Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania major

UniProt:

Q4QHX1_LEIMA

TriTrypDb:

LmjF.09.0530 , LMJLV39_090011100 , LMJSD75_090010800

Length:

997

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0005930	axoneme	2	2
GO:0019005	SCF ubiquitin ligase complex	5	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	8
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4QHX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHX1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	722	726	PF00656	0.626
CLV_C14_Caspase3-7	781	785	PF00656	0.656
CLV_NRD_NRD_1	131	133	PF00675	0.609
CLV_NRD_NRD_1	523	525	PF00675	0.570
CLV_NRD_NRD_1	875	877	PF00675	0.686
CLV_PCSK_KEX2_1	131	133	PF00082	0.686
CLV_PCSK_KEX2_1	523	525	PF00082	0.570
CLV_PCSK_KEX2_1	586	588	PF00082	0.533
CLV_PCSK_KEX2_1	875	877	PF00082	0.686
CLV_PCSK_KEX2_1	934	936	PF00082	0.746
CLV_PCSK_PC1ET2_1	586	588	PF00082	0.533
CLV_PCSK_PC1ET2_1	934	936	PF00082	0.746
CLV_PCSK_SKI1_1	147	151	PF00082	0.675
CLV_PCSK_SKI1_1	234	238	PF00082	0.480
CLV_PCSK_SKI1_1	496	500	PF00082	0.553
CLV_PCSK_SKI1_1	604	608	PF00082	0.553
CLV_PCSK_SKI1_1	612	616	PF00082	0.428
CLV_PCSK_SKI1_1	699	703	PF00082	0.677
CLV_PCSK_SKI1_1	731	735	PF00082	0.581
CLV_Separin_Metazoa	520	524	PF03568	0.502
DEG_APCC_DBOX_1	461	469	PF00400	0.524
DEG_APCC_DBOX_1	495	503	PF00400	0.592
DEG_APCC_DBOX_1	698	706	PF00400	0.577
DOC_CDC14_PxL_1	289	297	PF14671	0.507
DOC_CKS1_1	35	40	PF01111	0.560
DOC_CYCLIN_RxL_1	320	329	PF00134	0.517
DOC_CYCLIN_RxL_1	447	455	PF00134	0.415
DOC_CYCLIN_RxL_1	735	748	PF00134	0.655
DOC_CYCLIN_yCln2_LP_2	401	404	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	831	837	PF00134	0.698
DOC_CYCLIN_yCln2_LP_2	870	873	PF00134	0.699
DOC_MAPK_DCC_7	323	332	PF00069	0.516
DOC_MAPK_DCC_7	484	493	PF00069	0.544
DOC_MAPK_gen_1	419	428	PF00069	0.508
DOC_MAPK_gen_1	484	493	PF00069	0.500
DOC_MAPK_HePTP_8	481	493	PF00069	0.538
DOC_MAPK_MEF2A_6	323	332	PF00069	0.516
DOC_MAPK_MEF2A_6	484	493	PF00069	0.544
DOC_PP2B_LxvP_1	325	328	PF13499	0.402
DOC_PP2B_LxvP_1	400	403	PF13499	0.443
DOC_PP2B_LxvP_1	489	492	PF13499	0.466
DOC_PP2B_LxvP_1	502	505	PF13499	0.487
DOC_PP2B_LxvP_1	826	829	PF13499	0.686
DOC_PP2B_LxvP_1	831	834	PF13499	0.658
DOC_PP2B_LxvP_1	870	873	PF13499	0.699
DOC_USP7_MATH_1	142	146	PF00917	0.522
DOC_USP7_MATH_1	156	160	PF00917	0.507
DOC_USP7_MATH_1	2	6	PF00917	0.532
DOC_USP7_MATH_1	210	214	PF00917	0.617
DOC_USP7_MATH_1	227	231	PF00917	0.298
DOC_USP7_MATH_1	279	283	PF00917	0.418
DOC_USP7_MATH_1	360	364	PF00917	0.678
DOC_USP7_MATH_1	365	369	PF00917	0.667
DOC_USP7_MATH_1	480	484	PF00917	0.471
