Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHV1_LEIMA

TriTrypDb:

LmjF.09.0730 , LMJLV39_090013500 , LMJSD75_090013100

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHV1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	264	270	PF00089	0.593
CLV_NRD_NRD_1	114	116	PF00675	0.516
CLV_NRD_NRD_1	157	159	PF00675	0.626
CLV_NRD_NRD_1	163	165	PF00675	0.635
CLV_NRD_NRD_1	236	238	PF00675	0.507
CLV_NRD_NRD_1	33	35	PF00675	0.643
CLV_NRD_NRD_1	493	495	PF00675	0.520
CLV_PCSK_FUR_1	542	546	PF00082	0.571
CLV_PCSK_KEX2_1	114	116	PF00082	0.518
CLV_PCSK_KEX2_1	236	238	PF00082	0.507
CLV_PCSK_KEX2_1	33	35	PF00082	0.643
CLV_PCSK_KEX2_1	493	495	PF00082	0.520
CLV_PCSK_KEX2_1	544	546	PF00082	0.686
CLV_PCSK_KEX2_1	578	580	PF00082	0.572
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.620
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.571
CLV_PCSK_SKI1_1	325	329	PF00082	0.512
CLV_PCSK_SKI1_1	340	344	PF00082	0.453
CLV_PCSK_SKI1_1	52	56	PF00082	0.556
CLV_PCSK_SKI1_1	596	600	PF00082	0.632
DEG_Nend_UBRbox_2	1	3	PF02207	0.681
DEG_SPOP_SBC_1	64	68	PF00917	0.602
DOC_CYCLIN_RxL_1	322	331	PF00134	0.438
DOC_MAPK_gen_1	33	42	PF00069	0.577
DOC_MAPK_MEF2A_6	182	191	PF00069	0.581
DOC_MAPK_MEF2A_6	325	332	PF00069	0.519
DOC_PP2B_LxvP_1	509	512	PF13499	0.535
DOC_PP4_FxxP_1	235	238	PF00568	0.593
DOC_USP7_MATH_1	13	17	PF00917	0.601
DOC_USP7_MATH_1	245	249	PF00917	0.600
DOC_USP7_MATH_1	270	274	PF00917	0.625
DOC_USP7_MATH_1	517	521	PF00917	0.585
DOC_USP7_MATH_1	558	562	PF00917	0.705
DOC_USP7_MATH_1	65	69	PF00917	0.640
DOC_USP7_MATH_1	8	12	PF00917	0.596
DOC_WW_Pin1_4	17	22	PF00397	0.554
DOC_WW_Pin1_4	277	282	PF00397	0.591
DOC_WW_Pin1_4	443	448	PF00397	0.657
DOC_WW_Pin1_4	603	608	PF00397	0.522
LIG_14-3-3_CanoR_1	209	216	PF00244	0.719
LIG_14-3-3_CanoR_1	340	346	PF00244	0.479
LIG_14-3-3_CanoR_1	400	406	PF00244	0.597
LIG_14-3-3_CanoR_1	412	421	PF00244	0.440
LIG_14-3-3_CanoR_1	481	491	PF00244	0.746
LIG_14-3-3_CanoR_1	52	60	PF00244	0.644
LIG_14-3-3_CanoR_1	591	599	PF00244	0.519
LIG_14-3-3_CanoR_1	613	621	PF00244	0.624
LIG_Actin_WH2_2	335	351	PF00022	0.539
LIG_Actin_WH2_2	406	424	PF00022	0.568
LIG_AP2alpha_1	282	286	PF02296	0.600
LIG_BRCT_BRCA1_1	18	22	PF00533	0.584
LIG_BRCT_BRCA1_1	217	221	PF00533	0.523
LIG_eIF4E_1	317	323	PF01652	0.422
