Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHX3_LEIMA

TriTrypDb:

LmjF.09.0510 , LMJLV39_090010900 , LMJSD75_090010600

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.670
CLV_NRD_NRD_1	164	166	PF00675	0.579
CLV_NRD_NRD_1	168	170	PF00675	0.573
CLV_NRD_NRD_1	188	190	PF00675	0.672
CLV_NRD_NRD_1	197	199	PF00675	0.677
CLV_NRD_NRD_1	55	57	PF00675	0.448
CLV_NRD_NRD_1	81	83	PF00675	0.516
CLV_PCSK_KEX2_1	108	110	PF00082	0.711
CLV_PCSK_KEX2_1	164	166	PF00082	0.576
CLV_PCSK_KEX2_1	168	170	PF00082	0.576
CLV_PCSK_KEX2_1	188	190	PF00082	0.672
CLV_PCSK_KEX2_1	257	259	PF00082	0.800
CLV_PCSK_KEX2_1	55	57	PF00082	0.448
CLV_PCSK_KEX2_1	81	83	PF00082	0.516
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.756
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.791
CLV_PCSK_PC7_1	104	110	PF00082	0.765
CLV_PCSK_PC7_1	164	170	PF00082	0.599
CLV_PCSK_SKI1_1	136	140	PF00082	0.388
CLV_PCSK_SKI1_1	198	202	PF00082	0.504
CLV_PCSK_SKI1_1	309	313	PF00082	0.709
CLV_PCSK_SKI1_1	412	416	PF00082	0.600
DEG_SCF_FBW7_1	286	293	PF00400	0.769
DEG_SPOP_SBC_1	264	268	PF00917	0.587
DOC_CKS1_1	287	292	PF01111	0.772
DOC_CYCLIN_RxL_1	133	143	PF00134	0.516
DOC_MAPK_gen_1	55	63	PF00069	0.406
DOC_MAPK_gen_1	81	88	PF00069	0.491
DOC_MAPK_MEF2A_6	19	26	PF00069	0.386
DOC_MAPK_MEF2A_6	56	65	PF00069	0.390
DOC_PP1_RVXF_1	134	140	PF00149	0.425
DOC_PP2B_LxvP_1	63	66	PF13499	0.417
DOC_PP4_FxxP_1	32	35	PF00568	0.520
DOC_USP7_MATH_1	15	19	PF00917	0.552
DOC_USP7_MATH_1	206	210	PF00917	0.713
DOC_USP7_MATH_1	260	264	PF00917	0.618
DOC_USP7_MATH_1	265	269	PF00917	0.611
DOC_USP7_MATH_1	290	294	PF00917	0.774
DOC_USP7_MATH_1	341	345	PF00917	0.565
DOC_USP7_MATH_1	45	49	PF00917	0.554
DOC_WW_Pin1_4	146	151	PF00397	0.521
DOC_WW_Pin1_4	266	271	PF00397	0.704
DOC_WW_Pin1_4	286	291	PF00397	0.731
DOC_WW_Pin1_4	300	305	PF00397	0.773
DOC_WW_Pin1_4	34	39	PF00397	0.561
LIG_14-3-3_CanoR_1	198	203	PF00244	0.713
LIG_14-3-3_CanoR_1	205	213	PF00244	0.706
LIG_14-3-3_CanoR_1	44	50	PF00244	0.494
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	175	179	PF00533	0.741
LIG_CtBP_PxDLS_1	237	241	PF00389	0.659
LIG_EH_1	176	180	PF12763	0.691
LIG_FHA_1	115	121	PF00498	0.542
LIG_FHA_1	132	138	PF00498	0.503
LIG_FHA_1	151	157	PF00498	0.266
LIG_FHA_1	222	228	PF00498	0.630
LIG_FHA_1	354	360	PF00498	0.583
LIG_FHA_2	128	134	PF00498	0.626
LIG_FHA_2	296	302	PF00498	0.845
LIG_FHA_2	65	71	PF00498	0.569
LIG_LIR_Apic_2	29	35	PF02991	0.496
LIG_LIR_Gen_1	117	127	PF02991	0.545
LIG_LIR_Gen_1	329	339	PF02991	0.428
LIG_LIR_Nem_3	117	122	PF02991	0.542
LIG_LIR_Nem_3	157	162	PF02991	0.505
LIG_LIR_Nem_3	176	182	PF02991	0.744
LIG_LIR_Nem_3	329	334	PF02991	0.436
LIG_LIR_Nem_3	87	91	PF02991	0.464
LIG_Pex14_2	84	88	PF04695	0.492
LIG_PTB_Apo_2	74	81	PF02174	0.514
LIG_PTB_Phospho_1	74	80	PF10480	0.511
LIG_REV1ctd_RIR_1	412	416	PF16727	0.681
LIG_SH2_CRK	175	179	PF00017	0.664
LIG_SH2_CRK	331	335	PF00017	0.412
LIG_SH2_GRB2like	175	178	PF00017	0.661
LIG_SH2_GRB2like	90	93	PF00017	0.545
LIG_SH2_NCK_1	175	179	PF00017	0.738
LIG_SH2_NCK_1	331	335	PF00017	0.412
LIG_SH2_STAP1	116	120	PF00017	0.531
LIG_SH2_STAP1	223	227	PF00017	0.590
