Putative DNA photolyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA photolyase, putative

Species:

Leishmania major

UniProt:

Q4QHY9_LEIMA

TriTrypDb:

LmjF.09.0360 , LMJLV39_090009200 , LMJSD75_090008800

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHY9

Function

Biological processes
Term	Name	Level	Count
GO:0000719	photoreactive repair	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006290	pyrimidine dimer repair	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003824	catalytic activity	1	12
GO:0003904	deoxyribodipyrimidine photo-lyase activity	5	8
GO:0003913	DNA photolyase activity	4	8
GO:0005488	binding	1	2
GO:0016829	lyase activity	2	12
GO:0016830	carbon-carbon lyase activity	3	8
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050660	flavin adenine dinucleotide binding	4	2
GO:0071949	FAD binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	553	557	PF00656	0.644
CLV_NRD_NRD_1	104	106	PF00675	0.732
CLV_NRD_NRD_1	307	309	PF00675	0.388
CLV_NRD_NRD_1	352	354	PF00675	0.334
CLV_NRD_NRD_1	360	362	PF00675	0.289
CLV_NRD_NRD_1	538	540	PF00675	0.419
CLV_NRD_NRD_1	585	587	PF00675	0.601
CLV_NRD_NRD_1	610	612	PF00675	0.353
CLV_NRD_NRD_1	643	645	PF00675	0.365
CLV_NRD_NRD_1	678	680	PF00675	0.369
CLV_NRD_NRD_1	913	915	PF00675	0.724
CLV_PCSK_FUR_1	583	587	PF00082	0.628
CLV_PCSK_KEX2_1	104	106	PF00082	0.819
CLV_PCSK_KEX2_1	307	309	PF00082	0.388
CLV_PCSK_KEX2_1	352	354	PF00082	0.333
CLV_PCSK_KEX2_1	360	362	PF00082	0.287
CLV_PCSK_KEX2_1	538	540	PF00082	0.419
CLV_PCSK_KEX2_1	585	587	PF00082	0.585
CLV_PCSK_KEX2_1	643	645	PF00082	0.365
CLV_PCSK_SKI1_1	521	525	PF00082	0.491
CLV_PCSK_SKI1_1	626	630	PF00082	0.553
CLV_PCSK_SKI1_1	657	661	PF00082	0.520
CLV_PCSK_SKI1_1	713	717	PF00082	0.337
CLV_Separin_Metazoa	615	619	PF03568	0.453
CLV_Separin_Metazoa	764	768	PF03568	0.507
DEG_APCC_DBOX_1	520	528	PF00400	0.524
DEG_APCC_DBOX_1	634	642	PF00400	0.403
DEG_APCC_DBOX_1	712	720	PF00400	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.653
DEG_SCF_FBW7_1	17	22	PF00400	0.798
DEG_SCF_TRCP1_1	82	87	PF00400	0.511
DEG_SPOP_SBC_1	234	238	PF00917	0.576
DEG_SPOP_SBC_1	925	929	PF00917	0.519
DOC_CKS1_1	135	140	PF01111	0.743
DOC_CKS1_1	388	393	PF01111	0.531
DOC_CKS1_1	456	461	PF01111	0.542
DOC_CYCLIN_yCln2_LP_2	314	320	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	456	462	PF00134	0.518
DOC_MAPK_DCC_7	324	334	PF00069	0.489
DOC_MAPK_DCC_7	818	826	PF00069	0.487
DOC_MAPK_gen_1	307	316	PF00069	0.487
DOC_MAPK_gen_1	352	359	PF00069	0.581
DOC_MAPK_gen_1	595	605	PF00069	0.473
DOC_MAPK_HePTP_8	306	318	PF00069	0.487
DOC_MAPK_MEF2A_6	226	235	PF00069	0.534
DOC_MAPK_MEF2A_6	309	318	PF00069	0.482
DOC_MAPK_MEF2A_6	598	605	PF00069	0.459
DOC_MAPK_RevD_3	597	612	PF00069	0.486
