PlsC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHX5_LEIMA

TriTrypDb:

LmjF.09.0490 , LMJLV39_090010700 , LMJSD75_090010300

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QHX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHX5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.691
CLV_NRD_NRD_1	188	190	PF00675	0.359
CLV_NRD_NRD_1	209	211	PF00675	0.411
CLV_NRD_NRD_1	346	348	PF00675	0.299
CLV_NRD_NRD_1	380	382	PF00675	0.416
CLV_PCSK_KEX2_1	188	190	PF00082	0.351
CLV_PCSK_KEX2_1	346	348	PF00082	0.288
CLV_PCSK_KEX2_1	380	382	PF00082	0.408
CLV_PCSK_SKI1_1	246	250	PF00082	0.327
CLV_PCSK_SKI1_1	38	42	PF00082	0.419
CLV_PCSK_SKI1_1	392	396	PF00082	0.433
CLV_PCSK_SKI1_1	399	403	PF00082	0.438
CLV_PCSK_SKI1_1	69	73	PF00082	0.316
CLV_PCSK_SKI1_1	81	85	PF00082	0.252
DEG_APCC_DBOX_1	37	45	PF00400	0.357
DEG_APCC_DBOX_1	68	76	PF00400	0.326
DEG_APCC_DBOX_1	80	88	PF00400	0.442
DEG_Nend_UBRbox_2	1	3	PF02207	0.574
DEG_ODPH_VHL_1	72	85	PF01847	0.377
DEG_SIAH_1	94	102	PF03145	0.584
DEG_SPOP_SBC_1	371	375	PF00917	0.562
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.597
DOC_MAPK_gen_1	113	122	PF00069	0.526
DOC_MAPK_gen_1	188	195	PF00069	0.552
DOC_MAPK_gen_1	380	388	PF00069	0.566
DOC_MAPK_MEF2A_6	380	388	PF00069	0.566
DOC_PP1_RVXF_1	169	175	PF00149	0.588
DOC_PP1_RVXF_1	79	86	PF00149	0.507
DOC_PP2B_LxvP_1	249	252	PF13499	0.570
DOC_PP2B_LxvP_1	351	354	PF13499	0.525
DOC_PP2B_LxvP_1	71	74	PF13499	0.312
DOC_USP7_MATH_1	108	112	PF00917	0.713
DOC_USP7_MATH_1	16	20	PF00917	0.521
DOC_USP7_MATH_1	198	202	PF00917	0.529
DOC_USP7_MATH_1	259	263	PF00917	0.560
DOC_USP7_MATH_1	332	336	PF00917	0.613
DOC_USP7_MATH_1	337	341	PF00917	0.583
DOC_WW_Pin1_4	276	281	PF00397	0.603
DOC_WW_Pin1_4	311	316	PF00397	0.567
DOC_WW_Pin1_4	330	335	PF00397	0.641
DOC_WW_Pin1_4	405	410	PF00397	0.608
LIG_14-3-3_CanoR_1	210	219	PF00244	0.645
LIG_14-3-3_CanoR_1	346	352	PF00244	0.510
LIG_14-3-3_CanoR_1	38	48	PF00244	0.405
LIG_14-3-3_CanoR_1	381	387	PF00244	0.651
LIG_BRCT_BRCA1_1	191	195	PF00533	0.562
LIG_BRCT_BRCA1_1	313	317	PF00533	0.637
LIG_BRCT_BRCA1_1	41	45	PF00533	0.412
LIG_DLG_GKlike_1	189	196	PF00625	0.553
LIG_FHA_1	188	194	PF00498	0.529
LIG_FHA_1	298	304	PF00498	0.593
LIG_FHA_1	311	317	PF00498	0.620
LIG_FHA_1	50	56	PF00498	0.379
LIG_FHA_2	334	340	PF00498	0.641
LIG_Integrin_isoDGR_2	244	246	PF01839	0.406
LIG_LIR_Apic_2	274	280	PF02991	0.592
LIG_LIR_Gen_1	127	137	PF02991	0.493
LIG_LIR_Gen_1	291	302	PF02991	0.607
LIG_LIR_Gen_1	42	51	PF02991	0.476
LIG_LIR_LC3C_4	119	122	PF02991	0.513
LIG_LIR_Nem_3	127	132	PF02991	0.494
LIG_LIR_Nem_3	2	7	PF02991	0.561
LIG_LIR_Nem_3	291	297	PF02991	0.611
LIG_LIR_Nem_3	42	48	PF02991	0.408
