Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHX0_LEIMA

TriTrypDb:

LmjF.09.0540 , LMJLV39_090011200 , LMJSD75_090010900

Length:

1111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1045	1049	PF00656	0.655
CLV_C14_Caspase3-7	204	208	PF00656	0.656
CLV_C14_Caspase3-7	210	214	PF00656	0.669
CLV_C14_Caspase3-7	373	377	PF00656	0.634
CLV_C14_Caspase3-7	55	59	PF00656	0.738
CLV_C14_Caspase3-7	599	603	PF00656	0.704
CLV_NRD_NRD_1	113	115	PF00675	0.837
CLV_NRD_NRD_1	15	17	PF00675	0.860
CLV_NRD_NRD_1	287	289	PF00675	0.636
CLV_NRD_NRD_1	31	33	PF00675	0.557
CLV_NRD_NRD_1	333	335	PF00675	0.798
CLV_NRD_NRD_1	402	404	PF00675	0.793
CLV_NRD_NRD_1	479	481	PF00675	0.647
CLV_NRD_NRD_1	524	526	PF00675	0.832
CLV_NRD_NRD_1	634	636	PF00675	0.698
CLV_NRD_NRD_1	649	651	PF00675	0.706
CLV_NRD_NRD_1	668	670	PF00675	0.548
CLV_NRD_NRD_1	708	710	PF00675	0.616
CLV_NRD_NRD_1	821	823	PF00675	0.695
CLV_NRD_NRD_1	929	931	PF00675	0.731
CLV_NRD_NRD_1	971	973	PF00675	0.750
CLV_PCSK_FUR_1	969	973	PF00082	0.694
CLV_PCSK_KEX2_1	113	115	PF00082	0.837
CLV_PCSK_KEX2_1	15	17	PF00082	0.860
CLV_PCSK_KEX2_1	257	259	PF00082	0.853
CLV_PCSK_KEX2_1	287	289	PF00082	0.636
CLV_PCSK_KEX2_1	31	33	PF00082	0.557
CLV_PCSK_KEX2_1	333	335	PF00082	0.798
CLV_PCSK_KEX2_1	402	404	PF00082	0.791
CLV_PCSK_KEX2_1	479	481	PF00082	0.647
CLV_PCSK_KEX2_1	524	526	PF00082	0.793
CLV_PCSK_KEX2_1	585	587	PF00082	0.809
CLV_PCSK_KEX2_1	615	617	PF00082	0.790
CLV_PCSK_KEX2_1	620	622	PF00082	0.732
CLV_PCSK_KEX2_1	634	636	PF00082	0.602
CLV_PCSK_KEX2_1	708	710	PF00082	0.616
CLV_PCSK_KEX2_1	820	822	PF00082	0.731
CLV_PCSK_KEX2_1	929	931	PF00082	0.731
CLV_PCSK_KEX2_1	971	973	PF00082	0.779
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.853
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.809
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.627
CLV_PCSK_PC1ET2_1	620	622	PF00082	0.588
CLV_PCSK_PC1ET2_1	820	822	PF00082	0.704
CLV_PCSK_PC7_1	616	622	PF00082	0.613
CLV_PCSK_SKI1_1	161	165	PF00082	0.652
CLV_PCSK_SKI1_1	287	291	PF00082	0.789
CLV_PCSK_SKI1_1	410	414	PF00082	0.630
CLV_PCSK_SKI1_1	620	624	PF00082	0.727
CLV_PCSK_SKI1_1	73	77	PF00082	0.805
CLV_PCSK_SKI1_1	865	869	PF00082	0.780
DEG_SPOP_SBC_1	1084	1088	PF00917	0.653
DEG_SPOP_SBC_1	386	390	PF00917	0.715
DEG_SPOP_SBC_1	910	914	PF00917	0.705
DEG_SPOP_SBC_1	916	920	PF00917	0.806
DOC_CDC14_PxL_1	106	114	PF14671	0.731
DOC_CKS1_1	362	367	PF01111	0.741
DOC_CKS1_1	94	99	PF01111	0.770
DOC_CYCLIN_yCln2_LP_2	1068	1074	PF00134	0.757
DOC_CYCLIN_yCln2_LP_2	46	52	PF00134	0.623
