RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4QHY1_LEIMA

TriTrypDb:

LmjF.09.0430 , LMJLV39_090010100 , LMJSD75_090009700

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.628
CLV_NRD_NRD_1	201	203	PF00675	0.603
CLV_NRD_NRD_1	233	235	PF00675	0.598
CLV_NRD_NRD_1	368	370	PF00675	0.474
CLV_PCSK_FUR_1	199	203	PF00082	0.599
CLV_PCSK_KEX2_1	14	16	PF00082	0.351
CLV_PCSK_KEX2_1	201	203	PF00082	0.603
CLV_PCSK_KEX2_1	233	235	PF00082	0.598
CLV_PCSK_KEX2_1	368	370	PF00082	0.474
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.351
CLV_PCSK_SKI1_1	136	140	PF00082	0.426
CLV_PCSK_SKI1_1	319	323	PF00082	0.692
CLV_PCSK_SKI1_1	352	356	PF00082	0.607
CLV_PCSK_SKI1_1	42	46	PF00082	0.292
DEG_COP1_1	124	132	PF00400	0.447
DEG_Nend_Nbox_1	1	3	PF02207	0.508
DEG_SPOP_SBC_1	344	348	PF00917	0.662
DOC_CYCLIN_RxL_1	39	49	PF00134	0.292
DOC_CYCLIN_yCln2_LP_2	213	216	PF00134	0.651
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.357
DOC_MAPK_MEF2A_6	122	129	PF00069	0.436
DOC_PP2B_LxvP_1	127	130	PF13499	0.551
DOC_PP2B_LxvP_1	213	216	PF13499	0.651
DOC_PP2B_LxvP_1	445	448	PF13499	0.292
DOC_PP2B_LxvP_1	45	48	PF13499	0.351
DOC_PP2B_LxvP_1	85	88	PF13499	0.292
DOC_USP7_MATH_1	158	162	PF00917	0.677
DOC_USP7_MATH_1	16	20	PF00917	0.444
DOC_USP7_MATH_1	206	210	PF00917	0.615
DOC_USP7_MATH_1	251	255	PF00917	0.639
DOC_USP7_MATH_1	257	261	PF00917	0.636
DOC_USP7_MATH_1	301	305	PF00917	0.667
DOC_USP7_MATH_1	334	338	PF00917	0.702
DOC_USP7_MATH_1	345	349	PF00917	0.531
LIG_14-3-3_CanoR_1	20	27	PF00244	0.351
LIG_14-3-3_CanoR_1	201	206	PF00244	0.564
LIG_14-3-3_CanoR_1	233	240	PF00244	0.609
LIG_14-3-3_CanoR_1	352	357	PF00244	0.606
LIG_14-3-3_CanoR_1	58	68	PF00244	0.357
LIG_BRCT_BRCA1_1	6	10	PF00533	0.434
LIG_FHA_1	124	130	PF00498	0.460
LIG_FHA_1	137	143	PF00498	0.467
LIG_FHA_1	209	215	PF00498	0.610
LIG_FHA_1	429	435	PF00498	0.361
LIG_FHA_1	450	456	PF00498	0.328
LIG_FHA_1	76	82	PF00498	0.390
LIG_FHA_2	47	53	PF00498	0.444
LIG_FHA_2	61	67	PF00498	0.255
LIG_Integrin_isoDGR_2	165	167	PF01839	0.603
LIG_LIR_Gen_1	116	125	PF02991	0.391
LIG_LIR_Gen_1	79	90	PF02991	0.313
LIG_LIR_Nem_3	66	71	PF02991	0.314
LIG_LIR_Nem_3	79	85	PF02991	0.313
LIG_PDZ_Class_3	464	469	PF00595	0.512
LIG_SH2_NCK_1	306	310	PF00017	0.685
LIG_SH2_STAT5	306	309	PF00017	0.704
LIG_SH2_STAT5	407	410	PF00017	0.451
LIG_SH2_STAT5	54	57	PF00017	0.292
LIG_SH2_STAT5	82	85	PF00017	0.313
LIG_SH3_3	174	180	PF00018	0.638
LIG_SH3_3	295	301	PF00018	0.563
LIG_SH3_3	380	386	PF00018	0.476
