Glucosidase 2 subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glucosidase II beta subunit-like, putative

Species:

Leishmania major

UniProt:

Q4QHW3_LEIMA

TriTrypDb:

LmjF.09.0610 , LMJLV39_090011900 , LMJSD75_090011600

Length:

837

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0017177	glucosidase II complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0140534	endoplasmic reticulum protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QHW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHW3

Function

Biological processes
Term	Name	Level	Count
GO:0006491	N-glycan processing	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009100	glycoprotein metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.549
CLV_C14_Caspase3-7	651	655	PF00656	0.705
CLV_C14_Caspase3-7	67	71	PF00656	0.815
CLV_C14_Caspase3-7	702	706	PF00656	0.592
CLV_C14_Caspase3-7	793	797	PF00656	0.517
CLV_MEL_PAP_1	596	602	PF00089	0.356
CLV_NRD_NRD_1	108	110	PF00675	0.421
CLV_NRD_NRD_1	131	133	PF00675	0.395
CLV_NRD_NRD_1	261	263	PF00675	0.515
CLV_NRD_NRD_1	354	356	PF00675	0.484
CLV_NRD_NRD_1	422	424	PF00675	0.350
CLV_NRD_NRD_1	522	524	PF00675	0.509
CLV_NRD_NRD_1	549	551	PF00675	0.441
CLV_NRD_NRD_1	561	563	PF00675	0.436
CLV_NRD_NRD_1	671	673	PF00675	0.328
CLV_NRD_NRD_1	779	781	PF00675	0.374
CLV_PCSK_KEX2_1	131	133	PF00082	0.465
CLV_PCSK_KEX2_1	354	356	PF00082	0.487
CLV_PCSK_KEX2_1	421	423	PF00082	0.397
CLV_PCSK_KEX2_1	522	524	PF00082	0.509
CLV_PCSK_KEX2_1	549	551	PF00082	0.441
CLV_PCSK_KEX2_1	561	563	PF00082	0.436
CLV_PCSK_KEX2_1	671	673	PF00082	0.329
CLV_PCSK_KEX2_1	779	781	PF00082	0.374
CLV_PCSK_PC7_1	418	424	PF00082	0.346
CLV_PCSK_SKI1_1	132	136	PF00082	0.375
CLV_PCSK_SKI1_1	166	170	PF00082	0.383
CLV_PCSK_SKI1_1	289	293	PF00082	0.422
CLV_PCSK_SKI1_1	362	366	PF00082	0.412
CLV_PCSK_SKI1_1	381	385	PF00082	0.436
CLV_PCSK_SKI1_1	552	556	PF00082	0.450
CLV_PCSK_SKI1_1	711	715	PF00082	0.431
CLV_PCSK_SKI1_1	72	76	PF00082	0.436
CLV_PCSK_SKI1_1	825	829	PF00082	0.418
CLV_Separin_Metazoa	145	149	PF03568	0.663
CLV_Separin_Metazoa	589	593	PF03568	0.551
DEG_APCC_DBOX_1	188	196	PF00400	0.570
DEG_SCF_FBW7_1	731	737	PF00400	0.609
DEG_SPOP_SBC_1	759	763	PF00917	0.657
DEG_SPOP_SBC_1	84	88	PF00917	0.738
DOC_ANK_TNKS_1	410	417	PF00023	0.549
DOC_CKS1_1	168	173	PF01111	0.608
DOC_CKS1_1	219	224	PF01111	0.697
DOC_CKS1_1	314	319	PF01111	0.675
DOC_CKS1_1	553	558	PF01111	0.758
DOC_CKS1_1	731	736	PF01111	0.693
DOC_CKS1_1	813	818	PF01111	0.529
DOC_CYCLIN_RxL_1	286	295	PF00134	0.631
DOC_MAPK_gen_1	439	446	PF00069	0.678
DOC_MAPK_MEF2A_6	439	446	PF00069	0.570
DOC_MAPK_NFAT4_5	439	447	PF00069	0.570
