Hypothetical tetratricopeptide repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 8 protein

Species:

Leishmania major

UniProt:

Q4QHY0_LEIMA

TriTrypDb:

LmjF.09.0440 , LMJLV39_090010200 , LMJSD75_090009800

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	2
GO:0012506	vesicle membrane	4	2
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2
GO:0030665	clathrin-coated vesicle membrane	6	2
GO:0030666	endocytic vesicle membrane	5	2
GO:0030669	clathrin-coated endocytic vesicle membrane	6	2
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0032991	protein-containing complex	1	8
GO:0034464	BBSome	2	8
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0060170	ciliary membrane	5	2
GO:0097730	non-motile cilium	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QHY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHY0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	8
GO:0009987	cellular process	1	8
GO:0016043	cellular component organization	3	8
GO:0022607	cellular component assembly	4	8
GO:0030030	cell projection organization	4	8
GO:0030031	cell projection assembly	5	8
GO:0044782	cilium organization	5	8
GO:0060271	cilium assembly	6	8
GO:0070925	organelle assembly	5	8
GO:0071840	cellular component organization or biogenesis	2	8
GO:0120031	plasma membrane bounded cell projection assembly	6	8
GO:0120036	plasma membrane bounded cell projection organization	5	8
GO:1905515	non-motile cilium assembly	7	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	416	418	PF00675	0.406
CLV_NRD_NRD_1	517	519	PF00675	0.439
CLV_PCSK_KEX2_1	416	418	PF00082	0.406
CLV_PCSK_KEX2_1	510	512	PF00082	0.599
CLV_PCSK_KEX2_1	517	519	PF00082	0.439
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.510
CLV_PCSK_SKI1_1	113	117	PF00082	0.610
CLV_PCSK_SKI1_1	169	173	PF00082	0.437
CLV_PCSK_SKI1_1	180	184	PF00082	0.561
CLV_PCSK_SKI1_1	259	263	PF00082	0.423
CLV_PCSK_SKI1_1	275	279	PF00082	0.331
CLV_PCSK_SKI1_1	416	420	PF00082	0.413
CLV_PCSK_SKI1_1	517	521	PF00082	0.481
DEG_Nend_UBRbox_2	1	3	PF02207	0.480
DOC_ANK_TNKS_1	103	110	PF00023	0.692
DOC_CKS1_1	185	190	PF01111	0.665
DOC_CYCLIN_RxL_1	511	522	PF00134	0.492
DOC_MAPK_gen_1	167	174	PF00069	0.482
DOC_MAPK_gen_1	259	269	PF00069	0.445
DOC_MAPK_gen_1	413	423	PF00069	0.414
DOC_MAPK_gen_1	573	581	PF00069	0.500
DOC_MAPK_MEF2A_6	167	174	PF00069	0.482
DOC_MAPK_MEF2A_6	183	192	PF00069	0.410
DOC_MAPK_MEF2A_6	405	412	PF00069	0.413
DOC_PP2B_LxvP_1	525	528	PF13499	0.559
DOC_PP4_FxxP_1	282	285	PF00568	0.529