LIG_LIR_Nem_3	54	60	PF02991	0.228
LIG_NRBOX	66	72	PF00104	0.346
LIG_NRBOX	79	85	PF00104	0.451
LIG_Pex14_2	294	298	PF04695	0.552
LIG_SH2_CRK	142	146	PF00017	0.554
LIG_SH2_CRK	277	281	PF00017	0.605
LIG_SH2_NCK_1	277	281	PF00017	0.570
LIG_SH2_STAT3	221	224	PF00017	0.573
LIG_SH2_STAT5	60	63	PF00017	0.323
LIG_SH3_3	169	175	PF00018	0.533
LIG_SH3_3	17	23	PF00018	0.599
LIG_SH3_3	312	318	PF00018	0.537
LIG_SH3_3	89	95	PF00018	0.577
LIG_SH3_4	100	107	PF00018	0.669
LIG_SUMO_SIM_par_1	46	54	PF11976	0.340
LIG_Vh1_VBS_1	40	58	PF01044	0.419
MOD_CK1_1	109	115	PF00069	0.624
MOD_CK1_1	158	164	PF00069	0.677
MOD_CK1_1	262	268	PF00069	0.549
MOD_CK1_1	342	348	PF00069	0.603
MOD_CK1_1	404	410	PF00069	0.493
MOD_CK2_1	157	163	PF00069	0.678
MOD_CMANNOS	181	184	PF00535	0.384
MOD_GlcNHglycan	107	111	PF01048	0.680
MOD_GlcNHglycan	155	160	PF01048	0.627
MOD_GlcNHglycan	202	205	PF01048	0.564
MOD_GlcNHglycan	257	260	PF01048	0.430
MOD_GlcNHglycan	264	267	PF01048	0.512
MOD_GlcNHglycan	341	344	PF01048	0.611
MOD_GlcNHglycan	351	354	PF01048	0.454
MOD_GlcNHglycan	41	44	PF01048	0.375
MOD_GSK3_1	155	162	PF00069	0.553
MOD_GSK3_1	255	262	PF00069	0.495
MOD_GSK3_1	316	323	PF00069	0.455
MOD_GSK3_1	333	340	PF00069	0.550
MOD_GSK3_1	401	408	PF00069	0.527
MOD_N-GLC_1	262	267	PF02516	0.586
MOD_NEK2_1	297	302	PF00069	0.365
MOD_NEK2_1	304	309	PF00069	0.411
MOD_NEK2_1	370	375	PF00069	0.590
MOD_NEK2_1	39	44	PF00069	0.343
MOD_NEK2_1	401	406	PF00069	0.577
MOD_NEK2_1	83	88	PF00069	0.392
MOD_PIKK_1	175	181	PF00454	0.343
MOD_PK_1	28	34	PF00069	0.357
MOD_PKA_1	210	216	PF00069	0.515
MOD_PKA_2	187	193	PF00069	0.484
MOD_PKA_2	324	330	PF00069	0.407
MOD_Plk_1	148	154	PF00069	0.536
MOD_Plk_1	320	326	PF00069	0.503
MOD_Plk_4	124	130	PF00069	0.321
MOD_Plk_4	16	22	PF00069	0.391
MOD_Plk_4	51	57	PF00069	0.373
MOD_ProDKin_1	276	282	PF00069	0.507
MOD_ProDKin_1	311	317	PF00069	0.453
MOD_ProDKin_1	330	336	PF00069	0.572
MOD_ProDKin_1	405	411	PF00069	0.528
MOD_SUMO_rev_2	335	343	PF00179	0.647
MOD_SUMO_rev_2	385	394	PF00179	0.472
TRG_DiLeu_BaEn_2	389	395	PF01217	0.433
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.358
TRG_ENDOCYTIC_2	142	145	PF00928	0.437
TRG_ENDOCYTIC_2	398	401	PF00928	0.545
TRG_ER_diArg_1	379	381	PF00400	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK56	Leptomonas seymouri	63%	100%
A0A0S4IZ96	Bodo saltans	28%	100%
A0A1X0NMQ7	Trypanosomatidae	31%	97%
A0A3Q8IBV5	Leishmania donovani	92%	100%
A0A3S5IRZ0	Trypanosoma rangeli	33%	100%
A4H5M6	Leishmania braziliensis	77%	100%
A4HTW3	Leishmania infantum	92%	100%
D0A9C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AMQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BIH4	Trypanosoma cruzi	31%	100%