LeishMANIAdb
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Serine/threonine-protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
kinetoplastid-specific phospho-protein phosphatase, putative
Species:
Leishmania major
UniProt:
Q4QHX7_LEIMA
TriTrypDb:
LmjF.09.0470 , LMJLV39_090010500 * , LMJSD75_090010100
Length:
652

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 3
GO:0005737 cytoplasm 2 3
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

Q4QHX7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHX7

Function

Biological processes
Term Name Level Count
GO:0000724 double-strand break repair via homologous recombination 7 1
GO:0000725 recombinational repair 6 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006259 DNA metabolic process 4 1
GO:0006281 DNA repair 5 1
GO:0006302 double-strand break repair 6 1
GO:0006310 DNA recombination 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0033554 cellular response to stress 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0004721 phosphoprotein phosphatase activity 3 16
GO:0004722 protein serine/threonine phosphatase activity 4 16
GO:0016787 hydrolase activity 2 16
GO:0016788 hydrolase activity, acting on ester bonds 3 16
GO:0016791 phosphatase activity 5 16
GO:0017018 myosin phosphatase activity 5 16
GO:0042578 phosphoric ester hydrolase activity 4 16
GO:0140096 catalytic activity, acting on a protein 2 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 141 145 PF00656 0.593
CLV_C14_Caspase3-7 190 194 PF00656 0.705
CLV_C14_Caspase3-7 588 592 PF00656 0.356
CLV_NRD_NRD_1 260 262 PF00675 0.647
CLV_NRD_NRD_1 37 39 PF00675 0.699
CLV_PCSK_KEX2_1 260 262 PF00082 0.652
CLV_PCSK_KEX2_1 37 39 PF00082 0.662
CLV_PCSK_SKI1_1 261 265 PF00082 0.628
CLV_PCSK_SKI1_1 342 346 PF00082 0.384
CLV_PCSK_SKI1_1 369 373 PF00082 0.360
CLV_PCSK_SKI1_1 390 394 PF00082 0.313
CLV_PCSK_SKI1_1 421 425 PF00082 0.303
CLV_PCSK_SKI1_1 600 604 PF00082 0.326
DOC_CYCLIN_RxL_1 10 23 PF00134 0.491
DOC_CYCLIN_yClb3_PxF_3 104 110 PF00134 0.471
DOC_PP1_RVXF_1 259 266 PF00149 0.645
DOC_PP2B_LxvP_1 125 128 PF13499 0.559
DOC_PP4_FxxP_1 516 519 PF00568 0.300
DOC_SPAK_OSR1_1 165 169 PF12202 0.632
DOC_USP7_MATH_1 128 132 PF00917 0.521
DOC_USP7_MATH_1 148 152 PF00917 0.373
DOC_USP7_MATH_1 181 185 PF00917 0.657
DOC_USP7_MATH_1 243 247 PF00917 0.646
DOC_USP7_MATH_1 298 302 PF00917 0.462
DOC_USP7_MATH_1 60 64 PF00917 0.706
DOC_USP7_MATH_2 541 547 PF00917 0.325
DOC_WW_Pin1_4 144 149 PF00397 0.482
