Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 3

Species:

Leishmania major

UniProt:

Q4QHX2_LEIMA

TriTrypDb:

LmjF.09.0520 , LMJLV39_090011000 , LMJSD75_090010700

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHX2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0071889	14-3-3 protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.732
CLV_NRD_NRD_1	265	267	PF00675	0.538
CLV_NRD_NRD_1	410	412	PF00675	0.502
CLV_NRD_NRD_1	463	465	PF00675	0.588
CLV_NRD_NRD_1	565	567	PF00675	0.525
CLV_NRD_NRD_1	697	699	PF00675	0.553
CLV_NRD_NRD_1	716	718	PF00675	0.484
CLV_NRD_NRD_1	755	757	PF00675	0.753
CLV_PCSK_KEX2_1	214	216	PF00082	0.500
CLV_PCSK_KEX2_1	239	241	PF00082	0.537
CLV_PCSK_KEX2_1	410	412	PF00082	0.502
CLV_PCSK_KEX2_1	463	465	PF00082	0.588
CLV_PCSK_KEX2_1	565	567	PF00082	0.525
CLV_PCSK_KEX2_1	617	619	PF00082	0.616
CLV_PCSK_KEX2_1	697	699	PF00082	0.536
CLV_PCSK_KEX2_1	716	718	PF00082	0.717
CLV_PCSK_KEX2_1	755	757	PF00082	0.753
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.500
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.537
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.616
CLV_PCSK_SKI1_1	112	116	PF00082	0.576
CLV_PCSK_SKI1_1	229	233	PF00082	0.477
CLV_PCSK_SKI1_1	342	346	PF00082	0.508
CLV_PCSK_SKI1_1	400	404	PF00082	0.601
CLV_PCSK_SKI1_1	451	455	PF00082	0.446
CLV_PCSK_SKI1_1	466	470	PF00082	0.498
CLV_PCSK_SKI1_1	542	546	PF00082	0.503
CLV_PCSK_SKI1_1	58	62	PF00082	0.449
CLV_PCSK_SKI1_1	632	636	PF00082	0.714
CLV_PCSK_SKI1_1	71	75	PF00082	0.445
CLV_Separin_Metazoa	684	688	PF03568	0.504
DOC_CKS1_1	726	731	PF01111	0.532
DOC_CYCLIN_yCln2_LP_2	726	732	PF00134	0.549
DOC_MAPK_gen_1	239	247	PF00069	0.502
DOC_MAPK_HePTP_8	526	538	PF00069	0.496
DOC_MAPK_MEF2A_6	436	444	PF00069	0.509
DOC_MAPK_MEF2A_6	529	538	PF00069	0.488
DOC_PP4_FxxP_1	384	387	PF00568	0.630
DOC_USP7_MATH_1	30	34	PF00917	0.472
DOC_USP7_MATH_1	387	391	PF00917	0.637
DOC_USP7_MATH_1	543	547	PF00917	0.557
DOC_USP7_MATH_1	645	649	PF00917	0.770
DOC_USP7_MATH_1	710	714	PF00917	0.654
DOC_USP7_MATH_1	754	758	PF00917	0.794
DOC_USP7_UBL2_3	183	187	PF12436	0.691
DOC_USP7_UBL2_3	529	533	PF12436	0.570
DOC_WW_Pin1_4	417	422	PF00397	0.419
DOC_WW_Pin1_4	627	632	PF00397	0.722
DOC_WW_Pin1_4	641	646	PF00397	0.703
DOC_WW_Pin1_4	650	655	PF00397	0.741
DOC_WW_Pin1_4	675	680	PF00397	0.726
DOC_WW_Pin1_4	699	704	PF00397	0.603
DOC_WW_Pin1_4	725	730	PF00397	0.533
LIG_14-3-3_CanoR_1	158	164	PF00244	0.607
LIG_14-3-3_CanoR_1	259	264	PF00244	0.510
LIG_14-3-3_CanoR_1	484	490	PF00244	0.588
LIG_14-3-3_CanoR_1	542	548	PF00244	0.520
LIG_14-3-3_CanoR_1	626	631	PF00244	0.659
LIG_14-3-3_CanoR_1	646	651	PF00244	0.729
LIG_14-3-3_CanoR_1	697	701	PF00244	0.701
LIG_14-3-3_CanoR_1	764	769	PF00244	0.786
LIG_14-3-3_CanoR_1	92	101	PF00244	0.586
LIG_Actin_WH2_2	44	60	PF00022	0.482
LIG_APCC_ABBA_1	730	735	PF00400	0.500
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BIR_III_2	744	748	PF00653	0.794