DOC_USP7_MATH_1	688	692	PF00917	0.759
DOC_USP7_MATH_1	713	717	PF00917	0.602
DOC_USP7_MATH_1	762	766	PF00917	0.824
DOC_USP7_MATH_1	854	858	PF00917	0.688
DOC_USP7_MATH_1	929	933	PF00917	0.771
DOC_USP7_MATH_1	943	947	PF00917	0.603
DOC_USP7_MATH_1	975	979	PF00917	0.579
DOC_USP7_MATH_1	988	992	PF00917	0.631
DOC_WW_Pin1_4	236	241	PF00397	0.514
DOC_WW_Pin1_4	34	39	PF00397	0.793
DOC_WW_Pin1_4	860	865	PF00397	0.766
DOC_WW_Pin1_4	875	880	PF00397	0.597
DOC_WW_Pin1_4	891	896	PF00397	0.768
DOC_WW_Pin1_4	901	906	PF00397	0.717
LIG_14-3-3_CanoR_1	107	111	PF00244	0.476
LIG_14-3-3_CanoR_1	12	22	PF00244	0.638
LIG_14-3-3_CanoR_1	191	199	PF00244	0.563
LIG_14-3-3_CanoR_1	234	243	PF00244	0.578
LIG_14-3-3_CanoR_1	268	273	PF00244	0.470
LIG_14-3-3_CanoR_1	407	413	PF00244	0.551
LIG_14-3-3_CanoR_1	422	427	PF00244	0.345
LIG_14-3-3_CanoR_1	433	441	PF00244	0.388
LIG_14-3-3_CanoR_1	496	505	PF00244	0.530
LIG_14-3-3_CanoR_1	506	512	PF00244	0.444
LIG_14-3-3_CanoR_1	540	545	PF00244	0.520
LIG_14-3-3_CanoR_1	604	611	PF00244	0.544
LIG_14-3-3_CanoR_1	875	879	PF00244	0.679
LIG_14-3-3_CanoR_1	95	104	PF00244	0.628
LIG_14-3-3_CanoR_1	958	966	PF00244	0.749
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BIR_III_4	849	853	PF00653	0.667
LIG_BRCT_BRCA1_1	270	274	PF00533	0.481
LIG_BRCT_BRCA1_1	542	546	PF00533	0.450
LIG_BRCT_BRCA1_1	802	806	PF00533	0.726
LIG_BRCT_BRCA1_1	945	949	PF00533	0.677
LIG_FAT_LD_1	468	476	PF03623	0.458
LIG_FHA_1	267	273	PF00498	0.493
LIG_FHA_1	353	359	PF00498	0.633
LIG_FHA_1	373	379	PF00498	0.476
LIG_FHA_1	403	409	PF00498	0.457
LIG_FHA_1	423	429	PF00498	0.294
LIG_FHA_1	498	504	PF00498	0.372
LIG_FHA_1	595	601	PF00498	0.502
LIG_FHA_1	660	666	PF00498	0.533
LIG_FHA_1	823	829	PF00498	0.678
LIG_FHA_1	967	973	PF00498	0.571
LIG_FHA_2	543	549	PF00498	0.562
LIG_FHA_2	603	609	PF00498	0.549
LIG_FHA_2	779	785	PF00498	0.714
LIG_FHA_2	876	882	PF00498	0.689
LIG_GBD_Chelix_1	665	673	PF00786	0.464
LIG_Integrin_isoDGR_2	526	528	PF01839	0.619
LIG_LIR_LC3C_4	329	332	PF02991	0.456
LIG_LIR_Nem_3	275	281	PF02991	0.579
LIG_LIR_Nem_3	554	560	PF02991	0.518
LIG_LIR_Nem_3	946	952	PF02991	0.678
LIG_MAD2	450	458	PF02301	0.408
LIG_NRBOX	231	237	PF00104	0.522
LIG_NRBOX	339	345	PF00104	0.501
LIG_PCNA_yPIPBox_3	183	191	PF02747	0.500
LIG_Pex14_2	270	274	PF04695	0.481
LIG_SH2_CRK	278	282	PF00017	0.442
LIG_SH2_STAT3	130	133	PF00017	0.522
LIG_SH2_STAT3	916	919	PF00017	0.686
LIG_SH2_STAT5	189	192	PF00017	0.432
LIG_SH2_STAT5	195	198	PF00017	0.485
LIG_SH2_STAT5	916	919	PF00017	0.718
LIG_SH3_1	876	882	PF00018	0.706
LIG_SH3_3	193	199	PF00018	0.582
LIG_SH3_3	32	38	PF00018	0.761
LIG_SH3_3	58	64	PF00018	0.593
