Putative acyl-CoA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA binding protein, putative

Species:

Leishmania major

UniProt:

Q4QHU9_LEIMA

TriTrypDb:

LmjF.09.0750 , LMJLV39_090013700 , LMJSD75_090013300

Length:

999

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHU9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	8
GO:0000166	nucleotide binding	3	8
GO:0005488	binding	1	8
GO:0008289	lipid binding	2	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0033218	amide binding	2	8
GO:0036094	small molecule binding	2	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0120227	acyl-CoA binding	3	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:1901567	fatty acid derivative binding	3	8
GO:1901681	sulfur compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.699
CLV_C14_Caspase3-7	174	178	PF00656	0.742
CLV_C14_Caspase3-7	5	9	PF00656	0.612
CLV_C14_Caspase3-7	734	738	PF00656	0.729
CLV_C14_Caspase3-7	976	980	PF00656	0.504
CLV_NRD_NRD_1	19	21	PF00675	0.456
CLV_NRD_NRD_1	225	227	PF00675	0.540
CLV_NRD_NRD_1	320	322	PF00675	0.461
CLV_NRD_NRD_1	525	527	PF00675	0.714
CLV_NRD_NRD_1	700	702	PF00675	0.488
CLV_NRD_NRD_1	879	881	PF00675	0.500
CLV_NRD_NRD_1	994	996	PF00675	0.367
CLV_NRD_NRD_1	997	999	PF00675	0.421
CLV_PCSK_KEX2_1	319	321	PF00082	0.467
CLV_PCSK_KEX2_1	524	526	PF00082	0.712
CLV_PCSK_KEX2_1	700	702	PF00082	0.492
CLV_PCSK_KEX2_1	879	881	PF00082	0.500
CLV_PCSK_KEX2_1	981	983	PF00082	0.304
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.476
CLV_PCSK_PC1ET2_1	981	983	PF00082	0.304
CLV_PCSK_SKI1_1	301	305	PF00082	0.423
CLV_PCSK_SKI1_1	308	312	PF00082	0.393
CLV_PCSK_SKI1_1	502	506	PF00082	0.624
CLV_PCSK_SKI1_1	701	705	PF00082	0.494
CLV_PCSK_SKI1_1	83	87	PF00082	0.406
CLV_PCSK_SKI1_1	879	883	PF00082	0.497
CLV_PCSK_SKI1_1	943	947	PF00082	0.262
DEG_APCC_DBOX_1	300	308	PF00400	0.620
DEG_APCC_DBOX_1	82	90	PF00400	0.601
DEG_APCC_DBOX_1	871	879	PF00400	0.600
DEG_SPOP_SBC_1	243	247	PF00917	0.712
DEG_SPOP_SBC_1	747	751	PF00917	0.664
DOC_CKS1_1	230	235	PF01111	0.715
DOC_CYCLIN_RxL_1	305	313	PF00134	0.647
DOC_CYCLIN_RxL_1	653	663	PF00134	0.638
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.638
DOC_MAPK_gen_1	533	541	PF00069	0.485
DOC_MAPK_gen_1	700	711	PF00069	0.709
DOC_MAPK_MEF2A_6	502	510	PF00069	0.429
DOC_MAPK_MEF2A_6	595	604	PF00069	0.287
