabolic process 5 6
GO:0006164 purine nucleotide biosynthetic process 6 6
GO:0006171 cAMP biosynthetic process 8 6
GO:0006725 cellular aromatic compound metabolic process 3 6
GO:0006753 nucleoside phosphate metabolic process 4 6
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 6
GO:0009058 biosynthetic process 2 6
GO:0009117 nucleotide metabolic process 5 6
GO:0009150 purine ribonucleotide metabolic process 6 6
GO:0009152 purine ribonucleotide biosynthetic process 7 6
GO:0009165 nucleotide biosynthetic process 6 6
GO:0009187 cyclic nucleotide metabolic process 6 6
GO:0009190 cyclic nucleotide biosynthetic process 7 6
GO:0009259 ribonucleotide metabolic process 5 6
GO:0009260 ribonucleotide biosynthetic process 6 6
GO:0009987 cellular process 1 6
GO:0018130 heterocycle biosynthetic process 4 6
GO:0019438 aromatic compound biosynthetic process 4 6
GO:0019637 organophosphate metabolic process 3 6
GO:0019693 ribose phosphate metabolic process 4 6
GO:0034641 cellular nitrogen compound metabolic process 3 6
GO:0034654 nucleobase-containing compound biosynthetic process 4 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0044249 cellular biosynthetic process 3 6
GO:0044271 cellular nitrogen compound biosynthetic process 4 6
GO:0044281 small molecule metabolic process 2 6
GO:0046058 cAMP metabolic process 7 6
GO:0046390 ribose phosphate biosynthetic process 5 6
GO:0046483 heterocycle metabolic process 3 6
GO:0052652 cyclic purine nucleotide metabolic process 6 6
GO:0055086 nucleobase-containing small molecule metabolic process 3 6
GO:0071704 organic substance metabolic process 2 6
GO:0072521 purine-containing compound metabolic process 4 6
GO:0072522 purine-containing compound biosynthetic process 5 6
GO:0090407 organophosphate biosynthetic process 4 6
GO:1901135 carbohydrate derivative metabolic process 3 6
GO:1901137 carbohydrate derivative biosynthetic process 4 6
GO:1901293 nucleoside phosphate biosynthetic process 5 6
GO:1901360 organic cyclic compound metabolic process 3 6
GO:1901362 organic cyclic compound biosynthetic process 4 6
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1901566 organonitrogen compound biosynthetic process 4 6
GO:1901576 organic substance biosynthetic process 3 6
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 643 647 PF00656 0.477
CLV_C14_Caspase3-7 663 667 PF00656 0.464
CLV_NRD_NRD_1 128 130 PF00675 0.571
CLV_NRD_NRD_1 205 207 PF00675 0.521
CLV_NRD_NRD_1 594 596 PF00675 0.407