DOC_PP1_RVXF_1	47	53	PF00149	0.548
DOC_PP1_RVXF_1	655	661	PF00149	0.521
DOC_PP2B_LxvP_1	145	148	PF13499	0.629
DOC_PP2B_LxvP_1	17	20	PF13499	0.720
DOC_PP2B_LxvP_1	209	212	PF13499	0.674
DOC_PP2B_LxvP_1	314	317	PF13499	0.476
DOC_PP2B_LxvP_1	59	62	PF13499	0.651
DOC_PP2B_PxIxI_1	266	272	PF00149	0.502
DOC_PP2B_PxIxI_1	404	410	PF00149	0.647
DOC_PP4_FxxP_1	10	13	PF00568	0.732
DOC_PP4_FxxP_1	279	282	PF00568	0.476
DOC_PP4_FxxP_1	762	765	PF00568	0.517
DOC_USP7_MATH_1	171	175	PF00917	0.741
DOC_USP7_MATH_1	249	253	PF00917	0.562
DOC_USP7_MATH_1	280	284	PF00917	0.476
DOC_USP7_MATH_1	515	519	PF00917	0.524
DOC_USP7_MATH_1	549	553	PF00917	0.531
DOC_USP7_MATH_1	830	834	PF00917	0.633
DOC_USP7_MATH_1	924	928	PF00917	0.711
DOC_WW_Pin1_4	134	139	PF00397	0.730
DOC_WW_Pin1_4	15	20	PF00397	0.733
DOC_WW_Pin1_4	289	294	PF00397	0.487
DOC_WW_Pin1_4	387	392	PF00397	0.752
DOC_WW_Pin1_4	455	460	PF00397	0.533
DOC_WW_Pin1_4	51	56	PF00397	0.777
DOC_WW_Pin1_4	597	602	PF00397	0.383
DOC_WW_Pin1_4	606	611	PF00397	0.347
DOC_WW_Pin1_4	871	876	PF00397	0.596
LIG_14-3-3_CanoR_1	179	185	PF00244	0.649
LIG_14-3-3_CanoR_1	538	544	PF00244	0.440
LIG_14-3-3_CanoR_1	657	663	PF00244	0.515
LIG_14-3-3_CanoR_1	737	741	PF00244	0.487
LIG_14-3-3_CanoR_1	832	839	PF00244	0.637
LIG_Actin_WH2_2	350	365	PF00022	0.558
LIG_AP2alpha_2	743	745	PF02296	0.476
LIG_Clathr_ClatBox_1	450	454	PF01394	0.407
LIG_deltaCOP1_diTrp_1	645	654	PF00928	0.370
LIG_deltaCOP1_diTrp_1	727	734	PF00928	0.477
LIG_FHA_1	135	141	PF00498	0.736
LIG_FHA_1	156	162	PF00498	0.731
LIG_FHA_1	16	22	PF00498	0.770
LIG_FHA_1	179	185	PF00498	0.662
LIG_FHA_1	311	317	PF00498	0.581
LIG_FHA_1	337	343	PF00498	0.414
LIG_FHA_1	378	384	PF00498	0.663
LIG_FHA_1	487	493	PF00498	0.525
LIG_FHA_1	574	580	PF00498	0.444
LIG_FHA_1	667	673	PF00498	0.487
LIG_FHA_1	703	709	PF00498	0.476
LIG_FHA_2	201	207	PF00498	0.580
LIG_FHA_2	33	39	PF00498	0.686
LIG_FHA_2	388	394	PF00498	0.694
LIG_FHA_2	4	10	PF00498	0.768
LIG_FHA_2	505	511	PF00498	0.506
LIG_Integrin_isoDGR_2	151	153	PF01839	0.624
LIG_LIR_Apic_2	195	201	PF02991	0.620
LIG_LIR_Apic_2	278	282	PF02991	0.537
LIG_LIR_Apic_2	51	55	PF02991	0.544
LIG_LIR_Apic_2	7	13	PF02991	0.736
LIG_LIR_Apic_2	760	765	PF02991	0.517
LIG_LIR_Gen_1	541	549	PF02991	0.685
LIG_LIR_Gen_1	600	610	PF02991	0.445
LIG_LIR_Gen_1	645	654	PF02991	0.370
LIG_LIR_Gen_1	882	891	PF02991	0.658
LIG_LIR_Nem_3	275	279	PF02991	0.487
LIG_LIR_Nem_3	541	547	PF02991	0.629
LIG_LIR_Nem_3	600	605	PF02991	0.432
LIG_LIR_Nem_3	656	662	PF02991	0.510
LIG_LIR_Nem_3	739	745	PF02991	0.476
LIG_LIR_Nem_3	890	895	PF02991	0.647
LIG_LYPXL_SIV_4	484	492	PF13949	0.567
LIG_MYND_3	524	528	PF01753	0.558
LIG_NRBOX	715	721	PF00104	0.476
LIG_PCNA_yPIPBox_3	565	579	PF02747	0.539
LIG_PDZ_Class_2	929	934	PF00595	0.717
LIG_PTB_Apo_2	765	772	PF02174	0.545