DOC_MAPK_MEF2A_6	83	91	PF00069	0.556
DOC_MAPK_MEF2A_6	929	938	PF00069	0.529
DOC_PP1_RVXF_1	421	428	PF00149	0.308
DOC_PP1_RVXF_1	500	506	PF00149	0.432
DOC_PP1_RVXF_1	933	939	PF00149	0.514
DOC_PP4_FxxP_1	427	430	PF00568	0.233
DOC_PP4_FxxP_1	591	594	PF00568	0.478
DOC_PP4_MxPP_1	824	827	PF00568	0.700
DOC_USP7_MATH_1	243	247	PF00917	0.793
DOC_USP7_MATH_1	471	475	PF00917	0.519
DOC_USP7_MATH_1	742	746	PF00917	0.760
DOC_USP7_MATH_1	748	752	PF00917	0.763
DOC_USP7_MATH_1	754	758	PF00917	0.714
DOC_USP7_MATH_1	807	811	PF00917	0.730
DOC_USP7_MATH_1	897	901	PF00917	0.784
DOC_USP7_MATH_1	908	912	PF00917	0.646
DOC_WW_Pin1_4	146	151	PF00397	0.664
DOC_WW_Pin1_4	161	166	PF00397	0.711
DOC_WW_Pin1_4	190	195	PF00397	0.698
DOC_WW_Pin1_4	229	234	PF00397	0.737
DOC_WW_Pin1_4	235	240	PF00397	0.749
DOC_WW_Pin1_4	244	249	PF00397	0.625
DOC_WW_Pin1_4	345	350	PF00397	0.709
DOC_WW_Pin1_4	440	445	PF00397	0.518
DOC_WW_Pin1_4	452	457	PF00397	0.439
DOC_WW_Pin1_4	590	595	PF00397	0.459
DOC_WW_Pin1_4	637	642	PF00397	0.692
DOC_WW_Pin1_4	750	755	PF00397	0.643
DOC_WW_Pin1_4	783	788	PF00397	0.688
DOC_WW_Pin1_4	822	827	PF00397	0.737
LIG_14-3-3_CanoR_1	217	225	PF00244	0.687
LIG_14-3-3_CanoR_1	321	331	PF00244	0.736
LIG_14-3-3_CanoR_1	410	415	PF00244	0.744
LIG_14-3-3_CanoR_1	525	531	PF00244	0.516
LIG_14-3-3_CanoR_1	535	539	PF00244	0.461
LIG_14-3-3_CanoR_1	649	657	PF00244	0.640
LIG_14-3-3_CanoR_1	806	812	PF00244	0.717
LIG_14-3-3_CanoR_1	859	865	PF00244	0.680
LIG_14-3-3_CanoR_1	982	992	PF00244	0.580
LIG_BIR_III_4	177	181	PF00653	0.746
LIG_BRCT_BRCA1_1	454	458	PF00533	0.489
LIG_BRCT_BRCA1_1	597	601	PF00533	0.357
LIG_CaM_IQ_9	59	75	PF13499	0.539
LIG_CtBP_PxDLS_1	444	448	PF00389	0.459
LIG_deltaCOP1_diTrp_1	784	792	PF00928	0.689
LIG_EVH1_1	486	490	PF00568	0.478
LIG_EVH1_2	487	491	PF00568	0.478
LIG_FHA_1	182	188	PF00498	0.736
LIG_FHA_1	326	332	PF00498	0.720
LIG_FHA_1	346	352	PF00498	0.723
LIG_FHA_1	38	44	PF00498	0.559
LIG_FHA_2	100	106	PF00498	0.641
LIG_FHA_2	379	385	PF00498	0.677
LIG_FHA_2	650	656	PF00498	0.666
LIG_FHA_2	758	764	PF00498	0.695
LIG_FHA_2	868	874	PF00498	0.688
LIG_FHA_2	944	950	PF00498	0.462
LIG_HCF-1_HBM_1	79	82	PF13415	0.586
LIG_LIR_Gen_1	14	22	PF02991	0.662
LIG_LIR_Gen_1	455	465	PF02991	0.505
LIG_LIR_Gen_1	577	583	PF02991	0.452
LIG_LIR_Gen_1	598	609	PF02991	0.376
LIG_LIR_Gen_1	967	977	PF02991	0.462
