Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHT8_LEIMA

TriTrypDb:

LmjF.09.0860 , LMJLV39_090014800 , LMJSD75_090014600

Length:

106

Annotations

LeishMANIAdb annotations

A very small protein, that could also possibly be organellar (mitochondrial). A transit peptide cannot be excluded in the sequence.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	4
GO:0016020	membrane	2	8
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QHT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHT8

Function

Biological processes
Term	Name	Level	Count
GO:0008535	respiratory chain complex IV assembly	7	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0017004	cytochrome complex assembly	6	2
GO:0022607	cellular component assembly	4	2
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.375
CLV_NRD_NRD_1	27	29	PF00675	0.473
CLV_NRD_NRD_1	54	56	PF00675	0.557
CLV_PCSK_FUR_1	52	56	PF00082	0.581
CLV_PCSK_KEX2_1	22	24	PF00082	0.318
CLV_PCSK_KEX2_1	27	29	PF00082	0.371
CLV_PCSK_KEX2_1	54	56	PF00082	0.556
CLV_PCSK_KEX2_1	6	8	PF00082	0.467
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.443
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.473
CLV_PCSK_PC7_1	23	29	PF00082	0.420
DEG_Nend_UBRbox_3	1	3	PF02207	0.638
DOC_MAPK_gen_1	67	75	PF00069	0.420
DOC_PP2B_LxvP_1	75	78	PF13499	0.427
LIG_14-3-3_CanoR_1	14	21	PF00244	0.668
LIG_14-3-3_CanoR_1	23	31	PF00244	0.565
LIG_APCC_ABBA_1	44	49	PF00400	0.420
LIG_FHA_1	14	20	PF00498	0.631
LIG_LIR_Gen_1	85	91	PF02991	0.354
LIG_LIR_LC3C_4	26	31	PF02991	0.560
LIG_LIR_Nem_3	85	90	PF02991	0.393
LIG_RPA_C_Fungi	23	35	PF08784	0.319
LIG_SH2_CRK	41	45	PF00017	0.394
LIG_SH2_STAT5	4	7	PF00017	0.593
LIG_SH2_STAT5	41	44	PF00017	0.315
LIG_SH2_STAT5	45	48	PF00017	0.445
LIG_SH2_STAT5	8	11	PF00017	0.577
MOD_GlcNHglycan	35	38	PF01048	0.269
MOD_PIKK_1	13	19	PF00454	0.437
MOD_PK_1	55	61	PF00069	0.435
MOD_PKA_1	22	28	PF00069	0.642
MOD_PKA_2	13	19	PF00069	0.612
MOD_PKA_2	22	28	PF00069	0.633
TRG_ENDOCYTIC_2	41	44	PF00928	0.324
TRG_ENDOCYTIC_2	87	90	PF00928	0.475
TRG_ER_diArg_1	27	29	PF00400	0.622
TRG_ER_diArg_1	52	55	PF00400	0.544
TRG_ER_diArg_1	68	71	PF00400	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P760	Leptomonas seymouri	66%	100%
A0A0S4IM31	Bodo saltans	41%	85%
A0A3S5H6E0	Leishmania donovani	93%	100%
A4H5R7	Leishmania braziliensis	81%	100%
A4HU07	Leishmania infantum	93%	100%
D0A9H2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AMT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%