LIG_PTB_Phospho_1	765	771	PF10480	0.545
LIG_REV1ctd_RIR_1	286	292	PF16727	0.517
LIG_SH2_NCK_1	485	489	PF00017	0.562
LIG_SH2_NCK_1	532	536	PF00017	0.539
LIG_SH2_PTP2	602	605	PF00017	0.448
LIG_SH2_SRC	347	350	PF00017	0.487
LIG_SH2_SRC	751	754	PF00017	0.579
LIG_SH2_SRC	853	856	PF00017	0.556
LIG_SH2_STAP1	532	536	PF00017	0.616
LIG_SH2_STAP1	592	596	PF00017	0.458
LIG_SH2_STAP1	853	857	PF00017	0.556
LIG_SH2_STAT3	842	845	PF00017	0.624
LIG_SH2_STAT5	198	201	PF00017	0.609
LIG_SH2_STAT5	602	605	PF00017	0.350
LIG_SH2_STAT5	771	774	PF00017	0.532
LIG_SH2_STAT5	782	785	PF00017	0.433
LIG_SH2_STAT5	797	800	PF00017	0.476
LIG_SH2_STAT5	80	83	PF00017	0.601
LIG_SH2_STAT5	815	818	PF00017	0.476
LIG_SH2_STAT5	877	880	PF00017	0.634
LIG_SH3_3	138	144	PF00018	0.682
LIG_SH3_3	259	265	PF00018	0.540
LIG_SH3_3	385	391	PF00018	0.756
LIG_SH3_3	478	484	PF00018	0.444
LIG_SH3_3	52	58	PF00018	0.777
LIG_SH3_3	845	851	PF00018	0.676
LIG_SH3_3	860	866	PF00018	0.724
LIG_SH3_3	910	916	PF00018	0.687
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.414
LIG_SUMO_SIM_anti_2	458	465	PF11976	0.493
LIG_SUMO_SIM_par_1	143	149	PF11976	0.684
LIG_SUMO_SIM_par_1	230	239	PF11976	0.449
LIG_SUMO_SIM_par_1	338	345	PF11976	0.414
LIG_SUMO_SIM_par_1	401	411	PF11976	0.648
LIG_SUMO_SIM_par_1	57	64	PF11976	0.688
LIG_TRAF2_1	258	261	PF00917	0.414
LIG_TRAF2_1	369	372	PF00917	0.581
LIG_TRAF2_1	399	402	PF00917	0.675
LIG_TRAF2_1	543	546	PF00917	0.617
LIG_TRAF2_1	94	97	PF00917	0.669
LIG_UBA3_1	123	128	PF00899	0.725
LIG_WRC_WIRS_1	276	281	PF05994	0.413
LIG_WW_1	794	797	PF00397	0.344
MOD_CDC14_SPxK_1	292	295	PF00782	0.344
MOD_CDC14_SPxK_1	609	612	PF00782	0.353
MOD_CDK_SPK_2	606	611	PF00069	0.347
MOD_CDK_SPxK_1	289	295	PF00069	0.344
MOD_CDK_SPxK_1	606	612	PF00069	0.350
MOD_CDK_SPxxK_3	387	394	PF00069	0.533
MOD_CK1_1	169	175	PF00069	0.741
MOD_CK1_1	22	28	PF00069	0.750
MOD_CK1_1	221	227	PF00069	0.652
MOD_CK1_1	252	258	PF00069	0.242
MOD_CK1_1	48	54	PF00069	0.720
MOD_CK1_1	83	89	PF00069	0.716
MOD_CK2_1	169	175	PF00069	0.770
MOD_CK2_1	200	206	PF00069	0.588
MOD_CK2_1	22	28	PF00069	0.538
MOD_CK2_1	3	9	PF00069	0.775
MOD_CK2_1	366	372	PF00069	0.457
MOD_CK2_1	395	401	PF00069	0.733
MOD_CK2_1	504	510	PF00069	0.485
MOD_CK2_1	832	838	PF00069	0.599
MOD_Cter_Amidation	102	105	PF01082	0.734
MOD_GlcNHglycan	101	104	PF01048	0.582
MOD_GlcNHglycan	170	174	PF01048	0.742
MOD_GlcNHglycan	220	223	PF01048	0.749
MOD_GlcNHglycan	282	285	PF01048	0.259
MOD_GlcNHglycan	397	400	PF01048	0.668
MOD_GlcNHglycan	434	437	PF01048	0.641
MOD_GlcNHglycan	476	479	PF01048	0.530
MOD_GlcNHglycan	532	535	PF01048	0.579
MOD_GlcNHglycan	75	79	PF01048	0.648
MOD_GlcNHglycan	82	85	PF01048	0.696
MOD_GlcNHglycan	834	837	PF01048	0.620
MOD_GlcNHglycan	86	89	PF01048	0.717
