Prolyl endopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligopeptidase b

Species:

Leishmania major

UniProt:

Q4QHU7_LEIMA

TriTrypDb:

LmjF.09.0770 , LMJLV39_090013900 , LMJSD75_090013500

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QHU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHU7

PDB structure(s): 2xe4_A

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004252	serine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0070012	oligopeptidase activity	5	2
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.570
CLV_NRD_NRD_1	282	284	PF00675	0.336
CLV_NRD_NRD_1	366	368	PF00675	0.332
CLV_NRD_NRD_1	462	464	PF00675	0.490
CLV_NRD_NRD_1	55	57	PF00675	0.369
CLV_PCSK_KEX2_1	186	188	PF00082	0.394
CLV_PCSK_KEX2_1	366	368	PF00082	0.332
CLV_PCSK_KEX2_1	462	464	PF00082	0.461
CLV_PCSK_KEX2_1	546	548	PF00082	0.382
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.342
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.373
CLV_PCSK_SKI1_1	113	117	PF00082	0.354
CLV_PCSK_SKI1_1	125	129	PF00082	0.361
CLV_PCSK_SKI1_1	463	467	PF00082	0.505
CLV_PCSK_SKI1_1	542	546	PF00082	0.389
CLV_PCSK_SKI1_1	595	599	PF00082	0.430
CLV_PCSK_SKI1_1	719	723	PF00082	0.407
CLV_Separin_Metazoa	292	296	PF03568	0.561
DEG_APCC_DBOX_1	366	374	PF00400	0.532
DEG_APCC_DBOX_1	589	597	PF00400	0.385
DOC_CKS1_1	425	430	PF01111	0.520
DOC_CKS1_1	565	570	PF01111	0.389
DOC_MAPK_gen_1	18	25	PF00069	0.599
DOC_MAPK_gen_1	719	729	PF00069	0.552
DOC_MAPK_MEF2A_6	647	656	PF00069	0.373
DOC_MAPK_MEF2A_6	722	729	PF00069	0.512
DOC_PP1_RVXF_1	20	26	PF00149	0.577
DOC_PP1_RVXF_1	67	73	PF00149	0.459
DOC_PP2B_LxvP_1	328	331	PF13499	0.570
DOC_PP2B_PxIxI_1	651	657	PF00149	0.458
DOC_PP4_MxPP_1	38	41	PF00568	0.520
DOC_USP7_MATH_1	355	359	PF00917	0.570
DOC_USP7_UBL2_3	542	546	PF12436	0.373
DOC_USP7_UBL2_3	672	676	PF12436	0.373
DOC_USP7_UBL2_3	701	705	PF12436	0.484
DOC_WW_Pin1_4	268	273	PF00397	0.600
DOC_WW_Pin1_4	424	429	PF00397	0.520
DOC_WW_Pin1_4	432	437	PF00397	0.520
DOC_WW_Pin1_4	564	569	PF00397	0.389
DOC_WW_Pin1_4	638	643	PF00397	0.373
LIG_14-3-3_CanoR_1	125	132	PF00244	0.459
LIG_14-3-3_CanoR_1	187	191	PF00244	0.596
LIG_14-3-3_CanoR_1	22	26	PF00244	0.603
LIG_14-3-3_CanoR_1	372	377	PF00244	0.532
LIG_14-3-3_CanoR_1	462	468	PF00244	0.512
LIG_14-3-3_CanoR_1	547	551	PF00244	0.373
LIG_APCC_ABBA_1	242	247	PF00400	0.520
LIG_APCC_ABBAyCdc20_2	83	89	PF00400	0.606
LIG_BIR_II_1	1	5	PF00653	0.710
LIG_BRCT_BRCA1_1	694	698	PF00533	0.373
LIG_Clathr_ClatBox_1	688	692	PF01394	0.373
LIG_deltaCOP1_diTrp_1	621	625	PF00928	0.373
LIG_FHA_1	110	116	PF00498	0.511
LIG_FHA_1	260	266	PF00498	0.517
LIG_FHA_1	272	278	PF00498	0.499
LIG_FHA_1	288	294	PF00498	0.584
LIG_FHA_1	308	314	PF00498	0.513
LIG_FHA_1	400	406	PF00498	0.559
LIG_FHA_1	722	728	PF00498	0.508
LIG_FHA_2	126	132	PF00498	0.523
LIG_FHA_2	192	198	PF00498	0.626
LIG_FHA_2	200	206	PF00498	0.487
LIG_FHA_2	217	223	PF00498	0.493
LIG_FHA_2	428	434	PF00498	0.524
LIG_FHA_2	464	470	PF00498	0.492
LIG_FHA_2	547	553	PF00498	0.369
LIG_FHA_2	607	613	PF00498	0.373
LIG_FHA_2	616	622	PF00498	0.373
LIG_LIR_Apic_2	412	416	PF02991	0.603
LIG_LIR_Apic_2	623	628	PF02991	0.373
LIG_LIR_Gen_1	336	343	PF02991	0.546
LIG_LIR_Gen_1	358	368	PF02991	0.561
LIG_LIR_Gen_1	371	378	PF02991	0.561
LIG_LIR_Gen_1	421	428	PF02991	0.551
LIG_LIR_Gen_1	549	557	PF02991	0.373
LIG_LIR_LC3C_4	358	363	PF02991	0.598
LIG_LIR_Nem_3	182	188	PF02991	0.605
LIG_LIR_Nem_3	24	28	PF02991	0.507
LIG_LIR_Nem_3	336	341	PF02991	0.521
LIG_LIR_Nem_3	358	363	PF02991	0.570
LIG_LIR_Nem_3	421	425	PF02991	0.550
LIG_LIR_Nem_3	430	434	PF02991	0.513
LIG_LIR_Nem_3	549	553	PF02991	0.369
LIG_LIR_Nem_3	630	636	PF02991	0.373
LIG_LIR_Nem_3	650	654	PF02991	0.189
LIG_LYPXL_yS_3	651	654	PF13949	0.373
LIG_NRP_CendR_1	730	731	PF00754	0.590
LIG_PTB_Apo_2	246	253	PF02174	0.606
LIG_SH2_CRK	123	127	PF00017	0.606
LIG_SH2_CRK	422	426	PF00017	0.606
LIG_SH2_NCK_1	413	417	PF00017	0.575
LIG_SH2_SRC	103	106	PF00017	0.572
LIG_SH2_SRC	245	248	PF00017	0.526
LIG_SH2_SRC	27	30	PF00017	0.637
LIG_SH2_SRC	413	416	PF00017	0.625
LIG_SH2_SRC	537	540	PF00017	0.500
LIG_SH2_SRC	87	90	PF00017	0.552
LIG_SH2_STAP1	111	115	PF00017	0.524
LIG_SH2_STAP1	181	185	PF00017	0.566
LIG_SH2_STAP1	303	307	PF00017	0.532
LIG_SH2_STAP1	422	426	PF00017	0.592
LIG_SH2_STAP1	634	638	PF00017	0.493
LIG_SH2_STAP1	87	91	PF00017	0.599
LIG_SH2_STAT3	303	306	PF00017	0.606
LIG_SH2_STAT5	103	106	PF00017	0.503
LIG_SH2_STAT5	111	114	PF00017	0.510
LIG_SH2_STAT5	123	126	PF00017	0.389
LIG_SH2_STAT5	181	184	PF00017	0.531
LIG_SH2_STAT5	217	220	PF00017	0.520
LIG_SH2_STAT5	27	30	PF00017	0.602
LIG_SH2_STAT5	360	363	PF00017	0.606
LIG_SH2_STAT5	48	51	PF00017	0.606
LIG_SH2_STAT5	514	517	PF00017	0.384
LIG_SH2_STAT5	543	546	PF00017	0.385
LIG_SH2_STAT5	71	74	PF00017	0.545
LIG_SH3_2	37	42	PF14604	0.545
LIG_SH3_3	158	164	PF00018	0.515
LIG_SH3_3	204	210	PF00018	0.568