LIG_SH3_3	445	451	PF00018	0.357
LIG_SUMO_SIM_anti_2	431	436	PF11976	0.351
LIG_TRAF2_1	312	315	PF00917	0.612
MOD_CK1_1	105	111	PF00069	0.296
MOD_CK1_1	19	25	PF00069	0.409
MOD_CK1_1	208	214	PF00069	0.644
MOD_CK1_1	253	259	PF00069	0.676
MOD_CK1_1	304	310	PF00069	0.653
MOD_CK1_1	348	354	PF00069	0.774
MOD_CK1_1	449	455	PF00069	0.341
MOD_CK1_1	69	75	PF00069	0.351
MOD_CK2_1	105	111	PF00069	0.296
MOD_CK2_1	293	299	PF00069	0.689
MOD_CK2_1	309	315	PF00069	0.634
MOD_CK2_1	46	52	PF00069	0.444
MOD_CK2_1	60	66	PF00069	0.255
MOD_GlcNHglycan	156	159	PF01048	0.629
MOD_GlcNHglycan	192	195	PF01048	0.625
MOD_GlcNHglycan	226	229	PF01048	0.689
MOD_GlcNHglycan	235	238	PF01048	0.595
MOD_GlcNHglycan	244	247	PF01048	0.499
MOD_GlcNHglycan	252	256	PF01048	0.624
MOD_GlcNHglycan	68	71	PF01048	0.351
MOD_GSK3_1	100	107	PF00069	0.305
MOD_GSK3_1	145	152	PF00069	0.588
MOD_GSK3_1	154	161	PF00069	0.563
MOD_GSK3_1	201	208	PF00069	0.626
MOD_GSK3_1	253	260	PF00069	0.717
MOD_GSK3_1	289	296	PF00069	0.701
MOD_GSK3_1	344	351	PF00069	0.633
MOD_GSK3_1	60	67	PF00069	0.361
MOD_N-GLC_1	105	110	PF02516	0.319
MOD_N-GLC_1	158	163	PF02516	0.717
MOD_N-GLC_1	30	35	PF02516	0.313
MOD_NEK2_1	154	159	PF00069	0.581
MOD_NEK2_1	205	210	PF00069	0.633
MOD_NEK2_1	232	237	PF00069	0.662
MOD_NEK2_1	343	348	PF00069	0.656
MOD_NEK2_2	301	306	PF00069	0.609
MOD_OFUCOSY	443	450	PF10250	0.365
MOD_PIKK_1	206	212	PF00454	0.655
MOD_PIKK_1	309	315	PF00454	0.639
MOD_PKA_1	201	207	PF00069	0.601
MOD_PKA_1	233	239	PF00069	0.590
MOD_PKA_2	19	25	PF00069	0.351
MOD_PKA_2	201	207	PF00069	0.565
MOD_PKA_2	232	238	PF00069	0.656
MOD_PKB_1	199	207	PF00069	0.599
MOD_Plk_1	105	111	PF00069	0.338
MOD_Plk_1	30	36	PF00069	0.313
MOD_Plk_1	4	10	PF00069	0.450
MOD_Plk_4	208	214	PF00069	0.608
MOD_Plk_4	272	278	PF00069	0.667
MOD_Plk_4	301	307	PF00069	0.647
MOD_Plk_4	345	351	PF00069	0.788
MOD_Plk_4	428	434	PF00069	0.305
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.496
TRG_ENDOCYTIC_2	68	71	PF00928	0.314
TRG_ENDOCYTIC_2	82	85	PF00928	0.313
TRG_ER_diArg_1	199	202	PF00400	0.603
TRG_ER_diArg_1	232	234	PF00400	0.602
TRG_ER_diArg_1	368	371	PF00400	0.532
TRG_ER_diArg_1	396	399	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	398	403	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I698	Leptomonas seymouri	60%	98%
A0A3S5H6D0	Leishmania donovani	95%	100%
A4H5L9	Leishmania braziliensis	73%	100%
A4HTV7	Leishmania infantum	96%	100%
E9AMP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
V5BIH0	Trypanosoma cruzi	37%	100%