Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 5, putative

Species:

Leishmania major

UniProt:

Q4QHW0_LEIMA

TriTrypDb:

LmjF.09.0640 , LMJLV39_090012200 , LMJSD75_090011900

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	12
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QHW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHW0

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016409	palmitoyltransferase activity	5	12
GO:0016417	S-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	12
GO:0019707	protein-cysteine S-acyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.383
CLV_NRD_NRD_1	269	271	PF00675	0.231
CLV_NRD_NRD_1	409	411	PF00675	0.376
CLV_NRD_NRD_1	421	423	PF00675	0.284
CLV_NRD_NRD_1	452	454	PF00675	0.320
CLV_NRD_NRD_1	63	65	PF00675	0.340
CLV_PCSK_KEX2_1	163	165	PF00082	0.433
CLV_PCSK_KEX2_1	172	174	PF00082	0.472
CLV_PCSK_KEX2_1	190	192	PF00082	0.425
CLV_PCSK_KEX2_1	269	271	PF00082	0.231
CLV_PCSK_KEX2_1	454	456	PF00082	0.409
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.443
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.472
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.409
CLV_PCSK_PC7_1	168	174	PF00082	0.483
CLV_PCSK_SKI1_1	190	194	PF00082	0.386
CLV_PCSK_SKI1_1	288	292	PF00082	0.231
CLV_PCSK_SKI1_1	313	317	PF00082	0.456
CLV_PCSK_SKI1_1	41	45	PF00082	0.535
CLV_PCSK_SKI1_1	425	429	PF00082	0.370
CLV_PCSK_SKI1_1	454	458	PF00082	0.340
DEG_APCC_DBOX_1	287	295	PF00400	0.431
DEG_APCC_DBOX_1	412	420	PF00400	0.547
DEG_APCC_KENBOX_2	446	450	PF00400	0.552
DEG_Nend_Nbox_1	1	3	PF02207	0.683
DOC_ANK_TNKS_1	205	212	PF00023	0.556
DOC_CDC14_PxL_1	102	110	PF14671	0.355
DOC_CYCLIN_RxL_1	422	431	PF00134	0.558
DOC_MAPK_gen_1	285	293	PF00069	0.446
DOC_MAPK_gen_1	38	48	PF00069	0.335
DOC_MAPK_gen_1	422	430	PF00069	0.642
DOC_MAPK_HePTP_8	112	124	PF00069	0.246
DOC_MAPK_MEF2A_6	115	124	PF00069	0.322
DOC_MAPK_MEF2A_6	41	50	PF00069	0.335
DOC_MAPK_MEF2A_6	474	481	PF00069	0.583
DOC_PP1_RVXF_1	113	120	PF00149	0.298
DOC_PP2B_LxvP_1	430	433	PF13499	0.578
DOC_PP4_FxxP_1	134	137	PF00568	0.502
DOC_USP7_MATH_1	184	188	PF00917	0.767
DOC_USP7_MATH_1	215	219	PF00917	0.678
DOC_USP7_MATH_1	255	259	PF00917	0.460
DOC_USP7_UBL2_3	454	458	PF12436	0.586
DOC_WW_Pin1_4	193	198	PF00397	0.495
DOC_WW_Pin1_4	231	236	PF00397	0.667
LIG_14-3-3_CanoR_1	41	47	PF00244	0.335
LIG_Actin_WH2_2	371	389	PF00022	0.411
LIG_Actin_WH2_2	472	489	PF00022	0.571
LIG_Actin_WH2_2	95	111	PF00022	0.414
LIG_BRCT_BRCA1_1	55	59	PF00533	0.349
LIG_CtBP_PxDLS_1	335	339	PF00389	0.322
LIG_DCNL_PONY_1	1	4	PF03556	0.591
LIG_deltaCOP1_diTrp_1	126	134	PF00928	0.411