LIG_LIR_Nem_3	111	116	PF02991	0.569
LIG_LIR_Nem_3	14	19	PF02991	0.668
LIG_LIR_Nem_3	40	44	PF02991	0.604
LIG_LIR_Nem_3	402	408	PF02991	0.659
LIG_LIR_Nem_3	455	461	PF02991	0.505
LIG_LIR_Nem_3	577	582	PF02991	0.457
LIG_LIR_Nem_3	585	591	PF02991	0.475
LIG_LIR_Nem_3	598	604	PF02991	0.376
LIG_LIR_Nem_3	655	660	PF02991	0.600
LIG_LIR_Nem_3	686	692	PF02991	0.713
LIG_LIR_Nem_3	710	716	PF02991	0.592
LIG_LIR_Nem_3	79	85	PF02991	0.602
LIG_LIR_Nem_3	967	972	PF02991	0.462
LIG_MYND_2	373	377	PF01753	0.626
LIG_Pex14_2	401	405	PF04695	0.607
LIG_Pex14_2	435	439	PF04695	0.392
LIG_Pex14_2	505	509	PF04695	0.380
LIG_Pex14_2	597	601	PF04695	0.357
LIG_Pex14_2	657	661	PF04695	0.604
LIG_Pex14_2	938	942	PF04695	0.514
LIG_SH2_CRK	82	86	PF00017	0.559
LIG_SH2_NCK_1	714	718	PF00017	0.627
LIG_SH2_STAT3	984	987	PF00017	0.415
LIG_SH2_STAT5	145	148	PF00017	0.697
LIG_SH2_STAT5	298	301	PF00017	0.665
LIG_SH2_STAT5	362	365	PF00017	0.657
LIG_SH2_STAT5	57	60	PF00017	0.581
LIG_SH2_STAT5	579	582	PF00017	0.456
LIG_SH2_STAT5	588	591	PF00017	0.421
LIG_SH2_STAT5	645	648	PF00017	0.632
LIG_SH2_STAT5	984	987	PF00017	0.462
LIG_SH3_3	163	169	PF00018	0.718
LIG_SH3_3	173	179	PF00018	0.705
LIG_SH3_3	346	352	PF00018	0.652
LIG_SH3_3	367	373	PF00018	0.675
LIG_SH3_3	484	490	PF00018	0.484
LIG_SH3_3	612	618	PF00018	0.580
LIG_SH3_3	633	639	PF00018	0.653
LIG_SUMO_SIM_anti_2	390	395	PF11976	0.628
LIG_SUMO_SIM_anti_2	707	713	PF11976	0.642
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.615
LIG_SUMO_SIM_par_1	373	378	PF11976	0.632
LIG_SUMO_SIM_par_1	396	402	PF11976	0.555
LIG_SUMO_SIM_par_1	85	90	PF11976	0.586
LIG_SUMO_SIM_par_1	93	102	PF11976	0.648
LIG_TRAF2_1	723	726	PF00917	0.665
LIG_TRAF2_1	802	805	PF00917	0.723
LIG_TYR_ITIM	711	716	PF00017	0.636
LIG_UBA3_1	563	568	PF00899	0.444
LIG_UBA3_1	620	627	PF00899	0.647
LIG_UBA3_1	990	999	PF00899	0.611
MOD_CDC14_SPxK_1	640	643	PF00782	0.664
MOD_CDK_SPK_2	590	595	PF00069	0.442
MOD_CDK_SPxK_1	229	235	PF00069	0.821
MOD_CDK_SPxK_1	637	643	PF00069	0.674
MOD_CDK_SPxK_1	783	789	PF00069	0.678
MOD_CK1_1	14	20	PF00069	0.646
MOD_CK1_1	148	154	PF00069	0.665
MOD_CK1_1	364	370	PF00069	0.689
MOD_CK1_1	440	446	PF00069	0.505
MOD_CK1_1	454	460	PF00069	0.570
MOD_CK1_1	466	472	PF00069	0.572
MOD_CK1_1	749	755	PF00069	0.643
MOD_CK1_1	757	763	PF00069	0.728
MOD_CK1_1	793	799	PF00069	0.739