LIG_SH3_3	658	664	PF00018	0.559
LIG_SH3_3	831	837	PF00018	0.697
LIG_SH3_3	858	864	PF00018	0.660
LIG_SH3_3	876	882	PF00018	0.549
LIG_SUMO_SIM_anti_2	122	129	PF11976	0.648
LIG_SUMO_SIM_anti_2	396	401	PF11976	0.394
LIG_SUMO_SIM_anti_2	466	474	PF11976	0.520
LIG_SUMO_SIM_anti_2	597	602	PF11976	0.506
LIG_SUMO_SIM_par_1	122	129	PF11976	0.630
LIG_SUMO_SIM_par_1	374	379	PF11976	0.508
LIG_SUMO_SIM_par_1	424	429	PF11976	0.385
LIG_SUMO_SIM_par_1	450	455	PF11976	0.520
LIG_SUMO_SIM_par_1	824	830	PF11976	0.681
LIG_TRAF2_1	920	923	PF00917	0.780
LIG_TRAF2_1	994	997	PF00917	0.777
LIG_WRC_WIRS_1	205	210	PF05994	0.416
LIG_WRC_WIRS_1	267	272	PF05994	0.441
MOD_CK1_1	11	17	PF00069	0.661
MOD_CK1_1	282	288	PF00069	0.420
MOD_CK1_1	291	297	PF00069	0.432
MOD_CK1_1	508	514	PF00069	0.558
MOD_CK1_1	547	553	PF00069	0.516
MOD_CK1_1	632	638	PF00069	0.538
MOD_CK1_1	693	699	PF00069	0.596
MOD_CK1_1	714	720	PF00069	0.643
MOD_CK1_1	776	782	PF00069	0.691
MOD_CK1_1	821	827	PF00069	0.737
MOD_CK1_1	904	910	PF00069	0.717
MOD_CK1_1	911	917	PF00069	0.660
MOD_CK1_1	960	966	PF00069	0.797
MOD_CK2_1	14	20	PF00069	0.563
MOD_CK2_1	209	215	PF00069	0.667
MOD_CK2_1	323	329	PF00069	0.419
MOD_CK2_1	542	548	PF00069	0.567
MOD_CK2_1	721	727	PF00069	0.558
MOD_GlcNHglycan	212	215	PF01048	0.663
MOD_GlcNHglycan	255	259	PF01048	0.551
MOD_GlcNHglycan	377	381	PF01048	0.513
MOD_GlcNHglycan	4	7	PF01048	0.534
MOD_GlcNHglycan	427	431	PF01048	0.452
MOD_GlcNHglycan	443	446	PF01048	0.453
MOD_GlcNHglycan	528	531	PF01048	0.665
MOD_GlcNHglycan	695	698	PF01048	0.801
MOD_GlcNHglycan	711	714	PF01048	0.551
MOD_GlcNHglycan	747	750	PF01048	0.653
MOD_GlcNHglycan	788	792	PF01048	0.746
MOD_GlcNHglycan	820	823	PF01048	0.696
MOD_GlcNHglycan	856	859	PF01048	0.639
MOD_GlcNHglycan	945	948	PF01048	0.762
MOD_GlcNHglycan	977	980	PF01048	0.588
MOD_GSK3_1	254	261	PF00069	0.495
MOD_GSK3_1	372	379	PF00069	0.483
MOD_GSK3_1	4	11	PF00069	0.643
MOD_GSK3_1	402	409	PF00069	0.532
MOD_GSK3_1	422	429	PF00069	0.274
MOD_GSK3_1	540	547	PF00069	0.517
MOD_GSK3_1	709	716	PF00069	0.707
MOD_GSK3_1	818	825	PF00069	0.623
MOD_GSK3_1	903	910	PF00069	0.733
MOD_GSK3_1	914	921	PF00069	0.660
MOD_GSK3_1	929	936	PF00069	0.569
MOD_GSK3_1	957	964	PF00069	0.812
MOD_GSK3_1	966	973	PF00069	0.594
MOD_LATS_1	266	272	PF00433	0.499
MOD_LATS_1	574	580	PF00433	0.532
MOD_N-GLC_2	580	582	PF02516	0.366
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	106	111	PF00069	0.563
MOD_NEK2_1	204	209	PF00069	0.426
MOD_NEK2_1	288	293	PF00069	0.447
MOD_NEK2_1	376	381	PF00069	0.406
MOD_NEK2_1	426	431	PF00069	0.359
MOD_NEK2_1	441	446	PF00069	0.510
MOD_NEK2_1	471	476	PF00069	0.410
