TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid-specific dual specificity phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QHW9_LEIMA

TriTrypDb:

LmjF.09.0550 , LMJLV39_090011300 , LMJSD75_090011000

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHW9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0044237	cellular metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.511
CLV_C14_Caspase3-7	82	86	PF00656	0.628
CLV_NRD_NRD_1	149	151	PF00675	0.642
CLV_NRD_NRD_1	197	199	PF00675	0.561
CLV_NRD_NRD_1	202	204	PF00675	0.618
CLV_NRD_NRD_1	237	239	PF00675	0.654
CLV_NRD_NRD_1	454	456	PF00675	0.629
CLV_NRD_NRD_1	554	556	PF00675	0.388
CLV_NRD_NRD_1	567	569	PF00675	0.441
CLV_PCSK_FUR_1	565	569	PF00082	0.447
CLV_PCSK_KEX2_1	149	151	PF00082	0.642
CLV_PCSK_KEX2_1	196	198	PF00082	0.581
CLV_PCSK_KEX2_1	202	204	PF00082	0.597
CLV_PCSK_KEX2_1	239	241	PF00082	0.613
CLV_PCSK_KEX2_1	266	268	PF00082	0.445
CLV_PCSK_KEX2_1	454	456	PF00082	0.629
CLV_PCSK_KEX2_1	554	556	PF00082	0.388
CLV_PCSK_KEX2_1	565	567	PF00082	0.432
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.613
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.507
CLV_PCSK_PC7_1	193	199	PF00082	0.525
CLV_PCSK_SKI1_1	172	176	PF00082	0.647
CLV_PCSK_SKI1_1	433	437	PF00082	0.433
CLV_PCSK_SKI1_1	506	510	PF00082	0.401
DEG_APCC_DBOX_1	407	415	PF00400	0.446
DEG_SCF_FBW7_1	422	429	PF00400	0.447
DEG_SPOP_SBC_1	271	275	PF00917	0.433
DEG_SPOP_SBC_1	339	343	PF00917	0.592
DEG_SPOP_SBC_1	50	54	PF00917	0.545
DEG_SPOP_SBC_1	534	538	PF00917	0.517
DEG_SPOP_SBC_1	97	101	PF00917	0.647
DOC_MAPK_gen_1	23	31	PF00069	0.360
DOC_MAPK_gen_1	405	413	PF00069	0.513
DOC_MAPK_gen_1	565	575	PF00069	0.426
DOC_MAPK_MEF2A_6	183	192	PF00069	0.485
DOC_MAPK_MEF2A_6	23	31	PF00069	0.433
DOC_MAPK_MEF2A_6	405	413	PF00069	0.513
DOC_MAPK_MEF2A_6	565	573	PF00069	0.429
DOC_PP1_RVXF_1	504	511	PF00149	0.360
DOC_PP2B_LxvP_1	115	118	PF13499	0.683
DOC_PP2B_LxvP_1	185	188	PF13499	0.431
DOC_PP2B_LxvP_1	225	228	PF13499	0.560
DOC_PP2B_LxvP_1	409	412	PF13499	0.465
DOC_USP7_MATH_1	213	217	PF00917	0.720
DOC_USP7_MATH_1	234	238	PF00917	0.702
DOC_USP7_MATH_1	257	261	PF00917	0.520
DOC_USP7_MATH_1	270	274	PF00917	0.376
DOC_USP7_MATH_1	290	294	PF00917	0.749
DOC_USP7_MATH_1	308	312	PF00917	0.622
DOC_USP7_MATH_1	333	337	PF00917	0.659
DOC_USP7_MATH_1	339	343	PF00917	0.613
DOC_USP7_MATH_1	426	430	PF00917	0.426
DOC_USP7_MATH_1	463	467	PF00917	0.642
DOC_USP7_MATH_1	50	54	PF00917	0.654
DOC_USP7_MATH_1	502	506	PF00917	0.413
DOC_USP7_MATH_1	534	538	PF00917	0.507
DOC_USP7_MATH_1	98	102	PF00917	0.580
DOC_WW_Pin1_4	209	214	PF00397	0.562
DOC_WW_Pin1_4	306	311	PF00397	0.555
DOC_WW_Pin1_4	325	330	PF00397	0.579
DOC_WW_Pin1_4	335	340	PF00397	0.671
DOC_WW_Pin1_4	372	377	PF00397	0.623
