Zeta_toxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zeta toxin, putative

Species:

Leishmania major

UniProt:

Q4QHV9_LEIMA

TriTrypDb:

LmjF.09.0650 , LMJLV39_090012300 , LMJSD75_090012000

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHV9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	312	314	PF00675	0.506
CLV_NRD_NRD_1	462	464	PF00675	0.666
CLV_NRD_NRD_1	465	467	PF00675	0.686
CLV_NRD_NRD_1	581	583	PF00675	0.676
CLV_PCSK_FUR_1	460	464	PF00082	0.611
CLV_PCSK_KEX2_1	312	314	PF00082	0.527
CLV_PCSK_KEX2_1	331	333	PF00082	0.439
CLV_PCSK_KEX2_1	462	464	PF00082	0.672
CLV_PCSK_KEX2_1	465	467	PF00082	0.694
CLV_PCSK_KEX2_1	581	583	PF00082	0.676
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.439
CLV_PCSK_PC7_1	308	314	PF00082	0.493
CLV_PCSK_SKI1_1	234	238	PF00082	0.603
CLV_PCSK_SKI1_1	410	414	PF00082	0.468
CLV_PCSK_SKI1_1	449	453	PF00082	0.574
CLV_PCSK_SKI1_1	466	470	PF00082	0.589
CLV_PCSK_SKI1_1	535	539	PF00082	0.627
CLV_PCSK_SKI1_1	582	586	PF00082	0.669
CLV_PCSK_SKI1_1	61	65	PF00082	0.554
DEG_APCC_DBOX_1	60	68	PF00400	0.573
DEG_COP1_1	9	18	PF00400	0.753
DEG_SCF_FBW7_1	112	119	PF00400	0.796
DOC_CKS1_1	15	20	PF01111	0.719
DOC_CYCLIN_RxL_1	532	539	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.674
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.649
DOC_MAPK_DCC_7	122	132	PF00069	0.656
DOC_MAPK_gen_1	312	318	PF00069	0.461
DOC_MAPK_gen_1	331	337	PF00069	0.449
DOC_MAPK_gen_1	449	458	PF00069	0.563
DOC_MAPK_gen_1	523	532	PF00069	0.677
DOC_MAPK_MEF2A_6	122	130	PF00069	0.672
DOC_MAPK_MEF2A_6	196	203	PF00069	0.511
DOC_MAPK_MEF2A_6	339	347	PF00069	0.431
DOC_MAPK_RevD_3	297	313	PF00069	0.473
DOC_MAPK_RevD_3	316	332	PF00069	0.445
DOC_PP2B_LxvP_1	124	127	PF13499	0.666
DOC_PP2B_LxvP_1	154	157	PF13499	0.487
DOC_PP2B_LxvP_1	222	225	PF13499	0.513
DOC_PP2B_LxvP_1	612	615	PF13499	0.571
DOC_PP4_FxxP_1	117	120	PF00568	0.724
DOC_USP7_MATH_1	191	195	PF00917	0.606
DOC_USP7_MATH_1	209	213	PF00917	0.216
DOC_USP7_MATH_1	263	267	PF00917	0.540
DOC_USP7_MATH_1	513	517	PF00917	0.745
DOC_USP7_MATH_1	587	591	PF00917	0.691
DOC_WW_Pin1_4	108	113	PF00397	0.704
DOC_WW_Pin1_4	116	121	PF00397	0.678
DOC_WW_Pin1_4	3	8	PF00397	0.766
DOC_WW_Pin1_4	45	50	PF00397	0.759
DOC_WW_Pin1_4	509	514	PF00397	0.760
DOC_WW_Pin1_4	9	14	PF00397	0.683
LIG_14-3-3_CanoR_1	364	369	PF00244	0.604
LIG_14-3-3_CanoR_1	40	49	PF00244	0.677
LIG_14-3-3_CanoR_1	463	473	PF00244	0.617
LIG_14-3-3_CanoR_1	523	532	PF00244	0.575
LIG_14-3-3_CanoR_1	581	585	PF00244	0.703
LIG_14-3-3_CanoR_1	77	86	PF00244	0.569
LIG_BRCT_BRCA1_1	113	117	PF00533	0.678
