Ras family protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras family protein-like protein

Species:

Leishmania major

UniProt:

Q4QHT9_LEIMA

TriTrypDb:

LmjF.09.0850 , LMJLV39_090014700 , LMJSD75_090014500

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QHT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHT9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0003924	GTPase activity	7	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	240	242	PF00082	0.613
CLV_PCSK_KEX2_1	89	91	PF00082	0.311
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.613
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.311
CLV_PCSK_SKI1_1	163	167	PF00082	0.284
DEG_APCC_DBOX_1	47	55	PF00400	0.382
DEG_APCC_DBOX_1	70	78	PF00400	0.322
DOC_CDC14_PxL_1	57	65	PF14671	0.452
DOC_CKS1_1	17	22	PF01111	0.396
DOC_CYCLIN_RxL_1	10	19	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.372
DOC_MAPK_gen_1	48	55	PF00069	0.382
DOC_MAPK_HePTP_8	45	57	PF00069	0.383
DOC_MAPK_MEF2A_6	48	57	PF00069	0.379
DOC_MAPK_MEF2A_6	99	108	PF00069	0.263
DOC_PP1_RVXF_1	148	154	PF00149	0.263
DOC_PP2B_LxvP_1	55	58	PF13499	0.406
DOC_PP2B_PxIxI_1	101	107	PF00149	0.263
DOC_USP7_MATH_1	190	194	PF00917	0.238
DOC_USP7_MATH_1	206	210	PF00917	0.470
DOC_USP7_MATH_1	242	246	PF00917	0.701
DOC_USP7_MATH_1	34	38	PF00917	0.432
DOC_USP7_MATH_1	40	44	PF00917	0.424
DOC_WW_Pin1_4	126	131	PF00397	0.544
DOC_WW_Pin1_4	16	21	PF00397	0.395
DOC_WW_Pin1_4	23	28	PF00397	0.399
LIG_14-3-3_CanoR_1	11	16	PF00244	0.389
LIG_14-3-3_CanoR_1	124	128	PF00244	0.576
LIG_14-3-3_CanoR_1	183	189	PF00244	0.328
LIG_14-3-3_CanoR_1	241	248	PF00244	0.608
LIG_14-3-3_CanoR_1	35	45	PF00244	0.459
LIG_eIF4E_1	69	75	PF01652	0.377
LIG_FHA_1	101	107	PF00498	0.307
LIG_FHA_1	12	18	PF00498	0.390
LIG_FHA_2	63	69	PF00498	0.461
LIG_HP1_1	266	270	PF01393	0.322
LIG_LIR_Gen_1	193	201	PF02991	0.237
LIG_LIR_LC3C_4	324	328	PF02991	0.328
LIG_LIR_Nem_3	159	165	PF02991	0.265
LIG_LIR_Nem_3	187	191	PF02991	0.263
LIG_LIR_Nem_3	193	198	PF02991	0.263
LIG_LIR_Nem_3	66	72	PF02991	0.435
LIG_LYPXL_yS_3	69	72	PF13949	0.395
LIG_MYND_1	20	24	PF01753	0.392
LIG_PTB_Apo_2	164	171	PF02174	0.263
LIG_PTB_Phospho_1	164	170	PF10480	0.263
LIG_Rb_pABgroove_1	174	182	PF01858	0.328
LIG_SH2_NCK_1	170	174	PF00017	0.263
LIG_SH2_STAP1	309	313	PF00017	0.322
LIG_SH2_STAT5	100	103	PF00017	0.297
LIG_SH2_STAT5	18	21	PF00017	0.397
LIG_SH2_STAT5	201	204	PF00017	0.322
LIG_SH2_STAT5	91	94	PF00017	0.304
LIG_SH3_3	125	131	PF00018	0.624
LIG_SH3_3	17	23	PF00018	0.418
LIG_SH3_3	46	52	PF00018	0.587
LIG_SH3_3	55	61	PF00018	0.528
LIG_SUMO_SIM_par_1	13	19	PF11976	0.391
LIG_SUMO_SIM_par_1	73	79	PF11976	0.263
LIG_SxIP_EBH_1	138	150	PF03271	0.457
LIG_TYR_ITIM	67	72	PF00017	0.429
MOD_CK1_1	126	132	PF00069	0.587
MOD_CK1_1	16	22	PF00069	0.390
MOD_CK1_1	26	32	PF00069	0.413
MOD_CK1_1	312	318	PF00069	0.263
MOD_CK1_1	6	12	PF00069	0.391
MOD_CK2_1	190	196	PF00069	0.218
MOD_Cter_Amidation	238	241	PF01082	0.614
MOD_GlcNHglycan	136	139	PF01048	0.585
MOD_GlcNHglycan	142	145	PF01048	0.470
MOD_GlcNHglycan	155	159	PF01048	0.295
MOD_GlcNHglycan	208	211	PF01048	0.519
MOD_GlcNHglycan	215	218	PF01048	0.582
MOD_GlcNHglycan	242	245	PF01048	0.569
MOD_GlcNHglycan	249	252	PF01048	0.539
MOD_GlcNHglycan	310	314	PF01048	0.263
MOD_GlcNHglycan	8	11	PF01048	0.392
MOD_GSK3_1	122	129	PF00069	0.464
MOD_GSK3_1	242	249	PF00069	0.577
MOD_GSK3_1	308	315	PF00069	0.281
MOD_GSK3_1	36	43	PF00069	0.431
MOD_NEK2_1	3	8	PF00069	0.394
MOD_NEK2_1	44	49	PF00069	0.402
MOD_PIKK_1	26	32	PF00454	0.424
MOD_PKA_1	240	246	PF00069	0.606
MOD_PKA_2	123	129	PF00069	0.596
MOD_PKA_2	240	246	PF00069	0.606
MOD_PKA_2	34	40	PF00069	0.433
MOD_PKB_1	11	19	PF00069	0.424
MOD_PKB_1	287	295	PF00069	0.328
MOD_Plk_1	196	202	PF00069	0.299
MOD_Plk_1	275	281	PF00069	0.311
MOD_Plk_4	13	19	PF00069	0.391
MOD_Plk_4	190	196	PF00069	0.265
MOD_Plk_4	40	46	PF00069	0.416
MOD_ProDKin_1	126	132	PF00069	0.550
MOD_ProDKin_1	16	22	PF00069	0.395
MOD_ProDKin_1	23	29	PF00069	0.404
TRG_ENDOCYTIC_2	162	165	PF00928	0.263
TRG_ENDOCYTIC_2	69	72	PF00928	0.395
TRG_ER_diArg_1	286	289	PF00400	0.352
TRG_ER_diArg_1	48	51	PF00400	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE58	Leptomonas seymouri	64%	100%
A0A1X0NN55	Trypanosomatidae	39%	100%
A0A3Q8I8G7	Leishmania donovani	88%	100%
A4H5R6	Leishmania braziliensis	74%	100%
A4HU06	Leishmania infantum	88%	100%
A5D7F5	Bos taurus	31%	100%
E9AMT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q6IMK3	Danio rerio	32%	100%
Q6IML7	Rattus norvegicus	31%	100%
Q6IMM1	Gallus gallus	31%	100%
Q7ZYF1	Xenopus laevis	29%	100%
Q8CFP6	Mus musculus	31%	100%