Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHV6_LEIMA

TriTrypDb:

LmjF.09.0680 , LMJLV39_090012600 , LMJSD75_090012300

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.691
CLV_C14_Caspase3-7	284	288	PF00656	0.700
CLV_NRD_NRD_1	18	20	PF00675	0.594
CLV_NRD_NRD_1	197	199	PF00675	0.611
CLV_NRD_NRD_1	24	26	PF00675	0.635
CLV_NRD_NRD_1	243	245	PF00675	0.589
CLV_NRD_NRD_1	261	263	PF00675	0.533
CLV_NRD_NRD_1	325	327	PF00675	0.720
CLV_NRD_NRD_1	356	358	PF00675	0.604
CLV_PCSK_KEX2_1	18	20	PF00082	0.594
CLV_PCSK_KEX2_1	197	199	PF00082	0.608
CLV_PCSK_KEX2_1	243	245	PF00082	0.589
CLV_PCSK_KEX2_1	261	263	PF00082	0.533
CLV_PCSK_PC7_1	193	199	PF00082	0.579
CLV_PCSK_SKI1_1	187	191	PF00082	0.630
CLV_PCSK_SKI1_1	25	29	PF00082	0.622
CLV_PCSK_SKI1_1	357	361	PF00082	0.547
DEG_APCC_DBOX_1	120	128	PF00400	0.620
DEG_APCC_DBOX_1	356	364	PF00400	0.623
DOC_MAPK_gen_1	197	203	PF00069	0.628
DOC_MAPK_gen_1	261	267	PF00069	0.532
DOC_PP1_RVXF_1	348	355	PF00149	0.593
DOC_PP2B_LxvP_1	309	312	PF13499	0.691
DOC_USP7_MATH_1	140	144	PF00917	0.646
DOC_USP7_MATH_1	64	68	PF00917	0.573
DOC_USP7_MATH_1	87	91	PF00917	0.759
DOC_WW_Pin1_4	25	30	PF00397	0.609
DOC_WW_Pin1_4	329	334	PF00397	0.739
DOC_WW_Pin1_4	85	90	PF00397	0.701
LIG_14-3-3_CanoR_1	114	124	PF00244	0.612
LIG_14-3-3_CanoR_1	18	22	PF00244	0.543
LIG_14-3-3_CanoR_1	193	201	PF00244	0.533
LIG_14-3-3_CanoR_1	243	252	PF00244	0.696
LIG_14-3-3_CanoR_1	326	333	PF00244	0.712
LIG_EVH1_1	309	313	PF00568	0.689
LIG_EVH1_2	78	82	PF00568	0.716
LIG_FHA_1	222	228	PF00498	0.693
LIG_FHA_1	26	32	PF00498	0.591
LIG_FHA_1	280	286	PF00498	0.707
LIG_FHA_1	316	322	PF00498	0.758
LIG_GBD_Chelix_1	127	135	PF00786	0.580
LIG_LIR_Gen_1	159	169	PF02991	0.613
LIG_LIR_Gen_1	251	257	PF02991	0.620
LIG_LIR_Gen_1	289	300	PF02991	0.642
LIG_LIR_Gen_1	44	55	PF02991	0.577
LIG_LIR_Nem_3	159	164	PF02991	0.617
LIG_LIR_Nem_3	241	245	PF02991	0.675
LIG_LIR_Nem_3	251	256	PF02991	0.549
LIG_LIR_Nem_3	289	295	PF02991	0.655
LIG_LIR_Nem_3	44	50	PF02991	0.573
LIG_NRBOX	251	257	PF00104	0.611
LIG_PCNA_yPIPBox_3	4	18	PF02747	0.576
LIG_PROFILIN_1	310	316	PF00235	0.645
LIG_SH2_CRK	242	246	PF00017	0.657
LIG_SH2_SRC	107	110	PF00017	0.651
LIG_SH2_STAT5	134	137	PF00017	0.535
LIG_SH2_STAT5	346	349	PF00017	0.613
LIG_SH2_STAT5	41	44	PF00017	0.514
LIG_SH3_1	307	313	PF00018	0.755
