Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHT7_LEIMA

TriTrypDb:

LmjF.09.0870 , LMJLV39_090014900 , LMJSD75_090014700

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	462	466	PF00656	0.588
CLV_NRD_NRD_1	120	122	PF00675	0.673
CLV_NRD_NRD_1	151	153	PF00675	0.633
CLV_NRD_NRD_1	437	439	PF00675	0.658
CLV_NRD_NRD_1	456	458	PF00675	0.492
CLV_NRD_NRD_1	483	485	PF00675	0.529
CLV_NRD_NRD_1	9	11	PF00675	0.621
CLV_PCSK_KEX2_1	11	13	PF00082	0.527
CLV_PCSK_KEX2_1	119	121	PF00082	0.487
CLV_PCSK_KEX2_1	151	153	PF00082	0.633
CLV_PCSK_KEX2_1	456	458	PF00082	0.660
CLV_PCSK_KEX2_1	520	522	PF00082	0.566
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.527
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.487
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.566
CLV_PCSK_PC7_1	115	121	PF00082	0.551
CLV_PCSK_SKI1_1	120	124	PF00082	0.552
CLV_PCSK_SKI1_1	416	420	PF00082	0.603
CLV_PCSK_SKI1_1	439	443	PF00082	0.548
DEG_APCC_DBOX_1	287	295	PF00400	0.548
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DEG_SCF_FBW7_1	316	322	PF00400	0.671
DEG_SPOP_SBC_1	74	78	PF00917	0.674
DOC_CKS1_1	316	321	PF01111	0.672
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.652
DOC_MAPK_gen_1	520	526	PF00069	0.586
DOC_MAPK_RevD_3	443	457	PF00069	0.614
DOC_PP2B_LxvP_1	20	23	PF13499	0.674
DOC_PP2B_LxvP_1	445	448	PF13499	0.606
DOC_PP4_FxxP_1	300	303	PF00568	0.675
DOC_PP4_FxxP_1	374	377	PF00568	0.656
DOC_PP4_MxPP_1	441	444	PF00568	0.574
DOC_USP7_MATH_1	15	19	PF00917	0.607
DOC_USP7_MATH_1	268	272	PF00917	0.532
DOC_USP7_MATH_1	337	341	PF00917	0.634
DOC_USP7_MATH_1	75	79	PF00917	0.678
DOC_WW_Pin1_4	299	304	PF00397	0.720
DOC_WW_Pin1_4	315	320	PF00397	0.634
DOC_WW_Pin1_4	323	328	PF00397	0.642
DOC_WW_Pin1_4	392	397	PF00397	0.726
DOC_WW_Pin1_4	407	412	PF00397	0.574
LIG_14-3-3_CanoR_1	259	263	PF00244	0.645
LIG_14-3-3_CanoR_1	438	442	PF00244	0.559
LIG_Actin_WH2_2	88	104	PF00022	0.583
LIG_BRCT_BRCA1_1	339	343	PF00533	0.627
LIG_EVH1_1	442	446	PF00568	0.581
LIG_FHA_1	174	180	PF00498	0.472
LIG_FHA_1	381	387	PF00498	0.711
LIG_FHA_1	399	405	PF00498	0.573
LIG_FHA_1	417	423	PF00498	0.504
LIG_FHA_1	74	80	PF00498	0.676
LIG_FHA_2	142	148	PF00498	0.521
LIG_FHA_2	240	246	PF00498	0.600
LIG_FHA_2	351	357	PF00498	0.678
LIG_FHA_2	475	481	PF00498	0.527
LIG_LIR_Apic_2	372	377	PF02991	0.650
LIG_LIR_Gen_1	254	264	PF02991	0.508
LIG_LIR_Gen_1	493	502	PF02991	0.567
LIG_LIR_Nem_3	254	260	PF02991	0.511
LIG_LIR_Nem_3	493	497	PF02991	0.548
LIG_MYND_1	443	447	PF01753	0.595
LIG_PDZ_Class_2	521	526	PF00595	0.584
LIG_PDZ_Wminus1_1	524	526	PF00595	0.631
LIG_PTAP_UEV_1	305	310	PF05743	0.623
LIG_PTB_Apo_2	59	66	PF02174	0.690
LIG_SH2_CRK	367	371	PF00017	0.594
LIG_SH2_CRK	494	498	PF00017	0.559
LIG_SH2_CRK	98	102	PF00017	0.556
LIG_SH2_NCK_1	432	436	PF00017	0.592
LIG_SH2_PTP2	257	260	PF00017	0.514
LIG_SH2_STAP1	2	6	PF00017	0.580
LIG_SH2_STAT3	191	194	PF00017	0.446
LIG_SH2_STAT5	191	194	PF00017	0.482
LIG_SH2_STAT5	257	260	PF00017	0.514
LIG_SH2_STAT5	367	370	PF00017	0.580
LIG_SH2_STAT5	373	376	PF00017	0.569
LIG_SH2_STAT5	491	494	PF00017	0.542
LIG_SH3_2	444	449	PF14604	0.656