DOC_WW_Pin1_4 179 184 PF00397 0.655
DOC_WW_Pin1_4 193 198 PF00397 0.614
DOC_WW_Pin1_4 294 299 PF00397 0.523
DOC_WW_Pin1_4 320 325 PF00397 0.440
DOC_WW_Pin1_4 353 358 PF00397 0.344
DOC_WW_Pin1_4 384 389 PF00397 0.300
DOC_WW_Pin1_4 40 45 PF00397 0.741
DOC_WW_Pin1_4 520 525 PF00397 0.354
LIG_14-3-3_CanoR_1 251 259 PF00244 0.597
LIG_14-3-3_CanoR_1 29 35 PF00244 0.631
LIG_14-3-3_CanoR_1 38 44 PF00244 0.671
LIG_14-3-3_CanoR_1 465 473 PF00244 0.325
LIG_14-3-3_CanoR_1 50 58 PF00244 0.583
LIG_Actin_WH2_2 371 387 PF00022 0.300
LIG_AP2alpha_1 368 372 PF02296 0.300
LIG_AP2alpha_1 573 577 PF02296 0.414
LIG_BIR_II_1 1 5 PF00653 0.547
LIG_BIR_III_2 180 184 PF00653 0.610
LIG_BRCT_BRCA1_1 466 470 PF00533 0.277
LIG_BRCT_BRCA1_1 505 509 PF00533 0.414
LIG_deltaCOP1_diTrp_1 460 470 PF00928 0.282
LIG_EH1_1 372 380 PF00400 0.360
LIG_eIF4E_1 373 379 PF01652 0.282
LIG_FHA_1 145 151 PF00498 0.493
LIG_FHA_1 156 162 PF00498 0.600
LIG_FHA_1 279 285 PF00498 0.582
LIG_FHA_1 311 317 PF00498 0.485
LIG_FHA_1 474 480 PF00498 0.300
LIG_FHA_1 558 564 PF00498 0.404
LIG_FHA_1 69 75 PF00498 0.576
LIG_FHA_2 219 225 PF00498 0.643
LIG_FHA_2 43 49 PF00498 0.612
LIG_FHA_2 59 65 PF00498 0.660
LIG_FHA_2 634 640 PF00498 0.589
LIG_FHA_2 82 88 PF00498 0.586
LIG_LIR_Apic_2 513 519 PF02991 0.301
LIG_LIR_Apic_2 535 541 PF02991 0.268
LIG_LIR_Gen_1 380 388 PF02991 0.293
LIG_LIR_Gen_1 467 477 PF02991 0.310
LIG_LIR_Nem_3 380 384 PF02991 0.346
LIG_LIR_Nem_3 467 473 PF02991 0.310
LIG_LIR_Nem_3 513 518 PF02991 0.338
LIG_OCRL_FandH_1 360 372 PF00620 0.282
LIG_Pex14_2 285 289 PF04695 0.523
LIG_Pex14_2 368 372 PF04695 0.300
LIG_Pex14_2 573 577 PF04695 0.374
LIG_Pex14_2 579 583 PF04695 0.343
LIG_PTAP_UEV_1 104 109 PF05743 0.509
LIG_PTB_Apo_2 283 290 PF02174 0.585
LIG_PTB_Apo_2 301 308 PF02174 0.417
LIG_PTB_Apo_2 440 447 PF02174 0.414
LIG_PTB_Phospho_1 301 307 PF10480 0.416
LIG_SH2_CRK 307 311 PF00017 0.365
LIG_SH2_CRK 529 533 PF00017 0.414
LIG_SH2_STAP1 642 646 PF00017 0.451
LIG_SH2_STAT5 154 157 PF00017 0.768
LIG_SH2_STAT5 309 312 PF00017 0.333
LIG_SH2_STAT5 359 362 PF00017 0.282
LIG_SH2_STAT5 373 376 PF00017 0.312
LIG_SH2_STAT5 386 389 PF00017 0.312
LIG_SH2_STAT5 397 400 PF00017 0.351
LIG_SH2_STAT5 410 413 PF00017 0.343
LIG_SH2_STAT5 484 487 PF00017 0.402
LIG_SH2_STAT5 581 584 PF00017 0.279
LIG_SH2_STAT5 610 613 PF00017 0.414
LIG_SH3_3 102 108 PF00018 0.623
LIG_SH3_3 194 200 PF00018 0.743
LIG_SH3_3 228 234 PF00018 0.629
LIG_SH3_3 351 357 PF00018 0.504
