Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHX6_LEIMA

TriTrypDb:

LmjF.09.0480 , LMJLV39_090010600 , LMJSD75_090010200

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QHX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHX6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006813	potassium ion transport	7	2
GO:0009987	cellular process	1	2
GO:0030001	metal ion transport	6	2
GO:0032879	regulation of localization	3	6
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0034762	regulation of transmembrane transport	4	6
GO:0034765	regulation of monoatomic ion transmembrane transport	5	6
GO:0043269	regulation of monoatomic ion transport	5	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051049	regulation of transport	4	6
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0065007	biological regulation	1	6
GO:0071805	potassium ion transmembrane transport	6	2
GO:0098655	monoatomic cation transmembrane transport	4	2
GO:0098657	import into cell	4	2
GO:0098659	inorganic cation import across plasma membrane	5	2
GO:0098660	inorganic ion transmembrane transport	4	2
GO:0098662	inorganic cation transmembrane transport	5	2
GO:0098739	import across plasma membrane	3	2
GO:0099587	inorganic ion import across plasma membrane	4	2
GO:1990573	potassium ion import across plasma membrane	6	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	6
GO:0005216	monoatomic ion channel activity	4	6
GO:0005242	inward rectifier potassium channel activity	7	6
GO:0005244	voltage-gated monoatomic ion channel activity	4	6
GO:0005249	voltage-gated potassium channel activity	6	6
GO:0005261	monoatomic cation channel activity	5	6
GO:0005267	potassium channel activity	6	6
GO:0008324	monoatomic cation transmembrane transporter activity	4	6
GO:0015075	monoatomic ion transmembrane transporter activity	3	6
GO:0015079	potassium ion transmembrane transporter activity	6	6
GO:0015267	channel activity	4	6
GO:0015276	ligand-gated monoatomic ion channel activity	5	6
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	6
GO:0022803	passive transmembrane transporter activity	3	6
GO:0022832	voltage-gated channel activity	6	6
GO:0022834	ligand-gated channel activity	6	6
GO:0022836	gated channel activity	5	6
GO:0022843	voltage-gated monoatomic cation channel activity	5	6
GO:0022857	transmembrane transporter activity	2	6
GO:0022890	inorganic cation transmembrane transporter activity	4	6
GO:0046873	metal ion transmembrane transporter activity	5	6
GO:0099094	ligand-gated monoatomic cation channel activity	6	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.582
CLV_NRD_NRD_1	367	369	PF00675	0.710
CLV_NRD_NRD_1	493	495	PF00675	0.740
CLV_PCSK_KEX2_1	360	362	PF00082	0.799
CLV_PCSK_KEX2_1	367	369	PF00082	0.739
CLV_PCSK_KEX2_1	433	435	PF00082	0.686
CLV_PCSK_KEX2_1	553	555	PF00082	0.730
CLV_PCSK_KEX2_1	686	688	PF00082	0.624
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.799
