DEAD/DEAH box helicase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD/DEAH box helicase-like protein

Species:

Leishmania major

UniProt:

Q4QHU1_LEIMA

TriTrypDb:

LmjF.09.0830 , LMJLV39_090014500 , LMJSD75_090014300

Length:

776

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHU1

PDB structure(s): 7am2_BW

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003724	RNA helicase activity	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008186	ATP-dependent activity, acting on RNA	2	11
GO:0016787	hydrolase activity	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.496
CLV_NRD_NRD_1	149	151	PF00675	0.297
CLV_NRD_NRD_1	189	191	PF00675	0.282
CLV_NRD_NRD_1	226	228	PF00675	0.282
CLV_NRD_NRD_1	260	262	PF00675	0.282
CLV_NRD_NRD_1	318	320	PF00675	0.386
CLV_NRD_NRD_1	326	328	PF00675	0.415
CLV_NRD_NRD_1	356	358	PF00675	0.609
CLV_NRD_NRD_1	369	371	PF00675	0.542
CLV_NRD_NRD_1	392	394	PF00675	0.554
CLV_NRD_NRD_1	499	501	PF00675	0.566
CLV_NRD_NRD_1	507	509	PF00675	0.349
CLV_NRD_NRD_1	544	546	PF00675	0.296
CLV_NRD_NRD_1	635	637	PF00675	0.599
CLV_NRD_NRD_1	665	667	PF00675	0.568
CLV_NRD_NRD_1	719	721	PF00675	0.466
CLV_NRD_NRD_1	725	727	PF00675	0.501
CLV_PCSK_FUR_1	187	191	PF00082	0.282
CLV_PCSK_FUR_1	258	262	PF00082	0.282
CLV_PCSK_KEX2_1	189	191	PF00082	0.282
CLV_PCSK_KEX2_1	228	230	PF00082	0.282
CLV_PCSK_KEX2_1	260	262	PF00082	0.282
CLV_PCSK_KEX2_1	296	298	PF00082	0.275
CLV_PCSK_KEX2_1	356	358	PF00082	0.609
CLV_PCSK_KEX2_1	499	501	PF00082	0.511
CLV_PCSK_KEX2_1	507	509	PF00082	0.291
CLV_PCSK_KEX2_1	719	721	PF00082	0.466
CLV_PCSK_KEX2_1	725	727	PF00082	0.501
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.282
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.288
CLV_PCSK_SKI1_1	105	109	PF00082	0.455
CLV_PCSK_SKI1_1	192	196	PF00082	0.282
CLV_PCSK_SKI1_1	236	240	PF00082	0.299
CLV_PCSK_SKI1_1	251	255	PF00082	0.253
CLV_PCSK_SKI1_1	260	264	PF00082	0.282
CLV_PCSK_SKI1_1	500	504	PF00082	0.398
CLV_PCSK_SKI1_1	621	625	PF00082	0.406
CLV_PCSK_SKI1_1	63	67	PF00082	0.546
CLV_PCSK_SKI1_1	685	689	PF00082	0.463
CLV_PCSK_SKI1_1	736	740	PF00082	0.645
DEG_APCC_DBOX_1	472	480	PF00400	0.425
DEG_COP1_1	443	452	PF00400	0.727
DOC_CKS1_1	119	124	PF01111	0.514
DOC_CKS1_1	133	138	PF01111	0.354
DOC_CYCLIN_RxL_1	255	266	PF00134	0.496
DOC_CYCLIN_RxL_1	565	575	PF00134	0.562
DOC_MAPK_gen_1	177	186	PF00069	0.482
DOC_MAPK_gen_1	187	196	PF00069	0.482
DOC_MAPK_gen_1	255	264	PF00069	0.480
DOC_MAPK_gen_1	370	377	PF00069	0.581
DOC_MAPK_gen_1	507	513	PF00069	0.562