MOD_GlcNHglycan	860	863	PF01048	0.657
MOD_GlcNHglycan	889	892	PF01048	0.549
MOD_GSK3_1	15	22	PF00069	0.772
MOD_GSK3_1	424	431	PF00069	0.640
MOD_GSK3_1	441	448	PF00069	0.384
MOD_GSK3_1	586	593	PF00069	0.510
MOD_GSK3_1	74	81	PF00069	0.633
MOD_NEK2_1	123	128	PF00069	0.725
MOD_NEK2_1	21	26	PF00069	0.608
MOD_NEK2_1	299	304	PF00069	0.363
MOD_NEK2_1	310	315	PF00069	0.363
MOD_NEK2_1	336	341	PF00069	0.354
MOD_NEK2_1	342	347	PF00069	0.334
MOD_NEK2_1	530	535	PF00069	0.613
MOD_NEK2_1	639	644	PF00069	0.390
MOD_NEK2_1	658	663	PF00069	0.289
MOD_NEK2_1	702	707	PF00069	0.328
MOD_PIKK_1	155	161	PF00454	0.722
MOD_PIKK_1	221	227	PF00454	0.652
MOD_PIKK_1	342	348	PF00454	0.328
MOD_PIKK_1	547	553	PF00454	0.554
MOD_PIKK_1	590	596	PF00454	0.473
MOD_PKA_2	178	184	PF00069	0.728
MOD_PKA_2	186	192	PF00069	0.665
MOD_PKA_2	479	485	PF00069	0.428
MOD_PKA_2	537	543	PF00069	0.675
MOD_PKA_2	584	590	PF00069	0.521
MOD_PKA_2	639	645	PF00069	0.386
MOD_PKA_2	736	742	PF00069	0.328
MOD_PKB_1	361	369	PF00069	0.444
MOD_Plk_1	22	28	PF00069	0.732
MOD_Plk_1	310	316	PF00069	0.398
MOD_Plk_1	472	478	PF00069	0.516
MOD_Plk_1	74	80	PF00069	0.654
MOD_Plk_1	837	843	PF00069	0.565
MOD_Plk_2-3	371	377	PF00069	0.437
MOD_Plk_2-3	736	742	PF00069	0.328
MOD_Plk_4	336	342	PF00069	0.393
MOD_Plk_4	363	369	PF00069	0.395
MOD_Plk_4	441	447	PF00069	0.397
MOD_Plk_4	515	521	PF00069	0.618
MOD_Plk_4	574	580	PF00069	0.444
MOD_Plk_4	882	888	PF00069	0.671
MOD_ProDKin_1	134	140	PF00069	0.732
MOD_ProDKin_1	15	21	PF00069	0.732
MOD_ProDKin_1	289	295	PF00069	0.344
MOD_ProDKin_1	387	393	PF00069	0.754
MOD_ProDKin_1	455	461	PF00069	0.537
MOD_ProDKin_1	51	57	PF00069	0.777
MOD_ProDKin_1	597	603	PF00069	0.381
MOD_ProDKin_1	606	612	PF00069	0.350
MOD_ProDKin_1	871	877	PF00069	0.595
MOD_SUMO_rev_2	674	682	PF00179	0.328
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.732
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.743
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.668
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.344
TRG_DiLeu_LyEn_5	402	407	PF01217	0.691
TRG_ENDOCYTIC_2	276	279	PF00928	0.344
TRG_ENDOCYTIC_2	602	605	PF00928	0.448
TRG_ENDOCYTIC_2	613	616	PF00928	0.214
TRG_ENDOCYTIC_2	742	745	PF00928	0.337
TRG_ER_diArg_1	306	308	PF00400	0.405
TRG_ER_diArg_1	352	354	PF00400	0.423
TRG_ER_diArg_1	359	361	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXX3	Leptomonas seymouri	66%	92%
A0A0S4IZG6	Bodo saltans	40%	100%
A0A1X0NMQ9	Trypanosomatidae	55%	100%
A0A3S7WQJ5	Leishmania donovani	94%	100%
A0A422N7E2	Trypanosoma rangeli	56%	100%
A4H5L0	Leishmania braziliensis	83%	97%
A4HTU9	Leishmania infantum	94%	100%
D0A9A9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AMN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B2X6	Trypanosoma cruzi	58%	100%