DOC_USP7_MATH_1	191	195	PF00917	0.666
DOC_USP7_MATH_1	237	241	PF00917	0.740
DOC_USP7_MATH_1	296	300	PF00917	0.690
DOC_USP7_MATH_1	39	43	PF00917	0.606
DOC_USP7_MATH_1	47	51	PF00917	0.467
DOC_USP7_MATH_1	83	87	PF00917	0.684
DOC_USP7_UBL2_3	331	335	PF12436	0.343
DOC_USP7_UBL2_3	510	514	PF12436	0.589
DOC_WW_Pin1_4	184	189	PF00397	0.661
DOC_WW_Pin1_4	209	214	PF00397	0.662
DOC_WW_Pin1_4	226	231	PF00397	0.484
LIG_14-3-3_CanoR_1	447	455	PF00244	0.389
LIG_14-3-3_CanoR_1	46	52	PF00244	0.564
LIG_14-3-3_CanoR_1	73	83	PF00244	0.665
LIG_Actin_WH2_2	115	130	PF00022	0.687
LIG_Actin_WH2_2	167	182	PF00022	0.505
LIG_Actin_WH2_2	263	280	PF00022	0.474
LIG_Actin_WH2_2	37	54	PF00022	0.639
LIG_BRCT_BRCA1_1	3	7	PF00533	0.529
LIG_Clathr_ClatBox_1	161	165	PF01394	0.402
LIG_deltaCOP1_diTrp_1	253	256	PF00928	0.423
LIG_eIF4E_1	276	282	PF01652	0.470
LIG_FHA_1	122	128	PF00498	0.552
LIG_FHA_1	174	180	PF00498	0.496
LIG_FHA_1	185	191	PF00498	0.671
LIG_FHA_1	321	327	PF00498	0.454
LIG_FHA_1	423	429	PF00498	0.418
LIG_FHA_1	520	526	PF00498	0.443
LIG_FHA_1	529	535	PF00498	0.353
LIG_FHA_1	542	548	PF00498	0.475
LIG_FHA_2	339	345	PF00498	0.343
LIG_FHA_2	493	499	PF00498	0.474
LIG_GBD_Chelix_1	153	161	PF00786	0.399
LIG_LIR_Gen_1	116	127	PF02991	0.615
LIG_LIR_Gen_1	426	437	PF02991	0.371
LIG_LIR_Gen_1	548	558	PF02991	0.456
LIG_LIR_Gen_1	576	581	PF02991	0.508
LIG_LIR_Nem_3	116	122	PF02991	0.649
LIG_LIR_Nem_3	159	163	PF02991	0.439
LIG_LIR_Nem_3	375	380	PF02991	0.410
LIG_LIR_Nem_3	436	440	PF02991	0.292
LIG_LIR_Nem_3	464	469	PF02991	0.343
LIG_LIR_Nem_3	548	554	PF02991	0.453
LIG_LIR_Nem_3	576	581	PF02991	0.456
LIG_PDZ_Class_2	576	581	PF00595	0.508
LIG_PTAP_UEV_1	192	197	PF05743	0.670
LIG_PTB_Apo_2	475	482	PF02174	0.388
LIG_SH2_CRK	380	384	PF00017	0.391
LIG_SH2_CRK	415	419	PF00017	0.361
LIG_SH2_CRK	551	555	PF00017	0.460
LIG_SH2_CRK	90	94	PF00017	0.699
LIG_SH2_NCK_1	19	23	PF00017	0.612
LIG_SH2_NCK_1	90	94	PF00017	0.764
LIG_SH2_SRC	163	166	PF00017	0.424
LIG_SH2_SRC	19	22	PF00017	0.609
LIG_SH2_STAP1	346	350	PF00017	0.397
LIG_SH2_STAP1	438	442	PF00017	0.412
LIG_SH2_STAT3	438	441	PF00017	0.418
LIG_SH2_STAT5	160	163	PF00017	0.378
LIG_SH2_STAT5	276	279	PF00017	0.471
LIG_SH2_STAT5	333	336	PF00017	0.397
LIG_SH2_STAT5	438	441	PF00017	0.472
LIG_SH3_1	128	134	PF00018	0.561
LIG_SH3_2	230	235	PF14604	0.554
LIG_SH3_3	128	134	PF00018	0.514
LIG_SH3_3	178	184	PF00018	0.588
LIG_SH3_3	185	191	PF00018	0.664
LIG_SH3_3	210	216	PF00018	0.577
LIG_SH3_3	224	230	PF00018	0.616
LIG_SH3_3	41	47	PF00018	0.484
LIG_SH3_3	559	565	PF00018	0.457