DOC_MAPK_gen_1	598	608	PF00069	0.637
DOC_MAPK_gen_1	710	718	PF00069	0.530
DOC_MAPK_MEF2A_6	370	379	PF00069	0.517
DOC_MAPK_MEF2A_6	568	576	PF00069	0.482
DOC_MAPK_RevD_3	245	261	PF00069	0.482
DOC_PP1_RVXF_1	478	485	PF00149	0.443
DOC_PP1_RVXF_1	506	513	PF00149	0.502
DOC_PP2B_LxvP_1	195	198	PF13499	0.482
DOC_PP2B_LxvP_1	59	62	PF13499	0.566
DOC_PP4_FxxP_1	494	497	PF00568	0.518
DOC_PP4_FxxP_1	580	583	PF00568	0.482
DOC_PP4_FxxP_1	768	771	PF00568	0.587
DOC_USP7_MATH_1	2	6	PF00917	0.752
DOC_USP7_MATH_1	277	281	PF00917	0.586
DOC_USP7_MATH_1	448	452	PF00917	0.737
DOC_USP7_UBL2_3	621	625	PF12436	0.517
DOC_WW_Pin1_4	118	123	PF00397	0.526
DOC_WW_Pin1_4	132	137	PF00397	0.327
DOC_WW_Pin1_4	759	764	PF00397	0.668
DOC_WW_Pin1_4	90	95	PF00397	0.449
DOC_WW_Pin1_4	97	102	PF00397	0.440
LIG_14-3-3_CanoR_1	150	155	PF00244	0.594
LIG_14-3-3_CanoR_1	327	332	PF00244	0.559
LIG_14-3-3_CanoR_1	473	477	PF00244	0.568
LIG_14-3-3_CanoR_1	499	503	PF00244	0.558
LIG_14-3-3_CanoR_1	658	664	PF00244	0.428
LIG_APCC_ABBA_1	570	575	PF00400	0.482
LIG_APCC_ABBAyCdc20_2	499	505	PF00400	0.483
LIG_APCC_ABBAyCdc20_2	545	551	PF00400	0.482
LIG_BIR_II_1	1	5	PF00653	0.749
LIG_BIR_III_3	1	5	PF00653	0.636
LIG_BRCT_BRCA1_1	220	224	PF00533	0.496
LIG_BRCT_BRCA1_1	527	531	PF00533	0.595
LIG_FHA_1	107	113	PF00498	0.438
LIG_FHA_1	119	125	PF00498	0.426
LIG_FHA_1	197	203	PF00498	0.482
LIG_FHA_1	257	263	PF00498	0.534
LIG_FHA_1	306	312	PF00498	0.482
LIG_FHA_1	316	322	PF00498	0.506
LIG_FHA_1	426	432	PF00498	0.755
LIG_FHA_1	493	499	PF00498	0.421
LIG_FHA_1	517	523	PF00498	0.511
LIG_FHA_1	555	561	PF00498	0.476
LIG_FHA_1	56	62	PF00498	0.539
LIG_FHA_1	582	588	PF00498	0.471
LIG_FHA_1	648	654	PF00498	0.477
LIG_FHA_2	140	146	PF00498	0.496
LIG_FHA_2	239	245	PF00498	0.513
LIG_GBD_Chelix_1	616	624	PF00786	0.482
LIG_LIR_Apic_2	164	170	PF02991	0.482
LIG_LIR_Apic_2	180	185	PF02991	0.482
LIG_LIR_Gen_1	113	123	PF02991	0.408
LIG_LIR_Gen_1	308	317	PF02991	0.586
LIG_LIR_Gen_1	360	369	PF02991	0.513
LIG_LIR_Gen_1	520	531	PF02991	0.455
LIG_LIR_Gen_1	547	553	PF02991	0.535
LIG_LIR_Gen_1	659	664	PF02991	0.447
LIG_LIR_Nem_3	266	272	PF02991	0.471
LIG_LIR_Nem_3	308	313	PF02991	0.586
LIG_LIR_Nem_3	334	340	PF02991	0.480
LIG_LIR_Nem_3	360	365	PF02991	0.478
LIG_LIR_Nem_3	469	474	PF02991	0.567
LIG_LIR_Nem_3	520	526	PF02991	0.482
LIG_LIR_Nem_3	547	552	PF02991	0.535
LIG_LIR_Nem_3	659	663	PF02991	0.442
LIG_LIR_Nem_3	683	687	PF02991	0.455
LIG_NRBOX	364	370	PF00104	0.425
LIG_PCNA_yPIPBox_3	141	151	PF02747	0.562
LIG_Pex14_1	684	688	PF04695	0.457
