Phosphoglycerate mutase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania major

UniProt:

Q4QHW8_LEIMA

TriTrypDb:

LmjF.09.0560 , LMJLV39_090011400 , LMJSD75_090011100

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	183	185	PF00082	0.571
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.571
CLV_PCSK_SKI1_1	183	187	PF00082	0.641
DOC_CDC14_PxL_1	185	193	PF14671	0.558
DOC_CKS1_1	250	255	PF01111	0.584
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.579
DOC_MAPK_MEF2A_6	141	150	PF00069	0.450
DOC_MAPK_MEF2A_6	90	98	PF00069	0.548
DOC_PP2B_LxvP_1	156	159	PF13499	0.532
DOC_PP2B_LxvP_1	186	189	PF13499	0.567
DOC_PP4_FxxP_1	127	130	PF00568	0.558
DOC_PP4_FxxP_1	250	253	PF00568	0.534
DOC_USP7_MATH_1	85	89	PF00917	0.655
DOC_USP7_MATH_1	9	13	PF00917	0.457
DOC_WW_Pin1_4	142	147	PF00397	0.478
DOC_WW_Pin1_4	220	225	PF00397	0.606
DOC_WW_Pin1_4	249	254	PF00397	0.525
DOC_WW_Pin1_4	29	34	PF00397	0.463
DOC_WW_Pin1_4	62	67	PF00397	0.409
LIG_14-3-3_CanoR_1	10	18	PF00244	0.535
LIG_14-3-3_CanoR_1	141	146	PF00244	0.556
LIG_14-3-3_CanoR_1	177	185	PF00244	0.381
LIG_14-3-3_CanoR_1	242	246	PF00244	0.590
LIG_14-3-3_CanoR_1	69	78	PF00244	0.409
LIG_Actin_WH2_2	56	71	PF00022	0.527
LIG_APCC_ABBA_1	94	99	PF00400	0.448
LIG_EH_1	151	155	PF12763	0.583
LIG_EVH1_2	158	162	PF00568	0.533
LIG_FHA_1	193	199	PF00498	0.557
LIG_FHA_1	225	231	PF00498	0.460
LIG_FHA_1	250	256	PF00498	0.592
LIG_FHA_1	62	68	PF00498	0.395
LIG_FHA_1	77	83	PF00498	0.408
LIG_FHA_1	91	97	PF00498	0.491
LIG_FHA_2	213	219	PF00498	0.599
LIG_GBD_Chelix_1	41	49	PF00786	0.463
LIG_LIR_Apic_2	124	130	PF02991	0.557
LIG_LIR_Apic_2	218	224	PF02991	0.705
LIG_LIR_Apic_2	248	253	PF02991	0.602
LIG_LIR_Apic_2	25	29	PF02991	0.463
LIG_LIR_Gen_1	227	235	PF02991	0.427
LIG_LIR_Nem_3	104	110	PF02991	0.410
LIG_LIR_Nem_3	223	229	PF02991	0.455
LIG_SH2_CRK	221	225	PF00017	0.514
LIG_SH2_CRK	26	30	PF00017	0.535
LIG_SH2_NCK_1	134	138	PF00017	0.554
LIG_SH2_SRC	97	100	PF00017	0.479
LIG_SH2_STAT5	226	229	PF00017	0.453
LIG_SH2_STAT5	48	51	PF00017	0.409
LIG_SH2_STAT5	53	56	PF00017	0.409
LIG_SH2_STAT5	97	100	PF00017	0.501
LIG_SH3_2	256	261	PF14604	0.589
LIG_SH3_3	116	122	PF00018	0.608
LIG_SH3_3	152	158	PF00018	0.517
LIG_SH3_3	250	256	PF00018	0.573
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.580
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.523
LIG_SUMO_SIM_par_1	184	190	PF11976	0.639
LIG_SUMO_SIM_par_1	59	65	PF11976	0.463
LIG_TRFH_1	154	158	PF08558	0.512
MOD_CDK_SPxxK_3	62	69	PF00069	0.409
MOD_CK1_1	115	121	PF00069	0.410
MOD_CK1_1	32	38	PF00069	0.463
MOD_CK2_1	115	121	PF00069	0.645
MOD_CK2_1	170	176	PF00069	0.546
MOD_CK2_1	212	218	PF00069	0.440
MOD_CK2_1	234	240	PF00069	0.619
MOD_GlcNHglycan	235	239	PF01048	0.676
MOD_GlcNHglycan	87	90	PF01048	0.675
MOD_GSK3_1	220	227	PF00069	0.586
MOD_GSK3_1	230	237	PF00069	0.442
MOD_NEK2_1	169	174	PF00069	0.501
MOD_NEK2_1	22	27	PF00069	0.463
MOD_NEK2_2	160	165	PF00069	0.647
MOD_PIKK_1	176	182	PF00454	0.378
MOD_PKA_2	140	146	PF00069	0.626
MOD_PKA_2	176	182	PF00069	0.378
MOD_PKA_2	241	247	PF00069	0.592
MOD_PKA_2	9	15	PF00069	0.463
MOD_Plk_1	170	176	PF00069	0.546
MOD_Plk_4	115	121	PF00069	0.644
MOD_Plk_4	192	198	PF00069	0.513
MOD_Plk_4	201	207	PF00069	0.450
MOD_ProDKin_1	142	148	PF00069	0.473
MOD_ProDKin_1	220	226	PF00069	0.596
MOD_ProDKin_1	249	255	PF00069	0.524
MOD_ProDKin_1	29	35	PF00069	0.463
MOD_ProDKin_1	62	68	PF00069	0.409
MOD_SUMO_rev_2	190	196	PF00179	0.615
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.544
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.516
TRG_ENDOCYTIC_2	107	110	PF00928	0.514
TRG_ENDOCYTIC_2	226	229	PF00928	0.453
TRG_ER_FFAT_2	216	227	PF00635	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q9	Leptomonas seymouri	61%	100%
A0A0S4JZY4	Bodo saltans	38%	91%
A0A3S7WQN5	Leishmania donovani	93%	100%
A4H5N3	Leishmania braziliensis	78%	83%
A4HTX7	Leishmania infantum	92%	100%
E9AMQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%