DOC_MAPK_RevD_3	407	423	PF00069	0.530
DOC_PP1_RVXF_1	685	691	PF00149	0.607
DOC_PP2B_LxvP_1	291	294	PF13499	0.620
DOC_PP4_FxxP_1	104	107	PF00568	0.538
DOC_PP4_FxxP_1	38	41	PF00568	0.645
DOC_USP7_MATH_1	364	368	PF00917	0.741
DOC_USP7_MATH_1	475	479	PF00917	0.581
DOC_USP7_MATH_1	494	498	PF00917	0.564
DOC_USP7_MATH_1	648	652	PF00917	0.637
DOC_USP7_MATH_1	726	730	PF00917	0.687
DOC_USP7_MATH_1	759	763	PF00917	0.657
DOC_USP7_MATH_1	83	87	PF00917	0.756
DOC_USP7_UBL2_3	710	714	PF12436	0.666
DOC_WW_Pin1_4	167	172	PF00397	0.608
DOC_WW_Pin1_4	218	223	PF00397	0.673
DOC_WW_Pin1_4	313	318	PF00397	0.716
DOC_WW_Pin1_4	319	324	PF00397	0.734
DOC_WW_Pin1_4	362	367	PF00397	0.686
DOC_WW_Pin1_4	552	557	PF00397	0.660
DOC_WW_Pin1_4	621	626	PF00397	0.698
DOC_WW_Pin1_4	630	635	PF00397	0.673
DOC_WW_Pin1_4	730	735	PF00397	0.667
DOC_WW_Pin1_4	78	83	PF00397	0.778
DOC_WW_Pin1_4	812	817	PF00397	0.511
LIG_14-3-3_CanoR_1	109	114	PF00244	0.641
LIG_14-3-3_CanoR_1	227	232	PF00244	0.670
LIG_14-3-3_CanoR_1	354	361	PF00244	0.693
LIG_14-3-3_CanoR_1	536	542	PF00244	0.651
LIG_14-3-3_CanoR_1	592	596	PF00244	0.657
LIG_14-3-3_CanoR_1	630	634	PF00244	0.624
LIG_14-3-3_CanoR_1	676	682	PF00244	0.652
LIG_14-3-3_CanoR_1	72	80	PF00244	0.640
LIG_14-3-3_CanoR_1	779	785	PF00244	0.605
LIG_APCC_ABBA_1	124	129	PF00400	0.502
LIG_BIR_II_1	1	5	PF00653	0.406
LIG_BRCT_BRCA1_1	100	104	PF00533	0.506
LIG_BRCT_BRCA1_1	678	682	PF00533	0.686
LIG_CaM_IQ_9	346	362	PF13499	0.592
LIG_deltaCOP1_diTrp_1	7	12	PF00928	0.281
LIG_eIF4E_1	515	521	PF01652	0.625
LIG_FHA_1	119	125	PF00498	0.584
LIG_FHA_1	162	168	PF00498	0.571
LIG_FHA_1	204	210	PF00498	0.548
LIG_FHA_1	219	225	PF00498	0.606
LIG_FHA_1	363	369	PF00498	0.696
LIG_FHA_1	448	454	PF00498	0.603
LIG_FHA_1	622	628	PF00498	0.596
LIG_FHA_1	723	729	PF00498	0.675
LIG_FHA_1	747	753	PF00498	0.674
LIG_FHA_2	168	174	PF00498	0.571
LIG_FHA_2	392	398	PF00498	0.675
LIG_FHA_2	537	543	PF00498	0.696
LIG_FHA_2	553	559	PF00498	0.618
LIG_FHA_2	65	71	PF00498	0.807
LIG_FHA_2	710	716	PF00498	0.684
LIG_IRF3_LxIS_1	267	274	PF10401	0.582
LIG_LIR_Apic_2	101	107	PF02991	0.570
LIG_LIR_Apic_2	37	41	PF02991	0.644
LIG_LIR_Gen_1	173	183	PF02991	0.540
LIG_LIR_Gen_1	391	398	PF02991	0.695
LIG_LIR_Nem_3	173	179	PF02991	0.531
LIG_LIR_Nem_3	226	231	PF02991	0.665
LIG_LIR_Nem_3	386	392	PF02991	0.603
LIG_LIR_Nem_3	457	462	PF02991	0.567
LIG_LIR_Nem_3	513	518	PF02991	0.564
LIG_LIR_Nem_3	643	649	PF02991	0.624
LIG_LIR_Nem_3	7	11	PF02991	0.285
LIG_LIR_Nem_3	729	735	PF02991	0.740
LIG_LYPXL_yS_3	518	521	PF13949	0.635
LIG_PDZ_Class_3	832	837	PF00595	0.619
LIG_Pex14_1	12	16	PF04695	0.373
LIG_SH2_SRC	413	416	PF00017	0.532