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.679
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.730
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.624
CLV_PCSK_SKI1_1	12	16	PF00082	0.556
CLV_PCSK_SKI1_1	239	243	PF00082	0.610
CLV_PCSK_SKI1_1	259	263	PF00082	0.539
CLV_PCSK_SKI1_1	308	312	PF00082	0.701
CLV_PCSK_SKI1_1	361	365	PF00082	0.760
CLV_PCSK_SKI1_1	554	558	PF00082	0.675
CLV_PCSK_SKI1_1	60	64	PF00082	0.443
CLV_PCSK_SKI1_1	630	634	PF00082	0.575
CLV_PCSK_SKI1_1	84	88	PF00082	0.491
DEG_Nend_Nbox_1	1	3	PF02207	0.745
DEG_SPOP_SBC_1	382	386	PF00917	0.478
DEG_SPOP_SBC_1	486	490	PF00917	0.573
DOC_CYCLIN_yCln2_LP_2	373	379	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	613	619	PF00134	0.356
DOC_MAPK_gen_1	202	210	PF00069	0.603
DOC_MAPK_gen_1	254	262	PF00069	0.308
DOC_MAPK_gen_1	605	613	PF00069	0.403
DOC_MAPK_HePTP_8	623	635	PF00069	0.392
DOC_MAPK_MEF2A_6	581	590	PF00069	0.459
DOC_MAPK_MEF2A_6	626	635	PF00069	0.394
DOC_PP1_RVXF_1	237	243	PF00149	0.386
DOC_PP1_RVXF_1	257	263	PF00149	0.245
DOC_PP2B_LxvP_1	29	32	PF13499	0.727
DOC_PP2B_LxvP_1	373	376	PF13499	0.476
DOC_PP2B_LxvP_1	633	636	PF13499	0.417
DOC_PP4_FxxP_1	34	37	PF00568	0.733
DOC_USP7_MATH_1	378	382	PF00917	0.599
DOC_USP7_MATH_1	486	490	PF00917	0.557
DOC_USP7_MATH_1	521	525	PF00917	0.516
DOC_USP7_MATH_1	564	568	PF00917	0.541
DOC_USP7_MATH_1	709	713	PF00917	0.403
DOC_USP7_MATH_1	73	77	PF00917	0.697
DOC_USP7_UBL2_3	360	364	PF12436	0.655
DOC_WW_Pin1_4	427	432	PF00397	0.496
DOC_WW_Pin1_4	501	506	PF00397	0.528
DOC_WW_Pin1_4	52	57	PF00397	0.721
DOC_WW_Pin1_4	534	539	PF00397	0.493
DOC_WW_Pin1_4	624	629	PF00397	0.408
DOC_WW_Pin1_4	71	76	PF00397	0.587
LIG_14-3-3_CanoR_1	118	123	PF00244	0.613
LIG_14-3-3_CanoR_1	202	210	PF00244	0.501
LIG_14-3-3_CanoR_1	239	248	PF00244	0.382
LIG_14-3-3_CanoR_1	3	8	PF00244	0.760
LIG_14-3-3_CanoR_1	367	376	PF00244	0.519
LIG_14-3-3_CanoR_1	421	431	PF00244	0.559
LIG_14-3-3_CanoR_1	434	438	PF00244	0.497
LIG_14-3-3_CanoR_1	594	602	PF00244	0.439
LIG_14-3-3_CanoR_1	608	614	PF00244	0.276
LIG_14-3-3_CanoR_1	81	90	PF00244	0.708
LIG_APCC_ABBA_1	629	634	PF00400	0.410
LIG_APCC_ABBA_1	705	710	PF00400	0.399
LIG_BRCT_BRCA1_1	473	477	PF00533	0.526
LIG_BRCT_BRCA1_1	546	550	PF00533	0.489
LIG_BRCT_BRCA1_1	79	83	PF00533	0.679
LIG_CtBP_PxDLS_1	726	730	PF00389	0.436
LIG_deltaCOP1_diTrp_1	256	262	PF00928	0.359
LIG_EH1_1	143	151	PF00400	0.385
LIG_eIF4E_1	144	150	PF01652	0.385
LIG_FHA_1	107	113	PF00498	0.562
LIG_FHA_1	132	138	PF00498	0.529
LIG_FHA_1	203	209	PF00498	0.532
LIG_FHA_1	231	237	PF00498	0.431
LIG_FHA_1	93	99	PF00498	0.763
LIG_FHA_2	190	196	PF00498	0.593
LIG_FHA_2	599	605	PF00498	0.445
LIG_FHA_2	673	679	PF00498	0.426
LIG_FHA_2	733	739	PF00498	0.541
LIG_KLC1_Yacidic_2	600	604	PF13176	0.443
LIG_LIR_Gen_1	130	141	PF02991	0.532
LIG_LIR_Gen_1	212	221	PF02991	0.385
LIG_LIR_Gen_1	243	252	PF02991	0.382
LIG_LIR_Gen_1	717	726	PF02991	0.390
LIG_LIR_Nem_3	116	122	PF02991	0.656
LIG_LIR_Nem_3	123	128	PF02991	0.552