LIG_EVH1_2	548	552	PF00568	0.493
LIG_FHA_1	151	157	PF00498	0.516
LIG_FHA_1	357	363	PF00498	0.539
LIG_FHA_1	437	443	PF00498	0.588
LIG_FHA_1	46	52	PF00498	0.554
LIG_FHA_1	763	769	PF00498	0.765
LIG_FHA_2	160	166	PF00498	0.657
LIG_FHA_2	189	195	PF00498	0.657
LIG_FHA_2	374	380	PF00498	0.541
LIG_FHA_2	499	505	PF00498	0.472
LIG_IBAR_NPY_1	567	569	PF08397	0.598
LIG_LIR_Apic_2	699	703	PF02991	0.694
LIG_LIR_Gen_1	217	226	PF02991	0.584
LIG_LIR_Gen_1	242	252	PF02991	0.494
LIG_LIR_Gen_1	321	327	PF02991	0.581
LIG_LIR_Gen_1	515	526	PF02991	0.538
LIG_LIR_Gen_1	572	578	PF02991	0.694
LIG_LIR_Gen_1	702	710	PF02991	0.615
LIG_LIR_Nem_3	242	247	PF02991	0.462
LIG_LIR_Nem_3	250	255	PF02991	0.434
LIG_LIR_Nem_3	308	314	PF02991	0.508
LIG_LIR_Nem_3	349	355	PF02991	0.464
LIG_LIR_Nem_3	379	384	PF02991	0.532
LIG_LIR_Nem_3	490	496	PF02991	0.613
LIG_LIR_Nem_3	514	520	PF02991	0.533
LIG_LIR_Nem_3	572	576	PF02991	0.697
LIG_LIR_Nem_3	59	64	PF02991	0.577
LIG_LIR_Nem_3	702	708	PF02991	0.615
LIG_Pex14_2	350	354	PF04695	0.437
LIG_PTB_Apo_2	246	253	PF02174	0.536
LIG_REV1ctd_RIR_1	91	101	PF16727	0.442
LIG_SH2_CRK	301	305	PF00017	0.524
LIG_SH2_GRB2like	314	317	PF00017	0.549
LIG_SH2_GRB2like	489	492	PF00017	0.635
LIG_SH2_NCK_1	573	577	PF00017	0.733
LIG_SH2_SRC	314	317	PF00017	0.550
LIG_SH2_SRC	392	395	PF00017	0.592
LIG_SH2_SRC	573	576	PF00017	0.673
LIG_SH2_STAP1	489	493	PF00017	0.628
LIG_SH2_STAT3	189	192	PF00017	0.714
LIG_SH2_STAT3	489	492	PF00017	0.605
LIG_SH2_STAT3	527	530	PF00017	0.700
LIG_SH2_STAT5	168	171	PF00017	0.669
LIG_SH2_STAT5	189	192	PF00017	0.714
LIG_SH2_STAT5	292	295	PF00017	0.640
LIG_SH2_STAT5	314	317	PF00017	0.437
LIG_SH2_STAT5	392	395	PF00017	0.592
LIG_SH2_STAT5	505	508	PF00017	0.504
LIG_SH2_STAT5	518	521	PF00017	0.536
LIG_SH2_STAT5	551	554	PF00017	0.473
LIG_SH2_STAT5	705	708	PF00017	0.641
LIG_SH2_STAT5	83	86	PF00017	0.503
LIG_SH3_3	531	537	PF00018	0.604
LIG_SH3_3	648	654	PF00018	0.794
LIG_SH3_3	673	679	PF00018	0.635
LIG_SH3_3	682	688	PF00018	0.588
LIG_Sin3_3	479	486	PF02671	0.454
LIG_SUMO_SIM_anti_2	450	457	PF11976	0.469
LIG_SUMO_SIM_par_1	452	457	PF11976	0.517
LIG_TRAF2_1	162	165	PF00917	0.630
LIG_TRAF2_1	231	234	PF00917	0.504
LIG_TRAF2_1	472	475	PF00917	0.538
LIG_TRAF2_1	670	673	PF00917	0.672
LIG_UBA3_1	180	187	PF00899	0.732
LIG_WRPW_2	70	73	PF00400	0.346
LIG_WW_1	548	551	PF00397	0.490
LIG_WW_3	547	551	PF00397	0.503
MOD_CDK_SPK_2	627	632	PF00069	0.752
MOD_CDK_SPK_2	641	646	PF00069	0.703
MOD_CK1_1	150	156	PF00069	0.496
MOD_CK1_1	170	176	PF00069	0.430
MOD_CK1_1	262	268	PF00069	0.635
MOD_CK1_1	356	362	PF00069	0.536
MOD_CK1_1	395	401	PF00069	0.550
MOD_CK1_1	41	47	PF00069	0.647
MOD_CK1_1	420	426	PF00069	0.438
MOD_CK1_1	485	491	PF00069	0.567
MOD_CK1_1	561	567	PF00069	0.708
MOD_CK1_1	699	705	PF00069	0.603
MOD_CK1_1	749	755	PF00069	0.725
MOD_CK1_1	762	768	PF00069	0.693
MOD_CK2_1	159	165	PF00069	0.585
MOD_CK2_1	170	176	PF00069	0.600
MOD_CK2_1	188	194	PF00069	0.604