LIG_SH3_3	34	40	PF00018	0.545
LIG_SH3_3	610	616	PF00018	0.373
LIG_SUMO_SIM_anti_2	290	295	PF11976	0.609
LIG_SUMO_SIM_anti_2	310	317	PF11976	0.512
LIG_SUMO_SIM_par_1	310	317	PF11976	0.510
LIG_TRAF2_1	136	139	PF00917	0.600
LIG_UBA3_1	279	284	PF00899	0.352
LIG_WW_1	40	43	PF00397	0.488
LIG_WW_3	39	43	PF00397	0.389
MOD_CK1_1	189	195	PF00069	0.286
MOD_CK1_1	2	8	PF00069	0.743
MOD_CK1_1	271	277	PF00069	0.363
MOD_CK1_1	336	342	PF00069	0.425
MOD_CK1_1	424	430	PF00069	0.385
MOD_CK2_1	125	131	PF00069	0.355
MOD_CK2_1	173	179	PF00069	0.407
MOD_CK2_1	199	205	PF00069	0.493
MOD_CK2_1	216	222	PF00069	0.493
MOD_CK2_1	615	621	PF00069	0.373
MOD_CMANNOS	622	625	PF00535	0.373
MOD_Cter_Amidation	364	367	PF01082	0.389
MOD_GlcNHglycan	174	178	PF01048	0.430
MOD_GlcNHglycan	199	202	PF01048	0.519
MOD_GlcNHglycan	252	255	PF01048	0.385
MOD_GlcNHglycan	576	579	PF01048	0.384
MOD_GlcNHglycan	694	697	PF01048	0.373
MOD_GlcNHglycan	698	701	PF01048	0.373
MOD_GlcNHglycan	709	712	PF01048	0.373
MOD_GlcNHglycan	75	78	PF01048	0.530
MOD_GlcNHglycan	9	12	PF01048	0.678
MOD_GlcNHglycan	96	102	PF01048	0.381
MOD_GSK3_1	169	176	PF00069	0.398
MOD_GSK3_1	216	223	PF00069	0.466
MOD_GSK3_1	3	10	PF00069	0.737
MOD_GSK3_1	368	375	PF00069	0.374
MOD_GSK3_1	420	427	PF00069	0.396
MOD_GSK3_1	495	502	PF00069	0.549
MOD_GSK3_1	542	549	PF00069	0.373
MOD_GSK3_1	611	618	PF00069	0.373
MOD_GSK3_1	692	699	PF00069	0.373
MOD_LATS_1	525	531	PF00433	0.493
MOD_NEK2_1	307	312	PF00069	0.430
MOD_NEK2_1	350	355	PF00069	0.490
MOD_NEK2_1	405	410	PF00069	0.401
MOD_NEK2_1	420	425	PF00069	0.354
MOD_NEK2_1	483	488	PF00069	0.504
MOD_NEK2_1	721	726	PF00069	0.548
MOD_NEK2_2	399	404	PF00069	0.481
MOD_PIKK_1	189	195	PF00454	0.286
MOD_PIKK_1	266	272	PF00454	0.520
MOD_PIKK_1	377	383	PF00454	0.286
MOD_PIKK_1	405	411	PF00454	0.428
MOD_PIKK_1	483	489	PF00454	0.595
MOD_PIKK_1	566	572	PF00454	0.458
MOD_PKA_1	186	192	PF00069	0.488
MOD_PKA_1	546	552	PF00069	0.373
MOD_PKA_2	186	192	PF00069	0.481
MOD_PKA_2	21	27	PF00069	0.613
MOD_PKA_2	546	552	PF00069	0.373
MOD_Plk_1	210	216	PF00069	0.406
MOD_Plk_1	220	226	PF00069	0.380
MOD_Plk_1	3	9	PF00069	0.629
MOD_Plk_1	336	342	PF00069	0.515
MOD_Plk_1	420	426	PF00069	0.465
MOD_Plk_2-3	179	185	PF00069	0.473
MOD_Plk_4	211	217	PF00069	0.466
MOD_Plk_4	427	433	PF00069	0.373
MOD_Plk_4	473	479	PF00069	0.434
MOD_ProDKin_1	268	274	PF00069	0.484
MOD_ProDKin_1	424	430	PF00069	0.373
MOD_ProDKin_1	432	438	PF00069	0.373