LIG_SH3_3 413 419 PF00018 0.318
LIG_SH3_3 504 510 PF00018 0.381
LIG_SUMO_SIM_anti_2 115 120 PF11976 0.395
LIG_SUMO_SIM_anti_2 404 409 PF11976 0.314
LIG_SUMO_SIM_anti_2 498 506 PF11976 0.365
LIG_SUMO_SIM_par_1 115 120 PF11976 0.491
LIG_SUMO_SIM_par_1 15 23 PF11976 0.499
LIG_SUMO_SIM_par_1 618 624 PF11976 0.334
LIG_TRAF2_1 585 588 PF00917 0.282
LIG_TRAF2_1 636 639 PF00917 0.633
LIG_TRAF2_1 9 12 PF00917 0.553
LIG_UBA3_1 334 342 PF00899 0.457
LIG_UBA3_1 411 415 PF00899 0.311
LIG_WRC_WIRS_1 311 316 PF05994 0.475
LIG_WRC_WIRS_1 378 383 PF05994 0.282
LIG_WRC_WIRS_1 512 517 PF05994 0.300
MOD_CDC14_SPxK_1 196 199 PF00782 0.619
MOD_CDC14_SPxK_1 43 46 PF00782 0.544
MOD_CDK_SPxK_1 193 199 PF00069 0.624
MOD_CDK_SPxK_1 384 390 PF00069 0.300
MOD_CDK_SPxK_1 40 46 PF00069 0.536
MOD_CDK_SPxxK_3 520 527 PF00069 0.325
MOD_CK1_1 106 112 PF00069 0.562
MOD_CK1_1 160 166 PF00069 0.651
MOD_CK1_1 167 173 PF00069 0.632
MOD_CK1_1 297 303 PF00069 0.428
MOD_CK1_1 353 359 PF00069 0.395
MOD_CK1_1 42 48 PF00069 0.802
MOD_CK1_1 51 57 PF00069 0.799
MOD_CK1_1 63 69 PF00069 0.732
MOD_CK1_1 81 87 PF00069 0.600
MOD_CK2_1 222 228 PF00069 0.740
MOD_CK2_1 6 12 PF00069 0.568
MOD_CK2_1 633 639 PF00069 0.651
MOD_CK2_1 81 87 PF00069 0.738
MOD_GlcNHglycan 101 104 PF01048 0.543
MOD_GlcNHglycan 105 108 PF01048 0.451
MOD_GlcNHglycan 171 174 PF01048 0.714
MOD_GlcNHglycan 201 204 PF01048 0.617
MOD_GlcNHglycan 207 210 PF01048 0.663
MOD_GlcNHglycan 237 240 PF01048 0.776
MOD_GlcNHglycan 434 437 PF01048 0.319
MOD_GlcNHglycan 438 441 PF01048 0.322
MOD_GlcNHglycan 466 469 PF01048 0.452
MOD_GlcNHglycan 493 496 PF01048 0.360
MOD_GlcNHglycan 54 57 PF01048 0.679
MOD_GlcNHglycan 597 600 PF01048 0.392
MOD_GlcNHglycan 607 610 PF01048 0.362
MOD_GlcNHglycan 64 68 PF01048 0.710
MOD_GlcNHglycan 90 93 PF01048 0.724
MOD_GlcNHglycan 97 100 PF01048 0.629
MOD_GSK3_1 106 113 PF00069 0.437
MOD_GSK3_1 123 130 PF00069 0.423
MOD_GSK3_1 144 151 PF00069 0.543
MOD_GSK3_1 160 167 PF00069 0.593
MOD_GSK3_1 189 196 PF00069 0.728
MOD_GSK3_1 218 225 PF00069 0.762
MOD_GSK3_1 294 301 PF00069 0.492
MOD_GSK3_1 432 439 PF00069 0.355
MOD_GSK3_1 48 55 PF00069 0.836
MOD_GSK3_1 600 607 PF00069 0.311
MOD_GSK3_1 68 75 PF00069 0.665
MOD_GSK3_1 95 102 PF00069 0.652
MOD_N-GLC_1 213 218 PF02516 0.529
MOD_N-GLC_1 222 227 PF02516 0.753
MOD_N-GLC_1 39 44 PF02516 0.748
MOD_N-GLC_1 442 447 PF02516 0.414
MOD_N-GLC_1 543 548 PF02516 0.414
MOD_N-GLC_1 78 83 PF02516 0.756
MOD_N-GLC_2 318 320 PF02516 0.387
