ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

Q4QHY8_LEIMA

TriTrypDb:

LmjF.09.0365 , LMJLV39_090009300 , LMJSD75_090008900

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	67	69	PF00675	0.549
CLV_PCSK_KEX2_1	67	69	PF00082	0.567
CLV_PCSK_SKI1_1	148	152	PF00082	0.463
CLV_PCSK_SKI1_1	169	173	PF00082	0.395
CLV_PCSK_SKI1_1	47	51	PF00082	0.535
DEG_SPOP_SBC_1	180	184	PF00917	0.315
DOC_CDC14_PxL_1	150	158	PF14671	0.315
DOC_CYCLIN_RxL_1	164	173	PF00134	0.345
DOC_CYCLIN_RxL_1	44	54	PF00134	0.513
DOC_MAPK_MEF2A_6	164	172	PF00069	0.245
DOC_MAPK_MEF2A_6	195	204	PF00069	0.294
DOC_PP4_FxxP_1	151	154	PF00568	0.374
DOC_USP7_MATH_1	18	22	PF00917	0.660
LIG_14-3-3_CanoR_1	124	132	PF00244	0.405
LIG_14-3-3_CanoR_1	195	204	PF00244	0.427
LIG_14-3-3_CanoR_1	22	31	PF00244	0.555
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_eIF4E_1	197	203	PF01652	0.345
LIG_EVH1_2	154	158	PF00568	0.315
LIG_FHA_1	181	187	PF00498	0.458
LIG_FHA_2	22	28	PF00498	0.610
LIG_Pex14_2	145	149	PF04695	0.539
LIG_Pex14_2	158	162	PF04695	0.327
LIG_SH2_CRK	197	201	PF00017	0.315
LIG_SH2_STAP1	197	201	PF00017	0.294
LIG_SH2_STAT3	191	194	PF00017	0.345
LIG_SUMO_SIM_anti_2	198	206	PF11976	0.294
LIG_SUMO_SIM_par_1	200	206	PF11976	0.345
LIG_TRAF2_1	58	61	PF00917	0.496
MOD_CK1_1	21	27	PF00069	0.677
MOD_CK2_1	21	27	PF00069	0.626
MOD_CK2_1	55	61	PF00069	0.464
MOD_GlcNHglycan	124	127	PF01048	0.537
MOD_GlcNHglycan	197	200	PF01048	0.375
MOD_GlcNHglycan	205	208	PF01048	0.477
MOD_GSK3_1	1	8	PF00069	0.629
MOD_GSK3_1	18	25	PF00069	0.671
MOD_NEK2_1	1	6	PF00069	0.660
MOD_NEK2_1	202	207	PF00069	0.502
MOD_PKA_2	21	27	PF00069	0.583
TRG_DiLeu_BaEn_1	166	171	PF01217	0.245
TRG_DiLeu_BaEn_1	52	57	PF01217	0.527
TRG_DiLeu_BaEn_4	60	66	PF01217	0.473
TRG_DiLeu_LyEn_5	166	171	PF01217	0.245
TRG_ENDOCYTIC_2	140	143	PF00928	0.515
TRG_ENDOCYTIC_2	197	200	PF00928	0.315
TRG_ER_diArg_1	67	69	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCZ4	Leptomonas seymouri	54%	88%
A0A3S7WQK8	Leishmania donovani	95%	100%
A4H5L1	Leishmania braziliensis	78%	100%
A4HTV0	Leishmania infantum	95%	100%
E9AMN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%