LIG_Pex14_2	300	304	PF04695	0.482
LIG_REV1ctd_RIR_1	510	518	PF16727	0.562
LIG_SH2_CRK	182	186	PF00017	0.482
LIG_SH2_GRB2like	172	175	PF00017	0.482
LIG_SH2_PTP2	310	313	PF00017	0.586
LIG_SH2_PTP2	660	663	PF00017	0.422
LIG_SH2_SRC	677	680	PF00017	0.470
LIG_SH2_STAP1	22	26	PF00017	0.635
LIG_SH2_STAP1	549	553	PF00017	0.562
LIG_SH2_STAT5	167	170	PF00017	0.496
LIG_SH2_STAT5	26	29	PF00017	0.656
LIG_SH2_STAT5	269	272	PF00017	0.482
LIG_SH2_STAT5	302	305	PF00017	0.513
LIG_SH2_STAT5	310	313	PF00017	0.513
LIG_SH2_STAT5	323	326	PF00017	0.389
LIG_SH2_STAT5	474	477	PF00017	0.538
LIG_SH2_STAT5	589	592	PF00017	0.482
LIG_SH2_STAT5	660	663	PF00017	0.418
LIG_SH2_STAT5	677	680	PF00017	0.384
LIG_SH3_3	130	136	PF00018	0.513
LIG_SH3_3	244	250	PF00018	0.562
LIG_SH3_3	372	378	PF00018	0.548
LIG_SH3_3	436	442	PF00018	0.623
LIG_SH3_3	487	493	PF00018	0.439
LIG_SH3_3	684	690	PF00018	0.569
LIG_SH3_3	760	766	PF00018	0.574
LIG_SH3_3	768	774	PF00018	0.567
LIG_SUMO_SIM_anti_2	244	249	PF11976	0.480
LIG_SUMO_SIM_anti_2	659	665	PF11976	0.448
LIG_SUMO_SIM_par_1	428	436	PF11976	0.726
LIG_TRAF2_1	123	126	PF00917	0.457
LIG_TRAF2_1	441	444	PF00917	0.673
LIG_TYR_ITIM	267	272	PF00017	0.335
LIG_TYR_ITSM	306	313	PF00017	0.480
LIG_UBA3_1	193	200	PF00899	0.378
LIG_UBA3_1	365	371	PF00899	0.558
MOD_CDC14_SPxK_1	93	96	PF00782	0.484
MOD_CDK_SPxK_1	90	96	PF00069	0.464
MOD_CK1_1	134	140	PF00069	0.529
MOD_CK1_1	16	22	PF00069	0.668
MOD_CK1_1	29	35	PF00069	0.719
MOD_CK1_1	38	44	PF00069	0.686
MOD_CK1_1	420	426	PF00069	0.614
MOD_CK1_1	554	560	PF00069	0.334
MOD_CK1_1	593	599	PF00069	0.439
MOD_CK1_1	659	665	PF00069	0.431
MOD_CK2_1	139	145	PF00069	0.335
MOD_CK2_1	395	401	PF00069	0.493
MOD_CK2_1	452	458	PF00069	0.691
MOD_CK2_1	72	78	PF00069	0.447
MOD_Cter_Amidation	325	328	PF01082	0.421
MOD_Cter_Amidation	505	508	PF01082	0.378
MOD_GlcNHglycan	38	41	PF01048	0.671
MOD_GlcNHglycan	395	398	PF01048	0.470
MOD_GlcNHglycan	420	423	PF01048	0.719
MOD_GlcNHglycan	443	448	PF01048	0.727
MOD_GlcNHglycan	454	457	PF01048	0.691
MOD_GlcNHglycan	527	530	PF01048	0.434
MOD_GlcNHglycan	553	556	PF01048	0.335
MOD_GlcNHglycan	592	595	PF01048	0.434
MOD_GlcNHglycan	617	620	PF01048	0.400
MOD_GlcNHglycan	771	774	PF01048	0.699
MOD_GSK3_1	16	23	PF00069	0.630
MOD_GSK3_1	214	221	PF00069	0.355
MOD_GSK3_1	223	230	PF00069	0.355
MOD_GSK3_1	27	34	PF00069	0.698
MOD_GSK3_1	3	10	PF00069	0.732
MOD_GSK3_1	311	318	PF00069	0.350
MOD_GSK3_1	327	334	PF00069	0.516
MOD_GSK3_1	38	45	PF00069	0.642
MOD_GSK3_1	448	455	PF00069	0.713
MOD_GSK3_1	68	75	PF00069	0.450