MOD_N-GLC_2 336 338 PF02516 0.456
MOD_NEK2_1 110 115 PF00069 0.546
MOD_NEK2_1 133 138 PF00069 0.566
MOD_NEK2_1 155 160 PF00069 0.690
MOD_NEK2_1 191 196 PF00069 0.648
MOD_NEK2_1 330 335 PF00069 0.354
MOD_NEK2_1 564 569 PF00069 0.289
MOD_NEK2_1 593 598 PF00069 0.362
MOD_NEK2_1 605 610 PF00069 0.331
MOD_NEK2_1 68 73 PF00069 0.753
MOD_NEK2_2 410 415 PF00069 0.381
MOD_NEK2_2 442 447 PF00069 0.300
MOD_PIKK_1 160 166 PF00454 0.702
MOD_PK_1 350 356 PF00069 0.403
MOD_PKA_2 155 161 PF00069 0.662
MOD_PKA_2 164 170 PF00069 0.548
MOD_PKA_2 198 204 PF00069 0.694
MOD_PKA_2 205 211 PF00069 0.497
MOD_PKA_2 464 470 PF00069 0.325
MOD_PKA_2 491 497 PF00069 0.360
MOD_PKA_2 51 57 PF00069 0.841
MOD_PKA_2 557 563 PF00069 0.325
MOD_PKA_2 95 101 PF00069 0.667
MOD_PKB_1 50 58 PF00069 0.616
MOD_Plk_1 110 116 PF00069 0.483
MOD_Plk_1 133 139 PF00069 0.540
MOD_Plk_1 267 273 PF00069 0.653
MOD_Plk_1 401 407 PF00069 0.282
MOD_Plk_1 429 435 PF00069 0.282
MOD_Plk_1 442 448 PF00069 0.282
MOD_Plk_2-3 543 549 PF00069 0.331
MOD_Plk_4 112 118 PF00069 0.476
MOD_Plk_4 128 134 PF00069 0.354
MOD_Plk_4 429 435 PF00069 0.296
MOD_Plk_4 511 517 PF00069 0.300
MOD_ProDKin_1 144 150 PF00069 0.478
MOD_ProDKin_1 179 185 PF00069 0.655
MOD_ProDKin_1 193 199 PF00069 0.616
MOD_ProDKin_1 294 300 PF00069 0.511
MOD_ProDKin_1 320 326 PF00069 0.435
MOD_ProDKin_1 353 359 PF00069 0.340
MOD_ProDKin_1 384 390 PF00069 0.300
MOD_ProDKin_1 40 46 PF00069 0.745
MOD_ProDKin_1 520 526 PF00069 0.354
MOD_SUMO_rev_2 339 344 PF00179 0.402
TRG_DiLeu_BaEn_3 339 345 PF01217 0.376
TRG_DiLeu_BaLyEn_6 625 630 PF01217 0.344
TRG_ENDOCYTIC_2 307 310 PF00928 0.369
TRG_ENDOCYTIC_2 529 532 PF00928 0.360
TRG_ER_diArg_1 259 261 PF00400 0.678
TRG_ER_diArg_1 49 52 PF00400 0.688
TRG_Pf-PMV_PEXEL_1 16 21 PF00026 0.473
TRG_Pf-PMV_PEXEL_1 267 272 PF00026 0.547

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5U5 Leptomonas seymouri 73% 96%
A0A0S4IYE4 Bodo saltans 56% 100%
A0A0S4J323 Bodo saltans 27% 100%
A0A1X0NPA5 Trypanosomatidae 57% 100%
A0A3Q8I8M6 Leishmania donovani 33% 100%
A0A3R7NXP6 Trypanosoma rangeli 56% 100%
A0A3S5H6D4 Leishmania donovani 97% 100%
A4H5M4 Leishmania braziliensis 85% 100%
A4HTW1 Leishmania infantum 96% 100%
A4HVT0 Leishmania infantum 33% 100%
D0A9C5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AMP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9APH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
Q4QG03 Leishmania major 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS