Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHV4_LEIMA

TriTrypDb:

LmjF.09.0700 , LMJLV39_090013200 , LMJSD75_090012800

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.597
CLV_C14_Caspase3-7	431	435	PF00656	0.639
CLV_NRD_NRD_1	197	199	PF00675	0.635
CLV_NRD_NRD_1	242	244	PF00675	0.538
CLV_NRD_NRD_1	256	258	PF00675	0.483
CLV_NRD_NRD_1	355	357	PF00675	0.688
CLV_PCSK_FUR_1	195	199	PF00082	0.534
CLV_PCSK_KEX2_1	197	199	PF00082	0.569
CLV_PCSK_KEX2_1	242	244	PF00082	0.538
CLV_PCSK_KEX2_1	255	257	PF00082	0.447
CLV_PCSK_KEX2_1	264	266	PF00082	0.589
CLV_PCSK_KEX2_1	355	357	PF00082	0.748
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.652
CLV_PCSK_PC7_1	351	357	PF00082	0.660
CLV_PCSK_SKI1_1	274	278	PF00082	0.638
CLV_PCSK_SKI1_1	287	291	PF00082	0.548
CLV_Separin_Fungi	346	352	PF03568	0.590
DEG_Kelch_Keap1_1	25	30	PF01344	0.504
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DEG_SCF_FBW7_1	6	12	PF00400	0.540
DEG_SCF_FBW7_2	71	76	PF00400	0.569
DEG_SPOP_SBC_1	125	129	PF00917	0.565
DEG_SPOP_SBC_1	21	25	PF00917	0.755
DOC_CKS1_1	6	11	PF01111	0.537
DOC_MAPK_gen_1	187	194	PF00069	0.576
DOC_MAPK_gen_1	195	202	PF00069	0.436
DOC_MAPK_gen_1	252	262	PF00069	0.561
DOC_MAPK_gen_1	264	271	PF00069	0.541
DOC_MAPK_MEF2A_6	187	194	PF00069	0.576
DOC_PP4_MxPP_1	366	369	PF00568	0.644
DOC_SPAK_OSR1_1	307	311	PF12202	0.651
DOC_USP7_MATH_1	119	123	PF00917	0.657
DOC_USP7_MATH_1	283	287	PF00917	0.615
DOC_USP7_MATH_1	296	300	PF00917	0.600
DOC_USP7_MATH_1	330	334	PF00917	0.707
DOC_USP7_MATH_1	338	342	PF00917	0.558
DOC_USP7_MATH_1	369	373	PF00917	0.554
DOC_USP7_MATH_1	400	404	PF00917	0.655
DOC_WW_Pin1_4	12	17	PF00397	0.632
DOC_WW_Pin1_4	2	7	PF00397	0.666
DOC_WW_Pin1_4	218	223	PF00397	0.633
DOC_WW_Pin1_4	297	302	PF00397	0.728
DOC_WW_Pin1_4	334	339	PF00397	0.680
DOC_WW_Pin1_4	69	74	PF00397	0.687
LIG_14-3-3_CanoR_1	138	144	PF00244	0.575
LIG_14-3-3_CanoR_1	163	167	PF00244	0.737
LIG_14-3-3_CanoR_1	174	178	PF00244	0.562
LIG_14-3-3_CanoR_1	250	255	PF00244	0.527
LIG_14-3-3_CanoR_1	257	263	PF00244	0.559
LIG_14-3-3_CanoR_1	340	344	PF00244	0.721
LIG_14-3-3_CanoR_1	388	396	PF00244	0.557
LIG_14-3-3_CanoR_1	419	423	PF00244	0.688
LIG_APCC_ABBAyCdc20_2	231	237	PF00400	0.406
LIG_BRCT_BRCA1_1	272	276	PF00533	0.628
LIG_CtBP_PxDLS_1	448	452	PF00389	0.596
LIG_FHA_1	279	285	PF00498	0.634
LIG_FHA_1	80	86	PF00498	0.601
LIG_FHA_2	224	230	PF00498	0.545
LIG_GBD_Chelix_1	31	39	PF00786	0.545
LIG_LIR_Apic_2	375	380	PF02991	0.638
LIG_LIR_Apic_2	442	448	PF02991	0.611
LIG_LIR_Apic_2	97	101	PF02991	0.648
LIG_LIR_Gen_1	141	150	PF02991	0.635
LIG_LIR_Nem_3	141	147	PF02991	0.678
LIG_LIR_Nem_3	239	244	PF02991	0.501
LIG_LIR_Nem_3	3	7	PF02991	0.599
LIG_LIR_Nem_3	372	377	PF02991	0.682
LIG_SH2_CRK	144	148	PF00017	0.562
LIG_SH2_CRK	241	245	PF00017	0.503
LIG_SH2_CRK	378	382	PF00017	0.686
LIG_SH2_CRK	98	102	PF00017	0.647
LIG_SH2_GRB2like	377	380	PF00017	0.616
LIG_SH2_PTP2	445	448	PF00017	0.606
LIG_SH2_STAP1	374	378	PF00017	0.649
LIG_SH2_STAT3	155	158	PF00017	0.641
LIG_SH2_STAT5	445	448	PF00017	0.606
LIG_SH3_2	6	11	PF14604	0.609
LIG_SH3_3	103	109	PF00018	0.744
LIG_SH3_3	3	9	PF00018	0.599
LIG_SH3_3	80	86	PF00018	0.659
LIG_SUMO_SIM_anti_2	450	455	PF11976	0.594
LIG_SUMO_SIM_par_1	447	452	PF11976	0.595
LIG_SUMO_SIM_par_1	81	87	PF11976	0.608
LIG_TRAF2_1	226	229	PF00917	0.536
LIG_WRC_WIRS_1	1	6	PF05994	0.604
LIG_WRC_WIRS_1	251	256	PF05994	0.548
MOD_CDK_SPxK_1	334	340	PF00069	0.681
MOD_CDK_SPxK_1	5	11	PF00069	0.534
MOD_CK1_1	129	135	PF00069	0.561
MOD_CK1_1	148	154	PF00069	0.599
MOD_CK1_1	161	167	PF00069	0.571
MOD_CK1_1	176	182	PF00069	0.514
MOD_CK1_1	22	28	PF00069	0.730
MOD_CK1_1	297	303	PF00069	0.726
MOD_CK1_1	372	378	PF00069	0.596
MOD_CK1_1	384	390	PF00069	0.634
MOD_CK1_1	5	11	PF00069	0.576
MOD_CK1_1	84	90	PF00069	0.785
MOD_CK2_1	223	229	PF00069	0.559
MOD_CK2_1	24	30	PF00069	0.676
MOD_Cter_Amidation	195	198	PF01082	0.640
MOD_Cter_Amidation	60	63	PF01082	0.520
MOD_GlcNHglycan	115	118	PF01048	0.628
MOD_GlcNHglycan	131	134	PF01048	0.535
MOD_GlcNHglycan	147	150	PF01048	0.643
MOD_GlcNHglycan	296	299	PF01048	0.688
MOD_GlcNHglycan	374	377	PF01048	0.619
MOD_GlcNHglycan	383	386	PF01048	0.594
MOD_GSK3_1	125	132	PF00069	0.582
MOD_GSK3_1	154	161	PF00069	0.655
MOD_GSK3_1	20	27	PF00069	0.647
MOD_GSK3_1	270	277	PF00069	0.685
MOD_GSK3_1	330	337	PF00069	0.734
MOD_GSK3_1	339	346	PF00069	0.589
MOD_GSK3_1	384	391	PF00069	0.629
MOD_GSK3_1	392	399	PF00069	0.639
MOD_GSK3_1	413	420	PF00069	0.700
MOD_GSK3_1	428	435	PF00069	0.754
MOD_GSK3_1	5	12	PF00069	0.634
MOD_LATS_1	409	415	PF00433	0.614
MOD_N-GLC_1	119	124	PF02516	0.644
MOD_N-GLC_1	158	163	PF02516	0.686
MOD_N-GLC_1	223	228	PF02516	0.629
MOD_N-GLC_1	334	339	PF02516	0.726
MOD_N-GLC_1	370	375	PF02516	0.644
MOD_N-GLC_1	388	393	PF02516	0.573
MOD_N-GLC_1	411	416	PF02516	0.674
MOD_NEK2_1	110	115	PF00069	0.636
MOD_NEK2_1	20	25	PF00069	0.638
MOD_NEK2_1	381	386	PF00069	0.665
MOD_NEK2_1	396	401	PF00069	0.537
MOD_NEK2_1	449	454	PF00069	0.598
MOD_NEK2_2	119	124	PF00069	0.644
MOD_NEK2_2	339	344	PF00069	0.617
MOD_NEK2_2	392	397	PF00069	0.552
MOD_PIKK_1	126	132	PF00454	0.597
MOD_PIKK_1	154	160	PF00454	0.579
MOD_PIKK_1	439	445	PF00454	0.627
MOD_PKA_2	110	116	PF00069	0.671
MOD_PKA_2	137	143	PF00069	0.654
MOD_PKA_2	145	151	PF00069	0.626
MOD_PKA_2	162	168	PF00069	0.546
MOD_PKA_2	173	179	PF00069	0.563
MOD_PKA_2	339	345	PF00069	0.739
MOD_PKA_2	358	364	PF00069	0.710
MOD_PKA_2	418	424	PF00069	0.591
MOD_PKB_1	349	357	PF00069	0.589
MOD_Plk_1	119	125	PF00069	0.642
MOD_Plk_1	161	167	PF00069	0.719
MOD_Plk_1	223	229	PF00069	0.607
MOD_Plk_1	370	376	PF00069	0.576
MOD_Plk_1	392	398	PF00069	0.551
MOD_Plk_1	428	434	PF00069	0.714
MOD_Plk_1	449	455	PF00069	0.599
MOD_Plk_2-3	428	434	PF00069	0.643
MOD_Plk_4	119	125	PF00069	0.642
MOD_Plk_4	449	455	PF00069	0.599
MOD_ProDKin_1	12	18	PF00069	0.632
MOD_ProDKin_1	2	8	PF00069	0.666
MOD_ProDKin_1	218	224	PF00069	0.635
MOD_ProDKin_1	297	303	PF00069	0.729
MOD_ProDKin_1	334	340	PF00069	0.683
MOD_ProDKin_1	69	75	PF00069	0.688
MOD_SUMO_rev_2	228	232	PF00179	0.421
MOD_SUMO_rev_2	30	38	PF00179	0.513
MOD_SUMO_rev_2	56	64	PF00179	0.582
TRG_DiLeu_BaEn_4	239	245	PF01217	0.498
TRG_ENDOCYTIC_2	144	147	PF00928	0.564
TRG_ENDOCYTIC_2	241	244	PF00928	0.533
TRG_ENDOCYTIC_2	251	254	PF00928	0.490
TRG_ENDOCYTIC_2	378	381	PF00928	0.686
TRG_ER_diArg_1	194	197	PF00400	0.570
TRG_ER_diArg_1	241	243	PF00400	0.527
TRG_ER_diArg_1	254	257	PF00400	0.494
TRG_ER_diArg_1	349	352	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQN7	Leishmania donovani	76%	89%
A4H5Q1	Leishmania braziliensis	42%	100%
A4HTZ1	Leishmania infantum	76%	89%
E9AMS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	89%