LIG_BRCT_BRCA1_1	570	574	PF00533	0.677
LIG_FAT_LD_1	302	310	PF03623	0.444
LIG_FHA_1	160	166	PF00498	0.353
LIG_FHA_1	228	234	PF00498	0.411
LIG_FHA_1	442	448	PF00498	0.584
LIG_FHA_1	99	105	PF00498	0.588
LIG_FHA_2	260	266	PF00498	0.580
LIG_FHA_2	404	410	PF00498	0.554
LIG_FHA_2	416	422	PF00498	0.477
LIG_HP1_1	103	107	PF01393	0.655
LIG_LIR_Apic_2	114	120	PF02991	0.720
LIG_LIR_Gen_1	184	191	PF02991	0.516
LIG_LIR_Gen_1	409	420	PF02991	0.495
LIG_LIR_Gen_1	422	433	PF02991	0.509
LIG_LIR_Gen_1	494	504	PF02991	0.569
LIG_LIR_Gen_1	607	617	PF02991	0.651
LIG_LIR_Nem_3	184	189	PF02991	0.517
LIG_LIR_Nem_3	245	251	PF02991	0.521
LIG_LIR_Nem_3	29	34	PF02991	0.576
LIG_LIR_Nem_3	378	382	PF02991	0.464
LIG_LIR_Nem_3	409	415	PF02991	0.509
LIG_LIR_Nem_3	422	428	PF02991	0.501
LIG_LIR_Nem_3	494	500	PF02991	0.683
LIG_LIR_Nem_3	57	62	PF02991	0.519
LIG_LIR_Nem_3	607	612	PF02991	0.663
LIG_NRBOX	305	311	PF00104	0.494
LIG_NRBOX	85	91	PF00104	0.585
LIG_OCRL_FandH_1	411	423	PF00620	0.507
LIG_Pex14_2	248	252	PF04695	0.509
LIG_RPA_C_Plants	369	380	PF08784	0.535
LIG_SH2_CRK	425	429	PF00017	0.511
LIG_SH2_NCK_1	94	98	PF00017	0.569
LIG_SH2_STAP1	94	98	PF00017	0.607
LIG_SH2_STAT3	291	294	PF00017	0.459
LIG_SH2_STAT5	152	155	PF00017	0.543
LIG_SH2_STAT5	327	330	PF00017	0.455
LIG_SH2_STAT5	375	378	PF00017	0.514
LIG_SH2_STAT5	94	97	PF00017	0.630
LIG_SH3_3	10	16	PF00018	0.810
LIG_SH3_3	123	129	PF00018	0.662
LIG_SH3_3	344	350	PF00018	0.447
LIG_SH3_3	498	504	PF00018	0.708
LIG_SH3_3	507	513	PF00018	0.584
LIG_SUMO_SIM_par_1	101	111	PF11976	0.691
LIG_SUMO_SIM_par_1	128	134	PF11976	0.614
LIG_SUMO_SIM_par_1	397	404	PF11976	0.492
LIG_WRC_WIRS_1	376	381	PF05994	0.494
MOD_CDC14_SPxK_1	119	122	PF00782	0.663
MOD_CDK_SPxK_1	112	118	PF00069	0.719
MOD_CK1_1	111	117	PF00069	0.661
MOD_CK1_1	229	235	PF00069	0.513
MOD_CK1_1	266	272	PF00069	0.553
MOD_CK1_1	45	51	PF00069	0.767
MOD_CK1_1	474	480	PF00069	0.724
MOD_CK1_1	546	552	PF00069	0.711
MOD_CK1_1	57	63	PF00069	0.562
MOD_CK1_1	590	596	PF00069	0.796
MOD_CK1_1	6	12	PF00069	0.761
MOD_CK2_1	20	26	PF00069	0.661
MOD_CK2_1	251	257	PF00069	0.485
MOD_CK2_1	278	284	PF00069	0.564
MOD_CK2_1	351	357	PF00069	0.516
MOD_CK2_1	415	421	PF00069	0.580
MOD_CK2_1	47	53	PF00069	0.788
MOD_GlcNHglycan	139	142	PF01048	0.627
MOD_GlcNHglycan	193	196	PF01048	0.474
MOD_GlcNHglycan	206	209	PF01048	0.339
MOD_GlcNHglycan	268	271	PF01048	0.766
MOD_GlcNHglycan	272	276	PF01048	0.719
MOD_GlcNHglycan	280	283	PF01048	0.529
MOD_GlcNHglycan	466	469	PF01048	0.732
MOD_GlcNHglycan	476	479	PF01048	0.504
MOD_GlcNHglycan	481	484	PF01048	0.798