CLV_NRD_NRD_1 782 784 PF00675 0.621
CLV_PCSK_KEX2_1 128 130 PF00082 0.570
CLV_PCSK_KEX2_1 205 207 PF00082 0.525
CLV_PCSK_KEX2_1 250 252 PF00082 0.667
CLV_PCSK_KEX2_1 594 596 PF00082 0.407
CLV_PCSK_KEX2_1 782 784 PF00082 0.621
CLV_PCSK_PC1ET2_1 250 252 PF00082 0.667
CLV_PCSK_SKI1_1 129 133 PF00082 0.520
CLV_PCSK_SKI1_1 423 427 PF00082 0.441
CLV_PCSK_SKI1_1 442 446 PF00082 0.406
CLV_PCSK_SKI1_1 450 454 PF00082 0.390
CLV_PCSK_SKI1_1 537 541 PF00082 0.414
CLV_PCSK_SKI1_1 595 599 PF00082 0.295
CLV_PCSK_SKI1_1 721 725 PF00082 0.679
CLV_PCSK_SKI1_1 737 741 PF00082 0.521
CLV_PCSK_SKI1_1 766 770 PF00082 0.569
CLV_PCSK_SKI1_1 783 787 PF00082 0.581
DEG_APCC_DBOX_1 12 20 PF00400 0.767
DEG_APCC_DBOX_1 720 728 PF00400 0.406
DEG_SCF_FBW7_1 172 177 PF00400 0.353
DEG_SPOP_SBC_1 408 412 PF00917 0.597
DEG_SPOP_SBC_1 659 663 PF00917 0.445
DEG_SPOP_SBC_1 691 695 PF00917 0.421
DOC_CDC14_PxL_1 682 690 PF14671 0.424
DOC_CDC14_PxL_1 98 106 PF14671 0.371
DOC_CYCLIN_yCln2_LP_2 723 729 PF00134 0.354
DOC_CYCLIN_yCln2_LP_2 768 774 PF00134 0.417
DOC_MAPK_DCC_7 13 21 PF00069 0.590
DOC_MAPK_gen_1 13 21 PF00069 0.701
DOC_MAPK_MEF2A_6 13 21 PF00069 0.594
DOC_MAPK_MEF2A_6 730 738 PF00069 0.414
DOC_MAPK_MEF2A_6 750 758 PF00069 0.286
DOC_PP1_RVXF_1 735 741 PF00149 0.362
DOC_PP1_RVXF_1 75 82 PF00149 0.253
DOC_PP1_RVXF_1 764 770 PF00149 0.382
DOC_PP2B_LxvP_1 104 107 PF13499 0.347
DOC_PP2B_LxvP_1 772 775 PF13499 0.421
DOC_PP4_FxxP_1 147 150 PF00568 0.327
DOC_PP4_FxxP_1 490 493 PF00568 0.550
DOC_PP4_FxxP_1 788 791 PF00568 0.362
DOC_USP7_MATH_1 491 495 PF00917 0.578
DOC_USP7_MATH_1 569 573 PF00917 0.706
DOC_USP7_MATH_1 618 622 PF00917 0.528
DOC_USP7_MATH_1 659 663 PF00917 0.573
DOC_USP7_MATH_1 668 672 PF00917 0.509
DOC_USP7_MATH_1 691 695 PF00917 0.492
DOC_USP7_MATH_2 569 575 PF00917 0.677
DOC_USP7_MATH_2 668 674 PF00917 0.433
DOC_WW_Pin1_4 146 151 PF00397 0.360
DOC_WW_Pin1_4 170 175 PF00397 0.383
DOC_WW_Pin1_4 292 297 PF00397 0.320
DOC_WW_Pin1_4 311 316 PF00397 0.490
DOC_WW_Pin1_4 42 47 PF00397 0.354
DOC_WW_Pin1_4 561 566 PF00397 0.658
DOC_WW_Pin1_4 824 829 PF00397 0.501
LIG_14-3-3_CanoR_1 128 134 PF00244 0.490
LIG_14-3-3_CanoR_1 190 196 PF00244 0.438
LIG_14-3-3_CanoR_1 211 215 PF00244 0.438
LIG_14-3-3_CanoR_1 287 293 PF00244 0.424
LIG_14-3-3_CanoR_1 450 456 PF00244 0.535
LIG_14-3-3_CanoR_1 526 531 PF00244 0.649
LIG_14-3-3_CanoR_1 660 668 PF00244 0.470
LIG_14-3-3_CanoR_1 708 713 PF00244 0.432
LIG_14-3-3_CanoR_1 782 791 PF00244 0.416
LIG_14-3-3_CanoR_1 833 839 PF00244 0.417
