Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHX9_LEIMA

TriTrypDb:

LmjF.09.0450 , LMJLV39_090010300 , LMJSD75_090009900

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.604
CLV_C14_Caspase3-7	540	544	PF00656	0.437
CLV_C14_Caspase3-7	666	670	PF00656	0.604
CLV_MEL_PAP_1	350	356	PF00089	0.604
CLV_NRD_NRD_1	195	197	PF00675	0.638
CLV_NRD_NRD_1	372	374	PF00675	0.564
CLV_NRD_NRD_1	405	407	PF00675	0.524
CLV_NRD_NRD_1	479	481	PF00675	0.589
CLV_NRD_NRD_1	512	514	PF00675	0.507
CLV_NRD_NRD_1	680	682	PF00675	0.637
CLV_NRD_NRD_1	814	816	PF00675	0.453
CLV_NRD_NRD_1	853	855	PF00675	0.642
CLV_NRD_NRD_1	865	867	PF00675	0.537
CLV_PCSK_FUR_1	678	682	PF00082	0.622
CLV_PCSK_KEX2_1	195	197	PF00082	0.638
CLV_PCSK_KEX2_1	374	376	PF00082	0.573
CLV_PCSK_KEX2_1	404	406	PF00082	0.522
CLV_PCSK_KEX2_1	479	481	PF00082	0.527
CLV_PCSK_KEX2_1	512	514	PF00082	0.645
CLV_PCSK_KEX2_1	680	682	PF00082	0.660
CLV_PCSK_KEX2_1	814	816	PF00082	0.453
CLV_PCSK_KEX2_1	853	855	PF00082	0.642
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.560
CLV_PCSK_PC7_1	810	816	PF00082	0.508
CLV_PCSK_SKI1_1	196	200	PF00082	0.628
CLV_PCSK_SKI1_1	237	241	PF00082	0.488
CLV_PCSK_SKI1_1	242	246	PF00082	0.403
CLV_PCSK_SKI1_1	433	437	PF00082	0.523
CLV_PCSK_SKI1_1	483	487	PF00082	0.532
CLV_PCSK_SKI1_1	550	554	PF00082	0.483
CLV_PCSK_SKI1_1	572	576	PF00082	0.467
CLV_PCSK_SKI1_1	745	749	PF00082	0.443
CLV_PCSK_SKI1_1	766	770	PF00082	0.551
CLV_PCSK_SKI1_1	793	797	PF00082	0.439
CLV_PCSK_SKI1_1	801	805	PF00082	0.424
CLV_Separin_Metazoa	197	201	PF03568	0.620
CLV_Separin_Metazoa	210	214	PF03568	0.558
CLV_Separin_Metazoa	267	271	PF03568	0.385
CLV_Separin_Metazoa	600	604	PF03568	0.437
DEG_APCC_DBOX_1	194	202	PF00400	0.617
DEG_APCC_DBOX_1	241	249	PF00400	0.310
DEG_APCC_DBOX_1	372	380	PF00400	0.463
DEG_APCC_DBOX_1	457	465	PF00400	0.560
DEG_APCC_DBOX_1	478	486	PF00400	0.363
DEG_APCC_DBOX_1	809	817	PF00400	0.487
DEG_APCC_KENBOX_2	435	439	PF00400	0.485
DEG_Nend_UBRbox_2	1	3	PF02207	0.595
DOC_CKS1_1	328	333	PF01111	0.672
DOC_CKS1_1	858	863	PF01111	0.605
DOC_CYCLIN_RxL_1	193	203	PF00134	0.618
DOC_CYCLIN_RxL_1	237	247	PF00134	0.323
DOC_CYCLIN_RxL_1	763	772	PF00134	0.507
DOC_CYCLIN_RxL_1	790	800	PF00134	0.484
DOC_MAPK_gen_1	195	201	PF00069	0.630
DOC_MAPK_HePTP_8	313	325	PF00069	0.511
DOC_MAPK_MEF2A_6	316	325	PF00069	0.535
DOC_MAPK_MEF2A_6	550	557	PF00069	0.504
DOC_MAPK_NFAT4_5	550	558	PF00069	0.505
DOC_USP7_MATH_1	120	124	PF00917	0.581
DOC_USP7_MATH_1	155	159	PF00917	0.696
DOC_USP7_MATH_1	175	179	PF00917	0.529
DOC_USP7_MATH_1	262	266	PF00917	0.413
DOC_USP7_MATH_1	285	289	PF00917	0.612
DOC_USP7_MATH_1	305	309	PF00917	0.621
DOC_USP7_MATH_1	334	338	PF00917	0.650
DOC_USP7_MATH_1	344	348	PF00917	0.608
