Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHW2_LEIMA

TriTrypDb:

LmjF.09.0620 , LMJLV39_090012000 , LMJSD75_090011700

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.697
CLV_C14_Caspase3-7	376	380	PF00656	0.521
CLV_C14_Caspase3-7	644	648	PF00656	0.572
CLV_C14_Caspase3-7	83	87	PF00656	0.681
CLV_NRD_NRD_1	2	4	PF00675	0.768
CLV_NRD_NRD_1	355	357	PF00675	0.390
CLV_NRD_NRD_1	386	388	PF00675	0.510
CLV_NRD_NRD_1	471	473	PF00675	0.553
CLV_NRD_NRD_1	514	516	PF00675	0.599
CLV_NRD_NRD_1	635	637	PF00675	0.635
CLV_NRD_NRD_1	65	67	PF00675	0.691
CLV_PCSK_FUR_1	401	405	PF00082	0.732
CLV_PCSK_KEX2_1	2	4	PF00082	0.768
CLV_PCSK_KEX2_1	30	32	PF00082	0.746
CLV_PCSK_KEX2_1	355	357	PF00082	0.393
CLV_PCSK_KEX2_1	386	388	PF00082	0.510
CLV_PCSK_KEX2_1	403	405	PF00082	0.593
CLV_PCSK_KEX2_1	471	473	PF00082	0.553
CLV_PCSK_KEX2_1	514	516	PF00082	0.599
CLV_PCSK_KEX2_1	637	639	PF00082	0.553
CLV_PCSK_KEX2_1	64	66	PF00082	0.697
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.746
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.709
CLV_PCSK_PC1ET2_1	637	639	PF00082	0.553
CLV_PCSK_SKI1_1	108	112	PF00082	0.515
CLV_PCSK_SKI1_1	139	143	PF00082	0.453
CLV_PCSK_SKI1_1	327	331	PF00082	0.553
DEG_Nend_UBRbox_1	1	4	PF02207	0.704
DEG_SPOP_SBC_1	419	423	PF00917	0.729
DOC_ANK_TNKS_1	355	362	PF00023	0.392
DOC_CKS1_1	491	496	PF01111	0.514
DOC_CKS1_1	509	514	PF01111	0.613
DOC_CKS1_1	98	103	PF01111	0.535
DOC_MAPK_gen_1	184	191	PF00069	0.508
DOC_PP1_RVXF_1	116	122	PF00149	0.456
DOC_PP1_RVXF_1	635	642	PF00149	0.652
DOC_PP2B_LxvP_1	189	192	PF13499	0.615
DOC_PP4_FxxP_1	611	614	PF00568	0.689
DOC_PP4_MxPP_1	190	193	PF00568	0.441
DOC_USP7_MATH_1	300	304	PF00917	0.665
DOC_USP7_MATH_1	419	423	PF00917	0.707
DOC_USP7_MATH_1	518	522	PF00917	0.686
DOC_USP7_UBL2_3	125	129	PF12436	0.533
DOC_WW_Pin1_4	179	184	PF00397	0.734
DOC_WW_Pin1_4	19	24	PF00397	0.784
DOC_WW_Pin1_4	203	208	PF00397	0.639
DOC_WW_Pin1_4	241	246	PF00397	0.562
DOC_WW_Pin1_4	415	420	PF00397	0.683
DOC_WW_Pin1_4	490	495	PF00397	0.516
DOC_WW_Pin1_4	508	513	PF00397	0.612
DOC_WW_Pin1_4	56	61	PF00397	0.651
DOC_WW_Pin1_4	6	11	PF00397	0.766
DOC_WW_Pin1_4	97	102	PF00397	0.544
LIG_14-3-3_CanoR_1	118	124	PF00244	0.567
LIG_14-3-3_CanoR_1	275	284	PF00244	0.578
LIG_14-3-3_CanoR_1	327	334	PF00244	0.509
LIG_14-3-3_CanoR_1	404	413	PF00244	0.659
LIG_14-3-3_CanoR_1	439	445	PF00244	0.637
LIG_14-3-3_CanoR_1	603	607	PF00244	0.666
LIG_Actin_WH2_2	123	141	PF00022	0.534
LIG_Actin_WH2_2	589	605	PF00022	0.553
LIG_BRCT_BRCA1_1	260	264	PF00533	0.431
