Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHZ1_LEIMA

TriTrypDb:

LmjF.09.0345 , LMJLV39_090009000 , LMJSD75_090008600

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.577
CLV_NRD_NRD_1	211	213	PF00675	0.651
CLV_NRD_NRD_1	215	217	PF00675	0.622
CLV_PCSK_FUR_1	212	216	PF00082	0.620
CLV_PCSK_KEX2_1	132	134	PF00082	0.684
CLV_PCSK_KEX2_1	148	150	PF00082	0.525
CLV_PCSK_KEX2_1	213	215	PF00082	0.635
CLV_PCSK_KEX2_1	7	9	PF00082	0.554
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.640
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.714
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.543
CLV_PCSK_PC7_1	145	151	PF00082	0.554
CLV_PCSK_PC7_1	3	9	PF00082	0.548
CLV_PCSK_SKI1_1	62	66	PF00082	0.569
DOC_MAPK_gen_1	7	16	PF00069	0.516
DOC_MAPK_JIP1_4	10	16	PF00069	0.577
DOC_MAPK_MEF2A_6	7	15	PF00069	0.528
DOC_PP2B_PxIxI_1	10	16	PF00149	0.540
DOC_USP7_MATH_1	109	113	PF00917	0.567
DOC_USP7_MATH_1	116	120	PF00917	0.627
DOC_USP7_MATH_1	122	126	PF00917	0.674
DOC_USP7_MATH_1	131	135	PF00917	0.721
DOC_USP7_MATH_1	204	208	PF00917	0.734
DOC_WW_Pin1_4	118	123	PF00397	0.731
DOC_WW_Pin1_4	41	46	PF00397	0.643
LIG_14-3-3_CanoR_1	175	181	PF00244	0.549
LIG_14-3-3_CanoR_1	215	223	PF00244	0.657
LIG_FHA_1	183	189	PF00498	0.628
LIG_FHA_1	54	60	PF00498	0.559
LIG_FHA_2	217	223	PF00498	0.677
LIG_FHA_2	236	242	PF00498	0.484
LIG_LIR_Gen_1	90	101	PF02991	0.593
LIG_LIR_Nem_3	90	96	PF02991	0.641
LIG_NRP_CendR_1	247	250	PF00754	0.692
LIG_RPA_C_Fungi	143	155	PF08784	0.581
LIG_SH2_STAP1	60	64	PF00017	0.491
LIG_SH3_3	183	189	PF00018	0.549
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.544
MOD_CDK_SPK_2	41	46	PF00069	0.663
MOD_CDK_SPxxK_3	41	48	PF00069	0.635
MOD_CK1_1	40	46	PF00069	0.678
MOD_CK2_1	235	241	PF00069	0.610
MOD_CK2_1	41	47	PF00069	0.686
MOD_Cter_Amidation	210	213	PF01082	0.586
MOD_GlcNHglycan	118	121	PF01048	0.714
MOD_GlcNHglycan	150	153	PF01048	0.613
MOD_GlcNHglycan	53	56	PF01048	0.571
MOD_GlcNHglycan	89	92	PF01048	0.554
MOD_GSK3_1	114	121	PF00069	0.753
MOD_GSK3_1	122	129	PF00069	0.680
MOD_GSK3_1	144	151	PF00069	0.592
MOD_GSK3_1	36	43	PF00069	0.685
MOD_GSK3_1	80	87	PF00069	0.627
MOD_N-GLC_1	158	163	PF02516	0.474
MOD_NEK2_1	101	106	PF00069	0.584
MOD_NEK2_1	144	149	PF00069	0.643
MOD_NEK2_1	160	165	PF00069	0.496
MOD_NEK2_1	174	179	PF00069	0.444
MOD_NEK2_1	227	232	PF00069	0.561
MOD_PIKK_1	114	120	PF00454	0.540
MOD_PIKK_1	188	194	PF00454	0.669
MOD_PKA_1	148	154	PF00069	0.597
MOD_PKA_2	144	150	PF00069	0.624
MOD_PKA_2	174	180	PF00069	0.626
MOD_PKB_1	214	222	PF00069	0.660
MOD_Plk_1	182	188	PF00069	0.593
MOD_Plk_4	84	90	PF00069	0.570
MOD_ProDKin_1	118	124	PF00069	0.729
MOD_ProDKin_1	41	47	PF00069	0.641
MOD_SUMO_for_1	6	9	PF00179	0.543
TRG_DiLeu_BaEn_4	36	42	PF01217	0.558
TRG_ENDOCYTIC_2	71	74	PF00928	0.590
TRG_ER_diArg_1	148	150	PF00400	0.576
TRG_ER_diArg_1	212	215	PF00400	0.617
TRG_ER_diArg_1	247	250	PF00400	0.670
TRG_NLS_MonoCore_2	211	216	PF00514	0.663
TRG_NLS_MonoExtC_3	211	216	PF00514	0.663
TRG_NLS_MonoExtN_4	212	217	PF00514	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I643	Leptomonas seymouri	47%	100%
A0A3S7WQK0	Leishmania donovani	90%	100%
A4HTU7	Leishmania infantum	90%	100%
E9AI35	Leishmania braziliensis	71%	100%
E9AMN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%