MOD_CK1_1	810	816	PF00069	0.616
MOD_CK2_1	649	655	PF00069	0.635
MOD_CK2_1	704	710	PF00069	0.627
MOD_CK2_1	757	763	PF00069	0.702
MOD_CK2_1	810	816	PF00069	0.759
MOD_CK2_1	867	873	PF00069	0.684
MOD_CMANNOS	966	969	PF00535	0.262
MOD_Cter_Amidation	522	525	PF01082	0.695
MOD_GlcNHglycan	150	153	PF01048	0.470
MOD_GlcNHglycan	221	224	PF01048	0.507
MOD_GlcNHglycan	252	255	PF01048	0.565
MOD_GlcNHglycan	353	356	PF01048	0.471
MOD_GlcNHglycan	447	450	PF01048	0.702
MOD_GlcNHglycan	45	49	PF01048	0.453
MOD_GlcNHglycan	464	468	PF01048	0.779
MOD_GlcNHglycan	517	522	PF01048	0.702
MOD_GlcNHglycan	559	562	PF01048	0.640
MOD_GlcNHglycan	597	600	PF01048	0.384
MOD_GlcNHglycan	606	609	PF01048	0.431
MOD_GlcNHglycan	696	699	PF01048	0.500
MOD_GlcNHglycan	744	747	PF01048	0.633
MOD_GlcNHglycan	756	759	PF01048	0.519
MOD_GlcNHglycan	812	815	PF01048	0.531
MOD_GlcNHglycan	899	902	PF01048	0.532
MOD_GlcNHglycan	917	920	PF01048	0.258
MOD_GSK3_1	141	148	PF00069	0.634
MOD_GSK3_1	225	232	PF00069	0.739
MOD_GSK3_1	325	332	PF00069	0.713
MOD_GSK3_1	336	343	PF00069	0.629
MOD_GSK3_1	439	446	PF00069	0.539
MOD_GSK3_1	447	454	PF00069	0.611
MOD_GSK3_1	466	473	PF00069	0.523
MOD_GSK3_1	553	560	PF00069	0.442
MOD_GSK3_1	568	575	PF00069	0.343
MOD_GSK3_1	600	607	PF00069	0.383
MOD_GSK3_1	637	644	PF00069	0.636
MOD_GSK3_1	742	749	PF00069	0.776
MOD_GSK3_1	750	757	PF00069	0.659
MOD_GSK3_1	788	795	PF00069	0.754
MOD_GSK3_1	822	829	PF00069	0.772
MOD_N-GLC_1	437	442	PF02516	0.668
MOD_N-GLC_1	850	855	PF02516	0.489
MOD_N-GLC_2	275	277	PF02516	0.414
MOD_NEK2_1	120	125	PF00069	0.691
MOD_NEK2_1	310	315	PF00069	0.658
MOD_NEK2_1	439	444	PF00069	0.435
MOD_NEK2_1	44	49	PF00069	0.653
MOD_NEK2_1	447	452	PF00069	0.471
MOD_NEK2_1	470	475	PF00069	0.570
MOD_NEK2_1	491	496	PF00069	0.487
MOD_NEK2_1	544	549	PF00069	0.492
MOD_NEK2_1	554	559	PF00069	0.413
MOD_NEK2_1	589	594	PF00069	0.546
MOD_NEK2_1	600	605	PF00069	0.359
MOD_NEK2_1	778	783	PF00069	0.720
MOD_NEK2_1	792	797	PF00069	0.726
MOD_NEK2_1	828	833	PF00069	0.799
MOD_NEK2_1	923	928	PF00069	0.512
MOD_NEK2_1	983	988	PF00069	0.501
MOD_NEK2_1	994	999	PF00069	0.611
MOD_PIKK_1	796	802	PF00454	0.743
MOD_PIKK_1	983	989	PF00454	0.415
MOD_PIKK_1	99	105	PF00454	0.658
MOD_PKA_1	20	26	PF00069	0.660
MOD_PKA_2	218	224	PF00069	0.715
MOD_PKA_2	225	231	PF00069	0.761
MOD_PKA_2	534	540	PF00069	0.453