MOD_GlcNHglycan	49	52	PF01048	0.730
MOD_GlcNHglycan	497	500	PF01048	0.595
MOD_GlcNHglycan	525	528	PF01048	0.687
MOD_GlcNHglycan	561	564	PF01048	0.696
MOD_GlcNHglycan	90	93	PF01048	0.557
MOD_GSK3_1	108	115	PF00069	0.667
MOD_GSK3_1	157	164	PF00069	0.591
MOD_GSK3_1	209	216	PF00069	0.403
MOD_GSK3_1	259	266	PF00069	0.530
MOD_GSK3_1	41	48	PF00069	0.670
MOD_GSK3_1	415	422	PF00069	0.493
MOD_GSK3_1	472	479	PF00069	0.716
MOD_GSK3_1	491	498	PF00069	0.630
MOD_GSK3_1	509	516	PF00069	0.824
MOD_GSK3_1	554	561	PF00069	0.720
MOD_GSK3_1	590	597	PF00069	0.660
MOD_GSK3_1	613	620	PF00069	0.650
MOD_GSK3_1	88	95	PF00069	0.514
MOD_N-GLC_1	471	476	PF02516	0.713
MOD_NEK2_1	1	6	PF00069	0.786
MOD_NEK2_1	136	141	PF00069	0.570
MOD_NEK2_1	217	222	PF00069	0.411
MOD_NEK2_1	251	256	PF00069	0.482
MOD_NEK2_1	335	340	PF00069	0.567
MOD_NEK2_1	401	406	PF00069	0.491
MOD_NEK2_1	408	413	PF00069	0.519
MOD_NEK2_1	415	420	PF00069	0.474
MOD_NEK2_1	594	599	PF00069	0.796
MOD_NEK2_2	375	380	PF00069	0.568
MOD_PIKK_1	144	150	PF00454	0.738
MOD_PIKK_1	217	223	PF00454	0.411
MOD_PK_1	312	318	PF00069	0.461
MOD_PKA_1	312	318	PF00069	0.461
MOD_PKA_2	312	318	PF00069	0.461
MOD_PKA_2	464	470	PF00069	0.648
MOD_PKA_2	546	552	PF00069	0.711
MOD_PKA_2	580	586	PF00069	0.765
MOD_PKA_2	78	84	PF00069	0.591
MOD_PKB_1	362	370	PF00069	0.600
MOD_Plk_1	408	414	PF00069	0.493
MOD_Plk_4	213	219	PF00069	0.436
MOD_Plk_4	26	32	PF00069	0.502
MOD_Plk_4	312	318	PF00069	0.461
MOD_Plk_4	415	421	PF00069	0.510
MOD_Plk_4	554	560	PF00069	0.808
MOD_Plk_4	613	619	PF00069	0.767
MOD_ProDKin_1	108	114	PF00069	0.710
MOD_ProDKin_1	116	122	PF00069	0.675
MOD_ProDKin_1	14	20	PF00069	0.586
MOD_ProDKin_1	3	9	PF00069	0.765
MOD_ProDKin_1	45	51	PF00069	0.767
MOD_ProDKin_1	509	515	PF00069	0.761
MOD_SUMO_rev_2	139	147	PF00179	0.514
TRG_DiLeu_BaEn_1	319	324	PF01217	0.440
TRG_DiLeu_BaEn_1	613	618	PF01217	0.769
TRG_DiLeu_BaEn_4	607	613	PF01217	0.564
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.469
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.574
TRG_ENDOCYTIC_2	425	428	PF00928	0.544
TRG_ER_diArg_1	237	240	PF00400	0.517
TRG_ER_diArg_1	361	364	PF00400	0.557
TRG_ER_diArg_1	459	462	PF00400	0.638
TRG_ER_diArg_1	464	466	PF00400	0.671
TRG_ER_diArg_1	522	525	PF00400	0.730
TRG_ER_diArg_1	580	582	PF00400	0.735
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I622	Leptomonas seymouri	48%	93%
A0A3S5H6D7	Leishmania donovani	90%	97%
A4H5P6	Leishmania braziliensis	77%	97%
A4HTY6	Leishmania infantum	91%	97%
E9AMR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	97%