Histone h1-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone h1-like protein

Species:

Leishmania major

UniProt:

Q4QHT6_LEIMA

TriTrypDb:

LmjF.09.0880 , LMJLV39_090015000 , LMJSD75_090014800

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 4
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.442
CLV_NRD_NRD_1	159	161	PF00675	0.789
CLV_NRD_NRD_1	170	172	PF00675	0.518
CLV_NRD_NRD_1	178	180	PF00675	0.360
CLV_NRD_NRD_1	247	249	PF00675	0.462
CLV_NRD_NRD_1	435	437	PF00675	0.682
CLV_NRD_NRD_1	466	468	PF00675	0.702
CLV_PCSK_KEX2_1	159	161	PF00082	0.789
CLV_PCSK_KEX2_1	170	172	PF00082	0.518
CLV_PCSK_KEX2_1	178	180	PF00082	0.360
CLV_PCSK_KEX2_1	247	249	PF00082	0.462
CLV_PCSK_KEX2_1	368	370	PF00082	0.587
CLV_PCSK_KEX2_1	391	393	PF00082	0.569
CLV_PCSK_KEX2_1	473	475	PF00082	0.629
CLV_PCSK_KEX2_1	479	481	PF00082	0.576
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.614
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.542
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.629
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.576
CLV_PCSK_SKI1_1	3	7	PF00082	0.541
CLV_PCSK_SKI1_1	392	396	PF00082	0.574
CLV_PCSK_SKI1_1	436	440	PF00082	0.683
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DEG_SCF_FBW7_1	359	365	PF00400	0.548
DOC_CKS1_1	359	364	PF01111	0.550
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.621
DOC_PP2B_LxvP_1	297	300	PF13499	0.616
DOC_USP7_MATH_1	123	127	PF00917	0.634
DOC_USP7_MATH_1	271	275	PF00917	0.705
DOC_USP7_MATH_1	28	32	PF00917	0.553
DOC_USP7_MATH_1	362	366	PF00917	0.686
DOC_USP7_MATH_1	39	43	PF00917	0.629
DOC_USP7_MATH_1	462	466	PF00917	0.765
DOC_USP7_UBL2_3	314	318	PF12436	0.606
DOC_USP7_UBL2_3	391	395	PF12436	0.629
DOC_USP7_UBL2_3	424	428	PF12436	0.614
DOC_USP7_UBL2_3	433	437	PF12436	0.633
DOC_USP7_UBL2_3	440	444	PF12436	0.577
DOC_USP7_UBL2_3	468	472	PF12436	0.627
DOC_WW_Pin1_4	153	158	PF00397	0.533
DOC_WW_Pin1_4	195	200	PF00397	0.481
DOC_WW_Pin1_4	348	353	PF00397	0.587
DOC_WW_Pin1_4	358	363	PF00397	0.616
DOC_WW_Pin1_4	405	410	PF00397	0.640
LIG_14-3-3_CanoR_1	122	128	PF00244	0.521
LIG_14-3-3_CanoR_1	321	329	PF00244	0.657
LIG_14-3-3_CanoR_1	446	454	PF00244	0.673
LIG_14-3-3_CanoR_1	467	475	PF00244	0.629
LIG_Actin_WH2_2	322	339	PF00022	0.513
LIG_BIR_III_4	68	72	PF00653	0.555
LIG_Clathr_ClatBox_1	82	86	PF01394	0.621
LIG_FHA_1	199	205	PF00498	0.466
LIG_FHA_2	236	242	PF00498	0.605
LIG_FHA_2	288	294	PF00498	0.681
LIG_LIR_Nem_3	93	99	PF02991	0.540
LIG_NRP_CendR_1	483	484	PF00754	0.689
LIG_Pex14_2	100	104	PF04695	0.527
LIG_SH2_NCK_1	338	342	PF00017	0.528
LIG_SH2_STAP1	338	342	PF00017	0.528
LIG_SH2_STAT5	96	99	PF00017	0.544
LIG_SH3_1	395	401	PF00018	0.603
LIG_SH3_2	398	403	PF14604	0.612
LIG_SH3_3	193	199	PF00018	0.491
LIG_SH3_3	356	362	PF00018	0.645
LIG_SH3_3	395	401	PF00018	0.571
LIG_SH3_3	439	445	PF00018	0.643
LIG_SH3_4	433	440	PF00018	0.691
LIG_SUMO_SIM_anti_2	111	118	PF11976	0.591