MOD_ProDKin_1	564	570	PF00069	0.389
MOD_ProDKin_1	638	644	PF00069	0.373
MOD_SUMO_rev_2	143	153	PF00179	0.365
MOD_SUMO_rev_2	155	162	PF00179	0.396
MOD_SUMO_rev_2	179	188	PF00179	0.493
MOD_SUMO_rev_2	221	229	PF00179	0.377
MOD_SUMO_rev_2	53	59	PF00179	0.445
MOD_SUMO_rev_2	675	682	PF00179	0.409
TRG_DiLeu_BaLyEn_6	723	728	PF01217	0.545
TRG_ENDOCYTIC_2	123	126	PF00928	0.489
TRG_ENDOCYTIC_2	360	363	PF00928	0.475
TRG_ENDOCYTIC_2	422	425	PF00928	0.373
TRG_ENDOCYTIC_2	48	51	PF00928	0.473
TRG_ENDOCYTIC_2	634	637	PF00928	0.384
TRG_ENDOCYTIC_2	640	643	PF00928	0.390
TRG_ENDOCYTIC_2	651	654	PF00928	0.493
TRG_ER_diArg_1	294	297	PF00400	0.360
TRG_ER_diArg_1	462	464	PF00400	0.489
TRG_ER_diArg_1	729	731	PF00400	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J4	Leptomonas seymouri	81%	100%
A0A0N1PDP3	Leptomonas seymouri	25%	84%
A0A0S4J065	Bodo saltans	24%	79%
A0A0S4JND1	Bodo saltans	56%	98%
A0A1X0NKN5	Trypanosomatidae	25%	80%
A0A1X0NMH6	Trypanosomatidae	65%	100%
A0A3Q8IGZ3	Leishmania donovani	96%	100%
A0A3S5H5P5	Leishmania donovani	24%	81%
A0A422N761	Trypanosoma rangeli	66%	100%
A4H4J9	Leishmania braziliensis	24%	81%
A4H5Q8	Leishmania braziliensis	86%	100%
A4HSS5	Leishmania infantum	24%	81%
A4HTZ8	Leishmania infantum	96%	100%
A4ICB5	Leishmania infantum	25%	100%
A5LFV8	Macaca fascicularis	25%	100%
C9ZTC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	81%
D0A9G2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E2JFG1	Amanita bisporigera	22%	96%
E2JFG2	Amanita bisporigera	25%	100%
E9AKR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	81%
E9AMS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
H2E7Q7	Galerina marginata (strain CBS 339.88)	23%	99%
H2E7Q8	Galerina marginata (strain CBS 339.88)	25%	100%
O07834	Pseudoxanthomonas mexicana	38%	100%
O70196	Rattus norvegicus	25%	100%
P23687	Sus scrofa	25%	100%
P24555	Escherichia coli (strain K12)	36%	100%
P27028	Elizabethkingia meningoseptica	27%	100%
P27195	Elizabethkingia miricola	27%	100%
P48147	Homo sapiens	24%	100%
P55627	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	27%	97%
P55656	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	27%	100%
Q06903	Aeromonas hydrophila	25%	100%
Q4QJ45	Leishmania major	23%	81%
Q59536	Moraxella lacunata	38%	100%
Q5HZA6	Rattus norvegicus	25%	100%
Q9QUR6	Mus musculus	25%	100%
Q9XTA2	Bos taurus	25%	100%
V5B5S3	Trypanosoma cruzi	25%	85%
V5B860	Trypanosoma cruzi	63%	100%