MOD_GSK3_1	90	97	PF00069	0.432
MOD_N-GLC_1	680	685	PF02516	0.454
MOD_NEK2_1	131	136	PF00069	0.450
MOD_NEK2_1	20	25	PF00069	0.743
MOD_NEK2_1	238	243	PF00069	0.354
MOD_NEK2_1	256	261	PF00069	0.344
MOD_NEK2_1	278	283	PF00069	0.335
MOD_NEK2_1	395	400	PF00069	0.566
MOD_NEK2_1	531	536	PF00069	0.355
MOD_NEK2_1	590	595	PF00069	0.434
MOD_NEK2_1	656	661	PF00069	0.512
MOD_NEK2_1	673	678	PF00069	0.330
MOD_NEK2_1	72	77	PF00069	0.561
MOD_NEK2_2	734	739	PF00069	0.632
MOD_PIKK_1	305	311	PF00454	0.335
MOD_PIKK_1	47	53	PF00454	0.660
MOD_PIKK_1	70	76	PF00454	0.517
MOD_PKA_1	150	156	PF00069	0.356
MOD_PKA_1	227	233	PF00069	0.447
MOD_PKA_1	327	333	PF00069	0.554
MOD_PKA_1	393	399	PF00069	0.538
MOD_PKA_2	27	33	PF00069	0.759
MOD_PKA_2	472	478	PF00069	0.576
MOD_PKA_2	498	504	PF00069	0.528
MOD_PKA_2	506	512	PF00069	0.398
MOD_PKA_2	665	671	PF00069	0.567
MOD_Plk_1	673	679	PF00069	0.456
MOD_Plk_1	680	686	PF00069	0.459
MOD_Plk_2-3	425	431	PF00069	0.769
MOD_Plk_4	150	156	PF00069	0.335
MOD_Plk_4	38	44	PF00069	0.741
MOD_Plk_4	531	537	PF00069	0.335
MOD_Plk_4	659	665	PF00069	0.429
MOD_ProDKin_1	118	124	PF00069	0.520
MOD_ProDKin_1	132	138	PF00069	0.324
MOD_ProDKin_1	759	765	PF00069	0.665
MOD_ProDKin_1	90	96	PF00069	0.445
MOD_ProDKin_1	97	103	PF00069	0.435
MOD_SUMO_rev_2	244	253	PF00179	0.335
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.415
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.439
TRG_ENDOCYTIC_2	172	175	PF00928	0.335
TRG_ENDOCYTIC_2	269	272	PF00928	0.335
TRG_ENDOCYTIC_2	310	313	PF00928	0.480
TRG_ENDOCYTIC_2	549	552	PF00928	0.408
TRG_ENDOCYTIC_2	660	663	PF00928	0.418
TRG_ER_diArg_1	189	192	PF00400	0.335
TRG_ER_diArg_1	257	260	PF00400	0.335
TRG_ER_diArg_1	348	351	PF00400	0.450
TRG_ER_diArg_1	355	357	PF00400	0.498
TRG_ER_diArg_1	478	481	PF00400	0.470
TRG_ER_diArg_1	498	500	PF00400	0.243
TRG_ER_diArg_1	718	720	PF00400	0.474
TRG_NLS_MonoExtC_3	226	231	PF00514	0.355
TRG_NLS_MonoExtN_4	227	232	PF00514	0.355
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	260	265	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	480	485	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ75	Leptomonas seymouri	80%	95%
A0A1X0NMI3	Trypanosomatidae	61%	97%
A0A3S7WQS0	Leishmania donovani	97%	100%
A0A422N2G7	Trypanosoma rangeli	66%	100%
A4H5R4	Leishmania braziliensis	87%	100%
A4HU04	Leishmania infantum	96%	100%
D0A9G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AMT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5ASP0	Trypanosoma cruzi	65%	100%