Putative prefoldin subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prefoldin subunit 2, putative

Species:

Leishmania major

UniProt:

Q4QHV7_LEIMA

TriTrypDb:

LmjF.09.0670 , LMJLV39_090012500 , LMJSD75_090012200

Length:

138

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016272	prefoldin complex	2	11
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHV7

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0044183	protein folding chaperone	1	2
GO:0051082	unfolded protein binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	134	138	PF00082	0.553
CLV_PCSK_SKI1_1	89	93	PF00082	0.353
DEG_APCC_DBOX_1	88	96	PF00400	0.533
DOC_USP7_MATH_1	126	130	PF00917	0.770
DOC_USP7_MATH_1	3	7	PF00917	0.701
DOC_USP7_MATH_1	30	34	PF00917	0.496
LIG_Actin_WH2_2	81	98	PF00022	0.471
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_FHA_2	71	77	PF00498	0.440
LIG_PDZ_Class_2	133	138	PF00595	0.539
LIG_SUMO_SIM_par_1	68	73	PF11976	0.476
MOD_CK1_1	10	16	PF00069	0.510
MOD_CK1_1	2	8	PF00069	0.613
MOD_CK2_1	3	9	PF00069	0.651
MOD_CK2_1	70	76	PF00069	0.471
MOD_GlcNHglycan	1	4	PF01048	0.603
MOD_GlcNHglycan	27	31	PF01048	0.324
MOD_GSK3_1	122	129	PF00069	0.696
MOD_GSK3_1	26	33	PF00069	0.533
MOD_GSK3_1	3	10	PF00069	0.583
MOD_N-GLC_1	126	131	PF02516	0.522
MOD_N-GLC_1	3	8	PF02516	0.583
MOD_N-GLC_1	39	44	PF02516	0.333
MOD_Plk_1	26	32	PF00069	0.466
MOD_Plk_1	3	9	PF00069	0.551
MOD_Plk_1	70	76	PF00069	0.429
TRG_ENDOCYTIC_2	21	24	PF00928	0.444
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.253
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J2	Leptomonas seymouri	91%	99%
A0A0S4JE59	Bodo saltans	48%	97%
A0A1X0NMS2	Trypanosomatidae	49%	93%
A0A3S7WQR3	Leishmania donovani	96%	100%
A0A422NV63	Trypanosoma rangeli	47%	94%
A1A4P5	Bos taurus	38%	90%
A4HTY8	Leishmania infantum	96%	100%
A8WVJ9	Caenorhabditis briggsae	32%	97%
B0BN18	Rattus norvegicus	40%	90%
D0A9E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	95%
E9AMR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O70591	Mus musculus	42%	90%
Q55GN3	Dictyostelium discoideum	41%	100%
Q9LJ98	Arabidopsis thaliana	36%	93%
Q9N5M2	Caenorhabditis elegans	32%	98%
Q9UHV9	Homo sapiens	38%	90%
Q9UTC9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q9VTE5	Drosophila melanogaster	31%	97%
V5DJI3	Trypanosoma cruzi	57%	93%