LIG_SH2_STAP1	100	104	PF00017	0.492
LIG_SH2_STAP1	369	373	PF00017	0.646
LIG_SH2_STAP1	95	99	PF00017	0.493
LIG_SH2_STAT3	257	260	PF00017	0.792
LIG_SH2_STAT3	567	570	PF00017	0.653
LIG_SH2_STAT5	199	202	PF00017	0.530
LIG_SH2_STAT5	231	234	PF00017	0.616
LIG_SH2_STAT5	272	275	PF00017	0.716
LIG_SH2_STAT5	393	396	PF00017	0.703
LIG_SH2_STAT5	459	462	PF00017	0.570
LIG_SH2_STAT5	623	626	PF00017	0.707
LIG_SH2_STAT5	732	735	PF00017	0.738
LIG_SH2_STAT5	748	751	PF00017	0.546
LIG_SH2_STAT5	790	793	PF00017	0.513
LIG_SH2_STAT5	95	98	PF00017	0.521
LIG_SH3_1	255	261	PF00018	0.705
LIG_SH3_2	258	263	PF14604	0.738
LIG_SH3_3	165	171	PF00018	0.602
LIG_SH3_3	176	182	PF00018	0.534
LIG_SH3_3	216	222	PF00018	0.687
LIG_SH3_3	255	261	PF00018	0.725
LIG_SH3_3	274	280	PF00018	0.554
LIG_SH3_3	39	45	PF00018	0.680
LIG_SH3_3	569	575	PF00018	0.729
LIG_SH3_3	58	64	PF00018	0.694
LIG_SH3_3	692	698	PF00018	0.789
LIG_SH3_3	728	734	PF00018	0.619
LIG_SH3_3	79	85	PF00018	0.626
LIG_SH3_3	810	816	PF00018	0.589
LIG_SUMO_SIM_par_1	121	130	PF11976	0.640
LIG_SUMO_SIM_par_1	699	705	PF11976	0.691
LIG_TRAF2_1	170	173	PF00917	0.546
LIG_TRAF2_1	455	458	PF00917	0.560
LIG_TRFH_1	257	261	PF08558	0.666
MOD_CDC14_SPxK_1	322	325	PF00782	0.679
MOD_CDK_SPxK_1	319	325	PF00069	0.683
MOD_CDK_SPxxK_3	630	637	PF00069	0.624
MOD_CK1_1	118	124	PF00069	0.607
MOD_CK1_1	19	25	PF00069	0.351
MOD_CK1_1	391	397	PF00069	0.580
MOD_CK1_1	437	443	PF00069	0.530
MOD_CK1_1	447	453	PF00069	0.533
MOD_CK1_1	503	509	PF00069	0.643
MOD_CK1_1	621	627	PF00069	0.653
MOD_CK1_1	817	823	PF00069	0.544
MOD_CK1_1	86	92	PF00069	0.669
MOD_CK2_1	167	173	PF00069	0.582
MOD_CK2_1	364	370	PF00069	0.664
MOD_CK2_1	391	397	PF00069	0.683
MOD_CK2_1	452	458	PF00069	0.627
MOD_CK2_1	537	543	PF00069	0.625
MOD_CK2_1	552	558	PF00069	0.667
MOD_CK2_1	718	724	PF00069	0.641
MOD_GlcNHglycan	149	153	PF01048	0.484
MOD_GlcNHglycan	216	219	PF01048	0.414
MOD_GlcNHglycan	356	359	PF01048	0.481
MOD_GlcNHglycan	378	381	PF01048	0.403
MOD_GlcNHglycan	57	60	PF01048	0.505
MOD_GlcNHglycan	620	623	PF01048	0.477
MOD_GlcNHglycan	720	723	PF01048	0.488
MOD_GlcNHglycan	816	819	PF01048	0.298
MOD_GSK3_1	157	164	PF00069	0.640
MOD_GSK3_1	17	24	PF00069	0.297
MOD_GSK3_1	208	215	PF00069	0.560
MOD_GSK3_1	223	230	PF00069	0.622
MOD_GSK3_1	360	367	PF00069	0.667
MOD_GSK3_1	388	395	PF00069	0.609
MOD_GSK3_1	51	58	PF00069	0.742
MOD_GSK3_1	532	539	PF00069	0.651
MOD_GSK3_1	66	73	PF00069	0.813
MOD_GSK3_1	718	725	PF00069	0.685
MOD_GSK3_1	726	733	PF00069	0.687
MOD_GSK3_1	734	741	PF00069	0.665
MOD_GSK3_1	760	767	PF00069	0.792
MOD_GSK3_1	83	90	PF00069	0.680
MOD_N-GLC_1	437	442	PF02516	0.401