LIG_14-3-3_CterR_2 843 846 PF00244 0.453
LIG_Actin_WH2_2 499 514 PF00022 0.559
LIG_APCC_ABBA_1 257 262 PF00400 0.318
LIG_BRCT_BRCA1_1 710 714 PF00533 0.446
LIG_BRCT_BRCA1_1 813 817 PF00533 0.381
LIG_EH_1 238 242 PF12763 0.371
LIG_FHA_1 190 196 PF00498 0.502
LIG_FHA_1 382 388 PF00498 0.606
LIG_FHA_1 409 415 PF00498 0.542
LIG_FHA_1 552 558 PF00498 0.654
LIG_FHA_1 577 583 PF00498 0.668
LIG_FHA_1 702 708 PF00498 0.472
LIG_FHA_1 718 724 PF00498 0.389
LIG_FHA_1 744 750 PF00498 0.399
LIG_FHA_2 116 122 PF00498 0.329
LIG_FHA_2 171 177 PF00498 0.360
LIG_FHA_2 426 432 PF00498 0.602
LIG_FHA_2 495 501 PF00498 0.565
LIG_FHA_2 587 593 PF00498 0.582
LIG_FHA_2 661 667 PF00498 0.474
LIG_FHA_2 825 831 PF00498 0.458
LIG_GBD_Chelix_1 29 37 PF00786 0.256
LIG_LIR_Apic_2 473 479 PF02991 0.525
LIG_LIR_Apic_2 786 791 PF02991 0.416
LIG_LIR_Gen_1 118 127 PF02991 0.356
LIG_LIR_Gen_1 173 183 PF02991 0.418
LIG_LIR_Gen_1 284 292 PF02991 0.377
LIG_LIR_Gen_1 5 16 PF02991 0.580
LIG_LIR_Gen_1 741 749 PF02991 0.367
LIG_LIR_Gen_1 837 844 PF02991 0.412
LIG_LIR_Nem_3 118 123 PF02991 0.314
LIG_LIR_Nem_3 173 178 PF02991 0.421
LIG_LIR_Nem_3 221 225 PF02991 0.358
LIG_LIR_Nem_3 23 29 PF02991 0.512
LIG_LIR_Nem_3 284 288 PF02991 0.412
LIG_LIR_Nem_3 5 11 PF02991 0.581
LIG_LIR_Nem_3 60 66 PF02991 0.442
LIG_LIR_Nem_3 741 745 PF02991 0.370
LIG_LIR_Nem_3 748 754 PF02991 0.390
LIG_LIR_Nem_3 837 841 PF02991 0.417
LIG_MAD2 10 18 PF02301 0.615
LIG_MYND_1 14 18 PF01753 0.611
LIG_NRBOX 325 331 PF00104 0.309
LIG_NRBOX 586 592 PF00104 0.561
LIG_NRP_CendR_1 843 846 PF00754 0.653
LIG_PCNA_PIPBox_1 792 801 PF02747 0.385
LIG_Pex14_2 40 44 PF04695 0.340
LIG_SH2_CRK 742 746 PF00017 0.410
LIG_SH2_CRK 76 80 PF00017 0.313
LIG_SH2_CRK 8 12 PF00017 0.585
LIG_SH2_CRK 838 842 PF00017 0.454
LIG_SH2_NCK_1 66 70 PF00017 0.361
LIG_SH2_PTP2 185 188 PF00017 0.318
LIG_SH2_PTP2 26 29 PF00017 0.340
LIG_SH2_SRC 751 754 PF00017 0.382
LIG_SH2_STAP1 455 459 PF00017 0.560
LIG_SH2_STAP1 57 61 PF00017 0.359
LIG_SH2_STAT3 401 404 PF00017 0.606
LIG_SH2_STAT3 807 810 PF00017 0.287
LIG_SH2_STAT5 185 188 PF00017 0.318
LIG_SH2_STAT5 191 194 PF00017 0.337
LIG_SH2_STAT5 255 258 PF00017 0.350
LIG_SH2_STAT5 26 29 PF00017 0.404
LIG_SH2_STAT5 413 416 PF00017 0.558
LIG_SH2_STAT5 63 66 PF00017 0.368
LIG_SH2_STAT5 760 763 PF00017 0.335
LIG_SH2_STAT5 807 810 PF00017 0.312
LIG_SH2_STAT5 93 96 PF00017 0.362
LIG_SH3_3 293 299 PF00018 0.393
LIG_SH3_3 578 584 PF00018 0.719
LIG_SH3_3 635 641 PF00018 0.505
LIG_SH3_3 681 687 PF00018 0.514
