Metal-dependent protein hydrolase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0160), putative

Species:

Leishmania major

UniProt:

Q4QHU0_LEIMA

TriTrypDb:

LmjF.09.0840 , LMJLV39_090014600 , LMJSD75_090014400

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHU0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.432
CLV_NRD_NRD_1	272	274	PF00675	0.308
CLV_NRD_NRD_1	3	5	PF00675	0.402
CLV_NRD_NRD_1	335	337	PF00675	0.246
CLV_PCSK_KEX2_1	272	274	PF00082	0.335
CLV_PCSK_SKI1_1	250	254	PF00082	0.277
CLV_PCSK_SKI1_1	286	290	PF00082	0.402
CLV_PCSK_SKI1_1	381	385	PF00082	0.261
DEG_SPOP_SBC_1	327	331	PF00917	0.540
DOC_CKS1_1	104	109	PF01111	0.445
DOC_USP7_MATH_1	261	265	PF00917	0.525
DOC_USP7_MATH_1	327	331	PF00917	0.540
DOC_USP7_UBL2_3	108	112	PF12436	0.460
DOC_WW_Pin1_4	103	108	PF00397	0.448
DOC_WW_Pin1_4	139	144	PF00397	0.466
LIG_14-3-3_CanoR_1	114	122	PF00244	0.446
LIG_14-3-3_CanoR_1	158	168	PF00244	0.497
LIG_BIR_II_1	1	5	PF00653	0.461
LIG_BRCT_BRCA1_1	329	333	PF00533	0.540
LIG_Clathr_ClatBox_1	297	301	PF01394	0.458
LIG_FHA_2	329	335	PF00498	0.540
LIG_LIR_Gen_1	171	181	PF02991	0.455
LIG_LIR_Gen_1	253	262	PF02991	0.476
LIG_LIR_Nem_3	171	177	PF02991	0.455
LIG_LIR_Nem_3	246	252	PF02991	0.461
LIG_LIR_Nem_3	253	257	PF02991	0.500
LIG_REV1ctd_RIR_1	246	254	PF16727	0.398
LIG_SH2_CRK	341	345	PF00017	0.491
LIG_SH2_GRB2like	221	224	PF00017	0.526
LIG_SH2_SRC	133	136	PF00017	0.476
LIG_SH2_SRC	93	96	PF00017	0.559
LIG_SH2_STAP1	174	178	PF00017	0.540
LIG_SH2_STAT5	10	13	PF00017	0.361
LIG_SH2_STAT5	133	136	PF00017	0.445
LIG_SH2_STAT5	205	208	PF00017	0.468
LIG_SH2_STAT5	254	257	PF00017	0.540
LIG_SH2_STAT5	312	315	PF00017	0.445
LIG_SH3_2	140	145	PF14604	0.460
LIG_SH3_3	134	140	PF00018	0.475
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.427
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.488
LIG_SUMO_SIM_par_1	295	301	PF11976	0.492
LIG_TYR_ITIM	339	344	PF00017	0.491
LIG_WRC_WIRS_1	254	259	PF05994	0.429
LIG_WRC_WIRS_1	370	375	PF05994	0.460
MOD_CDC14_SPxK_1	142	145	PF00782	0.459
MOD_CDK_SPK_2	103	108	PF00069	0.445
MOD_CDK_SPxK_1	103	109	PF00069	0.491
MOD_CDK_SPxK_1	139	145	PF00069	0.466
MOD_CK1_1	150	156	PF00069	0.480
MOD_CK2_1	150	156	PF00069	0.462
MOD_CK2_1	159	165	PF00069	0.410
MOD_CK2_1	261	267	PF00069	0.534
MOD_CK2_1	328	334	PF00069	0.501
MOD_GlcNHglycan	1	4	PF01048	0.523
MOD_GlcNHglycan	116	119	PF01048	0.254
MOD_GlcNHglycan	277	281	PF01048	0.252
MOD_GlcNHglycan	349	352	PF01048	0.303
MOD_GlcNHglycan	363	366	PF01048	0.223
MOD_GSK3_1	110	117	PF00069	0.445
MOD_GSK3_1	150	157	PF00069	0.526
MOD_GSK3_1	16	23	PF00069	0.455
MOD_GSK3_1	203	210	PF00069	0.456
MOD_GSK3_1	34	41	PF00069	0.240
MOD_GSK3_1	96	103	PF00069	0.445
MOD_N-GLC_1	203	208	PF02516	0.288
MOD_N-GLC_1	38	43	PF02516	0.245
MOD_NEK2_1	100	105	PF00069	0.447
MOD_NEK2_1	149	154	PF00069	0.472
MOD_NEK2_1	255	260	PF00069	0.478
MOD_NEK2_1	276	281	PF00069	0.511
MOD_PIKK_1	203	209	PF00454	0.534
MOD_PKA_2	113	119	PF00069	0.445
MOD_Plk_4	16	22	PF00069	0.451
MOD_Plk_4	197	203	PF00069	0.491
MOD_Plk_4	250	256	PF00069	0.551
MOD_ProDKin_1	103	109	PF00069	0.448
MOD_ProDKin_1	139	145	PF00069	0.466
TRG_DiLeu_BaEn_2	355	361	PF01217	0.476
TRG_ENDOCYTIC_2	122	125	PF00928	0.445
TRG_ENDOCYTIC_2	174	177	PF00928	0.445
TRG_ENDOCYTIC_2	254	257	PF00928	0.476
TRG_ENDOCYTIC_2	312	315	PF00928	0.445
TRG_ENDOCYTIC_2	341	344	PF00928	0.491
TRG_ER_diArg_1	65	68	PF00400	0.451
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILK4	Leptomonas seymouri	78%	99%
A0A1X0NMG9	Trypanosomatidae	46%	90%
A0A3S7WQQ4	Leishmania donovani	94%	97%
A0A422N2F9	Trypanosoma rangeli	57%	99%
A4H5R5	Leishmania braziliensis	86%	97%
A4HU05	Leishmania infantum	94%	97%
D0A9H0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	98%
E9AMT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	97%
O17606	Caenorhabditis elegans	43%	100%
O84391	Chlamydia trachomatis (strain D/UW-3/Cx)	25%	100%
P40093	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q55G91	Dictyostelium discoideum	40%	100%
Q58DG1	Bos taurus	45%	100%
Q641W2	Rattus norvegicus	44%	100%
Q9HB07	Homo sapiens	44%	100%
Q9JK81	Mus musculus	43%	100%
Q9P7T6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
Q9Z862	Chlamydia pneumoniae	24%	100%
V5D8M5	Trypanosoma cruzi	56%	98%