DOC_MAPK_gen_1	31	38	PF00069	0.745
DOC_MAPK_MEF2A_6	232	239	PF00069	0.770
DOC_MAPK_MEF2A_6	73	81	PF00069	0.804
DOC_PP2B_LxvP_1	356	359	PF13499	0.615
DOC_USP7_MATH_1	1026	1030	PF00917	0.508
DOC_USP7_MATH_1	1074	1078	PF00917	0.767
DOC_USP7_MATH_1	1079	1083	PF00917	0.705
DOC_USP7_MATH_1	1096	1100	PF00917	0.562
DOC_USP7_MATH_1	1102	1106	PF00917	0.694
DOC_USP7_MATH_1	218	222	PF00917	0.858
DOC_USP7_MATH_1	268	272	PF00917	0.634
DOC_USP7_MATH_1	312	316	PF00917	0.786
DOC_USP7_MATH_1	377	381	PF00917	0.856
DOC_USP7_MATH_1	386	390	PF00917	0.633
DOC_USP7_MATH_1	4	8	PF00917	0.859
DOC_USP7_MATH_1	459	463	PF00917	0.754
DOC_USP7_MATH_1	485	489	PF00917	0.759
DOC_USP7_MATH_1	557	561	PF00917	0.825
DOC_USP7_MATH_1	598	602	PF00917	0.649
DOC_USP7_MATH_1	622	626	PF00917	0.813
DOC_USP7_MATH_1	694	698	PF00917	0.748
DOC_USP7_MATH_1	728	732	PF00917	0.753
DOC_USP7_MATH_1	877	881	PF00917	0.777
DOC_USP7_MATH_1	88	92	PF00917	0.819
DOC_USP7_MATH_1	894	898	PF00917	0.620
DOC_USP7_MATH_1	910	914	PF00917	0.652
DOC_USP7_MATH_1	916	920	PF00917	0.806
DOC_USP7_MATH_1	978	982	PF00917	0.640
DOC_WW_Pin1_4	114	119	PF00397	0.585
DOC_WW_Pin1_4	16	21	PF00397	0.839
DOC_WW_Pin1_4	214	219	PF00397	0.861
DOC_WW_Pin1_4	280	285	PF00397	0.782
DOC_WW_Pin1_4	354	359	PF00397	0.837
DOC_WW_Pin1_4	361	366	PF00397	0.744
DOC_WW_Pin1_4	402	407	PF00397	0.744
DOC_WW_Pin1_4	48	53	PF00397	0.799
DOC_WW_Pin1_4	535	540	PF00397	0.655
DOC_WW_Pin1_4	93	98	PF00397	0.823
DOC_WW_Pin1_4	931	936	PF00397	0.808
DOC_WW_Pin1_4	99	104	PF00397	0.754
LIG_14-3-3_CanoR_1	209	218	PF00244	0.759
LIG_14-3-3_CanoR_1	25	30	PF00244	0.760
LIG_14-3-3_CanoR_1	287	292	PF00244	0.788
LIG_14-3-3_CanoR_1	333	338	PF00244	0.694
LIG_14-3-3_CanoR_1	369	373	PF00244	0.790
LIG_AP2alpha_2	490	492	PF02296	0.762
LIG_BRCT_BRCA1_1	826	830	PF00533	0.759
LIG_eIF4E_1	979	985	PF01652	0.789
LIG_FHA_1	17	23	PF00498	0.852
LIG_FHA_1	391	397	PF00498	0.668
LIG_FHA_1	543	549	PF00498	0.717
LIG_FHA_1	64	70	PF00498	0.819
LIG_FHA_1	835	841	PF00498	0.730
LIG_FHA_1	866	872	PF00498	0.621
LIG_FHA_1	978	984	PF00498	0.798
LIG_FHA_2	453	459	PF00498	0.611
LIG_FHA_2	492	498	PF00498	0.827
LIG_FHA_2	984	990	PF00498	0.731
LIG_Integrin_isoDGR_2	667	669	PF01839	0.788
LIG_LIR_Apic_2	845	851	PF02991	0.773
LIG_LIR_Nem_3	74	79	PF02991	0.804
LIG_MYND_1	890	894	PF01753	0.753
LIG_PDZ_Class_2	1106	1111	PF00595	0.699
LIG_Pex14_2	946	950	PF04695	0.723
LIG_RPA_C_Fungi	204	216	PF08784	0.774
LIG_RPA_C_Fungi	474	486	PF08784	0.642
LIG_SH2_CRK	1006	1010	PF00017	0.484
LIG_SH2_CRK	848	852	PF00017	0.824