LIG_TRAF2_1	241	244	PF00917	0.693
LIG_TYR_ITIM	549	554	PF00017	0.468
LIG_WRC_WIRS_1	434	439	PF05994	0.471
LIG_WRC_WIRS_1	539	544	PF05994	0.441
MOD_CK1_1	126	132	PF00069	0.594
MOD_CK1_1	436	442	PF00069	0.423
MOD_CK1_1	541	547	PF00069	0.302
MOD_CK2_1	338	344	PF00069	0.343
MOD_CK2_1	386	392	PF00069	0.410
MOD_CK2_1	492	498	PF00069	0.478
MOD_Cter_Amidation	515	518	PF01082	0.478
MOD_GlcNHglycan	193	196	PF01048	0.664
MOD_GlcNHglycan	239	242	PF01048	0.658
MOD_GlcNHglycan	307	310	PF01048	0.666
MOD_GlcNHglycan	490	493	PF01048	0.391
MOD_GSK3_1	233	240	PF00069	0.720
MOD_GSK3_1	338	345	PF00069	0.469
MOD_GSK3_1	423	430	PF00069	0.519
MOD_GSK3_1	488	495	PF00069	0.465
MOD_GSK3_1	534	541	PF00069	0.414
MOD_N-GLC_1	286	291	PF02516	0.625
MOD_N-GLC_1	321	326	PF02516	0.535
MOD_N-GLC_1	47	52	PF02516	0.644
MOD_NEK2_1	1	6	PF00069	0.505
MOD_NEK2_1	386	391	PF00069	0.413
MOD_NEK2_1	442	447	PF00069	0.393
MOD_NEK2_1	519	524	PF00069	0.465
MOD_NEK2_1	534	539	PF00069	0.423
MOD_NEK2_1	547	552	PF00069	0.462
MOD_NEK2_1	7	12	PF00069	0.398
MOD_NEK2_1	74	79	PF00069	0.701
MOD_NEK2_2	123	128	PF00069	0.647
MOD_NEK2_2	433	438	PF00069	0.270
MOD_NEK2_2	47	52	PF00069	0.572
MOD_PIKK_1	457	463	PF00454	0.549
MOD_PK_1	99	105	PF00069	0.707
MOD_PKA_2	74	80	PF00069	0.605
MOD_PKB_1	73	81	PF00069	0.539
MOD_Plk_1	1	7	PF00069	0.633
MOD_Plk_1	286	292	PF00069	0.545
MOD_Plk_1	321	327	PF00069	0.533
MOD_Plk_1	442	448	PF00069	0.444
MOD_Plk_1	47	53	PF00069	0.706
MOD_Plk_1	547	553	PF00069	0.504
MOD_Plk_4	1	7	PF00069	0.542
MOD_Plk_4	14	20	PF00069	0.449
MOD_Plk_4	321	327	PF00069	0.533
MOD_Plk_4	433	439	PF00069	0.332
MOD_ProDKin_1	184	190	PF00069	0.662
MOD_ProDKin_1	209	215	PF00069	0.662
MOD_ProDKin_1	226	232	PF00069	0.484
MOD_SUMO_rev_2	159	168	PF00179	0.463
TRG_DiLeu_BaEn_2	2	8	PF01217	0.490
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.450
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.470
TRG_ENDOCYTIC_2	333	336	PF00928	0.397
TRG_ENDOCYTIC_2	380	383	PF00928	0.424
TRG_ENDOCYTIC_2	415	418	PF00928	0.363
TRG_ENDOCYTIC_2	551	554	PF00928	0.456
TRG_ER_diArg_1	415	417	PF00400	0.407
TRG_ER_diArg_1	517	519	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	517	521	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM3	Leptomonas seymouri	70%	87%
A0A1X0NMP5	Trypanosomatidae	41%	96%
A0A3S5H6D1	Leishmania donovani	94%	100%
A4H5M0	Leishmania braziliensis	89%	90%
A4HTV8	Leishmania infantum	94%	91%
E9AMP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q8TAM2	Homo sapiens	33%	100%