LIG_deltaCOP1_diTrp_1	80	88	PF00928	0.474
LIG_EH1_1	206	214	PF00400	0.545
LIG_eIF4E_1	289	295	PF01652	0.337
LIG_FHA_1	220	226	PF00498	0.619
LIG_FHA_1	331	337	PF00498	0.344
LIG_FHA_1	341	347	PF00498	0.314
LIG_FHA_1	373	379	PF00498	0.543
LIG_FHA_1	399	405	PF00498	0.594
LIG_FHA_1	459	465	PF00498	0.492
LIG_FHA_1	494	500	PF00498	0.555
LIG_FHA_2	131	137	PF00498	0.391
LIG_FHA_2	224	230	PF00498	0.710
LIG_FHA_2	380	386	PF00498	0.442
LIG_FHA_2	75	81	PF00498	0.546
LIG_GBD_Chelix_1	35	43	PF00786	0.528
LIG_Integrin_isoDGR_2	330	332	PF01839	0.513
LIG_LIR_Apic_2	133	137	PF02991	0.388
LIG_LIR_Apic_2	229	235	PF02991	0.665
LIG_LIR_Gen_1	118	127	PF02991	0.364
LIG_LIR_Gen_1	18	27	PF02991	0.378
LIG_LIR_Gen_1	300	309	PF02991	0.301
LIG_LIR_Gen_1	339	348	PF02991	0.257
LIG_LIR_Gen_1	97	108	PF02991	0.276
LIG_LIR_LC3C_4	118	123	PF02991	0.381
LIG_LIR_Nem_3	118	122	PF02991	0.311
LIG_LIR_Nem_3	18	24	PF02991	0.366
LIG_LIR_Nem_3	287	293	PF02991	0.453
LIG_LIR_Nem_3	300	306	PF02991	0.254
LIG_LIR_Nem_3	307	312	PF02991	0.188
LIG_LIR_Nem_3	339	344	PF02991	0.257
LIG_LIR_Nem_3	80	86	PF02991	0.439
LIG_LIR_Nem_3	97	103	PF02991	0.215
LIG_NRBOX	290	296	PF00104	0.411
LIG_NRBOX	38	44	PF00104	0.394
LIG_PCNA_TLS_4	474	481	PF02747	0.440
LIG_Pex14_1	324	328	PF04695	0.278
LIG_Pex14_2	356	360	PF04695	0.365
LIG_Pex14_2	84	88	PF04695	0.318
LIG_PTAP_UEV_1	481	486	PF05743	0.599
LIG_PTB_Apo_2	201	208	PF02174	0.545
LIG_PTB_Phospho_1	201	207	PF10480	0.542
LIG_Rb_pABgroove_1	462	470	PF01858	0.504
LIG_SH2_CRK	232	236	PF00017	0.655
LIG_SH2_NCK_1	214	218	PF00017	0.681
LIG_SH2_NCK_1	232	236	PF00017	0.668
LIG_SH2_PTP2	21	24	PF00017	0.289
LIG_SH2_PTP2	89	92	PF00017	0.266
LIG_SH2_SRC	21	24	PF00017	0.381
LIG_SH2_SRC	214	217	PF00017	0.668
LIG_SH2_SRC	271	274	PF00017	0.474
LIG_SH2_SRC	442	445	PF00017	0.631
LIG_SH2_STAT5	100	103	PF00017	0.274
LIG_SH2_STAT5	207	210	PF00017	0.513
LIG_SH2_STAT5	21	24	PF00017	0.289
LIG_SH2_STAT5	232	235	PF00017	0.604
LIG_SH2_STAT5	289	292	PF00017	0.337
LIG_SH2_STAT5	341	344	PF00017	0.235
LIG_SH2_STAT5	89	92	PF00017	0.279
LIG_SH3_2	482	487	PF14604	0.612
LIG_SH3_3	100	106	PF00018	0.349
LIG_SH3_3	234	240	PF00018	0.632
LIG_SH3_3	249	255	PF00018	0.391
LIG_SH3_3	394	400	PF00018	0.563
LIG_SH3_3	430	436	PF00018	0.608
LIG_SH3_3	479	485	PF00018	0.562
LIG_SUMO_SIM_anti_2	118	126	PF11976	0.287
LIG_SUMO_SIM_anti_2	401	406	PF11976	0.612
LIG_SUMO_SIM_par_1	118	126	PF11976	0.306
LIG_SUMO_SIM_par_1	394	401	PF11976	0.580
LIG_SUMO_SIM_par_1	426	431	PF11976	0.563
LIG_SUMO_SIM_par_1	89	95	PF11976	0.262
LIG_TRAF2_1	197	200	PF00917	0.599
LIG_TYR_ITIM	87	92	PF00017	0.281
LIG_UBA3_1	101	109	PF00899	0.382