LIG_SH2_CRK	979	983	PF00017	0.805
LIG_SH2_NCK_1	493	497	PF00017	0.825
LIG_SH2_NCK_1	848	852	PF00017	0.824
LIG_SH2_STAP1	979	983	PF00017	0.727
LIG_SH2_STAT3	173	176	PF00017	0.784
LIG_SH2_STAT3	317	320	PF00017	0.796
LIG_SH2_STAT5	1006	1009	PF00017	0.702
LIG_SH2_STAT5	493	496	PF00017	0.828
LIG_SH2_STAT5	753	756	PF00017	0.739
LIG_SH2_STAT5	801	804	PF00017	0.742
LIG_SH2_STAT5	944	947	PF00017	0.741
LIG_SH2_STAT5	979	982	PF00017	0.807
LIG_SH3_1	793	799	PF00018	0.680
LIG_SH3_1	833	839	PF00018	0.694
LIG_SH3_1	848	854	PF00018	0.554
LIG_SH3_1	887	893	PF00018	0.762
LIG_SH3_2	860	865	PF14604	0.741
LIG_SH3_3	112	118	PF00018	0.824
LIG_SH3_3	236	242	PF00018	0.760
LIG_SH3_3	356	362	PF00018	0.854
LIG_SH3_3	46	52	PF00018	0.623
LIG_SH3_3	74	80	PF00018	0.800
LIG_SH3_3	793	799	PF00018	0.680
LIG_SH3_3	833	839	PF00018	0.799
LIG_SH3_3	848	854	PF00018	0.595
LIG_SH3_3	857	863	PF00018	0.700
LIG_SH3_3	887	893	PF00018	0.762
LIG_SUMO_SIM_anti_2	980	987	PF11976	0.769
LIG_SUMO_SIM_par_1	980	987	PF11976	0.769
LIG_TRAF2_1	225	228	PF00917	0.626
LIG_TRAF2_1	296	299	PF00917	0.724
LIG_TRAF2_1	306	309	PF00917	0.728
LIG_TRAF2_1	318	321	PF00917	0.646
LIG_TRAF2_1	52	55	PF00917	0.732
LIG_TRAF2_1	682	685	PF00917	0.790
LIG_TRAF2_1	781	784	PF00917	0.593
LIG_TRFH_1	76	80	PF08558	0.799
LIG_WW_3	166	170	PF00397	0.859
LIG_WW_3	342	346	PF00397	0.614
LIG_WW_3	573	577	PF00397	0.827
LIG_WW_3	850	854	PF00397	0.756
MOD_CAAXbox	1108	1111	PF01239	0.698
MOD_CDK_SPxxK_3	280	287	PF00069	0.781
MOD_CK1_1	116	122	PF00069	0.556
MOD_CK1_1	251	257	PF00069	0.838
MOD_CK1_1	433	439	PF00069	0.822
MOD_CK1_1	464	470	PF00069	0.767
MOD_CK1_1	592	598	PF00069	0.713
MOD_CK1_1	7	13	PF00069	0.862
MOD_CK1_1	732	738	PF00069	0.662
MOD_CK1_1	834	840	PF00069	0.693
MOD_CK1_1	880	886	PF00069	0.768
MOD_CK1_1	917	923	PF00069	0.810
MOD_CK1_1	98	104	PF00069	0.815
MOD_CK2_1	214	220	PF00069	0.862
MOD_CK2_1	222	228	PF00069	0.733
MOD_CK2_1	292	298	PF00069	0.800
MOD_CK2_1	452	458	PF00069	0.622
MOD_CK2_1	527	533	PF00069	0.840
MOD_CK2_1	598	604	PF00069	0.781
MOD_CK2_1	711	717	PF00069	0.638
MOD_CK2_1	728	734	PF00069	0.537
MOD_CK2_1	767	773	PF00069	0.741
MOD_CK2_1	778	784	PF00069	0.544
MOD_Cter_Amidation	331	334	PF01082	0.796
MOD_Cter_Amidation	400	403	PF01082	0.754
MOD_Cter_Amidation	667	670	PF01082	0.785
MOD_DYRK1A_RPxSP_1	114	118	PF00069	0.784
MOD_GlcNHglycan	1076	1079	PF01048	0.691
MOD_GlcNHglycan	1098	1101	PF01048	0.806
MOD_GlcNHglycan	128	131	PF01048	0.845
MOD_GlcNHglycan	209	212	PF01048	0.813
MOD_GlcNHglycan	270	273	PF01048	0.614
