CULT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHW7_LEIMA

TriTrypDb:

LmjF.09.0570 , LMJLV39_090011500 , LMJSD75_090011200

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6	2
GO:0032991	protein-containing complex	1	2
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	5	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4QHW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHW7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.674
CLV_C14_Caspase3-7	315	319	PF00656	0.843
CLV_C14_Caspase3-7	430	434	PF00656	0.648
CLV_NRD_NRD_1	211	213	PF00675	0.672
CLV_NRD_NRD_1	231	233	PF00675	0.754
CLV_NRD_NRD_1	242	244	PF00675	0.650
CLV_NRD_NRD_1	382	384	PF00675	0.518
CLV_NRD_NRD_1	391	393	PF00675	0.523
CLV_NRD_NRD_1	79	81	PF00675	0.495
CLV_PCSK_FUR_1	379	383	PF00082	0.531
CLV_PCSK_KEX2_1	211	213	PF00082	0.672
CLV_PCSK_KEX2_1	381	383	PF00082	0.523
CLV_PCSK_KEX2_1	384	386	PF00082	0.517
CLV_PCSK_KEX2_1	391	393	PF00082	0.515
CLV_PCSK_KEX2_1	79	81	PF00082	0.499
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.522
DEG_APCC_DBOX_1	79	87	PF00400	0.481
DEG_SCF_FBW7_2	95	101	PF00400	0.683
DEG_SPOP_SBC_1	155	159	PF00917	0.626
DEG_SPOP_SBC_1	261	265	PF00917	0.809
DOC_ANK_TNKS_1	279	286	PF00023	0.758
DOC_CDC14_PxL_1	420	428	PF14671	0.580
DOC_CKS1_1	95	100	PF01111	0.558
DOC_MAPK_gen_1	391	397	PF00069	0.534
DOC_MAPK_gen_1	79	86	PF00069	0.465
DOC_MAPK_MEF2A_6	85	92	PF00069	0.473
DOC_PP1_RVXF_1	369	376	PF00149	0.628
DOC_PP2B_LxvP_1	160	163	PF13499	0.637
DOC_PP2B_LxvP_1	297	300	PF13499	0.838
DOC_PP2B_LxvP_1	395	398	PF13499	0.531
DOC_USP7_MATH_1	107	111	PF00917	0.702
DOC_USP7_MATH_1	11	15	PF00917	0.674
DOC_USP7_MATH_1	115	119	PF00917	0.610
DOC_USP7_MATH_1	255	259	PF00917	0.806
DOC_USP7_MATH_1	260	264	PF00917	0.847
DOC_USP7_MATH_1	268	272	PF00917	0.609
DOC_USP7_MATH_1	292	296	PF00917	0.818
DOC_USP7_MATH_1	3	7	PF00917	0.726
DOC_USP7_MATH_1	300	304	PF00917	0.687
DOC_USP7_MATH_1	32	36	PF00917	0.438
DOC_USP7_MATH_1	365	369	PF00917	0.475
DOC_WW_Pin1_4	1	6	PF00397	0.805
DOC_WW_Pin1_4	13	18	PF00397	0.542
DOC_WW_Pin1_4	262	267	PF00397	0.722
DOC_WW_Pin1_4	344	349	PF00397	0.545
DOC_WW_Pin1_4	487	492	PF00397	0.572
DOC_WW_Pin1_4	62	67	PF00397	0.573
DOC_WW_Pin1_4	94	99	PF00397	0.707
LIG_14-3-3_CanoR_1	153	163	PF00244	0.617
LIG_14-3-3_CanoR_1	243	249	PF00244	0.586
LIG_14-3-3_CanoR_1	391	396	PF00244	0.539
LIG_14-3-3_CanoR_1	454	460	PF00244	0.496
LIG_14-3-3_CanoR_1	94	98	PF00244	0.728
LIG_BIR_II_1	1	5	PF00653	0.805
LIG_BIR_III_4	148	152	PF00653	0.778
LIG_BRCT_BRCA1_1	431	435	PF00533	0.640
LIG_EH1_1	363	371	PF00400	0.625
LIG_EH1_1	413	421	PF00400	0.592
LIG_eIF4E_1	364	370	PF01652	0.517
LIG_FHA_1	18	24	PF00498	0.483
LIG_FHA_1	223	229	PF00498	0.579
LIG_FHA_1	388	394	PF00498	0.603
LIG_FHA_1	434	440	PF00498	0.608
LIG_FHA_2	243	249	PF00498	0.586
LIG_FHA_2	313	319	PF00498	0.845
LIG_LIR_Gen_1	35	45	PF02991	0.518
LIG_LIR_Gen_1	412	421	PF02991	0.579
LIG_LIR_Nem_3	178	183	PF02991	0.462
LIG_LIR_Nem_3	347	353	PF02991	0.503
LIG_LIR_Nem_3	35	40	PF02991	0.467
LIG_LIR_Nem_3	408	413	PF02991	0.562
LIG_PTAP_UEV_1	269	274	PF05743	0.763
LIG_SH2_CRK	421	425	PF00017	0.609
LIG_SH2_PTP2	89	92	PF00017	0.417
LIG_SH2_STAP1	183	187	PF00017	0.450
