Putative serine peptidase family S51, peptidase E

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin 1

Species:

Leishmania major

UniProt:

Q4QHW4_LEIMA

TriTrypDb:

LmjF.09.0600 , LMJLV39_090011800 , LMJSD75_090011500

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHW4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.429
CLV_NRD_NRD_1	112	114	PF00675	0.248
CLV_NRD_NRD_1	219	221	PF00675	0.339
CLV_NRD_NRD_1	292	294	PF00675	0.553
CLV_PCSK_KEX2_1	112	114	PF00082	0.237
CLV_PCSK_KEX2_1	163	165	PF00082	0.257
CLV_PCSK_KEX2_1	219	221	PF00082	0.339
CLV_PCSK_KEX2_1	229	231	PF00082	0.248
CLV_PCSK_KEX2_1	292	294	PF00082	0.418
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.257
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.248
CLV_PCSK_SKI1_1	164	168	PF00082	0.339
CLV_PCSK_SKI1_1	226	230	PF00082	0.245
CLV_PCSK_SKI1_1	263	267	PF00082	0.367
DEG_SPOP_SBC_1	325	329	PF00917	0.443
DOC_CKS1_1	264	269	PF01111	0.602
DOC_CKS1_1	34	39	PF01111	0.557
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.433
DOC_MAPK_DCC_7	68	77	PF00069	0.539
DOC_MAPK_gen_1	163	171	PF00069	0.457
DOC_MAPK_RevD_3	277	293	PF00069	0.407
DOC_PP2B_PxIxI_1	276	282	PF00149	0.329
DOC_PP4_FxxP_1	21	24	PF00568	0.422
DOC_USP7_MATH_1	134	138	PF00917	0.462
DOC_USP7_MATH_1	325	329	PF00917	0.546
DOC_WW_Pin1_4	263	268	PF00397	0.531
DOC_WW_Pin1_4	33	38	PF00397	0.542
LIG_14-3-3_CanoR_1	68	73	PF00244	0.462
LIG_AP2alpha_2	314	316	PF02296	0.430
LIG_APCC_ABBA_1	206	211	PF00400	0.448
LIG_BIR_II_1	1	5	PF00653	0.379
LIG_FHA_1	223	229	PF00498	0.515
LIG_FHA_1	271	277	PF00498	0.531
LIG_FHA_1	295	301	PF00498	0.533
LIG_FHA_1	37	43	PF00498	0.468
LIG_FHA_1	49	55	PF00498	0.404
LIG_FHA_1	60	66	PF00498	0.538
LIG_FHA_2	178	184	PF00498	0.566
LIG_FHA_2	93	99	PF00498	0.536
LIG_LIR_Apic_2	156	160	PF02991	0.490
LIG_LIR_Apic_2	19	24	PF02991	0.371
LIG_LIR_Gen_1	188	199	PF02991	0.441
LIG_LIR_Gen_1	221	232	PF02991	0.450
LIG_LIR_Gen_1	240	247	PF02991	0.442
LIG_LIR_Gen_1	314	322	PF02991	0.545
LIG_LIR_Nem_3	188	194	PF02991	0.440
LIG_LIR_Nem_3	240	245	PF02991	0.470
LIG_LIR_Nem_3	314	319	PF02991	0.428
LIG_NRBOX	118	124	PF00104	0.539
LIG_NRBOX	299	305	PF00104	0.453
LIG_SH2_NCK_1	253	257	PF00017	0.425
LIG_SH2_NCK_1	52	56	PF00017	0.480
LIG_SH2_PTP2	193	196	PF00017	0.448
LIG_SH2_STAP1	253	257	PF00017	0.443
LIG_SH2_STAT5	157	160	PF00017	0.539
LIG_SH2_STAT5	193	196	PF00017	0.445
LIG_SH2_STAT5	46	49	PF00017	0.445
LIG_SH3_3	261	267	PF00018	0.645
LIG_SH3_3	304	310	PF00018	0.467