LIG_SH3_3	300	306	PF00018	0.679
LIG_SH3_3	313	319	PF00018	0.616
LIG_SH3_3	336	342	PF00018	0.639
LIG_SH3_3	383	389	PF00018	0.643
LIG_SH3_3	405	411	PF00018	0.641
LIG_SH3_3	440	446	PF00018	0.629
LIG_SH3_3	509	515	PF00018	0.651
LIG_SH3_3	79	85	PF00018	0.662
LIG_SH3_CIN85_PxpxPR_1	444	449	PF14604	0.656
LIG_TRAF2_1	139	142	PF00917	0.565
LIG_TRAF2_1	252	255	PF00917	0.535
LIG_TYR_ITIM	365	370	PF00017	0.599
LIG_TYR_ITIM	492	497	PF00017	0.551
LIG_UBA3_1	185	193	PF00899	0.392
LIG_WRC_WIRS_1	1	6	PF05994	0.574
LIG_WW_2	443	446	PF00397	0.592
LIG_WW_3	446	450	PF00397	0.664
MOD_CK1_1	210	216	PF00069	0.658
MOD_CK1_1	238	244	PF00069	0.563
MOD_CK1_1	302	308	PF00069	0.698
MOD_CK1_1	317	323	PF00069	0.615
MOD_CK1_1	433	439	PF00069	0.458
MOD_CK1_1	493	499	PF00069	0.559
MOD_CK1_1	5	11	PF00069	0.703
MOD_CK1_1	78	84	PF00069	0.615
MOD_CK2_1	141	147	PF00069	0.469
MOD_CK2_1	350	356	PF00069	0.683
MOD_Cter_Amidation	518	521	PF01082	0.566
MOD_GlcNHglycan	17	20	PF01048	0.628
MOD_GlcNHglycan	237	240	PF01048	0.612
MOD_GlcNHglycan	306	309	PF01048	0.613
MOD_GlcNHglycan	339	342	PF01048	0.645
MOD_GlcNHglycan	377	380	PF01048	0.676
MOD_GlcNHglycan	432	435	PF01048	0.596
MOD_GSK3_1	221	228	PF00069	0.758
MOD_GSK3_1	235	242	PF00069	0.734
MOD_GSK3_1	307	314	PF00069	0.754
MOD_GSK3_1	315	322	PF00069	0.682
MOD_GSK3_1	348	355	PF00069	0.578
MOD_GSK3_1	375	382	PF00069	0.579
MOD_GSK3_1	412	419	PF00069	0.572
MOD_GSK3_1	433	440	PF00069	0.511
MOD_GSK3_1	74	81	PF00069	0.604
MOD_N-GLC_1	15	20	PF02516	0.614
MOD_N-GLC_1	500	505	PF02516	0.636
MOD_NEK2_1	207	212	PF00069	0.621
MOD_NEK2_1	350	355	PF00069	0.651
MOD_NEK2_1	463	468	PF00069	0.512
MOD_NEK2_1	492	497	PF00069	0.551
MOD_NEK2_1	58	63	PF00069	0.567
MOD_NEK2_2	75	80	PF00069	0.677
MOD_PIKK_1	173	179	PF00454	0.447
MOD_PIKK_1	307	313	PF00454	0.706
MOD_PKA_2	173	179	PF00069	0.434
MOD_PKA_2	258	264	PF00069	0.643
MOD_PKA_2	437	443	PF00069	0.683
MOD_PKA_2	463	469	PF00069	0.592
MOD_Plk_1	105	111	PF00069	0.478
MOD_Plk_1	449	455	PF00069	0.672
MOD_Plk_2-3	474	480	PF00069	0.555
MOD_Plk_4	187	193	PF00069	0.475
MOD_Plk_4	365	371	PF00069	0.567
MOD_Plk_4	437	443	PF00069	0.656
MOD_Plk_4	463	469	PF00069	0.513
MOD_Plk_4	75	81	PF00069	0.698
MOD_ProDKin_1	299	305	PF00069	0.720
MOD_ProDKin_1	315	321	PF00069	0.635
MOD_ProDKin_1	323	329	PF00069	0.639
MOD_ProDKin_1	392	398	PF00069	0.724
MOD_ProDKin_1	407	413	PF00069	0.573
MOD_SUMO_for_1	129	132	PF00179	0.480
MOD_SUMO_rev_2	33	37	PF00179	0.658
MOD_SUMO_rev_2	480	487	PF00179	0.599
TRG_ENDOCYTIC_2	257	260	PF00928	0.514
TRG_ENDOCYTIC_2	367	370	PF00928	0.601
TRG_ENDOCYTIC_2	494	497	PF00928	0.559
TRG_ENDOCYTIC_2	98	101	PF00928	0.546
TRG_ER_diArg_1	151	153	PF00400	0.649
TRG_ER_diArg_1	288	291	PF00400	0.718
TRG_ER_diArg_1	455	457	PF00400	0.643
TRG_NLS_MonoCore_2	117	122	PF00514	0.503
TRG_NLS_MonoExtN_4	115	122	PF00514	0.543
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J5	Leptomonas seymouri	42%	100%
A0A3Q8IBX4	Leishmania donovani	92%	100%
A4H5N6	Leishmania braziliensis	72%	100%
A4HU08	Leishmania infantum	92%	100%
E9AMT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%