LIG_SH2_STAP1	54	58	PF00017	0.528
LIG_SH2_STAT5	89	92	PF00017	0.417
LIG_SH3_1	421	427	PF00018	0.668
LIG_SH3_3	2	8	PF00018	0.628
LIG_SH3_3	225	231	PF00018	0.581
LIG_SH3_3	264	270	PF00018	0.758
LIG_SH3_3	359	365	PF00018	0.617
LIG_SH3_3	421	427	PF00018	0.668
LIG_SH3_3	92	98	PF00018	0.462
LIG_SUMO_SIM_anti_2	19	25	PF11976	0.458
LIG_TRAF2_1	236	239	PF00917	0.842
LIG_TRAF2_1	41	44	PF00917	0.558
MOD_CDK_SPK_2	94	99	PF00069	0.501
MOD_CK1_1	303	309	PF00069	0.755
MOD_CK1_1	312	318	PF00069	0.694
MOD_CK1_1	4	10	PF00069	0.804
MOD_CK1_1	434	440	PF00069	0.517
MOD_CK1_1	472	478	PF00069	0.692
MOD_CK1_1	479	485	PF00069	0.799
MOD_CK2_1	161	167	PF00069	0.521
MOD_CK2_1	303	309	PF00069	0.726
MOD_CK2_1	481	487	PF00069	0.773
MOD_DYRK1A_RPxSP_1	94	98	PF00069	0.528
MOD_GlcNHglycan	1	4	PF01048	0.745
MOD_GlcNHglycan	122	125	PF01048	0.599
MOD_GlcNHglycan	13	16	PF01048	0.618
MOD_GlcNHglycan	218	221	PF01048	0.687
MOD_GlcNHglycan	270	273	PF01048	0.819
MOD_GlcNHglycan	289	292	PF01048	0.735
MOD_GlcNHglycan	323	328	PF01048	0.778
MOD_GlcNHglycan	475	478	PF01048	0.721
MOD_GlcNHglycan	483	486	PF01048	0.630
MOD_GlcNHglycan	71	74	PF01048	0.466
MOD_GlcNHglycan	76	79	PF01048	0.489
MOD_GSK3_1	116	123	PF00069	0.672
MOD_GSK3_1	13	20	PF00069	0.607
MOD_GSK3_1	167	174	PF00069	0.572
MOD_GSK3_1	216	223	PF00069	0.703
MOD_GSK3_1	244	251	PF00069	0.761
MOD_GSK3_1	3	10	PF00069	0.713
MOD_GSK3_1	300	307	PF00069	0.819
MOD_GSK3_1	308	315	PF00069	0.723
MOD_GSK3_1	353	360	PF00069	0.355
MOD_GSK3_1	387	394	PF00069	0.594
MOD_GSK3_1	429	436	PF00069	0.688
MOD_GSK3_1	437	444	PF00069	0.585
MOD_GSK3_1	469	476	PF00069	0.574
MOD_N-GLC_1	188	193	PF02516	0.413
MOD_N-GLC_1	473	478	PF02516	0.660
MOD_N-GLC_1	62	67	PF02516	0.550
MOD_NEK2_1	25	30	PF00069	0.399
MOD_NEK2_1	400	405	PF00069	0.520
MOD_NEK2_2	156	161	PF00069	0.684
MOD_NEK2_2	168	173	PF00069	0.406
MOD_NEK2_2	88	93	PF00069	0.492
MOD_PIKK_1	255	261	PF00454	0.744
MOD_PKA_1	391	397	PF00069	0.534
MOD_PKA_2	242	248	PF00069	0.663
MOD_PKA_2	391	397	PF00069	0.506
MOD_PKA_2	400	406	PF00069	0.520
MOD_PKA_2	93	99	PF00069	0.608
MOD_Plk_1	175	181	PF00069	0.466
MOD_Plk_1	323	329	PF00069	0.724
MOD_Plk_2-3	304	310	PF00069	0.840
MOD_Plk_4	161	167	PF00069	0.568
MOD_Plk_4	168	174	PF00069	0.499
MOD_Plk_4	175	181	PF00069	0.418
MOD_Plk_4	309	315	PF00069	0.603
MOD_Plk_4	32	38	PF00069	0.517
MOD_Plk_4	365	371	PF00069	0.525
MOD_ProDKin_1	1	7	PF00069	0.805
MOD_ProDKin_1	13	19	PF00069	0.525
MOD_ProDKin_1	262	268	PF00069	0.724
MOD_ProDKin_1	344	350	PF00069	0.537
MOD_ProDKin_1	62	68	PF00069	0.564
MOD_ProDKin_1	94	100	PF00069	0.713
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.575
TRG_ENDOCYTIC_2	413	416	PF00928	0.571
TRG_ENDOCYTIC_2	89	92	PF00928	0.417
TRG_ER_diArg_1	211	213	PF00400	0.626
TRG_ER_diArg_1	379	382	PF00400	0.537
TRG_ER_diArg_1	383	386	PF00400	0.502
TRG_ER_diArg_1	391	393	PF00400	0.496
TRG_ER_diArg_1	79	81	PF00400	0.495
TRG_ER_FFAT_2	430	440	PF00635	0.459
TRG_NLS_MonoExtN_4	230	236	PF00514	0.795

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U2	Leptomonas seymouri	40%	100%
A0A3S7WQQ0	Leishmania donovani	91%	100%
A4H5N4	Leishmania braziliensis	70%	99%
A4HTX8	Leishmania infantum	91%	100%
E9AMQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%