Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania major

UniProt:

Q4QHW6_LEIMA

TriTrypDb:

LmjF.09.0580 , LMJLV39_090011600 , LMJSD75_090011300

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 80

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 30, no: 6
NetGPI	no	yes: 0, no: 36

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	37
GO:0016020	membrane	2	11
GO:0042995	cell projection	2	37
GO:0043226	organelle	2	37
GO:0043227	membrane-bounded organelle	3	37
GO:0110165	cellular anatomical entity	1	37
GO:0120025	plasma membrane bounded cell projection	3	37

Expansion

Sequence features

Q4QHW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.461
CLV_PCSK_FUR_1	4	8	PF00082	0.302
CLV_PCSK_KEX2_1	6	8	PF00082	0.461
CLV_PCSK_SKI1_1	219	223	PF00082	0.650
CLV_PCSK_SKI1_1	29	33	PF00082	0.647
DEG_APCC_DBOX_1	167	175	PF00400	0.236
DEG_MDM2_SWIB_1	118	125	PF02201	0.295
DOC_CYCLIN_RxL_1	126	136	PF00134	0.221
DOC_MAPK_gen_1	126	133	PF00069	0.326
DOC_MAPK_gen_1	4	12	PF00069	0.410
DOC_MAPK_MEF2A_6	6	14	PF00069	0.491
DOC_PP1_RVXF_1	127	134	PF00149	0.237
DOC_USP7_MATH_1	148	152	PF00917	0.320
DOC_USP7_MATH_1	162	166	PF00917	0.362
DOC_USP7_MATH_1	228	232	PF00917	0.328
DOC_USP7_MATH_1	249	253	PF00917	0.382
DOC_USP7_MATH_1	263	267	PF00917	0.348
DOC_USP7_MATH_1	35	39	PF00917	0.283
DOC_USP7_MATH_1	67	71	PF00917	0.325
DOC_USP7_MATH_1	96	100	PF00917	0.451
DOC_WW_Pin1_4	209	214	PF00397	0.253
LIG_14-3-3_CanoR_1	150	156	PF00244	0.241
LIG_14-3-3_CanoR_1	158	167	PF00244	0.263
LIG_14-3-3_CanoR_1	168	172	PF00244	0.272
LIG_14-3-3_CanoR_1	219	229	PF00244	0.316
LIG_14-3-3_CanoR_1	29	39	PF00244	0.417
LIG_14-3-3_CanoR_1	6	11	PF00244	0.390
LIG_Actin_WH2_2	145	160	PF00022	0.267
LIG_Actin_WH2_2	170	187	PF00022	0.312
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BRCT_BRCA1_1	222	226	PF00533	0.285
LIG_deltaCOP1_diTrp_1	61	66	PF00928	0.360
LIG_DLG_GKlike_1	6	13	PF00625	0.384
LIG_EH1_1	15	23	PF00400	0.182
LIG_FHA_1	139	145	PF00498	0.334
LIG_FHA_1	152	158	PF00498	0.284
LIG_FHA_1	220	226	PF00498	0.297
LIG_FHA_1	272	278	PF00498	0.264
LIG_FHA_1	76	82	PF00498	0.328
LIG_FHA_1	85	91	PF00498	0.296
LIG_FHA_2	108	114	PF00498	0.344
LIG_FHA_2	57	63	PF00498	0.280
LIG_GBD_Chelix_1	269	277	PF00786	0.320
LIG_LIR_Gen_1	145	152	PF02991	0.324
LIG_LIR_Gen_1	223	234	PF02991	0.311
LIG_LIR_Nem_3	121	125	PF02991	0.294
LIG_LIR_Nem_3	136	142	PF02991	0.317
LIG_LIR_Nem_3	65	69	PF02991	0.300
LIG_PDZ_Class_2	280	285	PF00595	0.591
LIG_Pex14_2	118	122	PF04695	0.302
LIG_Pex14_2	43	47	PF04695	0.284
LIG_PTB_Apo_2	80	87	PF02174	0.240
LIG_SH2_STAT5	194	197	PF00017	0.256
LIG_SH2_STAT5	68	71	PF00017	0.345
LIG_SH3_3	230	236	PF00018	0.515
LIG_SH3_3	46	52	PF00018	0.227
LIG_SUMO_SIM_anti_2	73	82	PF11976	0.234
LIG_SUMO_SIM_par_1	268	274	PF11976	0.380
LIG_SUMO_SIM_par_1	73	82	PF11976	0.244
LIG_WRC_WIRS_1	44	49	PF05994	0.228
MOD_CK1_1	151	157	PF00069	0.283
MOD_CK1_1	215	221	PF00069	0.411
MOD_CK1_1	56	62	PF00069	0.327
MOD_CK1_1	70	76	PF00069	0.407