DOC_USP7_MATH_1	349	353	PF00917	0.705
DOC_USP7_MATH_1	428	432	PF00917	0.599
DOC_USP7_MATH_1	642	646	PF00917	0.685
DOC_USP7_MATH_1	704	708	PF00917	0.605
DOC_USP7_MATH_1	732	736	PF00917	0.593
DOC_USP7_MATH_1	747	751	PF00917	0.534
DOC_WW_Pin1_4	125	130	PF00397	0.626
DOC_WW_Pin1_4	160	165	PF00397	0.734
DOC_WW_Pin1_4	178	183	PF00397	0.628
DOC_WW_Pin1_4	317	322	PF00397	0.641
DOC_WW_Pin1_4	327	332	PF00397	0.651
DOC_WW_Pin1_4	356	361	PF00397	0.686
DOC_WW_Pin1_4	645	650	PF00397	0.614
DOC_WW_Pin1_4	857	862	PF00397	0.677
DOC_WW_Pin1_4	915	920	PF00397	0.748
LIG_14-3-3_CanoR_1	213	221	PF00244	0.508
LIG_14-3-3_CanoR_1	353	358	PF00244	0.669
LIG_14-3-3_CanoR_1	389	397	PF00244	0.512
LIG_14-3-3_CanoR_1	42	52	PF00244	0.460
LIG_14-3-3_CanoR_1	585	593	PF00244	0.507
LIG_14-3-3_CanoR_1	705	713	PF00244	0.606
LIG_14-3-3_CanoR_1	731	741	PF00244	0.450
LIG_14-3-3_CanoR_1	890	895	PF00244	0.684
LIG_14-3-3_CanoR_1	907	913	PF00244	0.782
LIG_Actin_WH2_2	741	758	PF00022	0.532
LIG_Actin_WH2_2	788	806	PF00022	0.557
LIG_BIR_III_4	628	632	PF00653	0.496
LIG_CaM_IQ_9	215	231	PF13499	0.439
LIG_CaM_IQ_9	542	558	PF13499	0.509
LIG_FHA_1	213	219	PF00498	0.499
LIG_FHA_1	318	324	PF00498	0.676
LIG_FHA_1	364	370	PF00498	0.668
LIG_FHA_1	47	53	PF00498	0.548
LIG_FHA_1	470	476	PF00498	0.463
LIG_FHA_1	652	658	PF00498	0.760
LIG_FHA_1	923	929	PF00498	0.639
LIG_FHA_2	143	149	PF00498	0.693
LIG_FHA_2	22	28	PF00498	0.602
LIG_FHA_2	595	601	PF00498	0.428
LIG_FHA_2	719	725	PF00498	0.508
LIG_FHA_2	84	90	PF00498	0.554
LIG_FHA_2	901	907	PF00498	0.716
LIG_LIR_Apic_2	326	331	PF02991	0.675
LIG_LIR_Apic_2	707	713	PF02991	0.667
LIG_LIR_Gen_1	352	362	PF02991	0.562
LIG_LIR_Gen_1	55	65	PF02991	0.435
LIG_LIR_Gen_1	67	78	PF02991	0.392
LIG_LIR_Gen_1	724	732	PF02991	0.500
LIG_LIR_Gen_1	821	828	PF02991	0.427
LIG_LIR_Gen_1	89	99	PF02991	0.582
LIG_LIR_LC3C_4	654	659	PF02991	0.583
LIG_LIR_Nem_3	247	252	PF02991	0.450
LIG_LIR_Nem_3	352	357	PF02991	0.557
LIG_LIR_Nem_3	55	61	PF02991	0.442
LIG_LIR_Nem_3	582	587	PF02991	0.494
LIG_LIR_Nem_3	67	73	PF02991	0.393
LIG_LIR_Nem_3	724	730	PF02991	0.509
LIG_LIR_Nem_3	821	827	PF02991	0.401
LIG_LIR_Nem_3	89	94	PF02991	0.587
LIG_NRBOX	629	635	PF00104	0.402
LIG_NRBOX	764	770	PF00104	0.551
LIG_PCNA_PIPBox_1	561	570	PF02747	0.498
LIG_PCNA_yPIPBox_3	789	801	PF02747	0.421
LIG_PCNA_yPIPBox_3	841	852	PF02747	0.465
LIG_REV1ctd_RIR_1	237	246	PF16727	0.327
LIG_SH2_CRK	249	253	PF00017	0.474
LIG_SH2_CRK	328	332	PF00017	0.673
LIG_SH2_CRK	584	588	PF00017	0.539
LIG_SH2_CRK	70	74	PF00017	0.400
LIG_SH2_CRK	710	714	PF00017	0.568
LIG_SH2_CRK	727	731	PF00017	0.550
LIG_SH2_CRK	91	95	PF00017	0.499
LIG_SH2_PTP2	824	827	PF00017	0.524
LIG_SH2_SRC	258	261	PF00017	0.387
LIG_SH2_SRC	568	571	PF00017	0.475
LIG_SH2_STAP1	84	88	PF00017	0.543