MOD_NEK2_1	560	565	PF00069	0.458
MOD_NEK2_1	778	783	PF00069	0.811
MOD_NEK2_1	8	13	PF00069	0.645
MOD_NEK2_1	874	879	PF00069	0.617
MOD_NEK2_1	933	938	PF00069	0.806
MOD_NEK2_2	142	147	PF00069	0.496
MOD_NEK2_2	929	934	PF00069	0.726
MOD_PIKK_1	234	240	PF00454	0.571
MOD_PIKK_1	317	323	PF00454	0.520
MOD_PIKK_1	505	511	PF00454	0.541
MOD_PIKK_1	560	566	PF00454	0.567
MOD_PIKK_1	612	618	PF00454	0.470
MOD_PIKK_1	918	924	PF00454	0.706
MOD_PK_1	268	274	PF00069	0.494
MOD_PK_1	540	546	PF00069	0.517
MOD_PKA_2	106	112	PF00069	0.522
MOD_PKA_2	11	17	PF00069	0.675
MOD_PKA_2	190	196	PF00069	0.556
MOD_PKA_2	346	352	PF00069	0.524
MOD_PKA_2	406	412	PF00069	0.550
MOD_PKA_2	432	438	PF00069	0.536
MOD_PKA_2	505	511	PF00069	0.560
MOD_PKA_2	539	545	PF00069	0.458
MOD_PKA_2	762	768	PF00069	0.738
MOD_PKA_2	874	880	PF00069	0.680
MOD_PKA_2	957	963	PF00069	0.730
MOD_Plk_1	254	260	PF00069	0.480
MOD_Plk_1	323	329	PF00069	0.503
MOD_Plk_1	547	553	PF00069	0.416
MOD_Plk_1	635	641	PF00069	0.523
MOD_Plk_1	988	994	PF00069	0.639
MOD_Plk_4	204	210	PF00069	0.440
MOD_Plk_4	227	233	PF00069	0.526
MOD_Plk_4	279	285	PF00069	0.368
MOD_Plk_4	4	10	PF00069	0.618
MOD_Plk_4	408	414	PF00069	0.529
MOD_Plk_4	498	504	PF00069	0.563
MOD_Plk_4	547	553	PF00069	0.470
MOD_Plk_4	568	574	PF00069	0.544
MOD_Plk_4	715	721	PF00069	0.562
MOD_Plk_4	773	779	PF00069	0.692
MOD_ProDKin_1	236	242	PF00069	0.524
MOD_ProDKin_1	34	40	PF00069	0.791
MOD_ProDKin_1	860	866	PF00069	0.766
MOD_ProDKin_1	875	881	PF00069	0.598
MOD_ProDKin_1	891	897	PF00069	0.765
MOD_ProDKin_1	901	907	PF00069	0.716
MOD_SUMO_for_1	70	73	PF00179	0.545
TRG_DiLeu_BaEn_1	122	127	PF01217	0.643
TRG_DiLeu_BaEn_4	122	128	PF01217	0.648
TRG_DiLeu_BaEn_4	73	79	PF01217	0.479
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.520
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.427
TRG_ENDOCYTIC_2	278	281	PF00928	0.566
TRG_ER_diArg_1	130	132	PF00400	0.612
TRG_ER_diArg_1	344	347	PF00400	0.398
TRG_ER_diArg_1	522	524	PF00400	0.563
TRG_ER_diArg_1	874	876	PF00400	0.693
TRG_ER_diArg_1	9	12	PF00400	0.529
TRG_NES_CRM1_1	647	659	PF08389	0.524
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	450	455	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	740	745	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	935	939	PF00026	0.737

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQP1	Leishmania donovani	92%	100%
A0A422NV64	Trypanosoma rangeli	28%	92%
A4H5N0	Leishmania braziliensis	70%	100%
A4HTW7	Leishmania infantum	92%	100%
D0A9D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	95%
E9AMQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%