MOD_N-GLC_1	447	452	PF02516	0.345
MOD_N-GLC_1	579	584	PF02516	0.378
MOD_N-GLC_1	618	623	PF02516	0.393
MOD_N-GLC_1	628	633	PF02516	0.388
MOD_N-GLC_2	212	214	PF02516	0.400
MOD_NEK2_1	16	21	PF00069	0.399
MOD_NEK2_1	271	276	PF00069	0.714
MOD_NEK2_1	340	345	PF00069	0.641
MOD_NEK2_1	444	449	PF00069	0.633
MOD_NEK2_1	527	532	PF00069	0.717
MOD_NEK2_1	53	58	PF00069	0.709
MOD_NEK2_1	591	596	PF00069	0.566
MOD_NEK2_1	628	633	PF00069	0.698
MOD_NEK2_1	760	765	PF00069	0.743
MOD_NEK2_2	284	289	PF00069	0.519
MOD_NEK2_2	388	393	PF00069	0.650
MOD_NEK2_2	677	682	PF00069	0.639
MOD_PIKK_1	184	190	PF00454	0.637
MOD_PIKK_1	40	46	PF00454	0.665
MOD_PIKK_1	760	766	PF00454	0.680
MOD_PIKK_1	805	811	PF00454	0.557
MOD_PKA_1	109	115	PF00069	0.559
MOD_PKA_1	354	360	PF00069	0.633
MOD_PKA_2	108	114	PF00069	0.691
MOD_PKA_2	354	360	PF00069	0.686
MOD_PKA_2	591	597	PF00069	0.565
MOD_PKA_2	629	635	PF00069	0.642
MOD_Plk_1	527	533	PF00069	0.705
MOD_Plk_1	579	585	PF00069	0.565
MOD_Plk_1	618	624	PF00069	0.655
MOD_Plk_2-3	125	131	PF00069	0.639
MOD_Plk_2-3	452	458	PF00069	0.557
MOD_Plk_2-3	579	585	PF00069	0.611
MOD_Plk_4	100	106	PF00069	0.604
MOD_Plk_4	157	163	PF00069	0.622
MOD_Plk_4	227	233	PF00069	0.702
MOD_Plk_4	292	298	PF00069	0.563
MOD_Plk_4	364	370	PF00069	0.689
MOD_Plk_4	388	394	PF00069	0.567
MOD_Plk_4	591	597	PF00069	0.664
MOD_Plk_4	677	683	PF00069	0.716
MOD_Plk_4	738	744	PF00069	0.695
MOD_Plk_4	786	792	PF00069	0.569
MOD_Plk_4	794	800	PF00069	0.600
MOD_ProDKin_1	167	173	PF00069	0.606
MOD_ProDKin_1	218	224	PF00069	0.671
MOD_ProDKin_1	313	319	PF00069	0.719
MOD_ProDKin_1	362	368	PF00069	0.685
MOD_ProDKin_1	552	558	PF00069	0.655
MOD_ProDKin_1	621	627	PF00069	0.695
MOD_ProDKin_1	630	636	PF00069	0.671
MOD_ProDKin_1	730	736	PF00069	0.665
MOD_ProDKin_1	78	84	PF00069	0.776
MOD_ProDKin_1	812	818	PF00069	0.512
MOD_SUMO_rev_2	367	373	PF00179	0.608
MOD_SUMO_rev_2	702	712	PF00179	0.640
TRG_DiLeu_BaEn_1	157	162	PF01217	0.616
TRG_DiLeu_BaEn_1	528	533	PF01217	0.624
TRG_ENDOCYTIC_2	389	392	PF00928	0.657
TRG_ENDOCYTIC_2	393	396	PF00928	0.588
TRG_ENDOCYTIC_2	517	520	PF00928	0.548
TRG_ER_diArg_1	421	423	PF00400	0.619
TRG_ER_diArg_1	521	523	PF00400	0.700
TRG_ER_diArg_1	778	780	PF00400	0.666
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJC1	Leptomonas seymouri	53%	89%
A0A1X0NMP0	Trypanosomatidae	28%	99%
A0A3Q8I8J4	Leishmania donovani	93%	100%
A0A422NV59	Trypanosoma rangeli	30%	100%
A4HTY2	Leishmania infantum	93%	86%
D0A9D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AI37	Leishmania braziliensis	80%	100%
E9AMR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B314	Trypanosoma cruzi	28%	100%