MOD_CK2_1	30	36	PF00069	0.625
MOD_CK2_1	373	379	PF00069	0.568
MOD_CK2_1	456	462	PF00069	0.559
MOD_CK2_1	498	504	PF00069	0.455
MOD_CK2_1	601	607	PF00069	0.560
MOD_CK2_1	72	78	PF00069	0.452
MOD_GlcNHglycan	1	4	PF01048	0.669
MOD_GlcNHglycan	149	152	PF01048	0.483
MOD_GlcNHglycan	484	487	PF01048	0.542
MOD_GlcNHglycan	560	563	PF01048	0.597
MOD_GlcNHglycan	748	751	PF01048	0.703
MOD_GlcNHglycan	752	755	PF01048	0.667
MOD_GSK3_1	136	143	PF00069	0.604
MOD_GSK3_1	166	173	PF00069	0.610
MOD_GSK3_1	394	401	PF00069	0.649
MOD_GSK3_1	41	48	PF00069	0.615
MOD_GSK3_1	641	648	PF00069	0.723
MOD_GSK3_1	7	14	PF00069	0.516
MOD_GSK3_1	746	753	PF00069	0.677
MOD_GSK3_1	760	767	PF00069	0.641
MOD_LATS_1	202	208	PF00433	0.546
MOD_N-GLC_1	398	403	PF02516	0.583
MOD_N-GLC_1	457	462	PF02516	0.669
MOD_NEK2_1	136	141	PF00069	0.570
MOD_NEK2_1	147	152	PF00069	0.475
MOD_NEK2_1	327	332	PF00069	0.529
MOD_NEK2_1	39	44	PF00069	0.721
MOD_NEK2_1	454	459	PF00069	0.630
MOD_NEK2_1	593	598	PF00069	0.678
MOD_PIKK_1	140	146	PF00454	0.652
MOD_PIKK_1	188	194	PF00454	0.642
MOD_PIKK_1	204	210	PF00454	0.533
MOD_PIKK_1	92	98	PF00454	0.554
MOD_PK_1	764	770	PF00069	0.778
MOD_PKA_2	635	641	PF00069	0.683
MOD_PKA_2	645	651	PF00069	0.680
MOD_PKA_2	696	702	PF00069	0.687
MOD_PKA_2	710	716	PF00069	0.582
MOD_PKA_2	754	760	PF00069	0.756
MOD_PKB_1	90	98	PF00069	0.578
MOD_Plk_1	279	285	PF00069	0.601
MOD_Plk_1	398	404	PF00069	0.577
MOD_Plk_4	136	142	PF00069	0.600
MOD_Plk_4	185	191	PF00069	0.687
MOD_Plk_4	21	27	PF00069	0.485
MOD_Plk_4	7	13	PF00069	0.542
MOD_ProDKin_1	417	423	PF00069	0.419
MOD_ProDKin_1	627	633	PF00069	0.723
MOD_ProDKin_1	641	647	PF00069	0.700
MOD_ProDKin_1	650	656	PF00069	0.738
MOD_ProDKin_1	675	681	PF00069	0.724
MOD_ProDKin_1	699	705	PF00069	0.603
MOD_ProDKin_1	725	731	PF00069	0.536
MOD_SUMO_rev_2	379	384	PF00179	0.538
TRG_DiLeu_BaEn_1	127	132	PF01217	0.505
TRG_DiLeu_BaEn_1	450	455	PF01217	0.458
TRG_DiLeu_BaEn_4	109	115	PF01217	0.587
TRG_DiLeu_BaEn_4	672	678	PF01217	0.659
TRG_ENDOCYTIC_2	160	163	PF00928	0.571
TRG_ENDOCYTIC_2	218	221	PF00928	0.582
TRG_ENDOCYTIC_2	314	317	PF00928	0.439
TRG_ENDOCYTIC_2	352	355	PF00928	0.422
TRG_ENDOCYTIC_2	381	384	PF00928	0.536
TRG_ENDOCYTIC_2	493	496	PF00928	0.588
TRG_ENDOCYTIC_2	517	520	PF00928	0.537
TRG_ENDOCYTIC_2	551	554	PF00928	0.489
TRG_ENDOCYTIC_2	573	576	PF00928	0.731
TRG_ENDOCYTIC_2	705	708	PF00928	0.730
TRG_ER_diArg_1	463	466	PF00400	0.594
TRG_ER_diArg_1	708	711	PF00400	0.678
TRG_ER_diArg_1	715	717	PF00400	0.720
TRG_ER_diArg_1	90	93	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D7	Leptomonas seymouri	79%	100%
A0A1X0NMP1	Trypanosomatidae	56%	96%
A0A3R7MX09	Trypanosoma rangeli	56%	97%
A0A3S5H6D5	Leishmania donovani	97%	100%
A4H5M9	Leishmania braziliensis	89%	100%
A4HTW6	Leishmania infantum	97%	100%
D0A9D0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	96%
E9AMQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BSM8	Trypanosoma cruzi	54%	97%