LIG_FHA_1	118	124	PF00498	0.509
LIG_FHA_1	30	36	PF00498	0.591
LIG_FHA_1	342	348	PF00498	0.551
LIG_FHA_1	504	510	PF00498	0.537
LIG_FHA_2	305	311	PF00498	0.478
LIG_FHA_2	364	370	PF00498	0.553
LIG_FHA_2	436	442	PF00498	0.611
LIG_FHA_2	514	520	PF00498	0.623
LIG_FHA_2	92	98	PF00498	0.521
LIG_GBD_Chelix_1	293	301	PF00786	0.587
LIG_GBD_Chelix_1	318	326	PF00786	0.438
LIG_LIR_Gen_1	116	125	PF02991	0.495
LIG_LIR_Gen_1	608	619	PF02991	0.651
LIG_LIR_Nem_3	116	121	PF02991	0.493
LIG_LIR_Nem_3	344	348	PF02991	0.461
LIG_LIR_Nem_3	50	54	PF02991	0.484
LIG_LIR_Nem_3	608	614	PF02991	0.562
LIG_LIR_Nem_3	96	102	PF02991	0.492
LIG_Pex14_2	282	286	PF04695	0.648
LIG_SH2_CRK	324	328	PF00017	0.443
LIG_SH2_CRK	51	55	PF00017	0.541
LIG_SH2_PTP2	380	383	PF00017	0.496
LIG_SH2_SRC	380	383	PF00017	0.434
LIG_SH2_STAT3	602	605	PF00017	0.513
LIG_SH2_STAT5	317	320	PF00017	0.421
LIG_SH2_STAT5	380	383	PF00017	0.444
LIG_SH2_STAT5	388	391	PF00017	0.461
LIG_SH2_STAT5	53	56	PF00017	0.522
LIG_SH2_STAT5	602	605	PF00017	0.513
LIG_SH2_STAT5	91	94	PF00017	0.579
LIG_SH3_1	190	196	PF00018	0.642
LIG_SH3_3	15	21	PF00018	0.614
LIG_SH3_3	190	196	PF00018	0.642
LIG_SH3_3	381	387	PF00018	0.515
LIG_SH3_3	554	560	PF00018	0.639
LIG_Sin3_3	319	326	PF02671	0.437
LIG_SUMO_SIM_anti_2	382	387	PF11976	0.496
LIG_SUMO_SIM_par_1	326	331	PF11976	0.513
LIG_TRAF2_1	287	290	PF00917	0.522
LIG_TYR_ITIM	322	327	PF00017	0.431
LIG_TYR_ITIM	49	54	PF00017	0.482
MOD_CK1_1	16	22	PF00069	0.658
MOD_CK1_1	274	280	PF00069	0.645
MOD_CK1_1	29	35	PF00069	0.516
MOD_CK1_1	66	72	PF00069	0.612
MOD_CK2_1	284	290	PF00069	0.578
MOD_CK2_1	304	310	PF00069	0.386
MOD_CK2_1	363	369	PF00069	0.565
MOD_CK2_1	435	441	PF00069	0.610
MOD_CK2_1	513	519	PF00069	0.686
MOD_CK2_1	91	97	PF00069	0.524
MOD_CMANNOS	174	177	PF00535	0.481
MOD_Cter_Amidation	576	579	PF01082	0.614
MOD_GlcNHglycan	146	149	PF01048	0.598
MOD_GlcNHglycan	217	220	PF01048	0.524
MOD_GlcNHglycan	27	31	PF01048	0.511
MOD_GlcNHglycan	276	279	PF01048	0.670
MOD_GlcNHglycan	286	289	PF01048	0.533
MOD_GlcNHglycan	358	361	PF01048	0.543
MOD_GlcNHglycan	414	417	PF01048	0.540
MOD_GlcNHglycan	519	522	PF01048	0.627
MOD_GlcNHglycan	560	563	PF01048	0.661
MOD_GlcNHglycan	587	590	PF01048	0.710
MOD_GlcNHglycan	8	11	PF01048	0.735
MOD_GSK3_1	12	19	PF00069	0.578
MOD_GSK3_1	144	151	PF00069	0.627
MOD_GSK3_1	2	9	PF00069	0.729
MOD_GSK3_1	240	247	PF00069	0.713
MOD_GSK3_1	270	277	PF00069	0.674
MOD_GSK3_1	395	402	PF00069	0.565
MOD_GSK3_1	408	415	PF00069	0.468
MOD_GSK3_1	435	442	PF00069	0.835
MOD_GSK3_1	511	518	PF00069	0.594
MOD_GSK3_1	580	587	PF00069	0.632
MOD_GSK3_1	60	67	PF00069	0.538
MOD_GSK3_1	601	608	PF00069	0.518
MOD_NEK2_1	1	6	PF00069	0.670
MOD_NEK2_1	131	136	PF00069	0.543
MOD_NEK2_1	328	333	PF00069	0.461
MOD_NEK2_1	356	361	PF00069	0.602
MOD_NEK2_1	363	368	PF00069	0.408
MOD_NEK2_1	399	404	PF00069	0.536
MOD_NEK2_1	503	508	PF00069	0.701
MOD_NEK2_1	534	539	PF00069	0.670
MOD_NEK2_1	54	59	PF00069	0.614
MOD_NEK2_1	585	590	PF00069	0.664
MOD_NEK2_1	60	65	PF00069	0.555
MOD_NEK2_1	78	83	PF00069	0.569
MOD_NEK2_2	567	572	PF00069	0.493
MOD_PIKK_1	590	596	PF00454	0.550
MOD_PIKK_1	601	607	PF00454	0.475
MOD_PKA_2	208	214	PF00069	0.587
MOD_PKA_2	399	405	PF00069	0.609
MOD_PKA_2	482	488	PF00069	0.549
MOD_PKA_2	590	596	PF00069	0.487
MOD_PKA_2	612	618	PF00069	0.662
MOD_Plk_1	328	334	PF00069	0.535
MOD_Plk_1	580	586	PF00069	0.638
MOD_Plk_2-3	435	441	PF00069	0.595
MOD_Plk_4	117	123	PF00069	0.533
MOD_Plk_4	13	19	PF00069	0.615
MOD_Plk_4	245	251	PF00069	0.608
MOD_Plk_4	528	534	PF00069	0.638
MOD_Plk_4	580	586	PF00069	0.638
MOD_ProDKin_1	17	23	PF00069	0.554
MOD_ProDKin_1	277	283	PF00069	0.590
MOD_ProDKin_1	443	449	PF00069	0.655
MOD_ProDKin_1	603	609	PF00069	0.524
MOD_SUMO_for_1	416	419	PF00179	0.556
TRG_DiLeu_BaEn_4	471	477	PF01217	0.647
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.448
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.574
TRG_ENDOCYTIC_2	324	327	PF00928	0.435
TRG_ENDOCYTIC_2	380	383	PF00928	0.496
TRG_ENDOCYTIC_2	51	54	PF00928	0.493
TRG_ENDOCYTIC_2	600	603	PF00928	0.706
TRG_ENDOCYTIC_2	99	102	PF00928	0.488
TRG_ER_diArg_1	189	192	PF00400	0.586
TRG_ER_diArg_1	223	226	PF00400	0.509
TRG_ER_diArg_1	235	237	PF00400	0.495
TRG_ER_diArg_1	33	35	PF00400	0.673
TRG_ER_diArg_1	481	484	PF00400	0.665
TRG_ER_diArg_1	492	494	PF00400	0.524
TRG_NES_CRM1_1	376	390	PF08389	0.468
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV8	Leptomonas seymouri	38%	100%
A0A3S7WQR1	Leishmania donovani	90%	100%
A4H5Q4	Leishmania braziliensis	68%	96%
A4HTZ4	Leishmania infantum	90%	100%
E9AMS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%