LIG_LIR_Nem_3	130	136	PF02991	0.439
LIG_LIR_Nem_3	138	142	PF02991	0.246
LIG_LIR_Nem_3	170	176	PF02991	0.385
LIG_LIR_Nem_3	212	216	PF02991	0.385
LIG_LIR_Nem_3	243	248	PF02991	0.370
LIG_LIR_Nem_3	256	261	PF02991	0.309
LIG_LIR_Nem_3	315	321	PF02991	0.444
LIG_LIR_Nem_3	38	43	PF02991	0.655
LIG_LIR_Nem_3	572	577	PF02991	0.431
LIG_LIR_Nem_3	717	721	PF02991	0.392
LIG_Pex14_1	258	262	PF04695	0.374
LIG_PTB_Apo_2	212	219	PF02174	0.385
LIG_SH2_CRK	139	143	PF00017	0.342
LIG_SH2_CRK	40	44	PF00017	0.675
LIG_SH2_GRB2like	213	216	PF00017	0.385
LIG_SH2_GRB2like	689	692	PF00017	0.368
LIG_SH2_GRB2like	720	723	PF00017	0.378
LIG_SH2_PTP2	213	216	PF00017	0.385
LIG_SH2_SRC	144	147	PF00017	0.385
LIG_SH2_SRC	213	216	PF00017	0.385
LIG_SH2_STAP1	139	143	PF00017	0.385
LIG_SH2_STAT3	291	294	PF00017	0.409
LIG_SH2_STAT5	126	129	PF00017	0.588
LIG_SH2_STAT5	144	147	PF00017	0.275
LIG_SH2_STAT5	173	176	PF00017	0.407
LIG_SH2_STAT5	213	216	PF00017	0.506
LIG_SH2_STAT5	232	235	PF00017	0.316
LIG_SH2_STAT5	602	605	PF00017	0.530
LIG_SH2_STAT5	720	723	PF00017	0.378
LIG_SH3_3	11	17	PF00018	0.707
LIG_SH3_3	29	35	PF00018	0.654
LIG_SH3_3	320	326	PF00018	0.444
LIG_SH3_3	372	378	PF00018	0.548
LIG_SH3_3	50	56	PF00018	0.695
LIG_SH3_3	563	569	PF00018	0.482
LIG_SH3_3	625	631	PF00018	0.411
LIG_SH3_5	99	103	PF00018	0.596
LIG_Sin3_3	223	230	PF02671	0.455
LIG_SUMO_SIM_par_1	133	138	PF11976	0.369
LIG_SUMO_SIM_par_1	146	152	PF11976	0.276
LIG_SUMO_SIM_par_1	205	212	PF11976	0.385
LIG_SUMO_SIM_par_1	667	673	PF11976	0.373
LIG_TRAF2_1	526	529	PF00917	0.490
LIG_TYR_ITIM	137	142	PF00017	0.342
LIG_TYR_ITSM	36	43	PF00017	0.549
LIG_WRC_WIRS_1	114	119	PF05994	0.565
MOD_CDC14_SPxK_1	430	433	PF00782	0.580
MOD_CDC14_SPxK_1	627	630	PF00782	0.399
MOD_CDK_SPK_2	501	506	PF00069	0.659
MOD_CDK_SPxK_1	427	433	PF00069	0.614
MOD_CDK_SPxK_1	624	630	PF00069	0.424
MOD_CDK_SPxxK_3	427	434	PF00069	0.589
MOD_CDK_SPxxK_3	501	508	PF00069	0.596
MOD_CK1_1	316	322	PF00069	0.640
MOD_CK1_1	381	387	PF00069	0.780
MOD_CK1_1	391	397	PF00069	0.628
MOD_CK1_1	425	431	PF00069	0.754
MOD_CK1_1	436	442	PF00069	0.698
MOD_CK1_1	450	456	PF00069	0.717
MOD_CK1_1	457	463	PF00069	0.683
MOD_CK1_1	466	472	PF00069	0.552
MOD_CK1_1	479	485	PF00069	0.670
MOD_CK1_1	504	510	PF00069	0.603
MOD_CK1_1	523	529	PF00069	0.639
MOD_CK1_1	537	543	PF00069	0.595
MOD_CK1_1	641	647	PF00069	0.594
MOD_CK1_1	681	687	PF00069	0.498
MOD_CK1_1	74	80	PF00069	0.616
MOD_CK2_1	225	231	PF00069	0.418
MOD_CK2_1	382	388	PF00069	0.656
MOD_CK2_1	523	529	PF00069	0.632
MOD_CK2_1	672	678	PF00069	0.481
MOD_CK2_1	730	736	PF00069	0.650
MOD_Cter_Amidation	492	495	PF01082	0.607
MOD_Cter_Amidation	551	554	PF01082	0.619
MOD_GlcNHglycan	169	172	PF01048	0.385
MOD_GlcNHglycan	318	321	PF01048	0.654
MOD_GlcNHglycan	380	383	PF01048	0.769
MOD_GlcNHglycan	388	393	PF01048	0.671
MOD_GlcNHglycan	404	407	PF01048	0.818
MOD_GlcNHglycan	438	441	PF01048	0.689
MOD_GlcNHglycan	449	452	PF01048	0.707
MOD_GlcNHglycan	45	48	PF01048	0.642
MOD_GlcNHglycan	460	463	PF01048	0.677