LIG_SH3_3	31	37	PF00018	0.557
LIG_SH3_3	74	80	PF00018	0.483
LIG_SUMO_SIM_anti_2	98	103	PF11976	0.504
LIG_SUMO_SIM_par_1	22	28	PF11976	0.371
LIG_SUMO_SIM_par_1	280	286	PF11976	0.486
LIG_SUMO_SIM_par_1	98	103	PF11976	0.448
LIG_TRAF2_2	74	79	PF00917	0.491
LIG_UBA3_1	244	248	PF00899	0.491
LIG_UBA3_1	30	38	PF00899	0.507
MOD_CDK_SPK_2	33	38	PF00069	0.539
MOD_CK1_1	146	152	PF00069	0.480
MOD_CK1_1	328	334	PF00069	0.629
MOD_CK2_1	175	181	PF00069	0.529
MOD_CK2_1	54	60	PF00069	0.491
MOD_DYRK1A_RPxSP_1	263	267	PF00069	0.452
MOD_GlcNHglycan	1	4	PF01048	0.528
MOD_GlcNHglycan	102	105	PF01048	0.252
MOD_GlcNHglycan	136	139	PF01048	0.259
MOD_GlcNHglycan	145	148	PF01048	0.257
MOD_GlcNHglycan	15	18	PF01048	0.372
MOD_GlcNHglycan	150	153	PF01048	0.246
MOD_GlcNHglycan	254	257	PF01048	0.380
MOD_GlcNHglycan	328	331	PF01048	0.596
MOD_GSK3_1	100	107	PF00069	0.451
MOD_GSK3_1	142	149	PF00069	0.465
MOD_GSK3_1	185	192	PF00069	0.513
MOD_GSK3_1	19	26	PF00069	0.501
MOD_GSK3_1	259	266	PF00069	0.570
MOD_GSK3_1	268	275	PF00069	0.503
MOD_GSK3_1	29	36	PF00069	0.570
MOD_GSK3_1	294	301	PF00069	0.573
MOD_GSK3_1	324	331	PF00069	0.486
MOD_GSK3_1	56	63	PF00069	0.519
MOD_N-GLC_1	268	273	PF02516	0.561
MOD_N-GLC_1	85	90	PF02516	0.205
MOD_NEK2_1	13	18	PF00069	0.374
MOD_NEK2_1	187	192	PF00069	0.551
MOD_NEK2_1	210	215	PF00069	0.510
MOD_NEK2_1	54	59	PF00069	0.582
MOD_NEK2_1	92	97	PF00069	0.465
MOD_NEK2_2	104	109	PF00069	0.448
MOD_PIKK_1	210	216	PF00454	0.504
MOD_PIKK_1	54	60	PF00454	0.547
MOD_Plk_1	59	65	PF00069	0.491
MOD_Plk_2-3	23	29	PF00069	0.417
MOD_Plk_4	104	110	PF00069	0.444
MOD_Plk_4	153	159	PF00069	0.539
MOD_Plk_4	29	35	PF00069	0.559
MOD_Plk_4	328	334	PF00069	0.643
MOD_Plk_4	60	66	PF00069	0.527
MOD_ProDKin_1	263	269	PF00069	0.531
MOD_ProDKin_1	33	39	PF00069	0.542
TRG_DiLeu_BaEn_1	60	65	PF01217	0.491
TRG_ENDOCYTIC_2	193	196	PF00928	0.437
TRG_ER_diArg_1	111	113	PF00400	0.448
TRG_ER_diArg_1	194	197	PF00400	0.440
TRG_ER_diArg_1	218	220	PF00400	0.504
TRG_ER_diArg_1	292	294	PF00400	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I426	Leptomonas seymouri	72%	100%
A0A0S4KJ65	Bodo saltans	39%	93%
A0A1X0NMP2	Trypanosomatidae	47%	99%
A0A3S7WQM7	Leishmania donovani	96%	100%
A0A422NV72	Trypanosoma rangeli	49%	99%
A4H5P2	Leishmania braziliensis	84%	99%
A4HTY1	Leishmania infantum	96%	100%
D0A9D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AMR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P41179	Trypanosoma brucei brucei	33%	100%
V5BII1	Trypanosoma cruzi	48%	95%