AAA domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHU2_LEIMA

TriTrypDb:

LmjF.09.0820 , LMJLV39_090014400 , LMJSD75_090014200

Length:

530

Annotations

LeishMANIAdb annotations

Probably a secreted protein, similarly to its distant eukaryotic torsin homologs, involved in secretory processes. Also similar to bacterial ClpB ATPases, with chaperoning function.. Might be associated to known or unknown protein secretion pathways.. Localization: Endosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 2
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHU2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0016887	ATP hydrolysis activity	7	9
GO:0017076	purine nucleotide binding	4	9
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.403
CLV_C14_Caspase3-7	20	24	PF00656	0.475
CLV_C14_Caspase3-7	520	524	PF00656	0.656
CLV_NRD_NRD_1	115	117	PF00675	0.522
CLV_NRD_NRD_1	145	147	PF00675	0.363
CLV_NRD_NRD_1	447	449	PF00675	0.407
CLV_PCSK_KEX2_1	115	117	PF00082	0.548
CLV_PCSK_KEX2_1	145	147	PF00082	0.363
CLV_PCSK_KEX2_1	447	449	PF00082	0.407
DEG_APCC_KENBOX_2	439	443	PF00400	0.410
DEG_SCF_FBW7_1	488	495	PF00400	0.586
DEG_SCF_FBW7_2	56	62	PF00400	0.371
DEG_SPOP_SBC_1	492	496	PF00917	0.547
DOC_CKS1_1	489	494	PF01111	0.579
DOC_CKS1_1	56	61	PF01111	0.468
DOC_MAPK_DCC_7	96	106	PF00069	0.568
DOC_MAPK_gen_1	96	106	PF00069	0.542
DOC_MAPK_HePTP_8	126	138	PF00069	0.504
DOC_MAPK_MEF2A_6	129	138	PF00069	0.499
DOC_MAPK_MEF2A_6	152	159	PF00069	0.414
DOC_MAPK_MEF2A_6	469	478	PF00069	0.589
DOC_MAPK_MEF2A_6	99	108	PF00069	0.523
DOC_MAPK_RevD_3	134	147	PF00069	0.429
DOC_PP1_RVXF_1	473	479	PF00149	0.510
DOC_PP2B_LxvP_1	104	107	PF13499	0.504
DOC_USP7_MATH_1	276	280	PF00917	0.619
DOC_USP7_MATH_1	319	323	PF00917	0.725
DOC_USP7_MATH_1	325	329	PF00917	0.758
DOC_USP7_MATH_1	36	40	PF00917	0.677
DOC_USP7_MATH_1	390	394	PF00917	0.438
DOC_USP7_MATH_1	42	46	PF00917	0.551
DOC_USP7_MATH_1	492	496	PF00917	0.678
DOC_USP7_MATH_1	505	509	PF00917	0.726
DOC_USP7_MATH_1	51	55	PF00917	0.392
DOC_USP7_UBL2_3	61	65	PF12436	0.547
DOC_WW_Pin1_4	488	493	PF00397	0.563
DOC_WW_Pin1_4	55	60	PF00397	0.476
LIG_14-3-3_CanoR_1	172	180	PF00244	0.364
LIG_14-3-3_CanoR_1	351	357	PF00244	0.558
LIG_14-3-3_CanoR_1	401	411	PF00244	0.506
LIG_14-3-3_CanoR_1	490	498	PF00244	0.531
LIG_APCC_ABBA_1	458	463	PF00400	0.463
LIG_APCC_ABBA_1	474	479	PF00400	0.454
LIG_APCC_ABBAyCdc20_2	473	479	PF00400	0.415
LIG_FHA_1	168	174	PF00498	0.407
LIG_FHA_1	285	291	PF00498	0.659
LIG_FHA_1	80	86	PF00498	0.543
LIG_FHA_2	18	24	PF00498	0.529
LIG_FHA_2	199	205	PF00498	0.407
LIG_FHA_2	235	241	PF00498	0.480
LIG_FHA_2	359	365	PF00498	0.490
LIG_FHA_2	418	424	PF00498	0.502
LIG_Integrin_RGD_1	527	529	PF01839	0.565
LIG_LIR_Gen_1	370	379	PF02991	0.476
LIG_LIR_Gen_1	9	19	PF02991	0.507
LIG_LIR_LC3C_4	2	7	PF02991	0.370
LIG_LIR_Nem_3	201	206	PF02991	0.586
LIG_LIR_Nem_3	370	374	PF02991	0.400
LIG_LIR_Nem_3	383	389	PF02991	0.410
LIG_LIR_Nem_3	9	15	PF02991	0.483
LIG_SH2_CRK	375	379	PF00017	0.399
LIG_SH2_SRC	514	517	PF00017	0.540
LIG_SH2_STAP1	382	386	PF00017	0.464
LIG_SH2_STAT5	382	385	PF00017	0.481
LIG_SH2_STAT5	66	69	PF00017	0.406
LIG_SH2_STAT5	73	76	PF00017	0.396