MOD_GlcNHglycan	376	380	PF01048	0.776
MOD_GlcNHglycan	432	435	PF01048	0.863
MOD_GlcNHglycan	461	464	PF01048	0.713
MOD_GlcNHglycan	473	476	PF01048	0.666
MOD_GlcNHglycan	513	516	PF01048	0.704
MOD_GlcNHglycan	517	521	PF01048	0.721
MOD_GlcNHglycan	558	562	PF01048	0.821
MOD_GlcNHglycan	580	584	PF01048	0.737
MOD_GlcNHglycan	713	716	PF01048	0.724
MOD_GlcNHglycan	73	76	PF01048	0.811
MOD_GlcNHglycan	748	752	PF01048	0.548
MOD_GlcNHglycan	784	788	PF01048	0.710
MOD_GlcNHglycan	826	829	PF01048	0.791
MOD_GlcNHglycan	848	851	PF01048	0.792
MOD_GlcNHglycan	88	91	PF01048	0.602
MOD_GlcNHglycan	882	885	PF01048	0.819
MOD_GlcNHglycan	906	909	PF01048	0.842
MOD_GlcNHglycan	922	925	PF01048	0.520
MOD_GSK3_1	1026	1033	PF00069	0.640
MOD_GSK3_1	1074	1081	PF00069	0.757
MOD_GSK3_1	1085	1092	PF00069	0.657
MOD_GSK3_1	1098	1105	PF00069	0.625
MOD_GSK3_1	157	164	PF00069	0.651
MOD_GSK3_1	214	221	PF00069	0.794
MOD_GSK3_1	23	30	PF00069	0.564
MOD_GSK3_1	260	267	PF00069	0.633
MOD_GSK3_1	276	283	PF00069	0.624
MOD_GSK3_1	312	319	PF00069	0.867
MOD_GSK3_1	360	367	PF00069	0.796
MOD_GSK3_1	377	384	PF00069	0.620
MOD_GSK3_1	386	393	PF00069	0.658
MOD_GSK3_1	4	11	PF00069	0.821
MOD_GSK3_1	433	440	PF00069	0.840
MOD_GSK3_1	498	505	PF00069	0.737
MOD_GSK3_1	516	523	PF00069	0.513
MOD_GSK3_1	581	588	PF00069	0.698
MOD_GSK3_1	589	596	PF00069	0.676
MOD_GSK3_1	728	735	PF00069	0.657
MOD_GSK3_1	842	849	PF00069	0.649
MOD_GSK3_1	878	885	PF00069	0.846
MOD_GSK3_1	910	917	PF00069	0.719
MOD_GSK3_1	931	938	PF00069	0.799
MOD_GSK3_1	95	102	PF00069	0.845
MOD_N-GLC_1	1030	1035	PF02516	0.782
MOD_N-GLC_1	141	146	PF02516	0.739
MOD_N-GLC_1	161	166	PF02516	0.520
MOD_N-GLC_1	324	329	PF02516	0.746
MOD_N-GLC_1	670	675	PF02516	0.767
MOD_NEK2_1	1015	1020	PF00069	0.691
MOD_NEK2_1	375	380	PF00069	0.589
MOD_NEK2_1	502	507	PF00069	0.663
MOD_NEK2_1	511	516	PF00069	0.662
MOD_NEK2_1	589	594	PF00069	0.780
MOD_NEK2_1	767	772	PF00069	0.778
MOD_NEK2_1	846	851	PF00069	0.813
MOD_NEK2_1	878	883	PF00069	0.850
MOD_NEK2_1	983	988	PF00069	0.748
MOD_NEK2_2	1030	1035	PF00069	0.782
MOD_NEK2_2	446	451	PF00069	0.782
MOD_PIKK_1	1008	1014	PF00454	0.728
MOD_PIKK_1	260	266	PF00454	0.743
MOD_PIKK_1	316	322	PF00454	0.797
MOD_PIKK_1	333	339	PF00454	0.577
MOD_PIKK_1	390	396	PF00454	0.607
MOD_PIKK_1	464	470	PF00454	0.760
MOD_PIKK_1	609	615	PF00454	0.776
MOD_PIKK_1	761	767	PF00454	0.761
MOD_PKA_1	113	119	PF00069	0.829
MOD_PKA_1	287	293	PF00069	0.629
MOD_PKA_1	333	339	PF00069	0.792
MOD_PKA_1	479	485	PF00069	0.642
MOD_PKA_1	585	591	PF00069	0.806
MOD_PKA_1	620	626	PF00069	0.636