MOD_GlcNHglycan	478	481	PF01048	0.550
MOD_GlcNHglycan	49	52	PF01048	0.594
MOD_GlcNHglycan	509	512	PF01048	0.663
MOD_GlcNHglycan	643	646	PF01048	0.715
MOD_GlcNHglycan	652	655	PF01048	0.673
MOD_GlcNHglycan	84	87	PF01048	0.596
MOD_GSK3_1	127	134	PF00069	0.443
MOD_GSK3_1	240	247	PF00069	0.467
MOD_GSK3_1	35	42	PF00069	0.638
MOD_GSK3_1	352	359	PF00069	0.585
MOD_GSK3_1	378	385	PF00069	0.757
MOD_GSK3_1	404	411	PF00069	0.763
MOD_GSK3_1	43	50	PF00069	0.614
MOD_GSK3_1	446	453	PF00069	0.755
MOD_GSK3_1	454	461	PF00069	0.729
MOD_GSK3_1	463	470	PF00069	0.630
MOD_GSK3_1	472	479	PF00069	0.561
MOD_GSK3_1	52	59	PF00069	0.485
MOD_GSK3_1	520	527	PF00069	0.711
MOD_GSK3_1	552	559	PF00069	0.750
MOD_GSK3_1	650	657	PF00069	0.621
MOD_GSK3_1	67	74	PF00069	0.627
MOD_GSK3_1	672	679	PF00069	0.549
MOD_GSK3_1	681	688	PF00069	0.391
MOD_GSK3_1	730	737	PF00069	0.652
MOD_GSK3_1	88	95	PF00069	0.644
MOD_LATS_1	366	372	PF00433	0.660
MOD_N-GLC_1	105	110	PF02516	0.414
MOD_N-GLC_1	521	526	PF02516	0.639
MOD_NEK2_1	127	132	PF00069	0.463
MOD_NEK2_1	149	154	PF00069	0.359
MOD_NEK2_1	209	214	PF00069	0.463
MOD_NEK2_1	225	230	PF00069	0.305
MOD_NEK2_1	24	29	PF00069	0.695
MOD_NEK2_1	304	309	PF00069	0.597
MOD_NEK2_1	313	318	PF00069	0.556
MOD_NEK2_1	369	374	PF00069	0.594
MOD_NEK2_1	402	407	PF00069	0.717
MOD_NEK2_1	468	473	PF00069	0.704
MOD_NEK2_1	478	483	PF00069	0.594
MOD_NEK2_1	593	598	PF00069	0.498
MOD_NEK2_2	113	118	PF00069	0.565
MOD_PIKK_1	127	133	PF00454	0.463
MOD_PIKK_1	524	530	PF00454	0.544
MOD_PK_1	544	550	PF00069	0.542
MOD_PKA_1	433	439	PF00069	0.582
MOD_PKA_2	304	310	PF00069	0.679
MOD_PKA_2	433	439	PF00069	0.592
MOD_PKA_2	593	599	PF00069	0.505
MOD_PKA_2	88	94	PF00069	0.577
MOD_PKB_1	118	126	PF00069	0.528
MOD_Plk_1	194	200	PF00069	0.457
MOD_Plk_1	314	320	PF00069	0.542
MOD_Plk_1	463	469	PF00069	0.649
MOD_Plk_1	521	527	PF00069	0.638
MOD_Plk_2-3	189	195	PF00069	0.465
MOD_Plk_4	120	126	PF00069	0.516
MOD_Plk_4	137	143	PF00069	0.227
MOD_Plk_4	209	215	PF00069	0.385
MOD_Plk_4	24	30	PF00069	0.658
MOD_Plk_4	598	604	PF00069	0.538
MOD_Plk_4	609	615	PF00069	0.362
MOD_Plk_4	74	80	PF00069	0.622
MOD_ProDKin_1	427	433	PF00069	0.614
MOD_ProDKin_1	501	507	PF00069	0.659
MOD_ProDKin_1	52	58	PF00069	0.649
MOD_ProDKin_1	534	540	PF00069	0.609
MOD_ProDKin_1	624	630	PF00069	0.490
MOD_ProDKin_1	71	77	PF00069	0.454
MOD_SUMO_rev_2	19	27	PF00179	0.662
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.533
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.609
TRG_ENDOCYTIC_2	139	142	PF00928	0.375
TRG_ENDOCYTIC_2	144	147	PF00928	0.350
TRG_ENDOCYTIC_2	173	176	PF00928	0.385
TRG_ENDOCYTIC_2	213	216	PF00928	0.392
TRG_ENDOCYTIC_2	40	43	PF00928	0.595
TRG_ER_diArg_1	201	204	PF00400	0.437
TRG_ER_diArg_1	367	369	PF00400	0.593
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQM3	Leishmania donovani	89%	99%
A4H5M5	Leishmania braziliensis	60%	90%
A4HTW2	Leishmania infantum	88%	99%
E9AMP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%