LIG_SH3_3 723 729 PF00018 0.396
LIG_SH3_3 8 14 PF00018 0.678
LIG_SH3_3 816 822 PF00018 0.427
LIG_SUMO_SIM_anti_2 45 51 PF11976 0.339
LIG_SUMO_SIM_par_1 317 324 PF11976 0.317
LIG_SUMO_SIM_par_1 377 385 PF11976 0.570
LIG_TRAF2_1 428 431 PF00917 0.653
LIG_TYR_ITIM 749 754 PF00017 0.436
LIG_UBA3_1 47 55 PF00899 0.440
LIG_WRC_WIRS_1 219 224 PF05994 0.417
MOD_CDK_SPK_2 824 829 PF00069 0.528
MOD_CK1_1 213 219 PF00069 0.502
MOD_CK1_1 245 251 PF00069 0.418
MOD_CK1_1 311 317 PF00069 0.478
MOD_CK1_1 412 418 PF00069 0.455
MOD_CK1_1 494 500 PF00069 0.403
MOD_CK1_1 546 552 PF00069 0.638
MOD_CK1_1 611 617 PF00069 0.615
MOD_CK1_1 662 668 PF00069 0.668
MOD_CK1_1 678 684 PF00069 0.630
MOD_CK1_1 689 695 PF00069 0.620
MOD_CK2_1 170 176 PF00069 0.483
MOD_CK2_1 424 430 PF00069 0.482
MOD_CK2_1 494 500 PF00069 0.438
MOD_CK2_1 571 577 PF00069 0.615
MOD_CK2_1 666 672 PF00069 0.638
MOD_CK2_1 824 830 PF00069 0.674
MOD_GlcNHglycan 104 107 PF01048 0.426
MOD_GlcNHglycan 192 195 PF01048 0.562
MOD_GlcNHglycan 215 218 PF01048 0.515
MOD_GlcNHglycan 232 235 PF01048 0.256
MOD_GlcNHglycan 262 266 PF01048 0.481
MOD_GlcNHglycan 326 329 PF01048 0.427
MOD_GlcNHglycan 537 540 PF01048 0.543
MOD_GlcNHglycan 573 576 PF01048 0.558
MOD_GlcNHglycan 613 616 PF01048 0.667
MOD_GlcNHglycan 620 623 PF01048 0.685
MOD_GlcNHglycan 642 645 PF01048 0.664
MOD_GlcNHglycan 648 651 PF01048 0.732
MOD_GlcNHglycan 677 680 PF01048 0.687
MOD_GSK3_1 170 177 PF00069 0.488
MOD_GSK3_1 209 216 PF00069 0.631
MOD_GSK3_1 261 268 PF00069 0.539
MOD_GSK3_1 288 295 PF00069 0.351
MOD_GSK3_1 320 327 PF00069 0.380
MOD_GSK3_1 408 415 PF00069 0.431
MOD_GSK3_1 466 473 PF00069 0.544
MOD_GSK3_1 531 538 PF00069 0.657
MOD_GSK3_1 543 550 PF00069 0.711
MOD_GSK3_1 569 576 PF00069 0.797
MOD_GSK3_1 586 593 PF00069 0.402
MOD_GSK3_1 658 665 PF00069 0.721
MOD_GSK3_1 666 673 PF00069 0.683
MOD_GSK3_1 686 693 PF00069 0.627
MOD_GSK3_1 697 704 PF00069 0.609
MOD_N-GLC_1 102 107 PF02516 0.575
MOD_N-GLC_1 115 120 PF02516 0.577
MOD_N-GLC_1 129 134 PF02516 0.382
MOD_N-GLC_1 151 156 PF02516 0.450
MOD_N-GLC_1 209 214 PF02516 0.467
MOD_N-GLC_1 230 235 PF02516 0.426
MOD_N-GLC_1 260 265 PF02516 0.522
MOD_N-GLC_1 311 316 PF02516 0.467
MOD_NEK2_1 189 194 PF00069 0.384
MOD_NEK2_1 225 230 PF00069 0.356
MOD_NEK2_1 270 275 PF00069 0.576
MOD_NEK2_1 288 293 PF00069 0.415
MOD_NEK2_1 300 305 PF00069 0.376
MOD_NEK2_1 341 346 PF00069 0.638
MOD_NEK2_1 409 414 PF00069 0.460
MOD_NEK2_1 424 429 PF00069 0.445
MOD_NEK2_1 451 456 PF00069 0.403