DOC_WW_Pin1_4	413	418	PF00397	0.483
DOC_WW_Pin1_4	422	427	PF00397	0.428
DOC_WW_Pin1_4	524	529	PF00397	0.462
LIG_14-3-3_CanoR_1	149	155	PF00244	0.579
LIG_14-3-3_CanoR_1	26	32	PF00244	0.410
LIG_14-3-3_CanoR_1	408	412	PF00244	0.399
LIG_14-3-3_CanoR_1	433	439	PF00244	0.441
LIG_14-3-3_CanoR_1	506	511	PF00244	0.397
LIG_14-3-3_CanoR_1	93	98	PF00244	0.518
LIG_Actin_WH2_2	137	154	PF00022	0.577
LIG_Actin_WH2_2	179	195	PF00022	0.557
LIG_BRCT_BRCA1_1	506	510	PF00533	0.373
LIG_deltaCOP1_diTrp_1	355	359	PF00928	0.484
LIG_deltaCOP1_diTrp_1	518	522	PF00928	0.375
LIG_EVH1_1	115	119	PF00568	0.637
LIG_EVH1_2	119	123	PF00568	0.646
LIG_FHA_1	140	146	PF00498	0.511
LIG_FHA_1	206	212	PF00498	0.608
LIG_FHA_1	243	249	PF00498	0.557
LIG_FHA_1	408	414	PF00498	0.492
LIG_FHA_1	417	423	PF00498	0.447
LIG_FHA_1	426	432	PF00498	0.418
LIG_FHA_1	89	95	PF00498	0.619
LIG_FHA_1	98	104	PF00498	0.528
LIG_FHA_2	273	279	PF00498	0.534
LIG_FHA_2	341	347	PF00498	0.592
LIG_FHA_2	350	356	PF00498	0.461
LIG_FHA_2	388	394	PF00498	0.632
LIG_FHA_2	398	404	PF00498	0.448
LIG_FHA_2	435	441	PF00498	0.552
LIG_GBD_Chelix_1	27	35	PF00786	0.412
LIG_LIR_Gen_1	136	145	PF02991	0.533
LIG_LIR_Gen_1	169	177	PF02991	0.522
LIG_LIR_Gen_1	355	363	PF02991	0.426
LIG_LIR_Gen_1	579	589	PF02991	0.391
LIG_LIR_LC3C_4	24	29	PF02991	0.439
LIG_LIR_Nem_3	136	140	PF02991	0.532
LIG_LIR_Nem_3	169	173	PF02991	0.530
LIG_LIR_Nem_3	262	268	PF02991	0.440
LIG_LIR_Nem_3	355	359	PF02991	0.476
LIG_LIR_Nem_3	403	409	PF02991	0.463
LIG_Pex14_1	519	523	PF04695	0.380
LIG_Pex14_2	34	38	PF04695	0.446
LIG_Pex14_2	510	514	PF04695	0.357
LIG_SH2_CRK	265	269	PF00017	0.436
LIG_SH2_STAT5	107	110	PF00017	0.582
LIG_SH2_STAT5	133	136	PF00017	0.518
LIG_SH2_STAT5	424	427	PF00017	0.424
LIG_SH2_STAT5	563	566	PF00017	0.434
LIG_SH3_2	116	121	PF14604	0.644
LIG_SH3_3	110	116	PF00018	0.728
LIG_SH3_3	323	329	PF00018	0.518
LIG_SH3_CIN85_PxpxPR_1	116	121	PF14604	0.693
LIG_SUMO_SIM_par_1	27	33	PF11976	0.438
LIG_SUMO_SIM_par_1	469	476	PF11976	0.531
LIG_TRAF2_1	382	385	PF00917	0.553
LIG_TRAF2_1	437	440	PF00917	0.533
LIG_TYR_ITIM	404	409	PF00017	0.518
LIG_WW_3	111	115	PF00397	0.624
LIG_WW_3	118	122	PF00397	0.590
MOD_CDC14_SPxK_1	332	335	PF00782	0.678
MOD_CDK_SPxK_1	329	335	PF00069	0.665
MOD_CDK_SPxxK_3	413	420	PF00069	0.561
MOD_CK1_1	153	159	PF00069	0.658
MOD_CK1_1	162	168	PF00069	0.564
MOD_CK1_1	273	279	PF00069	0.489
MOD_CK1_1	281	287	PF00069	0.590
MOD_CK1_1	309	315	PF00069	0.657
MOD_CK1_1	338	344	PF00069	0.578
MOD_CK1_1	349	355	PF00069	0.421
MOD_CK1_1	416	422	PF00069	0.453
MOD_CK1_1	88	94	PF00069	0.636
MOD_CK1_1	96	102	PF00069	0.584
MOD_CK2_1	257	263	PF00069	0.490
MOD_CK2_1	291	297	PF00069	0.589
MOD_CK2_1	379	385	PF00069	0.581
MOD_CK2_1	397	403	PF00069	0.452