LIG_BRCT_BRCA1_1	566	570	PF00533	0.698
LIG_Clathr_ClatBox_1	53	57	PF01394	0.629
LIG_deltaCOP1_diTrp_1	582	585	PF00928	0.585
LIG_FHA_1	130	136	PF00498	0.539
LIG_FHA_1	140	146	PF00498	0.447
LIG_FHA_1	258	264	PF00498	0.394
LIG_FHA_1	345	351	PF00498	0.547
LIG_FHA_1	429	435	PF00498	0.666
LIG_FHA_1	474	480	PF00498	0.444
LIG_FHA_1	500	506	PF00498	0.464
LIG_FHA_1	607	613	PF00498	0.620
LIG_FHA_1	98	104	PF00498	0.538
LIG_FHA_2	109	115	PF00498	0.471
LIG_FHA_2	166	172	PF00498	0.722
LIG_FHA_2	331	337	PF00498	0.402
LIG_FHA_2	81	87	PF00498	0.662
LIG_LIR_Apic_2	609	614	PF02991	0.691
LIG_LIR_Apic_2	95	101	PF02991	0.589
LIG_LIR_Gen_1	244	254	PF02991	0.486
LIG_LIR_Gen_1	261	272	PF02991	0.305
LIG_LIR_Gen_1	368	378	PF02991	0.491
LIG_LIR_Gen_1	99	110	PF02991	0.570
LIG_LIR_Nem_3	244	250	PF02991	0.498
LIG_LIR_Nem_3	261	267	PF02991	0.311
LIG_LIR_Nem_3	99	105	PF02991	0.581
LIG_MYND_3	269	273	PF01753	0.569
LIG_NRP_CendR_1	649	652	PF00754	0.648
LIG_PTB_Apo_2	481	488	PF02174	0.545
LIG_PTB_Phospho_1	481	487	PF10480	0.545
LIG_SH2_CRK	194	198	PF00017	0.503
LIG_SH2_CRK	98	102	PF00017	0.582
LIG_SH2_NCK_1	98	102	PF00017	0.582
LIG_SH2_STAP1	259	263	PF00017	0.410
LIG_SH2_STAP1	366	370	PF00017	0.448
LIG_SH2_STAP1	566	570	PF00017	0.698
LIG_SH2_STAT3	334	337	PF00017	0.408
LIG_SH2_STAT5	259	262	PF00017	0.397
LIG_SH2_STAT5	343	346	PF00017	0.474
LIG_SH2_STAT5	487	490	PF00017	0.550
LIG_SH2_STAT5	516	519	PF00017	0.662
LIG_SH2_STAT5	98	101	PF00017	0.577
LIG_SH3_3	20	26	PF00018	0.567
LIG_SH3_3	283	289	PF00018	0.506
LIG_SH3_3	486	492	PF00018	0.418
LIG_SUMO_SIM_anti_2	502	507	PF11976	0.432
LIG_SUMO_SIM_par_1	451	457	PF11976	0.376
LIG_SUMO_SIM_par_1	52	57	PF11976	0.635
LIG_TRAF2_1	314	317	PF00917	0.590
LIG_TRAF2_1	333	336	PF00917	0.357
LIG_WRC_WIRS_1	94	99	PF05994	0.551
MOD_CDK_SPK_2	179	184	PF00069	0.553
MOD_CDK_SPxK_1	490	496	PF00069	0.515
MOD_CDK_SPxK_1	508	514	PF00069	0.592
MOD_CDK_SPxxK_3	179	186	PF00069	0.548
MOD_CDK_SPxxK_3	22	29	PF00069	0.551
MOD_CDK_SPxxK_3	508	515	PF00069	0.603
MOD_CK1_1	153	159	PF00069	0.597
MOD_CK1_1	19	25	PF00069	0.709
MOD_CK1_1	422	428	PF00069	0.692
MOD_CK1_1	437	443	PF00069	0.629
MOD_CK1_1	80	86	PF00069	0.675
MOD_CK2_1	108	114	PF00069	0.444
MOD_CK2_1	330	336	PF00069	0.415
MOD_Cter_Amidation	401	404	PF01082	0.708
MOD_GlcNHglycan	155	158	PF01048	0.597
MOD_GlcNHglycan	176	179	PF01048	0.810
MOD_GlcNHglycan	304	307	PF01048	0.675
MOD_GlcNHglycan	310	313	PF01048	0.664
MOD_GlcNHglycan	413	416	PF01048	0.774
MOD_GlcNHglycan	422	425	PF01048	0.670
MOD_GlcNHglycan	436	439	PF01048	0.704