MOD_PKA_2	648	654	PF00069	0.649
MOD_PKA_2	788	794	PF00069	0.736
MOD_PKA_2	858	864	PF00069	0.658
MOD_PKA_2	928	934	PF00069	0.431
MOD_PKB_1	217	225	PF00069	0.694
MOD_PKB_1	524	532	PF00069	0.488
MOD_Plk_1	14	20	PF00069	0.663
MOD_Plk_1	437	443	PF00069	0.466
MOD_Plk_1	554	560	PF00069	0.548
MOD_Plk_1	572	578	PF00069	0.360
MOD_Plk_1	87	93	PF00069	0.606
MOD_Plk_2-3	378	384	PF00069	0.635
MOD_Plk_2-3	844	850	PF00069	0.670
MOD_Plk_4	141	147	PF00069	0.698
MOD_Plk_4	310	316	PF00069	0.679
MOD_Plk_4	364	370	PF00069	0.694
MOD_Plk_4	378	384	PF00069	0.579
MOD_Plk_4	410	416	PF00069	0.700
MOD_Plk_4	454	460	PF00069	0.469
MOD_Plk_4	534	540	PF00069	0.453
MOD_Plk_4	554	560	PF00069	0.451
MOD_Plk_4	600	606	PF00069	0.307
MOD_Plk_4	627	633	PF00069	0.648
MOD_Plk_4	8	14	PF00069	0.603
MOD_Plk_4	87	93	PF00069	0.563
MOD_ProDKin_1	146	152	PF00069	0.669
MOD_ProDKin_1	161	167	PF00069	0.714
MOD_ProDKin_1	190	196	PF00069	0.695
MOD_ProDKin_1	229	235	PF00069	0.739
MOD_ProDKin_1	244	250	PF00069	0.751
MOD_ProDKin_1	345	351	PF00069	0.704
MOD_ProDKin_1	440	446	PF00069	0.520
MOD_ProDKin_1	452	458	PF00069	0.440
MOD_ProDKin_1	590	596	PF00069	0.455
MOD_ProDKin_1	637	643	PF00069	0.695
MOD_ProDKin_1	750	756	PF00069	0.642
MOD_ProDKin_1	783	789	PF00069	0.692
MOD_ProDKin_1	822	828	PF00069	0.739
MOD_SUMO_rev_2	930	936	PF00179	0.494
MOD_SUMO_rev_2	976	983	PF00179	0.504
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.630
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.655
TRG_ENDOCYTIC_2	579	582	PF00928	0.461
TRG_ENDOCYTIC_2	588	591	PF00928	0.413
TRG_ENDOCYTIC_2	713	716	PF00928	0.591
TRG_ENDOCYTIC_2	82	85	PF00928	0.559
TRG_ENDOCYTIC_2	939	942	PF00928	0.514
TRG_ENDOCYTIC_2	988	991	PF00928	0.538
TRG_ER_diArg_1	217	220	PF00400	0.754
TRG_ER_diArg_1	524	526	PF00400	0.515
TRG_ER_diArg_1	700	702	PF00400	0.745
TRG_ER_diArg_1	705	708	PF00400	0.625
TRG_ER_diArg_1	878	880	PF00400	0.693
TRG_NLS_Bipartite_1	981	999	PF00514	0.572
TRG_NLS_MonoExtC_3	994	999	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	658	663	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G9	Leptomonas seymouri	53%	100%
A0A3S7WQP7	Leishmania donovani	94%	100%
A4H5Q6	Leishmania braziliensis	72%	82%
A4HTZ6	Leishmania infantum	94%	100%
D0A9G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AMS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%