MOD_NEK2_1 470 475 PF00069 0.650
MOD_NEK2_1 590 595 PF00069 0.439
MOD_NEK2_1 677 682 PF00069 0.584
MOD_NEK2_1 761 766 PF00069 0.464
MOD_NEK2_1 84 89 PF00069 0.456
MOD_NEK2_2 255 260 PF00069 0.349
MOD_PIKK_1 277 283 PF00454 0.404
MOD_PIKK_1 576 582 PF00454 0.570
MOD_PIKK_1 84 90 PF00454 0.373
MOD_PKA_2 157 163 PF00069 0.433
MOD_PKA_2 189 195 PF00069 0.502
MOD_PKA_2 210 216 PF00069 0.534
MOD_PKA_2 659 665 PF00069 0.645
MOD_PKA_2 707 713 PF00069 0.505
MOD_Plk_1 121 127 PF00069 0.363
MOD_Plk_1 129 135 PF00069 0.390
MOD_Plk_1 209 215 PF00069 0.552
MOD_Plk_1 53 59 PF00069 0.393
MOD_Plk_1 64 70 PF00069 0.502
MOD_Plk_2-3 666 672 PF00069 0.592
MOD_Plk_4 129 135 PF00069 0.481
MOD_Plk_4 174 180 PF00069 0.447
MOD_Plk_4 218 224 PF00069 0.452
MOD_Plk_4 225 231 PF00069 0.414
MOD_Plk_4 321 327 PF00069 0.346
MOD_Plk_4 409 415 PF00069 0.398
MOD_Plk_4 491 497 PF00069 0.434
MOD_Plk_4 537 543 PF00069 0.575
MOD_ProDKin_1 146 152 PF00069 0.436
MOD_ProDKin_1 170 176 PF00069 0.463
MOD_ProDKin_1 292 298 PF00069 0.373
MOD_ProDKin_1 311 317 PF00069 0.609
MOD_ProDKin_1 42 48 PF00069 0.354
MOD_ProDKin_1 561 567 PF00069 0.572
MOD_ProDKin_1 824 830 PF00069 0.629
TRG_DiLeu_BaEn_1 448 453 PF01217 0.599
TRG_DiLeu_BaEn_1 753 758 PF01217 0.452
TRG_DiLeu_BaEn_4 370 376 PF01217 0.516
TRG_DiLeu_BaLyEn_6 43 48 PF01217 0.303
TRG_DiLeu_BaLyEn_6 447 452 PF01217 0.513
TRG_DiLeu_BaLyEn_6 723 728 PF01217 0.505
TRG_ENDOCYTIC_2 145 148 PF00928 0.471
TRG_ENDOCYTIC_2 26 29 PF00928 0.370
TRG_ENDOCYTIC_2 742 745 PF00928 0.429
TRG_ENDOCYTIC_2 751 754 PF00928 0.429
TRG_ENDOCYTIC_2 76 79 PF00928 0.372
TRG_ENDOCYTIC_2 8 11 PF00928 0.467
TRG_ENDOCYTIC_2 838 841 PF00928 0.583
TRG_ER_diArg_1 12 15 PF00400 0.563
TRG_ER_diArg_1 127 129 PF00400 0.384
TRG_ER_diArg_1 204 206 PF00400 0.376
TRG_ER_diArg_1 304 307 PF00400 0.522
TRG_ER_diArg_1 525 528 PF00400 0.518
TRG_ER_diArg_1 594 596 PF00400 0.498
TRG_ER_diArg_1 781 783 PF00400 0.513
TRG_Pf-PMV_PEXEL_1 721 725 PF00026 0.571

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C6 Leptomonas seymouri 50% 98%
A0A3S5H6C4 Leishmania donovani 89% 100%
A0A3S7WQJ6 Leishmania donovani 48% 100%
A4H5K7 Leishmania braziliensis 68% 100%
A4HTU4 Leishmania infantum 48% 100%
A4HTU5 Leishmania infantum 89% 100%
D0A9A6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 98%
E9AMN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9AMN2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 99%
Q4QHZ4 Leishmania major 49% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS