Cilia- and flagella-associated protein 299

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4464), putative

Species:

Leishmania major

UniProt:

Q4QHU6_LEIMA

TriTrypDb:

LmjF.09.0780 , LMJLV39_090014000 , LMJSD75_090013600

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QHU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.490
CLV_C14_Caspase3-7	67	71	PF00656	0.452
CLV_NRD_NRD_1	105	107	PF00675	0.212
CLV_NRD_NRD_1	222	224	PF00675	0.199
CLV_NRD_NRD_1	260	262	PF00675	0.196
CLV_NRD_NRD_1	72	74	PF00675	0.289
CLV_PCSK_KEX2_1	104	106	PF00082	0.209
CLV_PCSK_KEX2_1	130	132	PF00082	0.196
CLV_PCSK_KEX2_1	183	185	PF00082	0.210
CLV_PCSK_KEX2_1	220	222	PF00082	0.196
CLV_PCSK_KEX2_1	260	262	PF00082	0.196
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.252
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.227
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.219
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.196
CLV_PCSK_SKI1_1	139	143	PF00082	0.246
CLV_PCSK_SKI1_1	178	182	PF00082	0.209
CLV_PCSK_SKI1_1	42	46	PF00082	0.221
CLV_PCSK_SKI1_1	83	87	PF00082	0.209
CLV_Separin_Metazoa	133	137	PF03568	0.381
DOC_MAPK_gen_1	136	146	PF00069	0.396
DOC_MAPK_gen_1	218	228	PF00069	0.396
DOC_USP7_MATH_1	182	186	PF00917	0.452
DOC_USP7_MATH_2	235	241	PF00917	0.453
DOC_USP7_UBL2_3	175	179	PF12436	0.462
DOC_USP7_UBL2_3	220	224	PF12436	0.396
DOC_WW_Pin1_4	119	124	PF00397	0.452
DOC_WW_Pin1_4	19	24	PF00397	0.494
DOC_WW_Pin1_4	199	204	PF00397	0.490
DOC_WW_Pin1_4	229	234	PF00397	0.431
LIG_14-3-3_CanoR_1	164	173	PF00244	0.396
LIG_14-3-3_CanoR_1	29	33	PF00244	0.531
LIG_APCC_ABBAyCdc20_2	223	229	PF00400	0.490
LIG_BRCT_BRCA1_1	166	170	PF00533	0.458
LIG_BRCT_BRCA1_1	201	205	PF00533	0.396
LIG_Clathr_ClatBox_1	63	67	PF01394	0.490
LIG_FHA_1	135	141	PF00498	0.490
LIG_FHA_1	192	198	PF00498	0.396
LIG_FHA_1	20	26	PF00498	0.557
LIG_FHA_1	202	208	PF00498	0.396
LIG_FHA_1	210	216	PF00498	0.396
LIG_FHA_1	98	104	PF00498	0.453
LIG_FHA_2	47	53	PF00498	0.427
LIG_FHA_2	57	63	PF00498	0.377
LIG_KLC1_Yacidic_2	62	67	PF13176	0.452
LIG_LIR_Gen_1	202	213	PF02991	0.405
LIG_LIR_Nem_3	156	161	PF02991	0.414
LIG_LIR_Nem_3	167	173	PF02991	0.437
LIG_LIR_Nem_3	202	208	PF02991	0.402
LIG_LIR_Nem_3	46	50	PF02991	0.403
LIG_Pex14_1	11	15	PF04695	0.418
LIG_Pex14_2	170	174	PF04695	0.396
LIG_SH2_GRB2like	189	192	PF00017	0.405
LIG_SH2_NCK_1	255	259	PF00017	0.399
LIG_SH2_SRC	255	258	PF00017	0.422
LIG_SH2_STAP1	50	54	PF00017	0.402
LIG_SH2_STAT3	53	56	PF00017	0.396