LIG_SH3_3	232	238	PF00018	0.676
LIG_SH3_3	264	270	PF00018	0.613
LIG_SH3_3	307	313	PF00018	0.686
LIG_SH3_3	330	336	PF00018	0.717
LIG_SH3_3	83	89	PF00018	0.654
LIG_SH3_5	238	242	PF00018	0.627
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.703
LIG_WW_2	313	316	PF00397	0.594
MOD_CK1_1	113	119	PF00069	0.719
MOD_CK1_1	143	149	PF00069	0.621
MOD_CK1_1	152	158	PF00069	0.407
MOD_CK1_1	251	257	PF00069	0.620
MOD_CK1_1	275	281	PF00069	0.741
MOD_CK1_1	90	96	PF00069	0.789
MOD_CK2_1	143	149	PF00069	0.569
MOD_CK2_1	17	23	PF00069	0.622
MOD_Cter_Amidation	16	19	PF01082	0.667
MOD_GlcNHglycan	137	140	PF01048	0.699
MOD_GlcNHglycan	143	146	PF01048	0.609
MOD_GlcNHglycan	365	368	PF01048	0.650
MOD_GlcNHglycan	89	92	PF01048	0.766
MOD_GSK3_1	268	275	PF00069	0.755
MOD_GSK3_1	321	328	PF00069	0.749
MOD_GSK3_1	87	94	PF00069	0.772
MOD_NEK2_1	135	140	PF00069	0.599
MOD_NEK2_1	216	221	PF00069	0.691
MOD_NEK2_1	256	261	PF00069	0.558
MOD_NEK2_1	321	326	PF00069	0.808
MOD_NEK2_1	50	55	PF00069	0.530
MOD_NEK2_1	82	87	PF00069	0.787
MOD_NEK2_2	17	22	PF00069	0.667
MOD_PIKK_1	149	155	PF00454	0.628
MOD_PIKK_1	192	198	PF00454	0.476
MOD_PIKK_1	243	249	PF00454	0.703
MOD_PIKK_1	256	262	PF00454	0.502
MOD_PIKK_1	321	327	PF00454	0.741
MOD_PKA_1	243	249	PF00069	0.703
MOD_PKA_2	113	119	PF00069	0.635
MOD_PKA_2	141	147	PF00069	0.682
MOD_PKA_2	17	23	PF00069	0.546
MOD_PKA_2	192	198	PF00069	0.570
MOD_PKA_2	243	249	PF00069	0.703
MOD_PKA_2	275	281	PF00069	0.741
MOD_PKA_2	325	331	PF00069	0.724
MOD_PKB_1	274	282	PF00069	0.740
MOD_Plk_2-3	281	287	PF00069	0.681
MOD_Plk_4	152	158	PF00069	0.534
MOD_Plk_4	231	237	PF00069	0.686
MOD_Plk_4	248	254	PF00069	0.556
MOD_ProDKin_1	25	31	PF00069	0.605
MOD_ProDKin_1	329	335	PF00069	0.738
MOD_ProDKin_1	85	91	PF00069	0.704
MOD_SUMO_rev_2	20	28	PF00179	0.612
MOD_SUMO_rev_2	215	222	PF00179	0.707
TRG_ENDOCYTIC_2	242	245	PF00928	0.662
TRG_ENDOCYTIC_2	47	50	PF00928	0.573
TRG_ER_diArg_1	197	199	PF00400	0.596
TRG_ER_diArg_1	242	244	PF00400	0.595
TRG_ER_diArg_1	294	297	PF00400	0.702
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE5	Leptomonas seymouri	44%	93%
A0A3Q8I7G4	Leishmania donovani	95%	100%
A4H5P9	Leishmania braziliensis	76%	100%
A4HTY9	Leishmania infantum	95%	100%
E9AMR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BN47	Trypanosoma cruzi	27%	100%