LIG_SH2_STAT3	84	87	PF00017	0.535
LIG_SH2_STAT5	238	241	PF00017	0.414
LIG_SH2_STAT5	258	261	PF00017	0.508
LIG_SH2_STAT5	70	73	PF00017	0.398
LIG_SH2_STAT5	824	827	PF00017	0.524
LIG_SH3_1	328	334	PF00018	0.667
LIG_SH3_2	861	866	PF14604	0.604
LIG_SH3_3	149	155	PF00018	0.721
LIG_SH3_3	179	185	PF00018	0.746
LIG_SH3_3	328	334	PF00018	0.668
LIG_SH3_3	354	360	PF00018	0.559
LIG_SH3_3	855	861	PF00018	0.715
LIG_TRAF2_1	418	421	PF00917	0.546
LIG_TRAF2_1	491	494	PF00917	0.497
LIG_TRAF2_1	597	600	PF00917	0.503
LIG_TRAF2_1	774	777	PF00917	0.544
LIG_TRAF2_1	797	800	PF00917	0.469
LIG_TYR_ITIM	68	73	PF00017	0.474
LIG_UBA3_1	244	250	PF00899	0.489
LIG_UBA3_1	28	36	PF00899	0.549
MOD_CDK_SPK_2	327	332	PF00069	0.655
MOD_CDK_SPxK_1	127	133	PF00069	0.669
MOD_CK1_1	158	164	PF00069	0.667
MOD_CK1_1	178	184	PF00069	0.466
MOD_CK1_1	301	307	PF00069	0.718
MOD_CK1_1	312	318	PF00069	0.795
MOD_CK1_1	326	332	PF00069	0.601
MOD_CK1_1	352	358	PF00069	0.680
MOD_CK1_1	40	46	PF00069	0.468
MOD_CK1_1	423	429	PF00069	0.428
MOD_CK1_1	484	490	PF00069	0.509
MOD_CK1_1	645	651	PF00069	0.597
MOD_CK1_1	879	885	PF00069	0.602
MOD_CK1_1	914	920	PF00069	0.821
MOD_CK2_1	424	430	PF00069	0.502
MOD_CK2_1	484	490	PF00069	0.622
MOD_CK2_1	594	600	PF00069	0.516
MOD_CK2_1	718	724	PF00069	0.503
MOD_CK2_1	83	89	PF00069	0.545
MOD_DYRK1A_RPxSP_1	127	131	PF00069	0.614
MOD_GlcNHglycan	122	125	PF01048	0.723
MOD_GlcNHglycan	17	20	PF01048	0.639
MOD_GlcNHglycan	300	303	PF01048	0.703
MOD_GlcNHglycan	306	310	PF01048	0.734
MOD_GlcNHglycan	317	320	PF01048	0.520
MOD_GlcNHglycan	325	328	PF01048	0.527
MOD_GlcNHglycan	347	350	PF01048	0.691
MOD_GlcNHglycan	401	404	PF01048	0.650
MOD_GlcNHglycan	426	429	PF01048	0.642
MOD_GlcNHglycan	430	433	PF01048	0.585
MOD_GlcNHglycan	564	567	PF01048	0.420
MOD_GlcNHglycan	613	616	PF01048	0.503
MOD_GlcNHglycan	644	647	PF01048	0.613
MOD_GlcNHglycan	650	653	PF01048	0.631
MOD_GlcNHglycan	692	695	PF01048	0.703
MOD_GlcNHglycan	734	737	PF01048	0.517
MOD_GlcNHglycan	820	823	PF01048	0.441
MOD_GlcNHglycan	878	881	PF01048	0.732
MOD_GlcNHglycan	903	906	PF01048	0.693
MOD_GlcNHglycan	913	916	PF01048	0.700
MOD_GSK3_1	155	162	PF00069	0.748
MOD_GSK3_1	176	183	PF00069	0.649
MOD_GSK3_1	301	308	PF00069	0.747
MOD_GSK3_1	323	330	PF00069	0.662
MOD_GSK3_1	340	347	PF00069	0.585
MOD_GSK3_1	349	356	PF00069	0.696
MOD_GSK3_1	40	47	PF00069	0.435
MOD_GSK3_1	420	427	PF00069	0.527
MOD_GSK3_1	585	592	PF00069	0.440
MOD_GSK3_1	647	654	PF00069	0.623
MOD_GSK3_1	657	664	PF00069	0.721
MOD_GSK3_1	889	896	PF00069	0.634
MOD_GSK3_1	907	914	PF00069	0.661
MOD_GSK3_1	915	922	PF00069	0.618
MOD_N-GLC_1	689	694	PF02516	0.529
MOD_N-GLC_1	922	927	PF02516	0.813
MOD_NEK2_1	1	6	PF00069	0.761
MOD_NEK2_1	212	217	PF00069	0.523