MOD_CK2_1	86	92	PF00069	0.386
MOD_CMANNOS	63	66	PF00535	0.430
MOD_GlcNHglycan	160	163	PF01048	0.563
MOD_GlcNHglycan	222	225	PF01048	0.449
MOD_GlcNHglycan	230	233	PF01048	0.551
MOD_GlcNHglycan	98	101	PF01048	0.624
MOD_GSK3_1	138	145	PF00069	0.279
MOD_GSK3_1	158	165	PF00069	0.284
MOD_GSK3_1	184	191	PF00069	0.318
MOD_GSK3_1	215	222	PF00069	0.306
MOD_GSK3_1	271	278	PF00069	0.460
MOD_GSK3_1	43	50	PF00069	0.295
MOD_N-GLC_1	131	136	PF02516	0.522
MOD_N-GLC_1	158	163	PF02516	0.437
MOD_N-GLC_1	199	204	PF02516	0.611
MOD_N-GLC_2	207	209	PF02516	0.485
MOD_NEK2_1	118	123	PF00069	0.358
MOD_NEK2_1	131	136	PF00069	0.251
MOD_NEK2_1	138	143	PF00069	0.369
MOD_NEK2_1	157	162	PF00069	0.327
MOD_NEK2_1	184	189	PF00069	0.338
MOD_NEK2_1	43	48	PF00069	0.255
MOD_NEK2_1	86	91	PF00069	0.328
MOD_OFUCOSY	64	71	PF10250	0.528
MOD_PKA_1	6	12	PF00069	0.388
MOD_PKA_2	157	163	PF00069	0.353
MOD_PKA_2	167	173	PF00069	0.451
MOD_PKA_2	184	190	PF00069	0.293
MOD_PKA_2	6	12	PF00069	0.457
MOD_PKB_1	4	12	PF00069	0.372
MOD_Plk_1	199	205	PF00069	0.410
MOD_Plk_1	73	79	PF00069	0.306
MOD_Plk_4	151	157	PF00069	0.353
MOD_Plk_4	199	205	PF00069	0.418
MOD_Plk_4	212	218	PF00069	0.338
MOD_Plk_4	271	277	PF00069	0.473
MOD_Plk_4	53	59	PF00069	0.235
MOD_ProDKin_1	209	215	PF00069	0.248
TRG_ER_diArg_1	4	7	PF00400	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E6	Leptomonas seymouri	27%	100%
A0A0N0P2L4	Leptomonas seymouri	29%	96%
A0A0N0P4M2	Leptomonas seymouri	35%	100%
A0A1X0NKN8	Trypanosomatidae	33%	99%
A0A3Q8I9A6	Leishmania donovani	30%	74%
A0A3Q8I9D0	Leishmania donovani	30%	100%
A0A3Q8IIJ9	Leishmania donovani	26%	94%
A0A3S5H6D6	Leishmania donovani	92%	100%
A0A3S7WP69	Leishmania donovani	30%	100%
A0A3S7WPB2	Leishmania donovani	29%	100%
A0A3S7X4J4	Leishmania donovani	26%	94%
A4H4D2	Leishmania braziliensis	28%	98%
A4H4G6	Leishmania braziliensis	29%	100%
A4H5P0	Leishmania braziliensis	69%	99%
A4HJC8	Leishmania braziliensis	26%	94%
A4HSL2	Leishmania infantum	30%	100%
A4HTX9	Leishmania infantum	93%	100%
A4HVB0	Leishmania infantum	26%	71%
A4I6S4	Leishmania infantum	26%	94%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	94%
E9ACQ0	Leishmania major	28%	100%
E9AG65	Leishmania infantum	29%	100%
E9AGG5	Leishmania infantum	29%	68%
E9AGH0	Leishmania infantum	28%	76%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	84%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	73%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	78%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	68%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	83%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	68%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	94%
Q05091	Pyrus communis	26%	86%
Q25331	Leishmania major	33%	74%
Q4Q6B6	Leishmania major	28%	100%
Q4Q6B7	Leishmania major	28%	100%
Q4QGJ4	Leishmania major	33%	74%
Q4QGJ7	Leishmania major	33%	76%
Q4QGK6	Leishmania major	33%	74%
Q4QGL4	Leishmania major	30%	72%
Q4QJB2	Leishmania major	30%	100%
Q8GT95	Oryza sativa subsp. japonica	27%	86%