MOD_CK2_1	434	440	PF00069	0.511
MOD_CK2_1	534	540	PF00069	0.506
MOD_CMANNOS	519	522	PF00535	0.371
MOD_DYRK1A_RPxSP_1	335	339	PF00069	0.606
MOD_GlcNHglycan	301	304	PF01048	0.675
MOD_GlcNHglycan	314	317	PF01048	0.575
MOD_GlcNHglycan	335	338	PF01048	0.662
MOD_GlcNHglycan	348	351	PF01048	0.329
MOD_GlcNHglycan	397	400	PF01048	0.616
MOD_GlcNHglycan	53	56	PF01048	0.592
MOD_GlcNHglycan	81	84	PF01048	0.588
MOD_GlcNHglycan	95	98	PF01048	0.493
MOD_GSK3_1	1	8	PF00069	0.826
MOD_GSK3_1	135	142	PF00069	0.511
MOD_GSK3_1	155	162	PF00069	0.502
MOD_GSK3_1	205	212	PF00069	0.614
MOD_GSK3_1	272	279	PF00069	0.442
MOD_GSK3_1	299	306	PF00069	0.683
MOD_GSK3_1	308	315	PF00069	0.568
MOD_GSK3_1	325	332	PF00069	0.615
MOD_GSK3_1	335	342	PF00069	0.633
MOD_GSK3_1	422	429	PF00069	0.495
MOD_GSK3_1	502	509	PF00069	0.406
MOD_GSK3_1	524	531	PF00069	0.451
MOD_GSK3_1	9	16	PF00069	0.527
MOD_GSK3_1	93	100	PF00069	0.662
MOD_N-GLC_1	9	14	PF02516	0.612
MOD_NEK2_1	192	197	PF00069	0.599
MOD_NEK2_1	556	561	PF00069	0.359
MOD_NEK2_1	79	84	PF00069	0.643
MOD_PIKK_1	226	232	PF00454	0.662
MOD_PIKK_1	576	582	PF00454	0.396
MOD_PK_1	150	156	PF00069	0.583
MOD_PK_1	504	510	PF00069	0.411
MOD_PK_1	548	554	PF00069	0.439
MOD_PKA_2	192	198	PF00069	0.568
MOD_PKA_2	407	413	PF00069	0.462
MOD_PKB_1	150	158	PF00069	0.610
MOD_PKB_1	546	554	PF00069	0.458
MOD_Plk_1	281	287	PF00069	0.597
MOD_Plk_4	13	19	PF00069	0.569
MOD_Plk_4	281	287	PF00069	0.597
MOD_Plk_4	426	432	PF00069	0.421
MOD_Plk_4	506	512	PF00069	0.347
MOD_Plk_4	556	562	PF00069	0.366
MOD_ProDKin_1	209	215	PF00069	0.561
MOD_ProDKin_1	306	312	PF00069	0.553
MOD_ProDKin_1	325	331	PF00069	0.583
MOD_ProDKin_1	335	341	PF00069	0.665
MOD_ProDKin_1	372	378	PF00069	0.628
MOD_ProDKin_1	413	419	PF00069	0.477
MOD_ProDKin_1	422	428	PF00069	0.424
MOD_ProDKin_1	524	530	PF00069	0.473
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.594
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.572
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.486
TRG_ENDOCYTIC_2	265	268	PF00928	0.448
TRG_ENDOCYTIC_2	406	409	PF00928	0.431
TRG_ENDOCYTIC_2	424	427	PF00928	0.424
TRG_ER_diArg_1	149	152	PF00400	0.649
TRG_ER_diArg_1	196	198	PF00400	0.614
TRG_ER_diArg_1	201	203	PF00400	0.641
TRG_ER_diArg_1	238	241	PF00400	0.588
TRG_ER_diArg_1	554	556	PF00400	0.388
TRG_ER_diArg_1	564	567	PF00400	0.415
TRG_Pf-PMV_PEXEL_1	322	327	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	554	558	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	567	572	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F1	Leptomonas seymouri	34%	100%
A0A3S7WQM8	Leishmania donovani	89%	100%
A4H5N2	Leishmania braziliensis	66%	100%
A4HTX6	Leishmania infantum	88%	100%
E9AMQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%