LIG_SH3_2	56	61	PF14604	0.436
LIG_SH3_3	133	139	PF00018	0.455
LIG_SH3_3	148	154	PF00018	0.275
LIG_SH3_3	23	29	PF00018	0.657
LIG_SH3_3	331	337	PF00018	0.568
LIG_SH3_3	384	390	PF00018	0.454
LIG_SH3_3	45	51	PF00018	0.438
LIG_SH3_3	53	59	PF00018	0.429
LIG_Sin3_3	12	19	PF02671	0.539
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.500
LIG_SUMO_SIM_par_1	12	18	PF11976	0.527
LIG_SUMO_SIM_par_1	2	9	PF11976	0.474
LIG_SUMO_SIM_par_1	229	235	PF11976	0.362
LIG_UBA3_1	140	147	PF00899	0.462
MOD_CDK_SPxK_1	55	61	PF00069	0.560
MOD_CK1_1	242	248	PF00069	0.460
MOD_CK1_1	265	271	PF00069	0.693
MOD_CK1_1	279	285	PF00069	0.499
MOD_CK1_1	327	333	PF00069	0.658
MOD_CK1_1	40	46	PF00069	0.638
MOD_CK1_1	402	408	PF00069	0.496
MOD_CK1_1	419	425	PF00069	0.469
MOD_CK1_1	76	82	PF00069	0.589
MOD_CK2_1	204	210	PF00069	0.511
MOD_CK2_1	356	362	PF00069	0.500
MOD_CK2_1	435	441	PF00069	0.542
MOD_CK2_1	504	510	PF00069	0.699
MOD_CK2_1	91	97	PF00069	0.578
MOD_DYRK1A_RPxSP_1	55	59	PF00069	0.524
MOD_GlcNHglycan	17	20	PF01048	0.704
MOD_GlcNHglycan	244	247	PF01048	0.440
MOD_GlcNHglycan	265	268	PF01048	0.609
MOD_GlcNHglycan	297	300	PF01048	0.742
MOD_GlcNHglycan	330	333	PF01048	0.700
MOD_GlcNHglycan	392	395	PF01048	0.449
MOD_GlcNHglycan	401	404	PF01048	0.418
MOD_GlcNHglycan	437	440	PF01048	0.530
MOD_GlcNHglycan	507	510	PF01048	0.734
MOD_GlcNHglycan	70	73	PF01048	0.515
MOD_GlcNHglycan	82	85	PF01048	0.337
MOD_GSK3_1	172	179	PF00069	0.364
MOD_GSK3_1	194	201	PF00069	0.448
MOD_GSK3_1	259	266	PF00069	0.635
MOD_GSK3_1	279	286	PF00069	0.448
MOD_GSK3_1	319	326	PF00069	0.719
MOD_GSK3_1	352	359	PF00069	0.456
MOD_GSK3_1	36	43	PF00069	0.640
MOD_GSK3_1	415	422	PF00069	0.434
MOD_GSK3_1	488	495	PF00069	0.608
MOD_GSK3_1	51	58	PF00069	0.380
MOD_GSK3_1	76	83	PF00069	0.583
MOD_NEK2_1	261	266	PF00069	0.555
MOD_NEK2_1	324	329	PF00069	0.727
MOD_NEK2_1	374	379	PF00069	0.452
MOD_NEK2_1	415	420	PF00069	0.490
MOD_NEK2_2	73	78	PF00069	0.501
MOD_PIKK_1	172	178	PF00454	0.435
MOD_PIKK_1	336	342	PF00454	0.473
MOD_PIKK_1	453	459	PF00454	0.459
MOD_PIKK_1	497	503	PF00454	0.617
MOD_PKA_2	262	268	PF00069	0.643
MOD_Plk_1	234	240	PF00069	0.421
MOD_Plk_1	481	487	PF00069	0.530
MOD_Plk_2-3	204	210	PF00069	0.511
MOD_Plk_4	239	245	PF00069	0.486
MOD_Plk_4	374	380	PF00069	0.406
MOD_Plk_4	424	430	PF00069	0.388
MOD_Plk_4	6	12	PF00069	0.610
MOD_ProDKin_1	488	494	PF00069	0.574
MOD_ProDKin_1	55	61	PF00069	0.478
TRG_DiLeu_BaEn_2	423	429	PF01217	0.492
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.455
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.509
TRG_ENDOCYTIC_2	375	378	PF00928	0.422
TRG_ENDOCYTIC_2	388	391	PF00928	0.386
TRG_ER_diArg_1	114	116	PF00400	0.394
TRG_ER_diArg_1	144	146	PF00400	0.363
TRG_ER_diArg_1	212	215	PF00400	0.389
TRG_ER_diArg_1	446	448	PF00400	0.407
TRG_ER_diArg_1	473	476	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFB4	Leptomonas seymouri	63%	100%
A0A3Q8I8K7	Leishmania donovani	94%	100%
A0A3R7RCD3	Trypanosoma rangeli	37%	100%
A4H5R3	Leishmania braziliensis	79%	95%
A4HU03	Leishmania infantum	93%	100%
E9AMT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B864	Trypanosoma cruzi	36%	100%