MOD_GlcNHglycan	571	574	PF01048	0.540
MOD_GlcNHglycan	577	580	PF01048	0.481
MOD_GlcNHglycan	90	93	PF01048	0.433
MOD_GSK3_1	125	132	PF00069	0.583
MOD_GSK3_1	146	153	PF00069	0.607
MOD_GSK3_1	259	266	PF00069	0.482
MOD_GSK3_1	294	301	PF00069	0.517
MOD_GSK3_1	308	315	PF00069	0.573
MOD_GSK3_1	405	412	PF00069	0.644
MOD_GSK3_1	415	422	PF00069	0.544
MOD_GSK3_1	440	447	PF00069	0.623
MOD_GSK3_1	473	480	PF00069	0.533
MOD_GSK3_1	565	572	PF00069	0.579
MOD_GSK3_1	602	609	PF00069	0.580
MOD_GSK3_1	93	100	PF00069	0.611
MOD_LATS_1	217	223	PF00433	0.688
MOD_NEK2_1	1	6	PF00069	0.770
MOD_NEK2_1	119	124	PF00069	0.588
MOD_NEK2_1	146	151	PF00069	0.600
MOD_NEK2_1	202	207	PF00069	0.632
MOD_NEK2_1	294	299	PF00069	0.523
MOD_NEK2_1	381	386	PF00069	0.587
MOD_NEK2_1	434	439	PF00069	0.633
MOD_NEK2_1	473	478	PF00069	0.466
MOD_NEK2_1	602	607	PF00069	0.659
MOD_NEK2_2	259	264	PF00069	0.407
MOD_NEK2_2	93	98	PF00069	0.571
MOD_PIKK_1	147	153	PF00454	0.554
MOD_PIKK_1	312	318	PF00454	0.722
MOD_PIKK_1	381	387	PF00454	0.595
MOD_PIKK_1	437	443	PF00454	0.647
MOD_PKA_2	1	7	PF00069	0.768
MOD_PKA_2	119	125	PF00069	0.553
MOD_PKA_2	172	178	PF00069	0.689
MOD_PKA_2	434	440	PF00069	0.646
MOD_PKA_2	602	608	PF00069	0.664
MOD_Plk_4	259	265	PF00069	0.405
MOD_Plk_4	444	450	PF00069	0.475
MOD_Plk_4	607	613	PF00069	0.687
MOD_Plk_4	93	99	PF00069	0.659
MOD_ProDKin_1	179	185	PF00069	0.732
MOD_ProDKin_1	19	25	PF00069	0.778
MOD_ProDKin_1	203	209	PF00069	0.647
MOD_ProDKin_1	241	247	PF00069	0.624
MOD_ProDKin_1	415	421	PF00069	0.681
MOD_ProDKin_1	490	496	PF00069	0.519
MOD_ProDKin_1	508	514	PF00069	0.613
MOD_ProDKin_1	56	62	PF00069	0.643
MOD_ProDKin_1	6	12	PF00069	0.767
MOD_ProDKin_1	97	103	PF00069	0.540
MOD_SUMO_rev_2	317	326	PF00179	0.492
TRG_DiLeu_BaLyEn_6	539	544	PF01217	0.685
TRG_ENDOCYTIC_2	194	197	PF00928	0.502
TRG_ENDOCYTIC_2	487	490	PF00928	0.550
TRG_ER_diArg_1	1	3	PF00400	0.779
TRG_ER_diArg_1	118	121	PF00400	0.583
TRG_ER_diArg_1	183	186	PF00400	0.545
TRG_ER_diArg_1	470	472	PF00400	0.567
TRG_ER_diArg_1	513	515	PF00400	0.580
TRG_ER_diArg_1	63	66	PF00400	0.692
TRG_ER_diArg_1	636	639	PF00400	0.641
TRG_NES_CRM1_1	124	136	PF08389	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC90	Leptomonas seymouri	59%	88%
A0A3R7NXN4	Trypanosoma rangeli	35%	100%
A0A3S7WQN2	Leishmania donovani	94%	99%
A4H5P3	Leishmania braziliensis	82%	83%
A4HTY3	Leishmania infantum	95%	99%
D0A9D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AMR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DJH4	Trypanosoma cruzi	35%	100%