MOD_PKA_2	113	119	PF00069	0.829
MOD_PKA_2	157	163	PF00069	0.651
MOD_PKA_2	192	198	PF00069	0.735
MOD_PKA_2	223	229	PF00069	0.765
MOD_PKA_2	287	293	PF00069	0.629
MOD_PKA_2	312	318	PF00069	0.866
MOD_PKA_2	333	339	PF00069	0.792
MOD_PKA_2	368	374	PF00069	0.789
MOD_PKA_2	479	485	PF00069	0.679
MOD_PKA_2	585	591	PF00069	0.831
MOD_PKA_2	592	598	PF00069	0.763
MOD_PKA_2	620	626	PF00069	0.636
MOD_PKA_2	694	700	PF00069	0.738
MOD_PKA_2	823	829	PF00069	0.794
MOD_PKB_1	822	830	PF00069	0.706
MOD_Plk_1	1030	1036	PF00069	0.785
MOD_Plk_1	248	254	PF00069	0.604
MOD_Plk_1	276	282	PF00069	0.628
MOD_Plk_1	293	299	PF00069	0.688
MOD_Plk_1	543	549	PF00069	0.738
MOD_Plk_2-3	324	330	PF00069	0.824
MOD_Plk_4	119	125	PF00069	0.844
MOD_Plk_4	377	383	PF00069	0.700
MOD_Plk_4	498	504	PF00069	0.819
MOD_Plk_4	527	533	PF00069	0.840
MOD_Plk_4	585	591	PF00069	0.693
MOD_Plk_4	63	69	PF00069	0.817
MOD_Plk_4	978	984	PF00069	0.720
MOD_ProDKin_1	114	120	PF00069	0.750
MOD_ProDKin_1	16	22	PF00069	0.839
MOD_ProDKin_1	214	220	PF00069	0.862
MOD_ProDKin_1	280	286	PF00069	0.782
MOD_ProDKin_1	354	360	PF00069	0.840
MOD_ProDKin_1	361	367	PF00069	0.744
MOD_ProDKin_1	402	408	PF00069	0.745
MOD_ProDKin_1	48	54	PF00069	0.799
MOD_ProDKin_1	535	541	PF00069	0.659
MOD_ProDKin_1	93	99	PF00069	0.818
MOD_ProDKin_1	931	937	PF00069	0.804
MOD_SUMO_rev_2	1059	1068	PF00179	0.529
MOD_SUMO_rev_2	612	622	PF00179	0.732
TRG_DiLeu_BaLyEn_6	1035	1040	PF01217	0.816
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.854
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.804
TRG_ENDOCYTIC_2	1006	1009	PF00928	0.702
TRG_ENDOCYTIC_2	528	531	PF00928	0.650
TRG_ENDOCYTIC_2	979	982	PF00928	0.807
TRG_ER_diArg_1	112	114	PF00400	0.848
TRG_ER_diArg_1	168	171	PF00400	0.745
TRG_ER_diArg_1	287	289	PF00400	0.636
TRG_ER_diArg_1	310	313	PF00400	0.792
TRG_ER_diArg_1	821	824	PF00400	0.709
TRG_ER_diArg_1	928	930	PF00400	0.727
TRG_ER_diArg_1	969	972	PF00400	0.691
TRG_ER_diArg_1	990	993	PF00400	0.614
TRG_ER_FFAT_2	748	758	PF00635	0.742
TRG_NLS_MonoExtC_3	819	824	PF00514	0.670
TRG_NLS_MonoExtN_4	819	824	PF00514	0.670
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	576	580	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	725	730	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	962	967	PF00026	0.720

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGY4	Leishmania donovani	87%	100%
A4H5N1	Leishmania braziliensis	56%	100%
A4HTW8	Leishmania infantum	87%	100%
E9AMQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%