Prefoldin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin

Gene product:

prefoldin subunit, putative

Species:

Leishmania major

UniProt:

Q4QHU3_LEIMA

TriTrypDb:

LmjF.09.0810 , LMJLV39_090014300 , LMJSD75_090014000

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	2
GO:0016592	mediator complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4QHU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHU3

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0045944	positive regulation of transcription by RNA polymerase II	8	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	2
GO:0140110	transcription regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	172	174	PF00675	0.331
CLV_NRD_NRD_1	180	182	PF00675	0.301
CLV_PCSK_KEX2_1	116	118	PF00082	0.690
CLV_PCSK_KEX2_1	180	182	PF00082	0.325
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.690
CLV_PCSK_SKI1_1	169	173	PF00082	0.340
CLV_PCSK_SKI1_1	188	192	PF00082	0.285
CLV_PCSK_SKI1_1	198	202	PF00082	0.251
DEG_SCF_FBW7_1	7	13	PF00400	0.729
DOC_CKS1_1	7	12	PF01111	0.733
DOC_CYCLIN_yClb5_NLxxxL_5	40	49	PF00134	0.547
DOC_MAPK_gen_1	128	135	PF00069	0.512
DOC_MAPK_gen_1	186	193	PF00069	0.464
DOC_MAPK_MEF2A_6	128	135	PF00069	0.471
DOC_USP7_MATH_1	10	14	PF00917	0.669
DOC_USP7_MATH_1	101	105	PF00917	0.666
DOC_USP7_MATH_1	107	111	PF00917	0.653
DOC_USP7_MATH_1	112	116	PF00917	0.656
DOC_USP7_MATH_1	22	26	PF00917	0.504
DOC_USP7_UBL2_3	124	128	PF12436	0.419
DOC_WW_Pin1_4	103	108	PF00397	0.665
DOC_WW_Pin1_4	6	11	PF00397	0.682
DOC_WW_Pin1_4	97	102	PF00397	0.665
LIG_14-3-3_CanoR_1	198	207	PF00244	0.534
LIG_14-3-3_CanoR_1	77	82	PF00244	0.530
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_FHA_1	139	145	PF00498	0.528
LIG_FHA_1	199	205	PF00498	0.542
LIG_FHA_2	84	90	PF00498	0.646
LIG_LIR_Apic_2	121	126	PF02991	0.653
LIG_LIR_Gen_1	53	63	PF02991	0.483
LIG_LIR_Gen_1	76	84	PF02991	0.549
LIG_LIR_Nem_3	53	59	PF02991	0.506
LIG_LIR_Nem_3	76	81	PF02991	0.587
LIG_PDZ_Class_2	209	214	PF00595	0.586
LIG_PTB_Apo_2	134	141	PF02174	0.458
LIG_PTB_Phospho_1	134	140	PF10480	0.531
LIG_SH2_CRK	123	127	PF00017	0.425
LIG_SH2_CRK	56	60	PF00017	0.503
LIG_SH2_NCK_1	56	60	PF00017	0.464
LIG_SH2_STAP1	56	60	PF00017	0.536
LIG_SH2_STAT5	140	143	PF00017	0.540
LIG_SH3_3	156	162	PF00018	0.471
LIG_SH3_3	9	15	PF00018	0.723
LIG_SH3_4	124	131	PF00018	0.419
LIG_WRC_WIRS_1	78	83	PF05994	0.594
MOD_CK1_1	13	19	PF00069	0.600
MOD_CK1_1	97	103	PF00069	0.649
MOD_CK2_1	161	167	PF00069	0.317
MOD_CK2_1	77	83	PF00069	0.572
MOD_GlcNHglycan	103	106	PF01048	0.698
MOD_GlcNHglycan	14	18	PF01048	0.607
MOD_GlcNHglycan	24	27	PF01048	0.475
MOD_GlcNHglycan	96	99	PF01048	0.681
MOD_GSK3_1	6	13	PF00069	0.629
MOD_GSK3_1	73	80	PF00069	0.457
MOD_GSK3_1	83	90	PF00069	0.438
MOD_GSK3_1	97	104	PF00069	0.605
MOD_N-GLC_1	107	112	PF02516	0.634
MOD_N-GLC_1	184	189	PF02516	0.425
MOD_NEK2_1	36	41	PF00069	0.428
MOD_NEK2_1	55	60	PF00069	0.303
MOD_PIKK_1	138	144	PF00454	0.402
MOD_PIKK_1	47	53	PF00454	0.491
MOD_PKB_1	196	204	PF00069	0.425
MOD_Plk_1	107	113	PF00069	0.596
MOD_Plk_4	36	42	PF00069	0.448
MOD_Plk_4	44	50	PF00069	0.443
MOD_Plk_4	77	83	PF00069	0.504
MOD_ProDKin_1	6	12	PF00069	0.683
MOD_ProDKin_1	97	103	PF00069	0.664
TRG_DiLeu_BaEn_2	166	172	PF01217	0.322
TRG_ENDOCYTIC_2	56	59	PF00928	0.499
TRG_ENDOCYTIC_2	78	81	PF00928	0.602
TRG_ER_diArg_1	179	181	PF00400	0.458
TRG_ER_diArg_1	195	198	PF00400	0.300
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I625	Leptomonas seymouri	72%	100%
A0A0S4JD64	Bodo saltans	36%	87%
A0A1X0NN73	Trypanosomatidae	41%	100%
A0A3S7WQQ1	Leishmania donovani	94%	100%
A0A422N2I2	Trypanosoma rangeli	44%	100%
A4H5R2	Leishmania braziliensis	84%	100%
A4HU02	Leishmania infantum	94%	100%
D0A9G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AMT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q54ND3	Dictyostelium discoideum	22%	100%