LIG_SH2_STAP1	331	335	PF00017	0.412
LIG_SH2_STAP1	46	50	PF00017	0.431
LIG_SH2_STAT5	116	119	PF00017	0.496
LIG_SH2_STAT5	223	226	PF00017	0.609
LIG_SH2_STAT5	353	356	PF00017	0.447
LIG_SH2_STAT5	373	376	PF00017	0.436
LIG_SH2_STAT5	39	42	PF00017	0.496
LIG_SH2_STAT5	49	52	PF00017	0.326
LIG_SH2_STAT5	90	93	PF00017	0.509
LIG_SH3_3	231	237	PF00018	0.634
LIG_SH3_3	267	273	PF00018	0.722
LIG_SH3_3	280	286	PF00018	0.572
LIG_SH3_3	32	38	PF00018	0.492
LIG_SH3_3	360	366	PF00018	0.563
LIG_SUMO_SIM_anti_2	2	10	PF11976	0.511
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.571
LIG_SUMO_SIM_par_1	152	157	PF11976	0.429
LIG_SUMO_SIM_par_1	2	10	PF11976	0.477
LIG_SUMO_SIM_par_1	332	338	PF11976	0.489
LIG_TRAF2_1	229	232	PF00917	0.666
LIG_TYR_ITSM	115	122	PF00017	0.546
MOD_CK1_1	263	269	PF00069	0.760
MOD_CK1_1	300	306	PF00069	0.694
MOD_CK1_1	346	352	PF00069	0.555
MOD_CK2_1	341	347	PF00069	0.541
MOD_CK2_1	64	70	PF00069	0.555
MOD_GlcNHglycan	101	104	PF01048	0.690
MOD_GlcNHglycan	2	5	PF01048	0.474
MOD_GlcNHglycan	208	211	PF01048	0.707
MOD_GlcNHglycan	262	265	PF01048	0.694
MOD_GlcNHglycan	283	286	PF01048	0.763
MOD_GlcNHglycan	342	346	PF01048	0.574
MOD_GSK3_1	127	134	PF00069	0.564
MOD_GSK3_1	146	153	PF00069	0.310
MOD_GSK3_1	260	267	PF00069	0.664
MOD_GSK3_1	281	288	PF00069	0.797
MOD_GSK3_1	291	298	PF00069	0.696
MOD_GSK3_1	341	348	PF00069	0.589
MOD_GSK3_1	45	52	PF00069	0.546
MOD_N-GLC_1	114	119	PF02516	0.569
MOD_N-GLC_1	127	132	PF02516	0.573
MOD_NEK2_1	26	31	PF00069	0.387
MOD_NEK2_1	318	323	PF00069	0.629
MOD_NEK2_1	50	55	PF00069	0.390
MOD_NEK2_1	7	12	PF00069	0.470
MOD_PKA_1	198	204	PF00069	0.662
MOD_PKA_2	281	287	PF00069	0.790
MOD_PKB_1	196	204	PF00069	0.661
MOD_Plk_1	132	138	PF00069	0.571
MOD_Plk_1	329	335	PF00069	0.432
MOD_Plk_1	346	352	PF00069	0.474
MOD_Plk_4	150	156	PF00069	0.440
MOD_Plk_4	329	335	PF00069	0.432
MOD_Plk_4	45	51	PF00069	0.480
MOD_ProDKin_1	146	152	PF00069	0.516
MOD_ProDKin_1	266	272	PF00069	0.706
MOD_ProDKin_1	286	292	PF00069	0.729
MOD_ProDKin_1	300	306	PF00069	0.772
MOD_ProDKin_1	34	40	PF00069	0.559
MOD_SUMO_for_1	311	314	PF00179	0.763
MOD_SUMO_for_1	354	357	PF00179	0.554
MOD_SUMO_rev_2	406	414	PF00179	0.659
TRG_DiLeu_BaEn_1	329	334	PF01217	0.436
TRG_DiLeu_BaEn_4	313	319	PF01217	0.524
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.401
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.559
TRG_ENDOCYTIC_2	119	122	PF00928	0.541
TRG_ENDOCYTIC_2	159	162	PF00928	0.524
TRG_ENDOCYTIC_2	223	226	PF00928	0.609
TRG_ENDOCYTIC_2	331	334	PF00928	0.413
TRG_ER_diArg_1	168	170	PF00400	0.618
TRG_ER_diArg_1	188	190	PF00400	0.661
TRG_ER_diArg_1	202	205	PF00400	0.721
TRG_ER_diArg_1	280	283	PF00400	0.793
TRG_ER_diArg_1	54	56	PF00400	0.447
TRG_ER_diArg_1	80	82	PF00400	0.525
TRG_NLS_MonoExtN_4	104	111	PF00514	0.727
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB46	Leptomonas seymouri	61%	100%
A0A1X0NNC7	Trypanosomatidae	30%	100%
A0A3Q8IAS3	Leishmania donovani	93%	100%
A4H5M8	Leishmania braziliensis	78%	100%
A4HTW5	Leishmania infantum	91%	100%
E9AMQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5DJG9	Trypanosoma cruzi	34%	100%