Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHY6_LEIMA

TriTrypDb:

LmjF.09.0380 , LMJLV39_090009600 , LMJSD75_090009200

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHY6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.567
CLV_C14_Caspase3-7	209	213	PF00656	0.665
CLV_C14_Caspase3-7	342	346	PF00656	0.656
CLV_NRD_NRD_1	121	123	PF00675	0.705
CLV_NRD_NRD_1	200	202	PF00675	0.628
CLV_NRD_NRD_1	315	317	PF00675	0.458
CLV_PCSK_KEX2_1	121	123	PF00082	0.705
CLV_PCSK_KEX2_1	183	185	PF00082	0.638
CLV_PCSK_KEX2_1	199	201	PF00082	0.775
CLV_PCSK_KEX2_1	315	317	PF00082	0.448
CLV_PCSK_KEX2_1	336	338	PF00082	0.575
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.651
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.775
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.586
CLV_PCSK_SKI1_1	150	154	PF00082	0.456
CLV_PCSK_SKI1_1	247	251	PF00082	0.440
CLV_PCSK_SKI1_1	258	262	PF00082	0.455
CLV_PCSK_SKI1_1	291	295	PF00082	0.530
CLV_PCSK_SKI1_1	75	79	PF00082	0.403
DOC_CKS1_1	348	353	PF01111	0.529
DOC_CYCLIN_RxL_1	244	254	PF00134	0.493
DOC_MAPK_gen_1	147	155	PF00069	0.538
DOC_MAPK_gen_1	32	41	PF00069	0.505
DOC_MAPK_MEF2A_6	147	155	PF00069	0.494
DOC_MAPK_MEF2A_6	75	82	PF00069	0.393
DOC_USP7_MATH_1	27	31	PF00917	0.529
DOC_USP7_MATH_1	50	54	PF00917	0.601
DOC_USP7_UBL2_3	44	48	PF12436	0.601
DOC_WW_Pin1_4	347	352	PF00397	0.614
LIG_14-3-3_CanoR_1	121	126	PF00244	0.661
LIG_14-3-3_CanoR_1	18	24	PF00244	0.616
LIG_14-3-3_CanoR_1	231	237	PF00244	0.359
LIG_FHA_1	160	166	PF00498	0.608
LIG_FHA_1	170	176	PF00498	0.479
LIG_FHA_1	231	237	PF00498	0.511
LIG_FHA_2	112	118	PF00498	0.486
LIG_FHA_2	205	211	PF00498	0.661
LIG_FHA_2	348	354	PF00498	0.535
LIG_FHA_2	98	104	PF00498	0.442
LIG_LIR_Nem_3	322	327	PF02991	0.403
LIG_MAD2	37	45	PF02301	0.469
LIG_NRBOX	245	251	PF00104	0.428
LIG_RPA_C_Plants	150	161	PF08784	0.465
LIG_SH2_CRK	324	328	PF00017	0.516
LIG_SH2_STAT5	217	220	PF00017	0.558
LIG_SH2_STAT5	81	84	PF00017	0.492
LIG_SH3_3	345	351	PF00018	0.616
LIG_SH3_3	39	45	PF00018	0.475
LIG_SH3_4	44	51	PF00018	0.619
LIG_TYR_ITSM	320	327	PF00017	0.514
LIG_UBA3_1	354	362	PF00899	0.541
MOD_CK1_1	110	116	PF00069	0.531
MOD_CK1_1	135	141	PF00069	0.574
MOD_CK1_1	230	236	PF00069	0.377
MOD_CK1_1	296	302	PF00069	0.479
MOD_CK1_1	344	350	PF00069	0.552
MOD_CK2_1	111	117	PF00069	0.498
MOD_CK2_1	203	209	PF00069	0.777
MOD_CK2_1	97	103	PF00069	0.430
MOD_GlcNHglycan	109	112	PF01048	0.366
MOD_GlcNHglycan	134	137	PF01048	0.610
MOD_GlcNHglycan	179	182	PF01048	0.609
MOD_GlcNHglycan	56	59	PF01048	0.711
MOD_GlcNHglycan	91	94	PF01048	0.498
MOD_GSK3_1	107	114	PF00069	0.477
MOD_GSK3_1	117	124	PF00069	0.578
MOD_GSK3_1	199	206	PF00069	0.626
MOD_GSK3_1	50	57	PF00069	0.617
MOD_LATS_1	54	60	PF00433	0.575
MOD_NEK2_1	107	112	PF00069	0.340
MOD_NEK2_1	153	158	PF00069	0.382
MOD_NEK2_1	89	94	PF00069	0.568
MOD_PIKK_1	125	131	PF00454	0.603
MOD_PIKK_1	153	159	PF00454	0.374
MOD_PIKK_1	221	227	PF00454	0.579
MOD_PIKK_1	238	244	PF00454	0.387
MOD_PIKK_1	27	33	PF00454	0.515
MOD_PK_1	121	127	PF00069	0.616
MOD_PKA_1	121	127	PF00069	0.660
MOD_PKA_1	199	205	PF00069	0.673
MOD_PKA_2	121	127	PF00069	0.660
MOD_PKA_2	177	183	PF00069	0.637
MOD_PKA_2	199	205	PF00069	0.743
MOD_PKA_2	227	233	PF00069	0.552
MOD_PKA_2	238	244	PF00069	0.509
MOD_PKA_2	296	302	PF00069	0.577
MOD_Plk_2-3	97	103	PF00069	0.546
MOD_Plk_4	121	127	PF00069	0.679
MOD_Plk_4	213	219	PF00069	0.617
MOD_Plk_4	344	350	PF00069	0.711
MOD_ProDKin_1	347	353	PF00069	0.607
MOD_SUMO_for_1	280	283	PF00179	0.507
MOD_SUMO_rev_2	254	260	PF00179	0.491
TRG_DiLeu_BaEn_2	102	108	PF01217	0.540
TRG_DiLeu_BaLyEn_6	302	307	PF01217	0.537
TRG_ENDOCYTIC_2	324	327	PF00928	0.515
TRG_ER_diArg_1	314	316	PF00400	0.495
TRG_ER_diLys_1	361	364	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N2	Leptomonas seymouri	60%	77%
A0A1X0NPB5	Trypanosomatidae	22%	82%
A0A3R7K7T1	Trypanosoma rangeli	31%	90%
A0A3S7WQL0	Leishmania donovani	90%	79%
A4H5L4	Leishmania braziliensis	79%	78%
D0A9B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	88%
E9AMP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%