MOD_NEK2_1	345	350	PF00069	0.762
MOD_NEK2_1	37	42	PF00069	0.421
MOD_NEK2_1	611	616	PF00069	0.580
MOD_NEK2_1	633	638	PF00069	0.560
MOD_NEK2_1	657	662	PF00069	0.755
MOD_NEK2_1	82	87	PF00069	0.420
MOD_OFUCOSY	865	872	PF10250	0.517
MOD_PIKK_1	156	162	PF00454	0.548
MOD_PIKK_1	212	218	PF00454	0.516
MOD_PIKK_1	262	268	PF00454	0.554
MOD_PIKK_1	388	394	PF00454	0.601
MOD_PIKK_1	469	475	PF00454	0.606
MOD_PIKK_1	594	600	PF00454	0.486
MOD_PIKK_1	606	612	PF00454	0.413
MOD_PIKK_1	83	89	PF00454	0.636
MOD_PK_1	353	359	PF00069	0.561
MOD_PKA_1	680	686	PF00069	0.620
MOD_PKA_2	212	218	PF00069	0.516
MOD_PKA_2	352	358	PF00069	0.679
MOD_PKA_2	388	394	PF00069	0.593
MOD_PKA_2	589	595	PF00069	0.587
MOD_PKA_2	680	686	PF00069	0.692
MOD_PKA_2	704	710	PF00069	0.695
MOD_PKA_2	732	738	PF00069	0.541
MOD_PKA_2	889	895	PF00069	0.623
MOD_PKB_1	678	686	PF00069	0.621
MOD_Plk_1	420	426	PF00069	0.401
MOD_Plk_1	529	535	PF00069	0.505
MOD_Plk_2-3	823	829	PF00069	0.424
MOD_Plk_4	162	168	PF00069	0.710
MOD_Plk_4	251	257	PF00069	0.517
MOD_ProDKin_1	125	131	PF00069	0.627
MOD_ProDKin_1	160	166	PF00069	0.736
MOD_ProDKin_1	178	184	PF00069	0.633
MOD_ProDKin_1	317	323	PF00069	0.644
MOD_ProDKin_1	327	333	PF00069	0.650
MOD_ProDKin_1	356	362	PF00069	0.688
MOD_ProDKin_1	645	651	PF00069	0.616
MOD_ProDKin_1	857	863	PF00069	0.678
MOD_ProDKin_1	915	921	PF00069	0.747
MOD_SUMO_for_1	574	577	PF00179	0.484
MOD_SUMO_for_1	769	772	PF00179	0.525
MOD_SUMO_for_1	774	777	PF00179	0.523
MOD_SUMO_rev_2	230	239	PF00179	0.574
MOD_SUMO_rev_2	514	522	PF00179	0.630
MOD_SUMO_rev_2	565	574	PF00179	0.484
MOD_SUMO_rev_2	664	670	PF00179	0.548
TRG_DiLeu_BaEn_1	264	269	PF01217	0.368
TRG_DiLeu_BaEn_2	444	450	PF01217	0.436
TRG_DiLeu_BaLyEn_6	798	803	PF01217	0.462
TRG_ENDOCYTIC_2	249	252	PF00928	0.400
TRG_ENDOCYTIC_2	584	587	PF00928	0.492
TRG_ENDOCYTIC_2	70	73	PF00928	0.398
TRG_ENDOCYTIC_2	727	730	PF00928	0.432
TRG_ENDOCYTIC_2	824	827	PF00928	0.408
TRG_ENDOCYTIC_2	91	94	PF00928	0.474
TRG_ER_diArg_1	373	376	PF00400	0.457
TRG_ER_diArg_1	404	406	PF00400	0.584
TRG_ER_diArg_1	678	681	PF00400	0.654
TRG_ER_diArg_1	730	733	PF00400	0.511
TRG_ER_diArg_1	813	815	PF00400	0.481
TRG_ER_diArg_1	852	854	PF00400	0.622
TRG_NES_CRM1_1	216	231	PF08389	0.551
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	497	502	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	814	819	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F4	Leptomonas seymouri	55%	94%
A0A3S5H6D2	Leishmania donovani	94%	100%
A0A422NV62	Trypanosoma rangeli	29%	93%
A4H5M1	Leishmania braziliensis	76%	91%
A4HTV9	Leishmania infantum	94%	100%
D0A9C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	91%
E9AMP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BN30	Trypanosoma cruzi	29%	93%