LIG_WRC_WIRS_1	16	21	PF05994	0.386
LIG_WRC_WIRS_1	6	11	PF05994	0.359
MOD_CK1_1	111	117	PF00069	0.378
MOD_CK1_1	246	252	PF00069	0.399
MOD_CK2_1	223	229	PF00069	0.658
MOD_CK2_1	74	80	PF00069	0.426
MOD_GlcNHglycan	482	485	PF01048	0.592
MOD_GlcNHglycan	488	491	PF01048	0.577
MOD_GSK3_1	111	118	PF00069	0.364
MOD_GSK3_1	132	139	PF00069	0.473
MOD_GSK3_1	215	222	PF00069	0.550
MOD_GSK3_1	336	343	PF00069	0.394
MOD_GSK3_1	42	49	PF00069	0.221
MOD_N-GLC_1	336	341	PF02516	0.381
MOD_N-GLC_1	379	384	PF02516	0.266
MOD_NEK2_1	101	106	PF00069	0.381
MOD_NEK2_1	108	113	PF00069	0.339
MOD_NEK2_1	127	132	PF00069	0.430
MOD_NEK2_1	15	20	PF00069	0.378
MOD_NEK2_1	243	248	PF00069	0.337
MOD_NEK2_1	299	304	PF00069	0.376
MOD_NEK2_1	315	320	PF00069	0.238
MOD_NEK2_1	336	341	PF00069	0.405
MOD_NEK2_1	395	400	PF00069	0.495
MOD_NEK2_1	42	47	PF00069	0.405
MOD_NEK2_1	428	433	PF00069	0.532
MOD_NEK2_1	486	491	PF00069	0.601
MOD_NEK2_1	53	58	PF00069	0.252
MOD_NEK2_1	68	73	PF00069	0.443
MOD_NEK2_2	74	79	PF00069	0.576
MOD_OFUCOSY	296	301	PF10250	0.360
MOD_OFUCOSY	51	57	PF10250	0.361
MOD_PIKK_1	336	342	PF00454	0.331
MOD_PKA_2	253	259	PF00069	0.266
MOD_PKA_2	284	290	PF00069	0.287
MOD_PKA_2	406	412	PF00069	0.375
MOD_PKA_2	486	492	PF00069	0.606
MOD_Plk_1	336	342	PF00069	0.353
MOD_Plk_1	379	385	PF00069	0.300
MOD_Plk_1	389	395	PF00069	0.382
MOD_Plk_1	74	80	PF00069	0.329
MOD_Plk_4	115	121	PF00069	0.315
MOD_Plk_4	15	21	PF00069	0.306
MOD_Plk_4	340	346	PF00069	0.279
MOD_Plk_4	5	11	PF00069	0.341
MOD_ProDKin_1	193	199	PF00069	0.357
MOD_ProDKin_1	231	237	PF00069	0.597
MOD_SUMO_for_1	436	439	PF00179	0.537
MOD_SUMO_rev_2	417	424	PF00179	0.573
MOD_SUMO_rev_2	462	467	PF00179	0.430
TRG_DiLeu_BaEn_1	97	102	PF01217	0.360
TRG_DiLeu_BaEn_2	79	85	PF01217	0.409
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.493
TRG_ENDOCYTIC_2	100	103	PF00928	0.266
TRG_ENDOCYTIC_2	21	24	PF00928	0.288
TRG_ENDOCYTIC_2	341	344	PF00928	0.300
TRG_ENDOCYTIC_2	89	92	PF00928	0.266
TRG_ER_diArg_1	268	270	PF00400	0.266
TRG_ER_diArg_1	452	455	PF00400	0.511
TRG_NES_CRM1_1	340	352	PF08389	0.287
TRG_NES_CRM1_1	373	385	PF08389	0.301
TRG_NLS_MonoExtC_3	452	457	PF00514	0.507
TRG_NLS_MonoExtN_4	453	458	PF00514	0.476
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD29	Leptomonas seymouri	64%	98%
A0A0S4JKC0	Bodo saltans	36%	100%
A0A1X0NN08	Trypanosomatidae	47%	100%
A0A3Q8I8F6	Leishmania donovani	94%	100%
A0A3R7L7T0	Trypanosoma rangeli	48%	100%
A4H5P5	Leishmania braziliensis	81%	100%
A4HTY5	Leishmania infantum	94%	100%
D0A9E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AMR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BSN7	Trypanosoma cruzi	47%	97%