LIG_SH2_STAT5	149	152	PF00017	0.435
LIG_SH2_STAT5	158	161	PF00017	0.378
LIG_SH2_STAT5	173	176	PF00017	0.385
LIG_SH2_STAT5	21	24	PF00017	0.433
LIG_SH2_STAT5	249	252	PF00017	0.396
LIG_SH2_STAT5	53	56	PF00017	0.396
LIG_SH2_STAT5	65	68	PF00017	0.396
LIG_SH2_STAT5	96	99	PF00017	0.346
LIG_SH3_3	227	233	PF00018	0.409
LIG_SH3_5	245	249	PF00018	0.453
LIG_TRAF2_1	151	154	PF00917	0.418
LIG_TRAF2_1	87	90	PF00917	0.347
LIG_TYR_ITIM	253	258	PF00017	0.490
LIG_UBA3_1	124	130	PF00899	0.452
MOD_CK1_1	185	191	PF00069	0.452
MOD_CK2_1	148	154	PF00069	0.418
MOD_CK2_1	231	237	PF00069	0.453
MOD_CK2_1	4	10	PF00069	0.384
MOD_CK2_1	45	51	PF00069	0.406
MOD_CK2_1	84	90	PF00069	0.396
MOD_GlcNHglycan	107	110	PF01048	0.295
MOD_GlcNHglycan	113	116	PF01048	0.227
MOD_GlcNHglycan	150	153	PF01048	0.234
MOD_GlcNHglycan	154	158	PF01048	0.213
MOD_GSK3_1	119	126	PF00069	0.484
MOD_GSK3_1	15	22	PF00069	0.477
MOD_N-GLC_1	199	204	PF02516	0.197
MOD_N-GLC_1	237	242	PF02516	0.214
MOD_NEK2_1	134	139	PF00069	0.465
MOD_NEK2_1	208	213	PF00069	0.514
MOD_NEK2_1	45	50	PF00069	0.434
MOD_NEK2_1	97	102	PF00069	0.490
MOD_PIKK_1	15	21	PF00454	0.444
MOD_PKA_1	105	111	PF00069	0.452
MOD_PKA_2	105	111	PF00069	0.494
MOD_PKA_2	28	34	PF00069	0.526
MOD_Plk_1	153	159	PF00069	0.409
MOD_Plk_1	185	191	PF00069	0.399
MOD_Plk_1	209	215	PF00069	0.424
MOD_Plk_1	45	51	PF00069	0.422
MOD_Plk_2-3	46	52	PF00069	0.392
MOD_Plk_4	139	145	PF00069	0.421
MOD_Plk_4	185	191	PF00069	0.422
MOD_Plk_4	193	199	PF00069	0.422
MOD_Plk_4	21	27	PF00069	0.480
MOD_ProDKin_1	119	125	PF00069	0.452
MOD_ProDKin_1	19	25	PF00069	0.494
MOD_ProDKin_1	199	205	PF00069	0.490
MOD_ProDKin_1	229	235	PF00069	0.431
MOD_SUMO_for_1	129	132	PF00179	0.427
MOD_SUMO_rev_2	171	181	PF00179	0.490
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.409
TRG_ENDOCYTIC_2	255	258	PF00928	0.399
TRG_ER_diArg_1	163	166	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.209

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0T4	Leptomonas seymouri	91%	100%
A0A0S4IMY7	Bodo saltans	69%	100%
A0A1X0NN64	Trypanosomatidae	67%	100%
A0A3S5H6D9	Leishmania donovani	97%	100%
A0A422N781	Trypanosoma rangeli	71%	100%
A2AVJ0	Danio rerio	48%	100%
A4H5Q9	Leishmania braziliensis	92%	100%
A4HTZ9	Leishmania infantum	97%	100%
D0A9G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AMS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q2YDG2	Bos taurus	50%	100%
Q5PQ44	Xenopus laevis	52%	100%
Q6V702	Homo sapiens	49%	100%
Q810M1	Mus musculus	49%	100%