LIG_SUMO_SIM_par_1	81	88	PF11976	0.616
LIG_WW_3	433	437	PF00397	0.554
MOD_CDC14_SPxK_1	156	159	PF00782	0.530
MOD_CDK_SPK_2	348	353	PF00069	0.630
MOD_CDK_SPxK_1	153	159	PF00069	0.532
MOD_CDK_SPxxK_3	153	160	PF00069	0.531
MOD_CK1_1	143	149	PF00069	0.645
MOD_CK1_1	18	24	PF00069	0.573
MOD_CK1_1	184	190	PF00069	0.535
MOD_CK1_1	195	201	PF00069	0.438
MOD_CK1_1	276	282	PF00069	0.632
MOD_CK1_1	31	37	PF00069	0.657
MOD_CK2_1	235	241	PF00069	0.470
MOD_CK2_1	287	293	PF00069	0.677
MOD_GlcNHglycan	117	120	PF01048	0.685
MOD_GlcNHglycan	183	186	PF01048	0.528
MOD_GlcNHglycan	21	24	PF01048	0.646
MOD_GlcNHglycan	278	281	PF01048	0.601
MOD_GlcNHglycan	318	321	PF01048	0.645
MOD_GlcNHglycan	330	333	PF01048	0.578
MOD_GlcNHglycan	338	341	PF01048	0.556
MOD_GlcNHglycan	41	44	PF01048	0.391
MOD_GlcNHglycan	90	93	PF01048	0.567
MOD_GSK3_1	143	150	PF00069	0.557
MOD_GSK3_1	15	22	PF00069	0.603
MOD_GSK3_1	231	238	PF00069	0.504
MOD_GSK3_1	316	323	PF00069	0.655
MOD_GSK3_1	34	41	PF00069	0.605
MOD_GSK3_1	358	365	PF00069	0.654
MOD_GSK3_1	436	443	PF00069	0.640
MOD_GSK3_1	446	453	PF00069	0.543
MOD_GSK3_1	462	469	PF00069	0.573
MOD_N-GLC_1	219	224	PF02516	0.437
MOD_N-GLC_1	348	353	PF02516	0.619
MOD_N-GLC_1	88	93	PF02516	0.589
MOD_NEK2_1	16	21	PF00069	0.678
MOD_NEK2_1	203	208	PF00069	0.494
MOD_NEK2_1	219	224	PF00069	0.472
MOD_NEK2_1	336	341	PF00069	0.517
MOD_NEK2_1	49	54	PF00069	0.603
MOD_NEK2_2	58	63	PF00069	0.692
MOD_PIKK_1	184	190	PF00454	0.467
MOD_PIKK_1	203	209	PF00454	0.447
MOD_PIKK_1	265	271	PF00454	0.692
MOD_PIKK_1	273	279	PF00454	0.457
MOD_PIKK_1	49	55	PF00454	0.634
MOD_PIKK_1	61	67	PF00454	0.646
MOD_PK_1	450	456	PF00069	0.644
MOD_PKA_1	368	374	PF00069	0.636
MOD_PKA_1	436	442	PF00069	0.683
MOD_PKA_2	320	326	PF00069	0.660
MOD_PKA_2	336	342	PF00069	0.508
MOD_PKA_2	368	374	PF00069	0.654
MOD_PKA_2	445	451	PF00069	0.651
MOD_PKA_2	466	472	PF00069	0.695
MOD_PKA_2	6	12	PF00069	0.611
MOD_PKB_1	179	187	PF00069	0.533
MOD_Plk_1	110	116	PF00069	0.635
MOD_Plk_1	140	146	PF00069	0.659
MOD_Plk_1	219	225	PF00069	0.429
MOD_Plk_1	31	37	PF00069	0.482
MOD_Plk_4	110	116	PF00069	0.635
MOD_Plk_4	287	293	PF00069	0.629
MOD_Plk_4	325	331	PF00069	0.567
MOD_ProDKin_1	153	159	PF00069	0.532
MOD_ProDKin_1	195	201	PF00069	0.476
MOD_ProDKin_1	348	354	PF00069	0.592
MOD_ProDKin_1	358	364	PF00069	0.619
MOD_ProDKin_1	405	411	PF00069	0.637
MOD_SUMO_for_1	226	229	PF00179	0.429
TRG_ER_diArg_1	170	172	PF00400	0.570
TRG_ER_diArg_1	178	181	PF00400	0.424
TRG_ER_diArg_1	246	248	PF00400	0.479
TRG_ER_diArg_1	474	477	PF00400	0.542
TRG_NLS_MonoCore_2	472	477	PF00514	0.542
TRG_NLS_MonoExtC_3	471	476	PF00514	0.543
TRG_NLS_MonoExtN_4	472	477	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW1	Leptomonas seymouri	44%	94%
A0A3Q8I7H5	Leishmania donovani	89%	99%
A4H5N7	Leishmania braziliensis	58%	98%
A4HU09	Leishmania infantum	89%	99%
E9AMT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	94%